Table S1. The classification of clinical diagnosis, histological diagnosis by pathogenesis, and byhistopathology in J-RBR in 2010

Clinical diagnosis / Histological diagnosis by pathogenesis / Histological diagnosis by histopathology
Acute nephritic syndrome / Primary glomerular disease except IgA nephropathy / Minor glomerular abnormalities
Rapidly progressive nephritic syndrome / IgA nephropathy / Focal and segmental glomerulosclerosis
Recurrent or persistent hematuria / Purpura nephritis / Membranous nephropathy
Chronic nephritic syndrome / Lupus nephritis / Mesangial proliferative glomerulonephritis
Nephrotic syndrome / MPO-ANCA positive nephritis / Endocapillary proliferative glomerulonephritis
Renal disorder with metabolic disease / PR3-ANCA positive nephritis / Membranoproliferative glomerulonephritis (types I and III)
Renal disorder with collagen disease or vasculitis / Anti-glomerular basement membrane antibody nephritis / Dense deposit disease
Hypertensive nephropathy / Hypertensive nephrosclerosis / Crescentic and necrotizing glomerulonephritis
Inherited renal disease / Thrombotic microangiopathy / Sclerosing glomerulonephritis
Acute renal failure / Diabetic nephropathy / Nephrosclerosis
Drug-induced nephropathy / Amyloid nephropathy / Acute interstitial nephritis
Renal transplantation / Alport syndrome / Chronic interstitial nephritis
Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura (HUS/TTP)a / Thin basement membrane disease / Acute tubular necrosis
Congenital anomalies of the kidney and urinary tract (CAKUT)a / Infection-related nephropathy / Transplanted kidney
Polycystic kidney disease (PKD)a / Transplanted kidney / Others
Others / Others

a, added in 2010.

Table S2.Distribution of CKD stages and clinical parameters in male in IgA nephropathy in J-RBR: Combined data of 2009 and 2010

CKD stage / G1 / G2 / G3a/b / G4 / G5 / Total / P value*
Male / 299 / 376 / 325 / 62 / 17 / 1,083 / –
N (%) / 27.7 / 34.8 / 30.1 / 5.7 / 1.6 / 100.0 / –
Age, years, average
median / 22.1 ± 11.2
19 (16 – 25) / 40.5 ± 14.3
38 (30 – 52) / 51.7 ± 13.1
54 (42 – 61) / 60.0 ± 15.9
62 (51 – 73) / 49.0 ± 21.6
51 (34 – 60) / 40.0 ± 18.3
38 (24 – 56) / < 0.0001
< 0.0001
Body mass index / 21.4 ± 4.7 / 23.7 ± 3.7 / 24.0 ± 3.5 / 23.6 ± 3.8 / 23.1 ± 4.3 / 23.1 ± 4.1 / < 0.0001
Estimated GFR, mL/min/1.73m2 / 111.2
(97.2 – 138.2) / 74.0
(67.4 – 82.0) / 49.1
(41.7 – 55.0) / 25.3
(21.2 – 27.5) / 8.6
(5.6 – 13.4) / 70.5
(50.8 – 93.0) / < 0.0001
Proteinuria, g/day (n) / 0.31
(0.10 – 0.88) / 0.60
(0.24 – 1.19) / 1.01
(0.45 – 2.00) / 1.78
(0.80 – 3.20) / 2.91
(1.09 – 5.00) / 0.67
(0.24 – 1.44) / < 0.0001
Proteinuria, g/gCr (n) / 0.38
(0.12 – 0.90) / 0.59
(0.29 – 1.14) / 1.00
(0.48 – 1.83) / 1.68
(0.92 – 4.01) / 2.91
(1.56 – 4.20) / 0.70
(0.28 – 1.43) / < 0.0001
Sediment RBC ≥ 5/hpf (%) / 79.9 / 78.2 / 72.3 / 77.4 / 82.4 / 77.0 / 0.2016
Serum creatinine,m g/dL / 0.72
(0.62 – 0.80) / 0.92
(0.86 – 1.00) / 1.29
(1.15 – 1.46) / 2.27
(2.02 – 2.68) / 6.00
(4.04 – 10.0) / 0.97
(0.80 – 1.23) / < 0.0001
Serum albumin, g/dL / 4.23 ± 0.51 / 4.11 ± 0.53 / 3.82 ± 0.63 / 3.41 ± 0.65 / 3.28 ± 0.58 / 4.00 ± 0.61 / < 0.0001
Serum total cholesterol, mg/dL / 180.2 ± 38.9 / 199.9 ± 42.9 / 203.9 ± 51.1 / 205.6 ± 53.2 / 200.3 ± 45.3 / 195.9 ± 46.3 / < 0.0001
Systolic BP, mmHg / 116.6 ± 14.1 / 127.8 ± 14.9 / 130.8 ± 17.8 / 140.8 ± 22.2 / 152.0 ± 22.2 / 126.6 ± 17.7 / < 0.0001
Diastolic BP, mmHg / 68.1 ± 11.5 / 77.9 ± 12.2 / 79.8 ± 12.8 / 84.2 ± 14.6 / 89.5 ± 10.2 / 76.3 ± 13.4 / < 0.0001
Anti-hypertensive agents, % / 16.5 / 37.5 / 63.0 / 79.6 / 60.0 / 42.6 / < 0.0001
Diabetes mellitus, % / 2.8 / 3.3 / 7.6 / 29.3 / 0.0 / 5.9 / < 0.0001

Data are presented as the means ± SD or the medians (interquartile ranges). CKD, chronic kidney disease; GFR, glomerular filtration rate; BP, blood pressure. *ANOVA, Kruskal-Wallis or 2-test as appropriately. There are four (0.4%) missing value of the CKD stage because of inappropriate data of serum creatinine.

Table S3.Distribution of CKD stages and clinical parameters in female in IgA nephropathy in J-RBR: Combined data of 2009 and 2010

CKD stage / G1 / G2 / G3a/b / G4 / G5 / Total / P value*
Female / 364 / 468 / 226 / 49 / 13 / 1,094 / –
N (%) / 33.4 / 40.2 / 20.7 / 4.5 / 1.2 / 100.0 / –
Age, years, average
median / 24.7 ± 10.5
24 (18 – 30) / 40.1 ± 12.7
38 (31 – 49) / 49.7 ± 12.7
49 (42 – 60) / 50.3 ± 15.1
51 (38 – 63) / 42.8 ± 18.9
33 (27 – 64) / 37.5 ± 15.7
36 (25 – 49) / < 0.0001
< 0.0001
Body mass index / 20.7 ± 3.3 / 22.2 ± 3.7 / 23.0 ± 3.9 / 22.3 ± 5.1 / 23.7 ± 7.5 / 21.9 ± 3.9 / < 0.0001
Estimated GFR, mL/min/1.73m2 / 106.0
(96.4 – 123.0) / 76.3
(68.0 – 83.2) / 49.3
(42.2 – 54.0) / 22.8
(20.4 – 27.7) / 7.76
(6.24 – 11.3) / 78.4
(58.2 – 96.7) / < 0.0001
Proteinuria, g/day (n) / 0.30
(0.11 – 0.80) / 0.42
(0.20 – 0.94) / 0.85
(0.35 – 1.99) / 1.40
(0.70 – 2.57) / 2.70
(0.94 – 3.65) / 0.50
(0.20 – 1.10) / < 0.0001
Proteinuria, g/gCr (n) / 0.40
(0.15 – 0.95) / 0.67
(0.27 – 1.30) / 1.17
(0.58 – 2.48) / 1.75
(0.67 – 5.20) / 3.26
(0.80 – 5.18) / 0.70
(0.26 – 1.50) / < 0.0001
Sediment RBC ≥ 5/hpf (%) / 84.3 / 84.0 / 77.9 / 87.8 / 92.3 / 83.0 / 0.1633
Serum creatinine,m g/dL / 0.56
(0.50 – 0.60) / 0.70
(0.64 – 0.75) / 0.97
(0.90 – 1.10) / 1.89
(1.67 – 2.22) / 5.10
(4.10 – 7.24) / 0.69
(0.59 – 0.84) / < 0.0001
Serum albumin, g/dL / 4.09 ± 0.41 / 3.95 ± 0.44 / 3.75 ± 0.53 / 3.49 ± 0.61 / 3.15 ± 0.63 / 3.93 ± 0.49 / < 0.0001
Serum total cholesterol, mg/dL / 188.2 ± 35.8 / 208.0 ± 48.6 / 218.7 ± 49.9 / 219.1 ± 50.6 / 244.9 ± 64.6 / 204.4 ± 47.0 / < 0.0001
Systolic BP, mmHg / 111.8 ± 13.5 / 119.4 ± 16.4 / 129.5 ± 17.5 / 133.8 ± 22.5 / 142.6 ± 33.3 / 119.8 ± 17.9 / < 0.0001
Diastolic BP, mmHg / 67.2 ± 11.4 / 72.7 ± 11.9 / 77.6 ± 12.0 / 77.2 ± 16.0 / 86.0 ± 24.3 / 72.2 ± 12.9 / < 0.0001
Anti-hypertensive agents, % / 11.6 / 29.7 / 54.5 / 71.4 / 81.8 / 31.4 / < 0.0001
Diabetes mellitus, % / 0.4 / 2.9 / 7.9 / 11.4 / 0.0 / 3.4 / < 0.0001

Data are presented as the means ± SD or the medians (interquartile ranges). CKD, chronic kidney disease; GFR, glomerular filtration rate; BP, blood pressure. *ANOVA, Kruskal-Wallis or 2-test as appropriately. There are four (0.4%) missing value of the CKD stage because of inappropriate data of serum creatinine.

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