Additional data file 3

Enzymes regulated in fat metabolism, in type 2 diabetes mellitus
Fold Change
Accession ID / Gene Name
(Annotated January 14, 2004) / Cytogenetic Position / T2D vs. C / T2DN
vs. C /
T2DN vs. T2D
N34945 / FA / acetyl-Coenzyme A carboxylase beta- human / 12q24.1 / 1.28 / 1.67 / 1.30
R33303 / FA / protein kinase, AMP-activated, alpha 1 catalytic subunit / 5p12 / 1.11 / -1.06 / -1.18
AA464580 / FA / acetyl-Coenzyme A carboxylase alpha / 17q21 / 1.04 / 1.07 / 1.03
N78582 / FA / protein kinase, AMP-activated, beta 2 non-catalytic subunit / 1q21.1 / -1.01 / -1.26 / -1.24
AA136054 / FA / ATP citrate lyase / 17q12-q21 / -1.07 / -1.63 / -1.52
H64260 / FA / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / 7q35-q36 / -1.14 / 1.15 / 1.32
AA432271 / FA / protein kinase, AMP-activated, beta 1 non-catalytic subunit / 12q24.1 / -1.27 / -1.28 / -1.01
AA018676 / FA / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / 12q12-q14 / -1.27 / -1.18 / 1.08
AA426087 / FD / fatty-acid-Coenzyme A ligase, long-chain 6 / 5q31 / 1.51 / -1.09 / -1.65
AA405987 / FD / glycerol kinase 2 / 4q13 / 1.23 / -1.22 / -1.50
AA425861 / FD / enoyl Coenzyme A hydratase 1, peroxisomal / 19q13.1 / 1.13 / -1.14 / -1.29
AA663983 / FD / triosephosphate isomerase 1 / 12p13 / 1.06 / -1.18 / -1.25
AA621218 / FD / carnitine acetyltransferase / 9q34.1 / 1.04 / 1.04 / 1.00
AA633835 / FD / lipoprotein lipase / 8p22 / 1.04 / -1.28 / -1.33
H29215 / FD / fatty-acid-Coenzyme A ligase, long-chain 3 / 2q34-q35 / 1.04 / -1.20 / -1.24
T73556 / FD / fatty-acid-Coenzyme A ligase, long-chain 2 / 4q34-q35 / 1.01 / 1.05 / 1.04
AA005219 / FD / glycerol-3-phosphate dehydrogenase 2 (mitochondrial) / 2q24.1 / 1.00 / -1.13 / -1.13
AA676663 / FD / acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain / 12q22-qter / 1.00 / 1.03 / 1.04
T69767 / FD / ESTs, Highly similar to ECHB_HUMAN Trifunctional enzyme beta subunit, mitochondr / -1.01 / 1.45 / 1.47
AA458661 / FD / hydroxyacyl-Coenzyme A dehydrogenase, type II / Xp11.2 / -1.18 / -1.13 / 1.05
H96140 / FD / acyl-Coenzyme A dehydrogenase, short/branched chain / 10q25-q26 / -1.25 / 1.17 / 1.47
AA464163 / FD / acyl-Coenzyme A dehydrogenase, very long chain / 17p13-p11 / -1.28 / -1.41 / -1.10
H07926 / FD / acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase / 18q21.1 / -1.35 / 1.24 / 1.67
AA679352 / CH / farnesyl-diphosphate farnesyltransferase 1 / 8p23.1-p22 / -1.17 / -1.44 / -1.23
R06716 / CH / mevalonate kinase (mevalonic aciduria) / 12q24 / -1.30 / 1.30 / 1.70

T2D: type 2 diabetes mellitus without nephropathy, T2DN: type 2 diabetes mellitus with nephropathy,

C: controls without diabetes and nephropathy


FS: Fatty acid synthesis; FD: Fatty acid degradation; CH: Cholesterol synthesis

Up-regulated >1, Down-regulated <-1. The regulation was defined as a fold change between groups
Using a common error model and a modified z test after FDR correction for multiple comparisons).