CHAPTER 13

MEIOSIS AND SEXUAL LIFE CYCLES

I.Student misconceptions

  1. Many students have fundamental misunderstandings about chromosomes and their structure and behavior during meiosis. It is very common for students to be confused about ploidy and chromosome structure. Some students are uncertain about the significance of the centromere.
  2. Many students think that chromosomes with a single unreplicated chromatid are characteristic of haploid cells and that replicated chromosomes with two chromatids are characteristic of diploid cells.
  3. Some students think that chromosomes consisting of two chromatids are formed, not by replication, but when a maternal chromatid and a paternal chromatid come together during fertilization and join at the centromere.
  4. Some students do not realize that sister chromatids are joined at the centromere. These students will draw sister chromatids as independent entities throughout meiosis I.
  5. Other students think that all four chromatids of a tetrad are joined by a single centromere during prophase I.
  1. Students may be puzzled by the three types of sexual life cycles shown in Figure 13.6. Familiar with animal life cycles, they may think of meiosis as a sexual process producing gametes. The ideas that meiosis may produce asexual spores (as in plants and fungi) and that gametes may be produced by mitosis (as in plants) are difficult for these students to fully grasp.

II.Pre-test to identify student misconceptions prior to addressing the material covered in Chapter 13

  1. Identify each statement as TRUE or FALSE.
  2. In some organisms, spores are produced by meiosis. True
  3. In some organisms, spores are produced by mitosis. True
  4. In some organisms, gametes are produced by meiosis. True
  5. In some organisms, gametes are produced by mitosis. True
  6. In some organisms, single cells develop into multicellular adults by meiosis. False
  7. In some organisms, single cells develop into multicellular adults by mitosis. True

  1. Look at the cell in the figure above. Based on this figure, which of the following statements is true?
  2. This cell is haploid.
  3. This cell is diploid.
  1. The best explanation for your answer in the previous question is:
  2. Each chromosome consists of two chromatids.
  3. The cell contains two sets of chromosomes.
  1. This chromosome has two chromatids, joined at the centromere. The two chromatids were formed by:
  2. DNA replication of a single chromatid
  3. Fertilization, bringing together maternal and paternal chromatids
  1. How can instructors address and correct the misconceptions that students have about meiosis and sexual life cycles?
  1. The majority of students will have some confusion about the structures and processes of meiosis. And, of course, students who misunderstand meiosis often have difficulty with Mendelian and chromosomal genetics as well.

Most students have studied meiosis in high school. As a result, students are not fully attentive when they encounter the topic again in a first-year class. However, it is likely that they didn’t “get it” the first time and that unresolved misunderstandings will continue.

Think carefully about how to engage students in this important topic. Rather than asking students the questions they expect (for example, Compare and contrast meiosis and mitosis; Describe the events of prophase I),give problems that require students to reason about the process of meiosis. State specific combinations of alleles in daughter cells, and ask students to explain the steps that would produce each combination. Such questions will be more likely to reveal misunderstandings, both to students themselves and to their instructors.

Active learning techniques are crucial with this topic. The majority of students will not fully understand meiosis after reading the text, listening to lecture, and looking at static models or pictures. To diagnose and correct sources of student confusion, it is essential to have students draw the stages of meiosis or model the process with pipe cleaners or modeling clay.

How can an instructor address these fundamental misunderstandings? Clearly distinguish between the concepts of chromosome structure and chromosome number (ploidy) in all discussions of life cycles or the cell cycle. Explain explicitly how the replicated chromosome (with two chromatids joined by a centromere) arises during DNA synthesis, and address possible misunderstandings at the same time.

If students are asked to model the events of meiosis in lab, look carefully at their models for evidence of these common misunderstandings in order to address and resolve them.

  1. Of necessity, instructors mention replication while teaching meiosis. Early prophase I chromosomes may appear unreplicated in drawings and micrographs if they are not fully condensed. These features of instruction may cause student confusion about the timing of the processes of replication and meiosis. Many students think that replication occurs during early meiosis. This is not a trivial mistake. It is hard for students to fully understand the processes of condensation and DNA replication if they imagine that a condensing chromosome can replicate. It is best to address this potential misunderstanding explicitly, by pointing it out as a common source of error.
  1. Students often fail to draw the connections between Mendelian genetics and the process of meiosis. When teaching meiosis, emphasize the events leading to segregation and the independent assortment of chromosomes. When teaching genetics, ask students to explain how Mendel’s laws of segregation and independent assortment can be explained by the behavior of chromosomes during meiosis.
  1. The exercises below may be useful in recognizing and addressing student misconceptions about meiosis and sexual life cycles.

Modeling meiosis

Give students two colors of modeling clay to model maternal and paternal chromosomes. Use small labels for alleles.

  • The cell is diploid with 2n = 4.
  • The cell is heterozygous for three genes: a, b, and c.
  • The maternal alleles are aM, bM, cM; the paternal alleles are aP, bP, cP.
  • The a and b genes are on the same chromosome. The c gene is on the other chromosome.

Ask students to take their chromosomes through three stages:

  1. Model the chromosomes as thin, elongate, unreplicated chromosomes.
  2. Model DNA replication prior to meiosis.
  3. Condense the chromosomes in prophase I.

At this stage, students should show their chromosomes to an instructor. Check the student models for these features:

  1. Make sure that students construct each chromosome as two replicated chromatids joined at the centromere.
  2. Make sure that chromosomes are present as homologous pairs, with partners that are identical in size, shape, and centromere placement.
  3. Look at sister chromatids to make sure they have identical alleles.
  4. Check that the maternal alleles aMandbM and the paternal alleles aPandbP are on different chromosomes.

Ask students to model the events of meiosis that could lead to each of the following sets of haploid daughter cells:

  • aMbMcM ; aMbMcM ; aPbPcP ; aPbPcP
  • aMbMcP ; aMbMcP ; aPbPcM ; aPbPcM
  • aMbMcP ; aMbMcM ; aPbPcM ; aPbPcP
  • aMbMcM ; aMbPcM ; aPbMcP ; aPbPcP

Imagining life cycles

Ask students to draw a very general life cycle (2n  meiosis  n  fertilization). Then have them draw the human life cycle and confirm it by checking Figure 13.6b. Now ask them to imagine a life cycle in which the products of meiosis grew up to adulthood by mitosis, as in plants.

  1. Post-test to identify whether students have corrected their misconceptions

These are true/false questions. Identify each of the lettered answers as TRUE or FALSE.

  1. Which of the following statements is true?
  2. Plants produce gametes by meiosis. False
  3. In most fungi, the only diploid stage is the zygote. True
  4. In plants, both spores and zygotes grow into multicellular adults by mitosis. True
  5. Either haploid or diploid cells can divide by mitosis, but only diploid cells can divide by meiosis. True
  1. Two sister chromatids are joined at the centromere prior to meiosis.
  2. These chromatids make up a diploid chromosome. False
  3. The cell that contains these sister chromatids must be diploid. False
  4. The two sister chromatids were formed by DNA replication of a single chromatid. True
  5. Barring mutation, the two sister chromatids must be identical. True
  1. A cell contains two homologous sets of chromosomes.
  2. The cell that contains these homologous sets of chromosomes must be diploid. True
  3. Each homologous pair of chromosomes was formed by DNA replication of a single chromosome. False
  4. Barring mutation, the two chromosomes in a homologous pair must be identical. False
  5. One member of each homologous pair is from the maternal family line; the other member is from the paternal family line. True
  1. References

Kindfield, A.C.H. (1991). Confusing chromosome number and structure: A common student error. Journal of Biological Education, 25(3), 193201.

Kindfield, A.C.H. (1994). Understanding a basic biological process: Expert and novice models of meiosis. Science Education, 78(3), 255-283.

Student Misconceptions for Campbell Biology, 9th Edition, © Pearson Education, Inc.

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