Karmella A. Haynes, Ph.D.

Ira A. Fulton School of Biological and Health Systems Engineering

Arizona State University, 501E Tyler Mall ECG 346, Tempe, AZ85287-9707

Office (480) 965-4636, Cell (704) 302-7388

EDUCATION

8/08 – 7/11Harvard Medical School
Postdoctoral Research Fellow, Department of Systems Biology

7/06 – 7/08Davidson College
Postdoctoral Research Fellow and Adjunct Assistant Professor, Department of Biology

8/99 – 5/06Washington University in St. Louis
Ph.D., Molecular Genetics, Division of Biology and Biomedical Sciences

8/95 – 5/99Florida Agricultural and Mechanical University
B.S., Biology

RESEARCH TRAINING AND POSITIONS

8/11 – present Arizona State University, School of Biological and Health Systems Engineering
Assistant Professor
Research: Synthetic Biology, engineered human cell epigenetics

8/08 – 7/11Harvard Medical School, Department of Systems Biology

Postdoctoral Research Fellow

Research: Synthetic Biology, synthetic sensors in mammalian cell culture

Mentor: Pamela Silver

7/06  7/08Davidson College, Department of Biology

HHMI Teaching/ Research Postdoctoral Fellowship in Genomics

Research: Synthetic Biology, biocomputational engineering in E. coli

Mentor: A. Malcolm Campbell

8/99 – 5/06Washington University in St. Louis, Division of Biology and Biomedical Sciences

Graduate Student, Postdoctoral Research Associate

Research: Epigenetics, heterochromatin structure in D. melanogaster

Mentor: Sarah C.R. Elgin

6/98 – 8/98Massachusetts Institute of Technology, Minority Summer Research Program

6/97 – 8/97Undergraduate Research Intern

Research: Molecular Genetics, telomere structure in D. melanogaster

Mentor: Mary-Lou Pardue

RESEARCH PUBLICATIONS

Boyle PM, Burrill DR, Inniss MC, Agapakis CM, Deardon A, DeWerd JG, Gedeon AA, Quinn JY, Paull ML. Raman AM, Theilmann MR, Wang L, Winn JC, Medvedik O, Schellenberg K, Haynes KA, Viel A, Brenner TJ, Mathews S, Church GM, Shah JV, Silver PA. (2012) A BioBrick compatible strategy for genetic modification of plants. J Biol Eng. 6:8.

Haynes KA, Ceroni F, Flicker D, Younger A, Silver PA. (2012) A sensitive switch for visualizing natural gene silencing in single cells. ACS Syn Biol. 1:99-106.

Haynes KA, Silver PA. (2011) Synthetic reversal of epigenetic silencing. J. Biol. Chem. 286:27176-27182.

Haynes KA, Broderick ML, Brown AD, Butner TL, Dickson JO, Harden L, Heard LH, Jessen EJ, Malloy KJ, Ogden B, Rosemond S, Simpson S, Zwack E, Campbell AM, Eckdahl T, Heyer LJ, Poet J. (2008) Bacteria engineered to solve the Burnt Pancake Problem. J. Biol. Eng. 2:8.

Riddle NC, Leung W, Haynes KA, Granok HK, Wuller J, Elgin SCR. (2007) An investigation of heterochromatin domains on the fourth chromosome of Drosophila melanogaster. Genetics. 178:1177-1191.

Haynes KA, Gracheva E, Elgin SCR. (2007) A distinct type of heterochromatin within Drosophila melanogaster chromosome 4. Genetics. 175:1539-1542.

Haynes KA, Caudy A, Collins L, Elgin, SCR. (2006) Element 1360 and components of the RNAi system contribute to HP1-dependent silencing of a pericentric reporter. Curr. Biol. 16:2222-2227.

Sun, FL*, Haynes K*, Simpson CL, Lee SD, Collins L, Wuller J, Eissenberg JC, Elgin SC. (2004) cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Mol. Cell Biol. 18:8210-8220. *Authors contributed equally to this work

REVIEWS

Moe-Behrens G, Davis R, Haynes KA (2013) Preparing synthetic biology for the world. Frontiers in Micro Biotechnol. In press.

Silver PA, Haynes KA, Weiss R. (2012) Synthetic meets cell biology. Mol Biol of the Cell. 6:967.

Haynes KA, Silver PA. (2009) Eukaryotic systems broaden the scope of synthetic biology. J. Cell Biol. 187:589-596.

Haynes KA, Broderick ML, Brown AD, Butner TL, Harden L, Heard L, Jessen E, Malloy K, Ogden B, Rosemond S, Simpson S, Zwack E, Campbell AM, Eckdahl T, Heyer LJ, Poet J. (2007) Computing With Living Hardware. IET Synth. Biol. 1:44-47.

Haynes KA, Leibovitch BA, Rangwala SH, Craig C, Elgin SCR. (2004) Analyzing Heterochromatin Formation Using Chromosome 4 of Drosophila melanogaster. Cold Spring Harbor Symp. Quant. Biol. 69:267-272.

SELECTED MEDIA COVERAGE

Nelson, Bryn. Living computers solve complex math puzzle. MSNBC.com. June 6, 2008. Archive link:

Swaminathan, N. DNA Computer Puts Microbes to Work as Number Crunchers. Scientific American. May 30, 2008. Archive link:

National Public Radio. Calculating Bacteria: Real Computer Bugs? Talk of the Nation Science Friday with host Ira Flatow. May 23, 2008. Archive link:

Highfield, R. Bacteria can be turned into living computers. Telegraph, UK. May 20, 2008. Archive link:

Barry, P. I, Computer: Engineered bacteria become the first living computers. Science News. May 19, 2008. Archive link:

Meredith, D. Judges flip for bacterial computer. HHMI Bulletin. May, 2007.

INVITED ORAL PRESENTATIONS & SEMINARS

Haynes KA. Synthetic chromatin for engineering multicellular systems. 7th International Conference on Structural Biology and Functional Genomics. Singapore. Dec 2013.

Haynes KA, Silver PA, Hom C,Davis R, Laughlin B, Damadzadeh B. Synthetic epigenetics for mammalian cell engineering. SynBERC Fall Retreat. Cambridge, MA. Sept 2012.

Haynes KA, Silver PA. Advances in Synthetic Biology. US-Turkey Advanced Study Institute on Global Care Challenges. Antalya, Turkey. July 2012.

Haynes KA, Silver PA. No more magic bullets: Combining synthetic biology with Bioinformatics for engineering medicine. UNC Charlotte Bioinformatics Seminar Series. Charlotte, NC. Feb 2012.

Haynes KA, Silver PA.Rewiring the histone code using synthetic effectors. ASCB Annual Meeting. Denver, CO. Dec 2011.

Haynes KA, Silver PA. Rewiring the histone code with synthetic biology. 8th International Conference on Bioinformatics: From Genomics to Synthetic Biology. Atlanta, GA. Nov 2011

Haynes KA, Silver PA. Engineering Life: The roles of scientists, students and the public. National Centre for Biological Sciences, Tata Institute. Bangalore, India. May 2011.

Haynes KA, Silver PA. Controlling cell states by engaging synthetic factors with chromatin. New England Science Symposium. Boston, MA. Apr 2011. Presentation award winner

Haynes KA. MAGIC Tool: Student-friendly Software for Understanding DNA Microarray Experiments. New Jersey Biotechnology Educators Consortium Annual Conference. West Long Branch, NJ. Oct 2008.

Haynes KA. Reliable and Student-friendly Wet Lab Techniques for Constructing Parts and Devices. iGEM Teach the Teachers Workshop. Tianjin, China. June 2007.

Haynes KA. Creating living hardware using synthetic biology. FAMU Biological Sciences Colloquium seminar. Tallahassee, FL. Apr 2007.

Haynes KA, Caudy AA, Elgin SCR. A copy of repetitive element 1360 is required for silencing of a pericentric transgene in Drosophila melanogaster. The American Society for Biochemistry and Molecular Biology Annual Meeting. San Francisco, CA. Apr 2006.

Haynes KA, Caudy AA, Elgin SCR. A copy of repetitive element 1360 contributes to silencing of a pericentric transgene in Drosophila melanogaster. New England Science Symposium. Boston, MA. Mar 2006. Presentation award winner

Haynes KA, SunF-L, Lee S, Collins L, Simpson C, Wuller J, Caudy A, Elgin SCR. Competitive Formation of Heterochromatic and Euchromatic Domains In Drosophila melanogaster Chromosome Four. Minority Trainee Research Forum. San Diego, CA. Mar 2004.

Haynes KA, Collins L, Caudy A, Elgin SCR. Chromosome four of Drosophila melanogaster as a system for investigating heterochromatin. Midwest Drosophila Meeting. Allerton, IL. Oct 2004.

Haynes KA, Sun F-L, Oakeley, EJ, Craig, CA, Lee S, Collins L, Wuller J, Eissenberg J, Grunstein M, Rangwala S, Elgin SCR. Local Position Effects Demarcate Heterochromatic and Euchromatic Domains on Drosophila melanogaster Chromosome Four. Minority Trainee Research Forum. San Diego, CA. Mar 2003.

HONORS AND AWARDS

  • Cold Spring Harbor Laboratory (CSHL) Synthetic Biology course instructor, 2013, 2014
  • The Scientist Magazine’s Scientist to Watch, 2013
  • Synthetic Biology Leadership Excellence Program (SynBioLEAP) Travel Award, 2013
  • NIH Early Career Reviewer - MABS panel, 2013
  • BioBricks Foundation SB5.0 Travel Award, 2011
  • New England Science Symposium (NESS) Silen Presentation Award, 2011, 2006
  • Franklin Institute Science Makers featured scientist, 2011
  • Harvard Sustainability Grant, 2010
  • National Institutes of Health (NIH) Ruth L. Kirschtein National Service Award (NRSA), 2009
  • Journal of Biological Engineering (JBE) Outstanding Publication of 2008
  • National Cancer Institute (NCI) Training Grant Fellow, 2008

GRADUATE AND UNDERGRADUATE* STUDENT RESEARCH SUPERVISED

Arizona State University

  • ASU International Genetically Engineered Machines Competition (iGEM) Teams* (2012 – present)
  • Fulton Undergraduate Research Initiative (FURI)* (2012 – present): Amanda Ispas, Joseph Juliano, Brady Laughlin, Abhinav Markus, David Barclay, Cameron Gardner
  • School of Life Sciences Undergraduate Research Program (SOLUR)* (2013 – present): Ryan Muller, Brendan Fries
  • SynBERC Scholars Program* (2013 – present): Hiram Rivera-Passapera, Matsemela Moloi
  • Biomedical Engineering (BME) Masters Program (2012 – 2013): Vi Nguyen, David Dreher, Wesley Huston
  • Biomedical Engineering (BME) PhD Program (2012 – present): Behzad Damadzadeh, James Alling
  • Biological Design Program (2012 – present): Rene Davis

Harvard Medical School

  • Center for Systems Biology (CSB) Summer Research Program* (2009 – 2011)
  • Harvard iGEM Team* (2010)
  • Francesca Ceroni, visiting Ph.D. student from Università di Bologna (2010)
  • i2b2-HST Summer Institute*(2009)

Davidson College

  • Research Internships in Science and Engineering (RISE)* (2008)
  • Davidson-Missouri Western State iGEM Team* (2006 – 2007)

Washington University in St. Louis

  • Howard Hughes Medical Institute (HHMI) Fellows* (2003 – 2005)

PROFESSIONAL MEMBERSHIPS AND SERVICE

  • Affiliated Investigator – The Synthetic Biology Engineering Research Center (SynBERC)
  • Councilor (elected, 2012 - 2013) –Institute of Biological Engineering (IBE)
  • Head Judge (2011 – present)– International Genetically Engineered Machines Competition (iGEM)
  • The American Association for the Advancement of Science (AAAS)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)
  • The BioBricks Foundation (BBF)

RESEARCH SUPPORT

National Science Foundation Synthetic Biology Engineering Research Center

“Epigenetic control of pancreatic cells with DNA-packing sensors and actuators”

Awarded to Karmella Haynes (P.I.)

2013 - 2014

REFERENCES

Sarah C.R. Elgin (Ph.D. thesis advisor)

Professor of Biology

Department of Biology

Washington University

Box 1037, 1 Brookings Drive, St. Louis, MO 63130

Phone: 314-935-5348

E-mail:

A. Malcolm Campbell (postdoctoral advisor)

Professor of Biology

Biology Department

Davidson College

Box 7118, Davidson, NC 28035

Phone: 704-894-2692

E-mail:

Pamela A. Silver(postdoctoral advisor)

Professor of Systems Biology

Department of Systems Biology

Harvard Medical School

200 Longwood Avenue, Boston, MA 02115

Phone: 617-432-6401

E-mail: