MICHAEL FRANCIS WANGLER, M.D.
Assistant Professor, Department of Molecular and Human Genetics
Baylor College of Medicine
Mailing Address:
Jan and Dan Duncan Neurological Research Institute
1250 Moursund Street, Suite 1050
Mailstop NR-1125
Houston, TX 77030
Tel: 832-824-8716 Email:
Lab website:
Social Media: Twitter, LinkedIn
Education
1996-2000Bachelors of Science (B.S.), University of California San Diego.
2000-2001Masters of Science (M.S.), Division of Biology, University of California San Diego.
2001-2003Medical Student at University of New Mexico School of Medicine, Albuquerque
2003-2004Research Fellow, Doris Duke Clinical Research Fellowship for Medical Students at Washington University in St Louis.
2004-2006Medical Doctorate (M.D.), Baylor College of Medicine, Houston, Texas.
Residency Training
2006-2009Pediatric Resident, Baylor College of Medicine
2009-2011Medical Genetics Fellowship, Department of Molecular and Human Genetics, Baylor College of Medicine
Academic Appointments
2011-2016Non-tenure track faculty, Department of Molecular and Human Genetics, Baylor College of Medicine
2016-presentAssistant Professor, Department of Molecular and Human Genetics, Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital
Licensure and Board Certification
American Board of Medical Genetics 2011-present
American Board of Pediatrics 2009-present
Licensed Physician,Texas Medical Board
Other Experience and Professional Memberships
2014- presentScientific Advisory Board- Global Foundation for Peroxisomal Disorders (GFPD)
2014-presentCourse Director- Pediatric Resident Education in Medical Genetics
2014-present American Society of Human Genetics
2011-presentMember Genetic Society of America
2006-2009Member, American Academy of Pediatrics
2010-presentAd hoc peer review for Proceedings of the National Academy of Sciences, PLOS Genetics, PLOS One, Human Molecular Genetics, American Journal of Medical Genetics, Journal of Inherited Metabolic disease
Publons Profile (Reviews: 78th percentile)
Honors
2011Baylor College of Medicine Molecular and Human Genetics-“Most Outstanding Fellow”
2009Baylor College of Medicine Pediatric Residency- “Most Outstanding Research”
2001UC San Diego Vice-Chancellor Scholar Athlete Award
2000Phi Beta Kappa UC San Diego
Former and Current Trainees
Yu-Hsin Chao- Research technician 2013-present
Xi Luo -post doctoral fellow October 2015-present
Ning Liu- post doctoral fellow October 2015- present
Laurie Robak- medical genetics fellow February 2015-present
Sharon Li Cheng- medical student genetics research track 2015
Meredith Ventura- medical student genetics research track 2015
Teaching and Mentorship
Invited mentor for Trainee mentor lunch American College of Medical Genetics, March 10, 2016
Publications (#Citations taken from Google Scholar 12/2016)
Luo X, Rosenfeld JA, Yamamoto S, Harel T, , Pastore M, Bartholomew D, Delgado M, Rotenberg J, Lewis RA, Almannai M, Emrick L, , Ummat M, Bacino C, Eldomery M, Akdemir ZC, Xia F, Members of the UDN, Lotze T Lupski JR, Lalani S Yang Y, Lee B, , Bellen HJ, Wangler MF. “Missense de novo variants in the CACNA1A associated with severe early onset ataxias can be gain or loss of function in Drosophila.” Submitted.
Wangler MF#, Chao YH, Bayat V, Giagtzoglu N, Putluri, N, Coarfa C, Faust J, McNew J, Moser A,. Sardiello M, Baes M, Bellen HJ. “Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse” In revision #Corresponding Author
Wang J, Al-Ouran R, Hu Y, Kim SY, Wan YW, Wangler MF, Yamamoto S, Chao HT, Aram Comjean A, Mohr S, Members of UDN, Perrimon N, Liu Z, Bellen HJ “MARRVEL: Integration of human and model organism genetic resources to facilitate functional annotation of the human genome” In Press American Journal of Human Genetics
Eldomery MK, Coban-Akdemir Z, Harel T, Rosenfeld JA, Gambin T, Stray-Pedersen A, Küry S, Mercier S, Lessel D, Denecke J, Wiszniewski W, Penney S, Liu P, Bi W, Lalani SR, Schaaf CP, Wangler MF, Bacino CA, Lewis RA, Potocki L, Graham BH, Belmont JW, Scaglia F, Orange JS, Jhangiani SN, Chiang T, Doddapaneni H, Hu J, Muzny DM, Xia F, Beaudet AL, Boerwinkle E, Eng CM, Plon SE, Sutton VR, Gibbs RA, Posey JE, Yang Y, Lupski JR. (2017)“Lessons learned from additional research analyses of unsolved clinical exome cases.” Genome Med. Mar 21;9(1):26. doi: 10.1186/s13073-017-0412-6.PMID:28327206
Schoch K, Meng L, Szelinger S,Bearden DR,Stray-Pedersen A, Busk OL, Stong N,Liston E, Cohn RD, Scaglia F,Rosenfeld JA, Tarpinian J, Skraban CM, Deardorff M, Friedman JN, Adkemir ZC, Walley N, Mikati MA, Kranz PG, Jasien, J, McConkie-Rosell A, McDonald, M, Wechsler S, Freemark M, Kansagra S, Freedman S, Bali D, Zamora FM, Bale S, Nelson S, Lee H,Dorrani N, UCLA Clinical Genomics Center,Members of the UDN, Goldstein D, Xiao R,Yang Y,Posey JE,Martinez-Agosto JA, Lupski JR, Wangler MF#, Shashi V# (2017) “A Recurrent de novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts and Profound Developmental Delay” American Journal of Human GeneticsFeb 2;100(2):343-351.#Corresponding Authors
Wangler MF, Hu Y, Shulman J. (2017) “Drosophila and Genome-wide Association Studies: A Review and Resource for the Functional Dissection of Human Complex Traits.” Disease Models and MechanismsFeb 1;10(2):77-88. doi: 10.1242/dmm.027680. PMID:28151408
Yoon WH, Sandoval H, Nagarkar Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Arboleda V, Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ (2017) “Nardilysin chaperones mitochondrial Oxoglutarate dehydrogenase and protects against the demise of neurons in flies and human.” Neuron Jan 4;93(1):115-131.
Chao H-T, Davids M, Burke E, Pappas JG, Rosenfeld JA, McCarty A, Davis T, Wolfe L, Toro C, Tifft C, Xia F, Johnson TK, Warr CG, Members of the UDN, Yamamoto S, Adams D., Markello TC, Gahl WA, Bellen HJ, Wangler MF✝ Malicdan, MC✝ (2017) “A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3.” American Journal of Human GeneticsJan 5;100(1):128-137 ✝Corresponding Authors
Ventura MJ, Wheaton D, Xu M, Birch D, Bowne SJ, Sullivan LS, Daiger SP, Whitney AE, Jones RO, Moser AB, Chen R. Wangler MF. (2016) “Diagnosis of a mild peroxisomal phenotype with next-generation sequencing” AcceptedMolecular Genetics and Metabolism Reports Nov 11;9:75-78 PMID: 27872819 PMCID: PMC5109284
Donti TR, Cappuccio G, Neira J, Atwal PS, Miller MJ, Cardon AL, Sutton VR, Porter BE, Baumer FM, Wangler MF, Sun Q, Emrick LT, Elsea SH. (2016) “Diagnosis of adenylosuccindate lyase deficiency by metabolomics profiling in plasma reveals a phenotypic spectrum. Molecular Genetics and Metabolism Reports Jul 27; 8:61-6. PMID: 27504266 PMCID: PMC4969260
Chao Y-H, Robak L, Xia F, Koenig M, Adesina A, Bacino CA, Scaglia F, Bellen HJ, Wangler MF. (2016) “Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila”. Human Molecular GeneticsMay 1;25(9):1846-56 PMID 26931468 PMCID: PMC5007591
Braverman NE, Raymond GV, Rizzo WB, Moser AB, Wilkinson ME, Stone EM, Steinberg SJ, Wangler MF, Hacia JG, Bose M. (2015) “Peroxisome Biogenesis Disorders in the Zellweger Spectrum: an overview of current diagnosis, clinical manifestations and treatment guidelines.” Molecular Genetics and Metabolism Dec 23. pii: S1096-7192(15)30093-7 PMID: 26750748Cited 8 times
Bacino C, Chao Y-H, Seto E, Lotze T, Xia F, Moser A,Wangler MF(2015) “A homozygous mutation in PEX16 identified by whole-exome sequencing ending a diagnostic oddyssey”Molecular Genetics and Metabolism Reports, 2015 Dec 1;5:15-18.PMID:26644994 PMCID: PMC4669579
Wangler MF, Beaudet AL. ACTG2-Related Disorders. (2015) Jun 11. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: PMID:26072522
Wangler, MF, Bayat V, Bellen HJ (2015). "A mitochondrial translation defect identified by whole-exome sequencing expands the phenotypic spectrum for MARS2" Human Mutation Jun;36(6):iii. doi: 10.1002/humu.22811.
Wangler, MF, Yamamoto S, Bellen, H. (2015) “Fruitflies in Biomedical Research”Genetics, Jan 26. pii: genetics. 114.171785. PMID:25624315; PMCID:PMC4349060(Faculty of 1000) Cited 30 times
Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LM, de Ligt J, Jhangiani S, Xie Y, Tsang S, Parman Y, Sivaci M, Battaloglu E, Muzny DM, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Schulze KL, Boerwinkle EA, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF#, Bellen HJ#. (2014). “A Drosophila genetic resource to study human disease genes and its use for gene discovery in human exome data” Cell,Sep 25;159(1):200-14. doi: 10.1016/j.cell.2014.09.002. PMID: 25259927; PMCID:PMC4298142#Corresponding Authors. (Faculty of 1000). Cited 53 times
Faust, JE, Manisundaram A, Ivanova PT, Milne SB, Summerville JB, Brown HA, Wangler MF, Stern M, McNew JA. (2014) “Peroxisomes are Required for Lipid Metabolism and Muscle Function in Drosophila melanogaster.” PLOS OneJun 19;9(6):e100213. PMID:24945818; PMCID:PMC4063865
Xia F, Bainbridge M, Tan TY, Wangler MF, Scheuerle A, Zackai EH, Sutton VR, Nalam R, Zhu W, Nash M, Ryan M, Lee J, Lupski JR, Beaudet AL, Plon SE, Boerwinkle EA, Eng CM, Muzny DM, Yang Y, Gibbs RA. (2014). “De novo truncating mutations in the AHDC1 gene in patients with syndromic speech disability and sleep apnea” American Journal of Human Genetics May 1;94(5):784-9. PMID: 24791903; PMCID:PMC4067559Cited 12 times
Wangler MF, Gonzaga-Jauregui C, Gambin T, Penney S, Moss T, Chopra A, Probst FJ, Xia F, Yang Y, Werlin S, Eglite I, Kornejeva L, Bacino CA, Baldridge D, Neul J, Lehman EL, Larson A, Beuten J, Muzny DM, Jhangiani S, Baylor-Hopkins Center for Mendelian Genomics, Gibbs RA, Lupski JR, Beaudet A. (2014) “Heterozygous de novo and inherited mutations in ACTG2 underly Megacystis-microcolon intestinal hypoperistalsis syndrome.” PLOS GeneticsMar 27;10(3):e1004258 PMID:24676022; PMCID:PMC3967950Cited 21 times
Wangler MF, Chavan R, Hicks MJ, Nuchtern JG, Hegde M, Plon SE, Thompson PA. (2013) “Unusually early presentation of small-bowel adenocarcinoma in a patient with Peutz-Jeghers syndrome.” J Pediatri Hematol Oncol. May; 35(4): 323-8. PMID:23426006; PMCID:PMC3708690Cited 10 times
Wangler MF, Reiter LT, Zimm G, Trimble-Morgan J, Wu J, Bier E. (2011) “The antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila.” Protein & Cell Jul; 2(7): 554-63. PMID:21822800; PMCID:PMC3702159
Fruhman G, Landsverk ML, Lotze TE, Hunter JV, Wangler MF, Wong LJ, Scagllia F. (2011) “Atypical presentation of Leigh-like encephalopathy associated with a Leber Herediatry Optic Neuropathy primary mitochondrial DNA mutation” Molecular Genetics and MetabolismJun;103(2):153-60. PMID:21414825Cited 10 times
Tompson SW, Bacino CA, Safina NP, Bober MB, Proud VK, Funari T, Wangler MF, Nevarez L, Ala-Kokko L, Wilcox WR, Eyre DR, Krakow D, Cohn DH. (2010) “Fibrochondrogenesis results from mutations in the COL11A1 type XI collagen gene.” Am J Hum Genet. 87(5): 708-712. PMCID: PMC2978944Cited 31 times
Plunkett J, Feitosa MF, Trusgnich M, Wangler M, Palomar L, Kistka ZA, DeFranco EA, Shen T, Stormo A, Puttonen H, Hallman M, Haataja R, Fellman V, Peltonen L, Palotie A, Daw EW, An P, Rice T, Teramo K, Borecki I, Muglia LJ. (2009) Mother’s genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Human Heredity 68(3)209-219. PMCID: PMC2869074Cited 38 times
Kistka ZA, Palomar L, Lee KA, Boslaugh S, Wangler MF, Cole FS, DeBaun MR, Muglia LJ. (2007) Racial Disparity in Recurrence of Preterm Birth. Am J Ob Gynecol. 196(2): 131.e1-6. Cited 142 times
Chang AS, Moley KH, Wangler M, Feinberg AP, DeBaun MR. (2005) Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertil Steril. 2005 83(2): 349-54. PMID:15705373Cited 208 times
Wangler MF, An P, Feinberg AP, Province M, DeBaun MR. (2005) The Inheritance Pattern of Beckwith Wiedemann syndrome is Heterogeneous in 291 Families with an affected Proband. Am J Med Genet A.137(1): 16-21. PMID:16007611PMCID:PMC3947567Cited 5 times
Wangler MF, Chang AS, Moley KH, Feinberg AP, DeBaun MR. (2005) Factors associated with preterm delivery in mothers of children with Beckwith-Wiedemann syndrome: a case cohort study from the BWS registry. Am J Med Genet A.134(2): 187-91. PMID:15723285Cited 32 times
Research Gate Profile
MyNCBI
Google Scholar
Book Chapters
Rednam S, Wangler MF, Neurocutaneous syndromes I. Rudolph’s PediatricsSubmitted
Wangler MF, Rizzo W, Braverman NE. Peroxisomal Disorders. Rudolph’s PediatricsSubmitted
Wangler, MF, Bellen HJ Drosophila models of human disease. Basic Science Methods for Clinical Researchers. Elsevier. In Press.
Chang AS, Moley KH, Wangler M, DeBaun MR. (2006) Evidence for and Against Associations between ART and Congenital Malformation Syndromes. Epigenetic Risks of Cloning. Akio Inui ed. Taylor & Francis Publishing, Boca Raton 2006.
Schaaf C, Wangler MF, Sutton VR, Bacino CA, Belmont JW, Craigen W. (2011) Genetics In: Lowry AW, Nag PK, Bhakta KY, eds. Texas Children's Hospital Handbook of Pediatrics and Neonatology. New York, NY: McGraw-Hill Professional Inc.
Platform and Invited Presentations
Wangler MF, Gonzaga-Jauregui C, Gambin T, Gibbs RA, Lupski JR, Beaudet A. (2014) “Heterozygous de novo and inherited mutations in ACTG2 underly Megacystis-microcolon intestinal hypoperistalsis syndrome.” Cold Spring Harbor Personal Precision Medicine: Personal Genomes and Pharmacogenomics November 13-16, 2013.
Wangler MF, Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman N, Bayat V, Pehlivan D., Penney S, Vissers L, Jhangiani S, Tsang S, Xie Y, Parman Y, Battaloglu E, Muzny D, Liu Z, Clark R, Curry C, Boerwinkle E, Dobyns W, Allikmets R, Gibbs R, Chen R, Lupski JR, Bellen H. “A Drosophila genetic resource to study human disease genes and its use for gene discovery in human exome data.”
October 19th, ASHG 2014 [Due to a severe injury, talk was given by a co-author].
Wangler MF “Accelerating functional annotation of Mendelian disease genes throughDrosophilabiology” Children’s Research Institute, UT Southwestern Dallas July 21st 2015
Robak L, Chao, Y-H, Xia F, Koenig M, Adesina A, Bacino C, Scaglia F, Bellen HJ, Wangler MF. “Missense mutations in the middle domain of DNM1L cause infantile encephalopathy in humans and peroxisomal and mitochondrial defects in Drosophila and humans” October 9th, ASHG 2015
Wangler MF“Insight into Peroxisomal Disorders from Exome Sequencing and Drosophila Genetics” October 27 2015, Steele Children’s Research Center at the University of Arizona
Wangler MF“Insight into Peroxisomal Disorders from Exome Sequencing and Drosophila Genetics” Washington University in St Louis November 12 2015
Wangler MF“Insight into Peroxisomal Disorders from Exome Sequencing and Drosophila Genetics” Friday December 11th 2015University of Washington, Medical Genetics.
Wangler MF “Genomic and Drosophila Functional Screens in Autism and Intellectual Disability” Monday January 23, 2017 UT Health Human Genetics Center
Grant Support
Simons Foundation: SFARI Functional Screen of Autism-Associated Variants
“In Vivo Functional Analysis of Autism Candidate Genes,”
Michael Wangler (PI) 8/1/2015-7/31/2018
The goal of this project is to study Autism associated variants from the Simons Simplex collection study. We will provide in vivo functional information of conserved genes using a combination of human genomics and Drosophila studies.
U54 NS093793Hugo Bellen (PI) 7/1/2015-6/30/2018
The major goal of this project is to establish a model organism screening center that will provide valuable in vivo function information of conserved genes that are likely to be involved in rare human diseases from the Undiagnosed Diseases Network (UDN) by performing genetic experiments in Drosophila and Zebrafish. Role: Drosophila Resource Core PI.
COMPLETED
Simmons Family Foundation Collaborative Research Grant Michael Wangler (PI) 03/15/2013-03/15/2014
The goal of this proposal is to utilize Drosophila melanogaster to identify metabolomic signatures and cellular pathways related to peroxisomal biogenesis defects. These identified biochemical pathways can then be validated in human cells and ultimately in human studies. Role: PI
1K08NS076547 Michael Wangler (PI)9/30/2011-8/31/2016
The proposal describes a five-year mentored laboratory training experience designed to lead to an independent academic career in clinically-relevant basic science. The research seeks to improve our understanding of peroxisomal biogenesis disorders at the molecular level by focusing on peroxisomal biogenesis in Drosophila.
Role: PI