Supplementary Table 1

Full Scale Pathway Analysis Results

KEGG pathway / p-value / Number of Genes / Number of miRNAs / Genes
Long-term potentiation / 1.52E-12 / 30 / 19 / CAMK2D,BRAF,PRKCA,ADCY1,CAMK4,CALM3,CALM1,PPP1CC,RAP1A,GRM5,GRIA1,KRAS,GRIA2,PPP3CA,PLCB1,PPP1R12A,PPP3CB,PRKX,CACNA1C,PRKCB,RPS6KA3,GNAQ,MAP2K1,MAPK1,CREBBP,GRIN2A,RAP1B,CHP2,PRKACB,PPP1CB
PI3K-Akt signaling pathway / 1.24E-11 / 103 / 23 / PHLPP2,PRLR,GSK3B,PRKCA,RBL2,TSC1,PDGFRA,GNG13,PPP2R5E,MYB,SOS2,PRKAA2,YWHAE,ITGA8,PIK3CB,THBS2,PPP2CA,CREB5,COL4A5,LAMB4,COL24A1,CDK2,CCND2,COL27A1,ITGB6,GNG12,ANGPT2,FGF10,IL7,ITGA3,LAMA1,CDKN1B,YWHAB,EFNA3,PPP2R2B,GNB1,KRAS,CDK6,LPAR6,FASLG,EFNA5,IFNAR2,YWHAQ,GHR,IKBKB,PTK2,ITGAV,CRTC2,COL2A1,TSC2,CCND1,JAK2,EIF4E,LPAR1,CCNE2,PPP2R2A,RELN,COL1A1,GNG7,EIF4B,GYS2,GNG2,PIK3R1,COL4A4,SOS1,FGF9,YWHAZ,ITGA10,EPHA2,KITLG,IRS1,CASP9,G6PC2,LAMC1,ITGA7,AKT3,COL11A1,EIF4E2,CREB3L2,ANGPT1,COL6A3,PDGFD,PIK3CA,COL4A6,FOXO3,FN1,PKN2,CDKN1A,MAP2K1,TNN,PTEN,SGK3,MAPK1,CSF1,GRB2,GNB4,JAK1,MDM2,NGFR,BCL2L11,PDGFRB,CHRM1,IL6R
Dopaminergic synapse / 7.66E-11 / 47 / 21 / CAMK2D,FOS,GSK3B,PRKCA,CACNA1A,GNG13,PPP2R5E,KIF5A,CALM3,CALM1,PPP2CA,CREB5,PPP1CC,MAPK14,GNG12,DRD1,SLC18A2,GRIA1,PPP2R2B,GNB1,GRIA2,PPP3CA,ARNTL,PLCB1,SLC6A3,CACNA1B,PPP3CB,MAOA,MAPK8,PPP2R2A,SCN1A,GNG7,GNG2,PRKX,CACNA1C,PRKCB,GNAQ,AKT3,CREB3L2,CACNA1D,GRIN2A,GNB4,KIF5C,GNAI1,PRKACB,PPP1CB,GRIA3
Non-small cell lung cancer / 9.59E-11 / 24 / 14 / BRAF,PRKCA,SOS2,PIK3CB,RXRG,TGFA,RARB,KRAS,CDK6,MST1,CCND1,RASSF5,PIK3R1,SOS1,CASP9,PRKCB,AKT3,PIK3CA,FOXO3,MAP2K1,RXRB,MAPK1,FHIT,GRB2
Neurotrophin signaling pathway / 1.17E-10 / 45 / 23 / CAMK2D,BRAF,GSK3B,NTRK2,SOS2,SH2B3,CAMK4,YWHAE,CALM3,CALM1,MAP3K3,CRK,PIK3CB,SORT1,RAP1A,MAPK14,NTRK3,PRKCD,MAP3K1,RHOA,NGFRAP1,KRAS,SHC3,FASLG,IKBKB,NTF4,MAPK8,KIDINS220,PIK3R1,SOS1,IRS1,CDC42,PSEN1,RPS6KA3,GAB1,SHC4,AKT3,PIK3CA,FOXO3,MAP2K1,MAPK1,GRB2,RAP1B,NGFR,MAP3K5
Chronic myeloid leukemia / 3.41E-10 / 30 / 19 / BRAF,TGFBR1,SOS2,CRK,RUNX1,PIK3CB,HDAC1,CTBP2,SMAD3,CDKN1B,KRAS,CDK6,SHC3,IKBKB,CBLB,CCND1,SMAD4,PIK3R1,SOS1,HDAC2,TGFB2,SHC4,AKT3,PIK3CA,MECOM,CDKN1A,MAP2K1,MAPK1,GRB2,MDM2
GABAergic synapse / 5.38E-09 / 36 / 17 / PLCL1,PRKCA,CACNA1A,GNG13,ADCY1,GPHN,GABARAPL2,HAP1,GABRG2,GNG12,GLS,GNB1,GABRB3,CACNA1B,GABRA5,GNG7,GABRG1,GNG2,GAD2,SAT2,PRKX,CACNA1C,PRKCB,GABRQ,GABRR1,GABRA4,GABRB2,CACNA1D,GLS2,GABRP,ADCY9,GNB4,GABRA2,SLC6A1,GNAI1,PRKACB
Prion diseases / 4.41E-08 / 9 / 9 / STIP1,HSPA5,NCAM2,PRNP,PRKX,LAMC1,MAP2K1,MAPK1,PRKACB
Focal adhesion / 1.28E-07 / 62 / 24 / BRAF,GSK3B,PRKCA,PDGFRA,SOS2,CRK,ITGA8,PIK3CB,PAK2,THBS2,COL4A5,LAMB4,COL24A1,PPP1CC,RAP1A,CCND2,COL27A1,ROCK2,ITGB6,ITGA3,LAMA1,RHOA,SHC3,VAV2,ARHGAP35,PTK2,ITGAV,COL2A1,PPP1R12A,CCND1,MAPK8,PARVA,DIAPH1,RELN,COL1A1,PIK3R1,COL4A4,SOS1,ITGA10,CDC42,PAK6,PRKCB,LAMC1,ITGA7,SHC4,AKT3,COL11A1,COL6A3,PDGFD,PIK3CA,COL4A6,FN1,MAP2K1,TNN,PTEN,MAPK1,GRB2,RAP1B,ARHGAP5,PDGFRB,XIAP,PPP1CB
Colorectal cancer / 1.54E-07 / 25 / 16 / BRAF,FOS,GSK3B,TGFBR1,SMAD2,TCF4,APC,PIK3CB,TCF7L1,SMAD3,RHOA,APPL1,KRAS,CCND1,SMAD4,MSH6,MAPK8,PIK3R1,CASP9,TGFB2,AKT3,PIK3CA,LEF1,MAP2K1,MAPK1
GnRH signaling pathway / 1.93E-07 / 32 / 15 / CAMK2D,HBEGF,PRKCA,ADCY1,SOS2,PTK2B,CALM3,CALM1,MAP3K3,MAPK14,PLA2G4F,PRKCD,MAP3K4,MAP3K1,KRAS,PLCB1,MAPK8,SOS1,PRKX,CDC42,CACNA1C,PRKCB,GNAQ,MAP2K1,MAP3K2,MAP2K4,CACNA1D,MAPK1,MMP14,GRB2,ADCY9,PRKACB
Small cell lung cancer / 1.93E-07 / 30 / 16 / PIK3CB,RXRG,COL4A5,LAMB4,CDK2,ITGA3,LAMA1,RARB,CDKN1B,CKS1B,CDK6,IKBKB,PTK2,ITGAV,CCND1,CCNE2,PTGS2,PIK3R1,COL4A4,CASP9,LAMC1,AKT3,PIK3CA,COL4A6,FN1,RXRB,PTEN,TRAF3,FHIT,XIAP
MAPK signaling pathway / 1.93E-07 / 78 / 25 / BRAF,FOS,NTRK2,PRKCA,PDGFRA,CACNA1A,TGFBR1,CACNA2D3,PTPRQ,SOS2,RASA2,ELK4,MAP3K3,CRK,PAK2,CACNB4,RAP1A,MAPK14,TAOK2,GNG12,FGF10,PLA2G4F,MAP4K3,RASGRP2,GADD45A,MAP3K4,MAP3K1,KRAS,FASLG,MST1,TAOK1,IKBKB,PPP3CA,NLK,NTF4,CACNA1B,PPP3CB,RAPGEF2,NFATC2,MAPK8,PPM1A,CACNA1E,SOS1,FGF9,PRKX,CDC42,CACNA1C,NF1,PRKCB,FAS,RPS6KA3,TGFB2,AKT3,MECOM,MAP2K1,STMN1,MAP3K2,MKNK1,RASGRP3,PPM1B,CACNG6,CACNA2D1,CACNB2,PTPN5,MEF2C,MAP2K4,CACNA1D,DUSP16,MAPK1,MAP3K7,GRB2,RAP1B,CHP2,CACNG1,MAP3K5,PDGFRB,ARRB1,PRKACB
Retrograde endocannabinoid signaling / 2.62E-07 / 40 / 17 / PRKCA,CACNA1A,GNG13,ADCY1,GABRG2,GRM5,MAPK14,SLC17A8,GNG12,GRIA1,GNB1,GRIA2,GABRB3,PLCB1,CACNA1B,GABRA5,MAPK8,GNG7,GABRG1,GNG2,PTGS2,PRKX,CACNA1C,PRKCB,GABRQ,GNAQ,GABRR1,NAPEPLD,GABRA4,GABRB2,CACNA1D,ABHD6,MAPK1,GABRP,ADCY9,GNB4,GABRA2,GNAI1,PRKACB,GRIA3
Wnt signaling pathway / 3.47E-07 / 53 / 21 / CAMK2D,GSK3B,PRKCA,DVL3,PPP2R5E,LRP6,TBL1X,WNT7A,SMAD2,BTRC,TCF4,APC,PPP2CA,CCND2,DKK2,ROCK2,TCF7L1,CTBP2,SMAD3,WNT3,CSNK1A1L,RHOA,PPP3CA,PRICKLE1,NLK,PLCB1,FZD4,NFAT5,CCND1,SMAD4,PPP3CB,NFATC2,MAPK8,CSNK1A1,PRKX,SIAH1,PSEN1,CACYBP,PRKCB,CSNK1E,CXXC4,RBX1,LEF1,SFRP1,DKK1,DAAM1,MAP3K7,CREBBP,FBXW11,TBL1XR1,CHP2,WNT9A,PRKACB
Insulin signaling pathway / 4.52E-07 / 44 / 21 / BRAF,GSK3B,TSC1,SOS2,PRKAA2,CALM3,CALM1,CRK,PIK3CB,PRKCI,PPP1CC,PTPN1,KRAS,SHC3,IKBKB,CBLB,PPP1R3A,TSC2,EIF4E,MAPK8,GYS2,PIK3R1,SOS1,PRKX,IRS1,PHKG2,HKDC1,G6PC2,PRKAB2,SHC4,AKT3,EIF4E2,PPARGC1A,PIK3CA,PPP1R3B,MAP2K1,MKNK1,PRKAR2B,MAPK1,PHKB,GRB2,PRKAG3,PRKACB,PPP1CB
Endometrial cancer / 4.82E-07 / 21 / 16 / CAMK2D,GSK3B,PRKCA,DVL3,PPP2R5E,LRP6,TBL1X,WNT7A,SMAD2,BTRC,TCF4,APC,PPP2CA,CCND2,DKK2,ROCK2,TCF7L1,CTBP2,SMAD3,WNT3,CSNK1A1L,RHOA,PPP3CA,PRICKLE1,NLK,PLCB1,FZD4,NFAT5,CCND1,SMAD4,PPP3CB,NFATC2,MAPK8,CSNK1A1,PRKX,SIAH1,PSEN1,CACYBP,PRKCB,CSNK1E,CXXC4,RBX1,LEF1,SFRP1,DKK1,DAAM1,MAP3K7,CREBBP,FBXW11,TBL1XR1,CHP2,WNT9A,PRKACB
Prostate cancer / 6.97E-07 / 31 / 17 / BRAF,GSK3B,PDGFRA,SOS2,TCF4,PIK3CB,CREB5,TGFA,CDK2,TCF7L1,CDKN1B,KRAS,IKBKB,CCND1,CCNE2,PIK3R1,SOS1,CASP9,AKT3,CREB3L2,PDGFD,PIK3CA,LEF1,CDKN1A,MAP2K1,PTEN,MAPK1,CREBBP,GRB2,MDM2,PDGFRB
Amphetamine addiction / 8.09E-07 / 29 / 14 / CAMK2D,FOS,PRKCA,GRIN3A,CAMK4,CALM3,CALM1,SIRT1,CREB5,HDAC1,PPP1CC,DRD1,SLC18A2,GRIA1,GRIA2,PPP3CA,SLC6A3,PPP3CB,MAOA,PRKX,CACNA1C,PRKCB,CREB3L2,CACNA1D,GRIN2A,CHP2,PRKACB,PPP1CB,GRIA3
Glutamatergic synapse / 1.18E-06 / 40 / 19 / PRKCA,GRIN3A,CACNA1A,GNG13,ADCY1,GRM5,SLC17A8,GNG12,PLA2G4F,SLC1A1,GRIA1,GLS,GNB1,CPD,GRIA2,PPP3CA,PLCB1,PPP3CB,GNG7,GNG2,SAT2,PRKX,CACNA1C,PRKCB,GNAQ,HOMER1,GRIK4,CACNA1D,GRM8,MAPK1,GRIN2A,GLS2,ADCY9,GNB4,CHP2,SLC1A2,GNAI1,PRKACB,GRIA3,GRIK3
Thyroid cancer / 1.40E-06 / 13 / 12 / BRAF,TCF4,RXRG,TCF7L1,KRAS,PAX8,CCND1,PPARG,LEF1,MAP2K1,RXRB,MAPK1,CCDC6
Pathways in cancer / 1.49E-06 / 98 / 26 / BRAF,FOS,GSK3B,PRKCA,DVL3,PDGFRA,TGFBR1,WNT7A,SOS2,SMAD2,TCF4,APC,CRK,RUNX1,PIK3CB,HDAC1,RXRG,TGFA,HHIP,COL4A5,LAMB4,CDK2,TCF7L1,RALA,FGF10,CTBP2,SMAD3,ITGA3,LAMA1,RARB,CDKN1B,WNT3,RHOA,APPL1,KRAS,CKS1B,CDK6,FASLG,MST1,PAX8,VHL,EPAS1,MITF,IKBKB,PTK2,CBLB,ITGAV,FH,FZD4,RUNX1T1,CCND1,SMAD4,MSH6,CCNE2,RASSF5,MAPK8,DAPK1,CSF2RA,PTGS2,PIK3R1,COL4A4,SOS1,FGF9,HDAC2,KITLG,CDC42,CASP9,PRKCB,FAS,LAMC1,TGFB2,PPARG,CASP8,AKT3,CTNNA3,PIK3CA,RBX1,LEF1,COL4A6,MECOM,FN1,CDKN1A,MAP2K1,SLC2A1,STAT1,RXRB,PTEN,MAPK1,CREBBP,TRAF3,GRB2,JAK1,MDM2,WNT9A,CCDC6,PDGFRB,XIAP,EGLN1
T cell receptor signaling pathway / 1.96E-06 / 35 / 19 / FOS,GSK3B,SOS2,PIK3CB,PAK2,TEC,MAPK14,RHOA,KRAS,VAV2,IKBKB,PPP3CA,CBLB,NFAT5,CD28,PPP3CB,NFATC2,ICOS,IL5,PIK3R1,SOS1,CDC42,PAK6,AKT3,PIK3CA,MALT1,IFNG,GRAP2,MAP2K1,CD3E,LCP2,MAPK1,MAP3K7,GRB2,CHP2
ErbB signaling pathway / 2.41E-06 / 32 / 17 / CAMK2D,BRAF,GSK3B,HBEGF,PRKCA,SOS2,CRK,PIK3CB,PAK2,TGFA,CDKN1B,KRAS,SHC3,PTK2,CBLB,MAPK8,PIK3R1,SOS1,PAK6,PRKCB,GAB1,SHC4,AKT3,PIK3CA,CDKN1A,MAP2K1,MAP2K4,MAPK1,ABL2,GRB2,ERBB4,EREG
Notch signaling pathway / 4.82E-06 / 18 / 12 / NUMB,DVL3,HDAC1,DTX4,CTBP2,NOTCH2,ADAM17,LFNG,DLL1,HDAC2,PSEN1,JAG1,RBPJ,KAT2B,DTX1,MAML2,DTX3L,CREBBP
Nicotine addiction / 4.93E-06 / 18 / 13 / GRIN3A,CACNA1A,GABRG2,SLC17A8,GRIA1,GRIA2,GABRB3,CACNA1B,GABRA5,GABRG1,GABRQ,GABRR1,GABRA4,GABRB2,GRIN2A,GABRP,GABRA2,GRIA3
p53 signaling pathway / 6.15E-06 / 24 / 13 / CCNG1,ZMAT3,CDS1,SFN,CDK2,CCND2,GADD45A,CDK6,TSC2,CCND1,CCNE2,SHISA5,EI24,SIAH1,CASP9,SESN2,MDM4,FAS,CASP8,CDKN1A,SESN3,PTEN,CCNG2,MDM2
Renal cell carcinoma / 7.98E-06 / 27 / 18 / BRAF,SOS2,CRK,PIK3CB,PAK2,TGFA,RAP1A,KRAS,VHL,EPAS1,FH,PIK3R1,SOS1,CDC42,PAK6,TGFB2,GAB1,AKT3,PIK3CA,RBX1,MAP2K1,SLC2A1,MAPK1,CREBBP,GRB2,RAP1B,EGLN1
mTOR signaling pathway / 1.21E-05 / 23 / 20 / BRAF,PRKCA,TSC1,RRAGD,PRKAA2,PIK3CB,RICTOR,IKBKB,TSC2,EIF4E,EIF4B,PIK3R1,IRS1,ULK3,PRKCB,RPS6KA3,AKT3,EIF4E2,PIK3CA,PTEN,MAPK1,RRAGC,RRAGB
Axon guidance / 1.38E-05 / 43 / 21 / EFNB2,SEMA6A,PLXNA2,GSK3B,EPHB2,PAK2,ARHGEF12,ROCK2,ROBO2,SEMA3C,SRGAP1,SEMA5B,EFNA3,RHOA,KRAS,EFNA5,EPHA7,EPHB3,PPP3CA,PTK2,NFAT5,SLIT2,PPP3CB,SRGAP3,DPYSL5,NFATC2,LIMK2,CFL2,SEMA3D,NRP1,EPHA2,CDC42,PAK6,EPHB6,PLXNC1,SEMA7A,RND1,EPHA4,UNC5D,MAPK1,CHP2,EPHB1,GNAI1
Calcium signaling pathway / 2.40E-05 / 53 / 21 / CAMK2D,PDE1C,PRKCA,PDGFRA,CACNA1A,BDKRB1,PTGFR,ADCY1,CAMK4,PTK2B,CALM3,CALM1,GRM5,BDKRB2,STIM2,DRD1,ITPKB,CHRM3,ADRB3,PTGER3,ATP2B1,PDE1B,PDE1A,PPP3CA,NOS1,RYR1,PLCB1,CACNA1B,PPP3CB,PLN,CACNA1E,PRKX,PHKG2,CACNA1C,PRKCB,GNAQ,TACR3,LHCGR,EDNRA,NOP9,ATP2A2,PPIF,CACNA1D,PHKB,GRIN2A,ADCY9,ADRA1D,CHP2,ERBB4,PDGFRB,PRKACB,VDAC3,CHRM1
mRNA surveillance pathway / 3.36E-05 / 30 / 16 / MSI2,SMG5,PPP2R5E,UPF3A,EIF4A3,CPSF7,PPP2CA,HBS1L,PPP1CC,GSPT2,CPSF6,PPP2R2B,CSTF3,DAZAP1,PNN,WDR82,PABPC3,PPP2R2A,CSTF1,RNMT,PABPC1L2A,RNGTT,NXT2,PABPN1,SMG7,UPF1,ACIN1,PCF11,PPP1CB,GSPT1
Hepatitis B / 3.36E-05 / 47 / 22 / FOS,PRKCA,TGFBR1,DDX3Y,DDX58,PTK2B,CCNA2,PIK3CB,CREB5,CDK2,SMAD3,CDKN1B,YWHAB,MAP3K1,KRAS,CDK6,DDX3X,FASLG,YWHAQ,IKBKB,NFAT5,CCND1,SMAD4,CCNE2,NFATC2,MAPK8,TIRAP,PIK3R1,YWHAZ,CASP9,PRKCB,FAS,TGFB2,CASP8,AKT3,CREB3L2,PIK3CA,CDKN1A,MAP2K1,STAT1,MAP2K4,PTEN,MAPK1,CREBBP,GRB2,JAK1,VDAC3
Cell cycle / 3.68E-05 / 44 / 20 / ESPL1,GSK3B,RBL2,CDS1,SMC1A,SFN,SMAD2,YWHAE,CDC14A,CCNA2,HDAC1,CDK2,CCND2,SMAD3,CDKN1B,MCM5,STAG2,YWHAB,WEE1,GADD45A,CCNH,CDK6,BUB3,YWHAQ,CDKN1C,CCND1,SMAD4,CCNE2,E2F5,CDC14B,RBL1,TTK,YWHAZ,HDAC2,CDC7,TGFB2,CDC27,RBX1,CDKN1A,PRKDC,CREBBP,RAD21,ORC5,MDM2
Glioma / 8.71E-05 / 26 / 14 / CAMK2D,BRAF,PRKCA,PDGFRA,SOS2,CALM3,CALM1,PIK3CB,TGFA,KRAS,CDK6,SHC3,CCND1,PIK3R1,SOS1,PRKCB,SHC4,AKT3,PIK3CA,CDKN1A,MAP2K1,PTEN,MAPK1,GRB2,MDM2,PDGFRB
Ubiquitin mediated proteolysis / 0.000116 / 40 / 22 / UBE2R2,UBE2Q2,BTRC,FBXW7,TRIM37,WWP1,SMURF2,NEDD4L,HUWE1,ITCH,DET1,UBE4A,RHOBTB1,PRPF19,MAP3K1,MID1,VHL,UBA2,UBA6,KLHL13,CBLB,CUL5,BIRC6,UBE2Q1,UBE2K,SIAH1,UBE2D4,NEDD4,UBE2D3,HERC4,UBE2D1,CDC27,RBX1,UBE2G1,CUL3,UBE2W,FBXW11,PIAS1,MDM2,XIAP
Vascular smooth muscle contraction / 0.000159 / 38 / 15 / BRAF,PRKCA,ADCY1,CALM3,CALM1,ARHGEF12,PPP1CC,ROCK2,PLA2G4F,KCNMA1,PRKCD,PLA2G6,RHOA,PPP1R12B,PLA2G2D,PLA2G3,PLCB1,PPP1R12A,PLA2G12A,CYP4A22,KCNMB2,PRKX,MYH11,CACNA1C,CALD1,PRKCB,GNAQ,MAP2K1,EDNRA,PRKCH,PRKG1,CACNA1D,MAPK1,ADCY9,CALCRL,ADRA1D,PRKACB,PPP1CB
TGF-beta signaling pathway / 0.000261 / 24 / 16 / TGFBR1,SMAD2,INHBB,THBS2,PPP2CA,SMURF2,ROCK2,PITX2,SMAD3,INHBA,ID4,RHOA,ACVR1,SMAD4,E2F5,RBL1,ACVR2A,ACVR1C,TGFB2,RBX1,IFNG,MAPK1,CREBBP,BMPR2
RNA transport / 0.000261 / 44 / 21 / EIF3F,NUP62,NUP85,UPF3A,NUP153,EIF4A3,TGS1,NUP210,XPOT,NUP160,FMR1,EIF1AX,EIF5,PNN,EIF4E,PABPC3,EIF3A,EIF4B,EIF4G1,PABPC1L2A,NXT2,EEF1A1,NUP50,FXR2,EIF4E2,NUP54,THOC2,NUP43,EIF1AY,NDC1,EIF4G3,EIF2S2,RAN,UPF1,ACIN1,XPO1,NUPL1,NUP205,EIF2B4,KPNB1,EIF4A1,CYFIP1,EIF4G2,XPO5
Cholinergic synapse / 0.000416 / 36 / 16 / CAMK2D,FOS,PRKCA,CACNA1A,GNG13,ADCY1,CAMK4,PIK3CB,CREB5,KCNQ5,GNG12,CHRM3,GNB1,KRAS,PLCB1,CACNA1B,JAK2,GNG7,GNG2,PIK3R1,PRKX,CACNA1C,PRKCB,KCNJ2,GNAQ,AKT3,CREB3L2,PIK3CA,MAP2K1,CACNA1D,MAPK1,ADCY9,GNB4,GNAI1,PRKACB,CHRM1
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis / 0.000452 / 9 / 7 / BST1,GPAA1,PIGK,PIGP,PIGV,PIGB,PIGN,PIGO,PIGA
Regulation of actin cytoskeleton / 0.000472 / 60 / 24 / ARPC5,BRAF,PDGFRA,BDKRB1,SSH2,WASL,SOS2,APC,CRK,ITGA8,PIK3CB,PAK2,ARHGEF12,PPP1CC,ROCK2,ITGB6,BDKRB2,MYH10,GNG12,FGF10,RDX,ITGA3,TIAM1,CHRM3,RHOA,ARHGEF6,KRAS,ABI2,VAV2,ARHGAP35,PTK2,ITGAV,PIKFYVE,PPP1R12A,PFN2,LIMK2,DIAPH1,DIAPH3,PIP4K2B,CFL2,PIK3R1,SOS1,FGF9,ITGA10,CDC42,PAK6,ITGA7,PDGFD,PIK3CA,FN1,MAP2K1,NCKAP1,MAPK1,DIAPH2,PIP4K2C,ENAH,CYFIP1,PDGFRB,PPP1CB,CHRM1
Transcriptional misregulation in cancer / 0.000669 / 51 / 23 / CCNT2,TMPRSS2,MMP3,LMO2,ELK4,RUNX1,HMGA2,HPGD,HDAC1,RXRG,CCND2,PAX5,GZMB,PBX1,CDKN1B,PAX8,SS18,CCNT1,PTK2,RUNX1T1,CDK9,MLF1,NR4A3,KLF3,WT1,ETV7,CD86,NCOR1,JMJD1C,ETV1,HDAC2,CDK14,DDX5,ATF1,MAF,KDM6A,BCL6,PPARG,WHSC1,KMT2A,MYCN,CDKN1A,TFE3,EYA1,MEF2C,RXRB,SIX4,PLAU,MDM2,NGFR,GRIA3
Vasopressin-regulated water reabsorption / 0.000757 / 17 / 10 / DCTN5,CREB5,DCTN2,DCTN4,RAB5A,AQP4,DYNC1LI2,RAB11A,DCTN1,DYNC2LI1,PRKX,CREB3L2,DYNC2H1,ADCY9,PRKACB,VAMP2,DYNLL2
Taurine and hypotaurine metabolism / 0.000845 / 5 / 4 / ADO,GAD2,GGT6,GGT1,CSAD
Glycerolipid metabolism / 0.001005 / 20 / 13 / LPIN1,DGKA,MOGAT3,ALDH3A2,DGKG,AGPAT1,AGPAT4,ARL1,DGKZ,GK,LPL,GPAM,LPIN2,AGPAT6,LCLAT1,DAK,DGKB,AGPAT3,MBOAT2,AGPAT9
VEGF signaling pathway / 0.001009 / 21 / 15 / PRKCA,PIK3CB,MAPK14,PLA2G4F,KRAS,PPP3CA,PTK2,NFAT5,PPP3CB,NFATC2,PTGS2,PIK3R1,CDC42,CASP9,PRKCB,AKT3,PIK3CA,MAP2K1,SH2D2A,MAPK1,CHP2
Pancreatic cancer / 0.001085 / 24 / 17 / BRAF,TGFBR1,SMAD2,PIK3CB,TGFA,RALA,SMAD3,ARHGEF6,KRAS,CDK6,IKBKB,CCND1,SMAD4,MAPK8,PIK3R1,CDC42,CASP9,TGFB2,AKT3,PIK3CA,MAP2K1,STAT1,MAPK1,JAK1
Circadian rhythm / 0.001146 / 12 / 11 / PRKAA2,BTRC,RORB,BHLHE41,ARNTL,CRY2,ROR1,PRKAB2,CSNK1E,RBX1,FBXW11,PRKAG3
Lysine degradation / 0.001434 / 17 / 13 / WHSC1L1,SETD7,ALDH3A2,SETD2,NSD1,ASH1L,AADAT,COLGALT2,SUV420H1,WHSC1,KMT2A,EHHADH,DLST,KMT2E,KMT2C,EHMT1,SUV39H1
Dorso-ventral axis formation / 0.003004 / 9 / 10 / SOS2,NOTCH2,KRAS,ETV7,SOS1,MAP2K1,MAPK1,GRB2,SPIRE2
Aldosterone-regulated sodium reabsorption / 0.003901 / 13 / 12 / PRKCA,SFN,PIK3CB,ATP1A2,NEDD4L,KRAS,PIK3R1,IRS1,PRKCB,PIK3CA,ATP1A1,SCNN1A,MAPK1
Acute myeloid leukemia / 0.005205 / 18 / 16 / BRAF,SOS2,TCF4,RUNX1,PIK3CB,TCF7L1,KRAS,IKBKB,RUNX1T1,CCND1,PIK3R1,SOS1,AKT3,PIK3CA,LEF1,MAP2K1,MAPK1,GRB2
B cell receptor signaling pathway / 0.010004 / 22 / 16 / FOS,GSK3B,SOS2,PIK3CB,KRAS,VAV2,IKBKB,PPP3CA,NFAT5,PPP3CB,NFATC2,PIK3R1,SOS1,PRKCB,AKT3,PIK3CA,MALT1,MAP2K1,RASGRP3,MAPK1,GRB2,CHP2
Melanogenesis / 0.011674 / 28 / 18 / CAMK2D,GSK3B,PRKCA,DVL3,ADCY1,WNT7A,CALM3,CALM1,TCF4,TCF7L1,WNT3,KRAS,MITF,PLCB1,FZD4,PRKX,KITLG,PRKCB,GNAQ,CREB3L2,LEF1,MAP2K1,MAPK1,CREBBP,ADCY9,WNT9A,GNAI1,PRKACB
Glycerophospholipid metabolism / 0.014214 / 27 / 13 / LPIN1,DGKA,MBOAT7,PLB1,PLA2G4F,GPD1,PLA2G6,DGKG,PLA2G2D,AGPAT1,PNPLA7,PLA2G3,AGPAT4,EPT1,DGKZ,PLA2G12A,GPAM,LPIN2,AGPAT6,LCLAT1,DGKB,TAZ,AGPAT3,CHKA,MBOAT2,LPGAT1,AGPAT9
Endocrine and other factor-regulated calcium reabsorption / 0.014984 / 16 / 10 / PRKCA,ATP1A2,AP2B1,BDKRB2,ATP2B1,PLCB1,RAB11A,PRKX,PRKCB,GNAQ,DNM3,ATP1A1,CALB1,ADCY9,AP2M1,PRKACB
D-Glutamine and D-glutamate metabolism / 0.01872 / 2 / 3 / GLS,GLS2
Dilated cardiomyopathy / 0.019596 / 25 / 14 / CACNA2D3,ADCY1,TPM1,ITGA8,CACNB4,ITGB6,SGCD,ITGA3,ITGAV,PLN,DAG1,ITGA10,PRKX,CACNA1C,SGCA,TGFB2,ITGA7,CACNG6,CACNA2D1,ATP2A2,CACNB2,CACNA1D,ADCY9,CACNG1,PRKACB
RNA degradation / 0.025991 / 21 / 14 / CNOT6,BTG4,SKIV2L2,TOB1,DDX6,C1D,TTC37,BTG2,DCP2,CNOT7,PABPC3,RQCD1,PABPC1L2A,XRN1,CNOT10,BTG3,CNOT1,EDC3,PAN3,CNOT6L,BTG1
Protein digestion and absorption / 0.027914 / 24 / 17 / KCNE3,ATP1A2,COL4A5,COL24A1,COL27A1,KCNJ13,SLC1A1,SLC16A10,COL21A1,COL2A1,COL15A1,SLC7A7,SLC7A8,COL1A1,SAT2,COL4A4,COL13A1,SLC36A1,COL11A1,KCNK5,COL6A3,COL4A6,DPP4,ATP1A1
Hypertrophic cardiomyopathy (HCM) / 0.02847 / 23 / 15 / CACNA2D3,TPM1,PRKAA2,ITGA8,CACNB4,ITGB6,SGCD,ITGA3,ITGAV,DAG1,ITGA10,CACNA1C,SGCA,PRKAB2,TGFB2,ITGA7,CACNG6,CACNA2D1,ATP2A2,CACNB2,CACNA1D,PRKAG3,CACNG1
Osteoclast differentiation / 0.030196 / 34 / 16 / TNFRSF11B,FOS,TGFBR1,CAMK4,PIK3CB,TEC,MAPK14,CALCR,SQSTM1,CYLD,SIRPA,IFNAR2,MITF,IKBKB,PPP3CA,PPP3CB,NFATC2,MAPK8,FOSL2,PIK3R1,TGFB2,PPARG,AKT3,PIK3CA,IFNG,MAP2K1,STAT1,LCP2,MAPK1,MAP3K7,CSF1,GRB2,CHP2,JAK1
Chemokine signaling pathway / 0.03031 / 47 / 22 / BRAF,CCL3L3,GSK3B,GNG13,ADCY1,WASL,SOS2,PTK2B,CRK,PIK3CB,RAP1A,ROCK2,GNG12,PRKCD,TIAM1,RASGRP2,GNB1,RHOA,KRAS,SHC3,VAV2,IKBKB,PTK2,PLCB1,JAK2,GNG7,GNG2,PIK3R1,SOS1,PRKX,CDC42,PRKCB,SHC4,AKT3,PIK3CA,FOXO3,MAP2K1,STAT1,CXCL9,MAPK1,GRB2,ADCY9,RAP1B,GNB4,GNAI1,ARRB1,PRKACB
Fc epsilon RI signaling pathway / 0.034118 / 20 / 13 / PRKCA,SOS2,PIK3CB,MAPK14,PLA2G4F,PRKCD,KRAS,VAV2,MAPK8,IL5,PIK3R1,SOS1,PRKCB,AKT3,PIK3CA,MAP2K1,MAP2K4,LCP2,MAPK1,GRB2
Long-term depression / 0.034118 / 22 / 15 / BRAF,PRKCA,CACNA1A,CRH,PPP2CA,GRM5,PLA2G4F,GRIA1,KRAS,GRIA2,NOS1,RYR1,PLCB1,PRKG2,PRKCB,GNAQ,MAP2K1,PRKG1,MAPK1,PPP1R17,GNAI1,GRIA3
Chagas disease (American trypanosomiasis) / 0.034118 / 28 / 18 / FOS,CCL3L3,TGFBR1,ADCY1,SMAD2,PIK3CB,PPP2CA,MAPK14,BDKRB2,SMAD3,PPP2R2B,FASLG,IKBKB,PLCB1,MAPK8,PPP2R2A,PIK3R1,FAS,TGFB2,CASP8,GNAQ,AKT3,PIK3CA,IFNG,CD3E,MAP2K4,MAPK1,GNAI1
Gap junction / 0.04458 / 26 / 17 / PRKCA,PDGFRA,ADCY1,SOS2,TUBA1B,GRM5,DRD1,KRAS,PLCB1,PRKG2,LPAR1,TUBA1C,SOS1,PRKX,PRKCB,GNAQ,PDGFD,MAP2K1,MAP3K2,PRKG1,MAPK1,GRB2,ADCY9,GNAI1,PDGFRB,PRKACB
Type II diabetes mellitus / 0.044897 / 14 / 10 / CACNA1A,PIK3CB,PRKCD,IKBKB,CACNA1B,MAPK8,CACNA1E,PIK3R1,IRS1,CACNA1C,HKDC1,PIK3CA,CACNA1D,MAPK1

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