*CHEMISTRY 436

GENERAL BIOCHEMISTRY II

SPRING2011

Instructor: Duane Smith, Jr., Ph.D.Course Section: CHEM 436 – 4 M

Office: Beauregard 134Meeting Room: BEA 210

Office Hours: MWF7:30 – 9:30 a.m.Meeting Time: MWF 10:45 – 11:40 a.m.

TR 9:00 a.m. – 12:00 noon

(or as arranged)

Phone: (985) 448-4165Email:

COURSE DESCRIPTION: *CHEM 436. Biochemistry II. 3-3-0. Prerequisite: CHEM 435. Pentose phosphate pathway; gluconeogenesis, metabolism of glycogen, fatty acids and amino acids; urea cycle; photosynthesis; biosynthesis of membrane lipids; steroids; amino acids; heme, nucleotides and integration of metabolism. Sp – odd years only. (26.0202)

PRE- & CO-REQUISITES: Prerequisite – Chemistry 435

REQUIRED TEXT: Lehninger Principles of Biochemistry, 5th ed., Nelson and Cox, 2008, W.H. Freeman Co., New York (ISBN–13: 978-0-7167-7108-1)

COURSE GOAL: To provide students with an understanding of the basic principles of biochemistry.

STUDENT OUTCOME OBJECTIVES: Upon successful completion of this course, the students will have content knowledge in these general subject areas:

  1. Structure and function of cell membranes
  2. Signal transduction pathways
  3. Cellular metabolism and energy transformation
  4. Photosynthesis and energy transformation

* CHEM 436 may be taken for graduate level credit; however to receive graduate level credit, the student must also successfully complete a 10-page research paper over one of the following content areas, and present a class lecture (45 minutes) over that topic area.

COURSE CONTENT:

  1. Membrane structure and function
  2. Receptor-mediated cell signaling
  3. Signal transduction cascades
  4. Photosynthesis
  5. Basic metabolic pathways in
  6. Glycolysis
  7. Citric acid cycle
  8. Oxidative phosphorylation
  9. Pentose phosphate shunt and gluconeogenesis

METHOD OF EVALUATION:

Grades will be based on a 10-point grading scale.

90 – 100A

80 – 89B

70 – 79C

60 – 69D

< 60F

Grades will be based on the average of four exams and one comprehensive final. Several topic area quizzes may also be given throughout the semester, and the average quiz grade may be counted as an extra exam grade. This grading policy may be amended due to any unforeseen changes in schedule.

COLLEGE AND CLASSROOM POLICIES:

Absence and Drop/Adds – Absences amounting to the equivalent of 10% of class time, whether consecutive or not, are grounds for the student being dropped from the course. You are expected to be present, prepared, and alert at all sessions. The responsibility for withdrawing from the course, if you decide not to continue, lie completely with the student. Failure to drop a course by the final deadline will result in your receiving a grade of “F”. The last day to drop the course with a “W” is Monday, March 28, 2011.

If a student misses a class, he or she is still responsible for the material covered during that class period. If a student misses an exam, a makeup will not be given unless the student notifies the instructor in advance of his or her absence. If no advance notice is given, the student must provide documentation as to the reason for having been absent, such as death of a close family friend (death notice), illness (doctor’s bill), or court appearance (summons).

Please notify the Instructor if you have a disability, so accommodations can be made. If you have a documented disability that requires assistance, you will need to register with the office of Disability Services for coordination of your academic accommodations. The Office of Disability Services is located in Peltier Hall, Room 100-A. The phone number is (985) 448-4430 (TDD 449-7002).

ACADEMIC GRIEVANCES: The proper procedure for filing a grade appeal or grievances related to other academic matters is listed in Section 5 of the Code of Student Conduct and at the following link:

CONTINUED LEARNING FOLLOWING AN EXTREME EMERGENCY: In order to make continued learning possible following an extreme emergency, students are responsible for:

  • reading regular emergency notification on the NSU website;
  • knowing how to use and access Blackboard (or university designated electronic delivery system);
  • being familiar with emergency guidelines;
  • evacuating with textbooks and other course materials;
  • knowing their Blackboard (or designated system) student login and password;
  • contacting faculty regarding their intentions for completing the course.

Faculty are responsible for:

  • their development in the use of the Blackboard (or designated) software;
  • having a plan for continuing their courses using only Blackboard and email;
  • continuing their course in whatever way suits the completion of the course best, and being creative in the continuation of these courses;
  • making adjustments or compensations to a student’s progress in special programs with labs, clinical sequences or the like, only in the immediate semester following the emergency.

Academic dishonesty will not be tolerated. The University’s Academic Honesty Policy, as stated in the “Code of Student Conduct” booklet will be followed.

No audible beepers,cellphones, or laptops will be allowed in class. Be sure that these devices are turned off as you enter the classroom. These devices are a distraction to the instructor as well as your classmates. If there is an emergency and you need to respond please let the instructor know of this before the class starts.

THIS SYLLABUS, IN NO WAY, IS TO BE MISCONSTRUED AS A CONTRACT, AND MAY BE AMENDED BY THE INSTRUCTOR AS DEEMED NECESSARY.

OUTLINE OF TOPICS

CHAPTER(S)POINTS

11 Membranes and Transport

12 Biosignalling

13 Bioenergetics

EXAM 1 (Fri., Feb. 11)100

14 Glycolysis, Gluconeogenesis, and Pentose Phosphate Shunt

15 Principles of Metabolic regulation

EXAM 2 (Fri., Mar. 4)100

16 The Citric Acid Cycle

17 Fatty Acid Catabolism

18 Amino Acid Oxidation and Production of Urea

Last day to drop course with a “W” grade is Monday, March28, 2011.

EXAM 3 (Fri., Apr. 1)100

19 Oxidative Phosphorylation

20 Carbohydrate Biosynthesis in Plants and Bacteria

EXAM 4 (Weds., May 4) 100

FINAL EXAM(1:00 – 3:00 p.m. Mon., May 9)100

TOTAL POINTS500

Monday – Wednesday – Friday

Date / Topic / Date / Topic / Date / Topic
Jan. 17 / Martin Luther King Holiday / Jan. 19 / First Day of Classes / Jan. 21
Jan. 24 / Jan. 26 / Jan. 28
Jan. 31 / Feb. 2 / Feb. 4
Feb. 7 / Feb. 9 / Feb. 11 / Exam 1
Chem 436
Feb. 14 / Feb. 16 / Feb. 18
Feb. 21 / Feb. 23 / Feb. 25
Feb. 28 / Mar. 2 / Mar. 4 / Exam 2
Chem 436
Mar. 7 / Mardi Gras Break / Mar. 9 / Ash Wednesday / Mar. 11
Mar. 14 / Mar. 16 / Mar. 18
Mar. 21 / Mar. 23 / Mar. 25
Mar. 28 / Mar. 30 / Apr. 1 / Exam 3
Chem 436
Apr. 4 / Apr. 6 / Apr. 8
Apr. 11 / Apr. 13 / Apr. 15
Apr. 18 / Apr. 20 / Apr. 22 / Good Friday
Apr. 25 / EASTER BREAK
(no classes) / Apr. 27 / EASTER BREAK
(no classes) / Apr. 29 / EASTER BREAK
(no classes)
May 2 / May 4 / Exam 4
Chem 436 / May 6 / FINAL EXAMS
May 9 / FINAL EXAMS
CHEM 436
1:00 – 3:00 / May 11 / FINAL EXAMS / May 12
THURS / Grades Due 9:00 a.m.