JF Antaki, pg 1 of 42

CURRICULUM VITAE

James Francis Antaki, PhD

Business Address:

CarnegieMellonUniversity

Department of Biomedical Engineering

700 Technology Drive, Suite 4321

Pittsburgh, PA15213

412/802-6431

Birth date: June 7, 1963

Birthplace: White Plains, NY

ACADEMIC APPOINTMENTS & PROFESSIONAL EXPERIENCE

7/2003 - presAssociate Professor, Biomedical Engineering,CarnegieMellonUniversity.

7/2003 - presAssociate Professor (courtesy), Computer Science, Carnegie Mellon University.

7/2003 - presAssociate Professor (adjunct), Surgery, University of Pittsburgh, PA.

7/2003 - pres.Associate Professor (adjunct), Bioengineering, University of Pittsburgh, PA.

11/2003 - presChief Creative Officer, LaunchPoint Technologies, LLC.

1996 - presPresident, AntakaMatics, Inc., Pittsburgh, PA (Medical & Musical Instrument Design)

1997 - 1999Assistant Professor of Bioengineering, University of Pittsburgh, PA.

1993 - 1999Lecturer of Engineering in Medicine, Biomedical Engineering Program, Carnegie Mellon University, PA.

1991 - 1999Director of Artificial Heart Research & Development, McGowanCenter for Artificial Organ Development, University of Pittsburgh, PA.

1991 - 1999Assistant Professor, Department of Surgery, School of Medicine, University of Pittsburgh, PA.

1991 - 1999Adjunct Assistant Professor, Department of Mechanical Engineering, School of Engineering, University of Pittsburgh, PA.

1987 - 1989Clinical Engineer, PresbyterianUniversityHospital, Artificial Heart Program, Pittsburgh, PA.

1985 - 1991Graduate Researcher, Department of Surgery, School of Medicine, University of Pittsburgh, PA.

1985Machine Designer, Mikron-Haesler, SA, Boudry, Switzerland.

1984 - 1985Mechanical Designer, Factron, division of Fairchild-Schlumberger, Troy, NY.

1984Assistant Mechanical Designer, Center for Manufacturing Productivity, Rensselaer Polytechnic Institute, NY.

1983Surveyor, Port Authority of New York and New Jersey, Risk Management Division, Journal Square, NJ.

1981 - 1982Assistant Manager, Hawthorne Auto Parts, Hawthorne, NY.

1977 - 1982Freelance TV and radio repairman. Freelance auto mechanic.

RESEARCH ACTIVITY

Artificial Heart Research and Development (1991 - present): This multifaceted research effort is aimed at improving the design of existing artificial heart devices, and toward the development of a novel magnetically-levitated, computer optimized blood pump -- named the Streamliner artificial heart. The theoretical arm of this research entails the use of mathematical models to describe and comprehend the flow fields within blood-wetted cardiovascular devices and for simulating the interaction of these devices with the cardiovascular system.

Experimental efforts include in-vitro flow visualization tests as well as in-vivo experiments, and human investigations. Collaboration is derived from investigators both within the University and from other institutions (including NASA/Langley Research Center, University of California Santa Barbara, and CarnegieMellonUniversity). A novel aspect of this research is the concept of coupling computer optimization with fluid dynamics analysis. The intent in combining these technologies is to provide artificial organ designers a powerful tool for rapidly developing devices with superior fluid dynamics.

In 1998, the Streamliner became the first maglev rotary pump to be implanted in animals. In 1999, this research was recognized by IEEE who granted their annual Control Systems Award to Antaki and BE Paden.

Blood Rheology & Damage (1991-present): This is a collaborative effort with Dr. Kameneva in the Department of Surgery at the University of Pittsburgh. It is directed at developing improved constitutive models for describing and predicting blood flow behavior -- in natural blood vessels and in artificial devices. This research is also aimed at understanding the implications of artificial circulatory support upon the damage of blood cells and alteration of the physical properties of blood.

Surgical Brachytherapy Device for Implantation of Radioactive Seeds (1997-present): In collaboration with the Department of Radiation Oncology at the University of Pittsburgh, developed instrument for laproscopically introducing radioactive pellets for radiation therapy. Collaborators include Joel Greenberger, MD, Richard L. Simmons, MD, and Philip Schauer, MD. US Patent pending.

Rapid Prototyping of Bronchial Stent for Lung Transplant Patient (1993): This project involved the use of serial CT imaging and stereolithography to produce a three-dimensional replica of the bronchial airway (lumen). The replica was then used to construct a custom-fit stent for a lung transplant patient. This involved coordinating cardiac clinical staff, radiologists, engineers and engineering students, and rapid-prototyping technicians.

Computational Fluid Dynamics and Optimization (1992-present): Computer-based initiative aimed to capitalize upon state-of-the-art supercomputing towards modeling and optimizing cardiovascular devices. Collaborators include O Ghattas, PhD and C Amon, PhD, from Carnegie Mellon, Y Husseini, PhD and T Gatsky, PhD, from NASA/ICASE, and KR Rajagopal, PhD, from the Department of Mechanical Engineering at TexasA&MUniversity.

Accelerated Testing of Pulmonary Occluder (1989): Designed experimental apparatus and protocol for accelerated testing.

Solvent Dissolution of Gallstones (1989): Assisted design of novel method for rapidly dissolving gallstones in-vivo: including specialized cannula and computer-controlled pumping circuit.

Measurement of Capsular Contracture (1988-1989): Capsular contracture is the leading cause of failure of breast implants. Compliance chambers used in artificial hearts also suffer from this failure mode. The objective of this series of studies was to assess the efficacy of a new breast implant design. Prototypes were implanted in rats and were tested for capsular contracture. My involvement included the design and fabrication of the testing apparatus and the subsequent analysis and interpretation of the biomechanical data. The majority of manufacturers have subsequently adopted similarly designed implants.

Cardiac Image Analysis (1987-1991): This research involved the development of three-dimensional computer techniques for tracking the motion of the heart from MRI and echocardiographic images. This research resulted in the development of unique fiduciary markers for motion tracking and computer programs for cardiac gated imaging.

Hemodynamic Pulse Duplicator Apparatus Development (1986-1992): Developed novel pulsatile perfusion circuit for conducting various vascular experiments in-vitro. US Patent issued.

Assessment of Ventricular Function (1985-1990): Studies conducted in humans to evaluate right ventricular function during mechanical left ventricular assistance. Cardiac data was obtained at the time of surgery by sonomicrometry and by high fidelity plethysmography. Novel strategies were developed for the fabrication and implantation of piezoelectric crystals to be used in sonomicrometry.

Myocardial Biomechanics (Thesis Topic): A study of the rheological (stress-strain) properties of the heart in humans. A nonlinear orthotropic biomechanical model of the intact heart was developed to quantify the relationship between myocardial stress, strain, and stiffness. Experimental data was obtained via NMR imaging coupled with three dimensional image reconstruction. Additional instrumentation was developed to measure ventricular pressure (via fiber optic pressure catheters) and electrocardiogram for the purpose of synchronizing NMR acquisition to the patient's heart beat -- a challenging task within the noisy NMR environment. Future work will include finite-element computer implementation of the model on the Cray supercomputer.

Capsule Summary of Contributions

  • 1988: First biomechanical study of capsular contracture.
  • 1990: First use of fiduciary markers for tracking cardiac motion with MRI.
  • 1992: First introduction of shape optimization to design of blood-wetted artificial organs.
  • 1994: First concerted research study of ventricular cannulation. First article published on this topic.
  • 1994: Introduced in-vitro vascular perfusion system based on feedback-controlled regulator.
  • 1995: First patent specifically related to control of rotary blood pumps.
  • 1995: Introduced theory of “accumulated damage” for shear-induced blood trauma.
  • 1996: Introduced shoe-generator design for powering artificial organs.
  • 1996: First use of liquid crystal for measurement of viscous shear.
  • 1998: Streamliner Heart-Assist Pump – first maglev rotary pump to be implanted in animals.
  • 1998: Introduction of concept of multi-objective control of rotary blood pumps.
  • 1990-9: First study of physiology and physics of harmonica playing.
  • 1998: First electric/acoustic harmonica.
  • 2003: Introduction of use of Expert System for decision support of artificial heart patients.

PATENTS ISSUED

  1. Prem E, ... JA Holmes, GW Burgreen, DA Borzelleca, JF Antaki. Touch Down of Blood Pump Impellers. US Patent 6761532, 7/13/04, Filed 3/14/2001 [assigned to Vascor, Inc.].
  2. Antaki JF. Enhanced Harmonica. US Patent 6,635,814 Filed 1/28/2002, Issued 10/21/2003.
  3. JohnsonGA, JF Antaki, JA Magovern, MR Frushell, TD Will, JA Holmes. Hard or Soft Tissue Closure. US Patent 6,485,504, Filed 6/22/2000 [assigned to Cardiac Assist Technologies, Inc.], Issued 11/26/2003
  4. Antaki JF, BE Paden, GW Burgreen, NJ Groom. Blood pump having a magnetically suspended rotor. US Patent 6,447,266 Filed 4/24/2001, Issued 9/10/2002.
  5. Antaki JF, BE Paden, GW Burgreen, NJ Groom. Magnetically suspended miniature fluid pump and method of designing the same. US Patent 6,447,265 Filed 9/20/1999, Issued 9/10/2002.
  6. Bearnson GB, PS Khanwilkar, JW Long, JC Ludlow, BE Paden, C Chen, DB Paden, DB Olsen, JF Antaki, PE Allaire, M Baloh. Pump Having a Magnetically Suspended Rotor with One Active Control Axis. US Patent 6,394,769 Filed 6/23/2000, Issued 5/28/2002 [assigned to MedQuest, Inc.].
  7. Antaki JF. Enhanced Harmonica. US Patent 6,359,204 Filed 2/2/2000, Issued 3/19/2002.
  8. Antaki JF. Harmonica having reed vibration conversion capability and associated retrofitting method. US Patent 6,326,532 Filed 12/2/1999, Issued 12/4/2001.
  9. Antaki JF. Harmonica Enclosure. US Patent 6,291,751 Filed 10/2000, Issued 9/18/2001.
  10. Antaki JF,J Greenberger, P Schauer, JA Holmes. Apparatus and a method for automatically introducing implants into soft tissue with adjustable spacing. US Patent 6,270,472 Filed 12/1998, Issued 8/7/2001.
  11. Antaki JF, BE Paden, GW Burgreen, NJ Groom. Blood Pump Having a Magnetically Suspended Rotor. US Patent 6,244,835 Filed 7/19/1999, Issued 6/12/2001.
  12. Antaki JF, GW Burgreen. Rotary Pump Having a Bearing Which Dissipates Heat. US Patent 6,093,001 Filed 6/1/1997, Issued 7/25/2000.
  13. Antaki JF, JR Boston, S Choi, K Butler, D Thomas, D Amin. Speed Control System for Implanted Blood Pumps. US Patent 6,066,086 Issued 5/23/2000.
  14. Antaki JF, BE Paden, GW Burgreen, NJ Groom. Magnetically Suspended Miniature Fluid Pump and Method of Making the Same. US Patent 6,015,272 Filed 6/26/1996, Issued 1/18/2000.
  15. Antaki JF, JR Boston, S Choi. Speed Control System for Implanted Blood Pumps. US Patent 5,888,242 Filed 9/1996, Issued 3/30/1999.
  16. Antaki JF, HS Borovetz, RF Labadie. Fluid Delivery Apparatus and Associated Method [Computer controlled apparatus for perfusing blood vessels to arbitrary hemodynamic loads]. US Patent 5,537,335 Issued 7/16/1996.

PATENTS PENDING

  1. Antaki J. Apparatus and method for reducing heart pump backflow. US Patent Application Filed ca. 6/14/2002.
  2. Antaki J., J Ludlow, and S Miles. Low profile inlet for rotary blood pump. US Patent Application Filed ca. 6/2002
  3. Heilman M, C Capone, C Parisi, R Sofranko, D Moore, E Prem, S Kolnik, J Antaki, B Paden, D Borzelleca. Method and Apparatus for Providing Limited Back-Flow in a Blood Pump During a Non-PumpingState. US Patent Application Filed ca. 4/3/2002 [assigned to Vascor, Inc.].
  4. Kameneva MV, JF Antaki. Denucleation of blood contact materials and surfaces. US Patent Application Filed 2/25/2000.
  5. Antaki JF, RK Meyer. Liquid Crystal Shear Sensor for Viscous Flows. (1995)US Patent Application 60/144,444 Filed 7/1999.

ADDITIONAL DESIGNS AND INVENTIONS

  1. Integrated Blood Pump-Oxygenator and Method of Designing Same (Submitted to University of Pittsburgh tech transfer office 8/1997).
  2. Improved Means for Detecting Cardiac Rejection (ca. 11/1995).
  3. A Bio-Compatible Ferro-fluidic Seal (ca. 11/1995).
  4. Gait-powered battery charging system for augmented artificial organ power supply -- uses piezoelectric array within midsole of shoe (Recipient of ASAIO/Medforte Innovation Award, 1995).
  5. Ventricular cannula for left ventricular circulatory assist -- prevents myocardial collapse, maximizes patency (included in US Patent pending) (1992).
  6. Harness for management of electrical and fluid lines for use with chronic in-vivo experimentation (1992).
  7. Microencapsulated myocardial marker --- 3 mm diameter microencapsulated copper sulfate ampule, used for fiduciary landmark in cardiac NMR imaging (1990).
  8. Surgical insertion tool for myocardial marker implantation -- vacuum operated tool for accurate placement of myocardial markers (1990).
  9. Polar cylindrical dissecting fixture for myocardial dissection -- allows accurate dissection of myocardial specimens from ventricular free wall in-vitro (1990).
  10. High-performance three-dimensional piezoelectric transducer for sonomicrometry -- allows rapid placement and alignment for obtaining three-dimensional myocardial displacement measurements (1989).

30.Apparatus for palpating silicone implants in rodents -- used to quantify degree of capsular contracture (1988).

31.Improved piezoelectric transducer for sonomicrometry -- incorporates guide suture for rapid placement of one-dimensional transducer (1987).

32.Insertion tool for piezoelectric transducer crystal -- facilitates insertion and placement of one-dimensional sonomicrometry crystal (1987).

33.Automated machine part loading assembly -- for rapidly and accurately loading hydraulic connector blanks from parts hopper into rotating vice turret (1985).

34.Circuit board test fixture -- automates process of loading circuit board to test station (1984).

35.Improved epoxy applicator for automatic filament winding (1983).

  1. High torque screwdriver (1982).
  2. Locking electrical plug -- prevents accidental disconnection from wall receptacle (ca. 1981).

38.Automotive regenerative braking and suspension system (ca. 1981).

EDUCATION

InstitutionDegreeYear ConferredField of Study

University of PittsburghPhD1991Mechanical Engineering

Pittsburgh, PA QPA: 3.78/4.0

Rensselaer PolytechnicBS1985Mechanical Engineering

Institute, Troy, NYMinor1985Electrical Engineering

QPA: 3.7/4.0

ADDITIONAL EDUCATION AND TRAINING

1997Introduction to Process Mapping. University of Pittsburgh Human Resources, PittsburghPA.

1995Magnetic Bearing Design - Short course, Dr. Paul Allaire and Dr. Eric Maslen, Alexandria, VA.

Advanced AutoCAD Techniques - Short course, Doug Salah, PittsburghPA.

1993Applied Three Dimensional Analysis of Turbomachinery. Short course, CETI, Norwich, VT.

How to be a Better Team Leader. Short course, Padget Thompson.

Management Problems for the Technical Person in a Leadership Role. Short course, Pryor.

1992Seminar: Managing Multiple Projects, Objectives, and Deadlines. Short course, Skillpath.

1990Pittsburgh Supercomputing Center, Fall Visualization Workshop, 2-day seminar, Pittsburgh, PA.

Motion Control Made Easy. 1-day seminar, Dr. J. Tal, Galil Motion Control, Inc., Farmington Hills, MI.

How to Be the Best Possible Boss. Pagett Thompson, Pittsburgh, PA.

1989ASYST 1-day Seminar on Data Acquisition & Control, Data Reduction and Analysis, Data- Presentation and Graphics.

Managing Multiple Demands. 1-day seminar, Ed Stetser, Pittsburgh, PA.

1988Cardiac Transplantation Workshop. B. Smith, Clinical Instructor, PresbyterianUniversityHospital, Pittsburgh, PA.

Total Artificial Heart (Jarvik 7-70, 7-100). Surgical ICU Nurse's Workshop, Pittsburgh, PA.

Biofluid Mechanics/Cardiovascular Dynamics. 40th Annual Conference in Medicine and Biology, Deter Liepch and StanleyE. Rittgers.

1987Symbion Total Artificial Heart Workshop (Jarvik 7-70, 7-100 TAH). Operator's Workshop, S. Langsford, Symbion, Inc., Pittsburgh, PA.

Novacor Left Ventricular Assist System (LVAS) Operator's Training. Workshop, Philip Miller, Director, Biomedical Engineering, Novacor Medical Corporation, Pittsburgh, PA.

TEACHING EXPERIENCE

Spring 04, 05BME 42-401: Bioengineering Senior Project

Spring 2001 - 2003BIOE-1161: Bioengineering Senior Design - II.

Fall 2000 - 2002BIOE-1160: Bioengineering Senior Design (“capstone” course in Bioengineering).

Fall 1997BME: Cardiovascular Organs Replacement (with HS Borovetz).

Fall 1996BME: Cardiovascular Organs Replacement (with HS Borovetz).

Spring 1996 BME: Quantitative Cardiovascular Physiology.

Fall 1995BME: Cardiovascular Organs Replacement (with HS Borovetz);

Bioprinciples (with WRWagner).

Fall 1992, 1993, 1994BME: Introduction to Biomaterials (with WR Wagner).

Spring 1993BME: Artificial Organs: Artificial Heart (with HS Borovetz).

Fall 1992 BME: Introduction to Biomechanics: Cardiac Mechanics.

Fall 1991ME2060: Introduction to Biomechanics: Blood Rheology;

Cardiac Biomechanics; Artificial Heart.

STUDENTS ADVISED - Currently Enrolled

Present DegreeStartExpected Degree

(Dept.)(Dept.) [mo/yr]

  1. Linda SantelicesBS (BME)9/02MS (BME) [4/05]

Development of Expert System for Optimal Care of Patients with Mechanical Circulatory Support.

  1. Samuel J HundMS (BME)9/05PhD (BME) [4/07]

Computational Fluid Dynamics Optimization of Blood Flow.

3.Rui ZhaoMS (BME)1/05PhD (BME) [4/08]

Multiscale Model of Blood Damage

4. Arielle DrummondBS9/04PhD(BME)

Anatomic and Surgical Model of Pediatric VAD Insertion

5. Timothy BachmanBS9/04MS(BME)

Development of Ventricular Access Techniques for Mechanical Circulatory Support

6. Dorian ArnoldBS9/04MS(BME)

Circulatory Simulator for Pediatric Applications

7. Bronwyn UberBS9/04PhD (BME) [4/08]

Decision Support System for Cardiac Care

STUDENTS ADVISED - Graduated (Degree, Department.)

  1. Samuel J Hund, BS (BME), [Computational Fluid Dynamics Optimization of Blood Flow.] 9/02 – 1/05
  2. Rui Zhao, MS(BME: UoP), [Multiscale Model of Blood Damage], 7/02 – 12/04
  3. Erik N Sorensen, PhD (BME) Computational Model of Platelet Mediated Thrombogenesis in Artificial Organs, 1997-10/2002.
  4. George Yanulis, MS (BME): Development of Bioprosthetic Diaphragm Assist Device, based on Polymetric Artificial Muscle, 2001-4/2002 [professional Masters.]
  5. Rebecca Gottleib-Meyer, PhD (BME),: Development of Liquid Crystal Technique for Direct Measurement of Blood Shear Stress. 1995-3/14/2001
  6. Leonardo Baloa, PhD (EE): Certainty-Weighted System for the Detection of Suction in Ventricular Assist Devices (co-advisor: JR Boston, EE Department). 1997-1/19/2001
  7. Seongjun Choi, PhD (EE) Modeling and control of left ventricular assist system. 1997-12/1998 (co-advisor, JR Boston)
  8. Alison Curtis, MS (BME),: A Multiple Modality Study of The Hemodynamics of Left Ventricular Apical Cannulations. 1997-11/20/1998
  9. Yih-Choung Yu, PhD (EEng),: Minimally Invasive Estimation of Cardiovascular Parameters. 1996-5/1998 (co-advisor: JR Boston)
  10. Krishna K. Yeleswarapu, PhD (MEng),: Evaluation of Continuum Models of Characterizing the Constitutive Behavior of Blood. 1991-5/1996
  11. Beichang "Bert" He, PhD (CEng), [Carnegie Mellon Univ.]: Shape Optimization of Navier Stokes Flows with Application to Artificial Heart Components (primary advisor: Omar Ghattas). 1992-5/1996
  12. Jeffrey L. Williams, MS (BMEng),: Starling-Responsive Mock Circulatory System for Left Ventricular Assist Controller Development. 1992-5/1995
  13. Tammy J. Dennis, MS (Meng),: Experimental and Theoretical Approach to Design of Artificial Heart Cannula. 1992-1994
  14. Darryl Breitenstein, MS (EEng),: Simulation of the Cardiovascular System for Model-Based Algorithm of Artificial Heart Control (co-advisor: JR Boston). 1992-1993
  15. Mark J. Gartner, MS (Meng), [CMU]: Computational Fluid Dynamics (CFD) Investigation of Blood Flow Within The Outflow Region of A Left Ventricular Assist Device. 1991-1992

POST-DOCTORAL STUDENTS

  1. Chengung Diao, Ph.D., University of Maryland, 2004. Flow visualization of Pediatric VAD. 5/2004-pres.
  2. Naik Taikeswar, PhD, University of Minnesota, 2003: Theoretical and experimental evaluation of red blood cell micromechanics. 9/2003-pres.
  3. Greg W. Burgreen, PhD, [OldDominionUniversity 1994]: Computational flow optimization of rotary blood pump. 7/1994-7/1995.

ADDITIONAL STUDENTS ADVISED (Outcome)

  1. David Wang, PhD, 11/04-pres, [served as mentor for CMU’s Entrepreneurship Program.]
  2. Martin Tabaksblatt, BS (EE) 7/03-6/04, Multi-objective Feedback Control of Artificial Hearts, (Accepted to MedicalSchool, Stony Brook.)
  3. Sara Doll, BS, (ca 2000-2002)[served as undergraduate mentor, and advisor on research project, Characterization of Stereo Stethoscope.]
  4. Kirk Lehmann, MS, “A Starling-Responsive Mock Circulatory Loop for Ventricular Assist Hemodynamic Simulation.” [5/1995-7/1996] (Industrial Position – Cardiac Assist Technologies,)
  5. Devin Amin, BS (EE), MD/PhD (EE) Adaptive physiologic control algorithm for

rotary blood pumps. [5/1996-4/1998]: (MedicalSchool, University of Pittsburgh.)

  1. Ahmed Nadeem, MS (EE); PhD (BME) Multidisciplinary optimization of magnetic bearing. [1/1996-4/1997]:
  2. Kunihisa Kono, MS (ME), [WasedaUniversity, TokyoJapan]: Development of mathematical hemolysis model by choosing energy dissipation as its main cause and some analysis from the fluid dynamical point of view (advisor: M. Umezu, WasedaUniv.). 5/2/1999(Returned to WasedaUniversity.)
  3. Stijn Vandenberghe, BS(BME), U. Ghent, Belgium – Visiting student. Optimization of hemodynamic control of rotary blood pumps. 12/2002-5/2003

SUMMER INTERNS ADVISED

  1. Thomas Robey, Thermoelectric Control of Heat Transfer, 1998.
  2. Benjamin Ewing, Modified rotary blood pump to minimize thermal blood trauma, 1998.
  3. Kirk Lehman, Development of digital controller for mock circulatory blood pump, 1997.
  4. Lauren DeRosett, Investigation of blood trauma due to magnetic and electric fields, 1996.
  5. Devin Amin, Investigation of physiology of control for pulseless perfusion, 1995.
  6. Leslie Sgroi, Further development of ventricular casting methodology, 1994.
  7. Amy Thompson, Development of ventricular casting methodology, 1993.
  8. Rania Hanna, Hemodynamic analysis of in-vivo evaluation of implantable LVAD, 1992.

SENIOR DESIGN PROJECTS ADVISED