Supplementary Fig.1.
Inhibitory rTMS applied on somatosensory cortex in Wilson’s disease patients with hand dystonia.
Journal of Neural Transmission,
Lozeron, Poujois, Meppiel, Masmoudi, Peron Magnan, Vicaut, Houdart, Guichard, Trocello, Woimant , Kubis.
Corresponding author: Nathalie Kubis,
-Service de Physiologie Clinique-Explorations Fonctionnelles, AP-HP, Hôpital Lariboisière, F-75475 Paris, France
-Université Paris Diderot, Sorbonne Paris Cité, F-75475 Paris, France
-INSERM UMR965, F-75475 Paris, France
Email address:
Supplementary Fig.1.
Flow, Accuracy and rhythmicity score (FAR score ). The FAR is a newly kinematic analysis of the written trace evaluating the writing flow, accuracy and rhythmicity (FAR) developed in the national reference centre for Wilson disease, Lariboisière Hospital (Paris). Subjects are always seated in the same position and use the same pen at each evaluation. (A). The first test assesses the writing flow. Patients repeatedly write the sentence “je respire le doux parfum des fleurs” (I’m breathing the delightful flagrance of flowers”) within one minute. This sentence consists of 30 characters. The number of written characters is noted and a flow score F (number of characters/min) is obtained. (B). The second test focuses on writing accuracy. Twelve spirals, with four convolutions in each spiral, are drawn in a sheet of paper. Patients have to trace inline, beginning in the centre of the spiral. They have to keep to the curve inside each spiral, without crossing the border. The number of convolutions correctly drawn in a minute define an accuracy score A; in the present example, the patient has drawn 6 spirals in a minute. Only 3 convolutions are noted in the first spiral because he crossed the line. The last spiral was not finished (only 2 convolutions done) due to the lack of time. (C, D). The third test evaluates the writing rhythmicity. Patients have to draw a wave between spots that are regularly spaced and vertically offset in a sheet of paper. Spots are arranged in two horizontal lines, in a staggered position so that the spots from the inferior line are between two spots of the superior line. The upper line has ten spots and the lower one has nine spots. In the first condition, the paper is in landscape orientation to evaluate the horizontal movement. Subject moves from left to right, beginning at the top of the sheet. Each line scores ten points if each dot is correctly circumvented. In this example, the R1 score is 55 (C). In the second condition, the paper is in a portrait orientation to score the vertical displacement. Example of vertical displacement (R2 score). Subject draws from top to bottom, beginning at the left top of the sheet. Each column scores ten points. If a dot is not circumvented, the point is not scored. In this example, the R2 score is 46 (D). The number of strokes drawn in a minute around the upper spots defines an R score. R1 corresponds to the score of the first condition and R2 the score of the second condition. The final score R is the sum of R1 and R2. During the exercise, the elbow and the wrist have to be on the table to keep their involvement to a minimum.
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