In 1992, You-Lin Tain graduated from China Medical University, Taiwan with an M.D. degree. He later received his residency training in pediatrics and fellow training in pediatric nephrology at Chang Gung Memorial Hospital (CGMH), Taiwan. From 1999 to 2002, Dr. Tain worked as an attending pediatrician at Kaohsiung CGMH, Taiwan. At the same time, he attained a master’s degree in biomedicine at the Chang Gung University, Taiwan.In 2003, he came to the U.S. with a pre-doctoral fellowship award from his hospital. In 2007, Dr. Tain graduated from the University ofFlorida GraduateSchool of Medicine with a Ph.D. in Physiology. Later he returned to Taiwan and worked at the Kaohsiung CGMH.Presently, he is an Associate Professor of Pediatrics at the Kaohsiung CGMH and Chang Gung University College of Medicine, and the Deputy Director of the Department of Pediatrics, Kaohsiung CGMH, Taiwan. His research interests include pediatric nephrology, free radical medicine, renal physiology, developmental programming, and hypertension.
In recent 5 years, Dr. Tain has14 grantsas PIand 6 grants as Co-PI from the National Sciences Council, National Health Research Institute, his hospital, and other resources in Taiwan. All of his projects focus on understanding how the NO/ROS imbalance contributes to hypertension and kidney disease. Five different but concurrently run sets of experiments aim to advance the understanding on NO pathway and NO-related therapies. The five approaches are: 1) The development and refinement of new methodologies to detect NO and other free radicals (e.g., EPR) in humans and experimental animals; 2) The discovery of source of reactive oxygen species (ROS) and its specific corresponding antioxidant for therapeutic use in hypertension and kidney disease; 3) The determination of the role of asymmetric dimethylarginine (ADMA, an endogenous NOS inhibitor) and its-related enzymes (e.g., PRMT and DDAH) in pediatric diseases (e.g., chronic kidney disease, hypertension); 4) The exploration of how NO/ROS imbalance affects epigenetic regulation in programmed hypertension and kidney diseases; and 5) The translational application of NO-related therapies (e.g., L-citrulline, antioxidants, and ADMA-lowering agents) in children with diseases attributed to NO deficiency.

Overall, Dr. Tain published 42 reports of which he first and/or corresponding authored on 25 in the past five years. The list of important publications related to this proposal is as follows.

  1. Tain YL, Huang LT, Lin IC, Lau YT, Lin CY. Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats. J Pineal Res. 49(4):390-398, 2010.
  2. Tain YL, Kao YH, Hsieh CS, Chen CC, Sheen JM, Lin IC, Huang LT. Melatonin blocks oxidative stress-induced increased asymmetric dimethylarginine. Free Radic Biol Med. 49(6):1088-98, 2010.
  3. Tain YL, Hsieh CS, Lin IC, Chen CC, Sheen JM, Huang LT. Effects of maternal L-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: the impact of nitric oxide pathway. Nitric Oxide. 23(1):34-41, 2010.
  4. Tain YL, Huang LT. Asymmetric dimethylarginine: Clinical applications in pediatric medicine. J FormosMed Assoc. 110(2):70-7, 2011.
  5. Tain YL, Hsu CN, Lin CY, Huang LT, Lau YT. Aliskiren prevents hypertension andreduces asymmetric dimethylarginine in young spontaneously hypertensive rats. EurJ Pharmacol. 670(2-3):561-5, 2011.
  6. Hsu CN, Huang LT, Lau YT, Lin CY, Tain YL. The combined ratios of L-arginine, asymmetric and symmetric dimethylarginine as biomarkers in spontaneously hypertensive rats. Transl Res, 159:90-98, 2012
  7. Huang LT, Hung JF, Chen CC, Hsieh CS, Yu HR, Hsu CN, Tain YL*. Endotoxemia exacerbates kidney injury and increases asymmetric dimethylarginine in young bile duct-ligated rats. Shock. 37: 441-8, 2012.
  8. Tain YL*, Hsu CN, Huang LT, Lau YT, Apocynin attenuates oxidative stress and hypertension in young spontaneously hypertensive rats independent of ADMA/NO pathway. Free Radical Res. 46: 68-76, 2012
  9. Tain YL, Lee WC, Hsu CN, Lee WC, Huang LT, Lee CT, Lin CY. Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers. PLoS ONE 8(2): e55420, 2013
  10. Lin YJ, Hsu CN, Lo MH, Huang CF, Chien SJ, Tain YL*. High Citrulline-to-Arginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease Cir J 77:181-7, 2013.