Full Public Report

File No: NA/260 December1997

NATIONALINDUSTRIALCHEMICALSNOTIFICATIONANDASSESSMENTSCHEME

FULL PUBLIC REPORT

IxolB251

ThisAssessmenthasbeencompiledinaccordancewiththeprovisions oftheIndustrialChemicals(NotificationandAssessment)Act1989(theAct),andRegulations.ThislegislationisanActoftheCommonwealthofAustralia.TheNationalIndustrialChemicalsNotificationandAssessmentScheme(NICNAS)isadministeredbyWorksafeAustraliawhichalsoconductstheoccupationalhealthsafetyassessment.TheassessmentofenvironmentalhazardisconductedbytheDepartmentoftheEnvironmentandtheassessmentofpublichealthisconductedbytheDepartmentofHealthandFamilyServices.

Forthepurposesofsubsection78(1)oftheAct,copiesofthisfullpublicreportmaybeinspectedbythepublicattheLibrary,WorksafeAustralia,92-94ParramattaRoad,Camperdown NSW2050,betweenthefollowinghours:

Monday - Wednesday8.30am-5.00pmThursday8.30am-8.00pm

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ForenquiriespleasecontacttheAdministrationCoordinatorat:

Street Address: 92ParramattaRdCamperdown,NSW2050,AUSTRALIA

Postal Address:GPOBox58,Sydney2001,AUSTRALIA

Telephone:(61)(02)9577-9466 FAX (61)(02)9577-9465

Director

ChemicalsNotificationandAssessment

NA/260

FULL PUBLIC REPORT

IxolB251

1.APPLICANT

AustralianUrethaneSystemsPtyLtdof5PrinceWilliamDriveSEVENHILLSNSW2147hassubmittedastandardnotificationstatementinsupportoftheirapplicationforanassessmentcertificateforIxolB251.

2.IDENTITYOFTHECHEMICAL

Trade Name:Ixol B 251

MethodofDetection

andDetermination:infrared(IR)spectroscopy

3.PHYSICALANDCHEMICALPROPERTIESAppearance at 20°C

and 101.3 kPa:darkbrown,viscousliquidwithaslightether-likeodour

MeltingPoint:-100°C

BoilingPoint:160°C(decomposition)

SpecificGravity:1.58

Vapour Pressure:0.47kPaat20°C

WaterSolubility:450 g.kg-1

PartitionCo-efficient

(n-octanol/water):log Kow=0.2(calculated)

HydrolysisasaFunction

ofpH:nosignificanthydrolysis(independentofpH)

Adsorption/Desorption:notdetermined(seecommentsbelow)DissociationConstant: notdetermined(seecommentsbelow)FlashPoint: 196°C

FlammabilityLimits:non-flammableAutoignitionTemperature:350°CExplosiveProperties: none

Reactivity/Stability:stableupto50°C

CommentsonPhysico-ChemicalProperties

Thepresenceofhydroxylgroupsonthenotifiedchemicalenablesittohydrogenbondwithwaterandasaresultimpartswatersolubility(1). Thesolubilitywasdeterminedgravimetricallybyequilibratingtheproduct,IxolB251,withwaterthenseparatingandremovingthewaterundervacuumat50Cfor50hours.

ThenotifiedchemicaldoesnotcontainanyfunctionalgroupswhicharelikelytoundergohydrolysisintheenvironmentalpHrange(pH4-9).

Becauseofitshighwatersolubilityandrelativelylowpartitioncoefficient,thechemicalisnotexpectedtoadsorbtoorganicmatterandsedimentstoanygreatextent.Highmobilityinwaterandsoilisexpected.

ThesubstancedoesnotcontainanygroupslikelytogainorloseaprotonintheenvironmentalpHrange.

4.PURITYOFTHECHEMICALDegreeofPurity:99.85%ToxicorHazardous

Impurities:none

Non-hazardousImpurities

(>1%byweight):none

Additives/Adjuvants:none

5.USE,VOLUMEANDFORMULATION

Thenotifiedchemicalistobeusedaspartofthecomponentsofafire-retardantpolyurethanefoamusedforinsulationinbuildings. Thefoammayalsobesprayedexternallyontobuildingsandcoated. Thenotifiedchemicalwillbeimportedneatin200Ldrumsatarateoflessthan100tonnesperannumforthefirst five years.

6.OCCUPATIONALEXPOSURE

Thenotifiedchemicalwillbetransportedbyroadtothenotifier’spremises.Transportandstorageofthedrumscontainingthenotifiedchemicalshouldnotresultinworkerexposureexceptintheeventofanaccident.

Thenotifiedchemicalwillbereformulatedatthenotifier’spremises.Forreformulationtooccuratasiteotherthanthatofthenotifier,asecondarynotificationwillberequired(seesection15below).

Reformulationoccursinastainlesssteelvessel. Thevesselischargedbyfittingavalvewitharotatingoutlet,tothedrum,andallowingthematerialtoflowintothetank. Thevalveisthenrotatedwhichpreventsspillagefromdripping,untilthe drumisplacedbackonastoragepallet. Followingmixingwithotherchemicals,insuchawaytoavoidsplashing,theresultantblendisfilledinto200litredrum. Thepotentialforexposureduringtheseoperationsisexpectedtobelimitedgiventheprecautionstaken.

Duringenduse,thepolyurethanefoamisproducedbymixingtheblendtogetherwithisocyanateinamachineandapplyingtothespacetobefilledorontobuildingsurfaces. Possibleapplicationsforthefoamareasinsulationinbuildingconstructionwhenfireretardancyisimportant. Thedrumcontainingtheblendisplacednearthemachine,thebungremovedandatransferpumpplacedinpositionandlockedintothe50mmbung. Whenthedrumisempty,thestandardprocedureistounlockthecollarandwithdrawthepump,whichhasliquidfreeexternalsides. Limiteddermalandocularexposuretoresiduesispossibleduringtheseoperations.

Dermal,ocularandinhalationalexposuretothenotifiedchemicalispossiblewhensprayingpolyurethanefoamwhilethefoamisstillintheformofaliquid. Itisrecommendedthatthisoperationshouldonlybecarriedoutusingapprovedpersonprotectiveequipment.

7.PUBLICEXPOSURE

Nopublicexposureisexpectedasaresultoftransportandstorageofthenotifiedchemicalfollowingimportationexceptintheeventofanaccident.Exposureofthepublicasaresultofindustrialuseislikelytobenegligible.Minorpublicexposuremayresultfromdisposalofunusedpolyurethanefoam.

8.ENVIRONMENTALEXPOSURERelease

Atthereformulationsite,thedrumsarestoredonapalletinapre-allocatedspaceiapalletrackingsystem. Thereislimitedopportunityforreleasetotheenvironmentduringthereformulationandrepackagingprocess. Decantingoftheliquidinto205drumsfordispatchtoendusersiscarriedoutusingaclosedpipeandpumpingsystem. TheemptydrumsandresidueofIxolB251aredisposedofbywayofrecyclers. Ifthedrumscannotbereused,theyarecrushedandlandfilled.

Mostenvironmentalexposurecomesfromin situsprayingofthepolyurethaneinsulationfoams. Thesewillbeusedbothinternally(mainlyforvoidfillinginsteel,brickorsomeothermediawherebothphysicalandUVaccessiseliminated)orexternally(ontowallsandexternalroofsofpoultryshedsorindustrialbuildingsortanks). Allexternalapplicationswillbecoatedwithahighgradecoating(i.e.urethane,acrylic,polyesterorpolyvinylester). Theinsulationfoamswillbeappliedusingcommerciallyavailabletypesofspraypourmachines. Themixturecontainingthenotifiedchemicalandisocyanatearemixedinamixingchamberwithinthegunbeforebeingexpelled. Themixture(includingthenotifiedchemical)reactswiththeisocyanatetoformtheinertfullycrosslinkedfoam(2).

Releasethroughthisprocesswillcomeasaresultofspillageduringpouringfromdrums,vapourand/oroverspray,andcleaningofapplicationequipment.Spillageproceduresareoutlinedinthematerialsafetydatasheet(MSDS),whicharetodikelargequantitiesofliquidwithsandorearth,andremovetheproductwithaninertabsorbent. Whensprayingin situstructures,sprayingiscarriedoutatcloserange,andthefoamstabilisesquickly. Thereforereleasetotheenvironmentwillbecontained. Applicationequipmentisseldomcleaned,asusuallyanothergradeortypeofsystemispumpedthroughthemachine.Ifcleaningdoestakeplace,oilorsimilarmaterialisusedasaflushingagent,andthismaterialiscollectedindrumsanddisposedofviaauthorisedliquidwastedisposalcompanies. EmptydrumsoftheIxolB251/mixtureareeitherreturnedtothesupplierforrefilling,orsoldtodrumrecyclers.

Itispossibletodivideflameretardantsintogroupsofadditiveandreactivechemicals. Reactiveflameretardantsareincorporatedintothepolymericmaterialbycovalentbondingbetweenthepolymerandtheflameretardant,whileadditiveflameretardantsareonlymixedwiththepolymer. Thissecondtypemaymigrateoutoftheproductsandcauseadiffusecontaminationofindoorandoutdoorenvironmentsduringthewholelifetimeoftheproduct. Reactiveflameretardantsareimmobilisedintheproductsandthusnotofthesameconcernforenvironmentalcontamination(3). Asthenotifiedchemicalwillbecovalentlylinkedtothefoammatrixitcanbeclassedasareactiveflameretardant. Hence,releasethroughrigidpolyurethanefoams(PURproducts)oncein situ,oraswastewillbelow.

ThecombustionoftheimportedproductorthePURsandPUIRs(polyurethanefoamsmodifiedbyisocyanuraterings)containingthenotifiedchemicalmayreleasetoxicgases,includinghydrogenchloride(HCl),hydrogenbromide(HBr)andcarbonmonoxide. Additionally,highlytoxicchlorinatedandbrominateddibenzodioxinsanddibenzofurans,formedthroughthede novosynthesis(4,5),maybereleasedwheneithertheimportedproductorPURsandPUIRscontainingthefireretardantareburned. Theamountproducedisdependentontheconcentrationofthefireretardantinthefinalproduct,andthetemperatureofthefire. CombustionofthePURsandPUIRsmayalsoreleasehydrogencyanide(HCN).

Fate

ThemajorityofthenotifiedchemicalwillsharethesamefateasthePURsandPUIRsintowhichithasbeenincorporated. Itisanticipatedthattheseproductswillbedisposedoftolandfillattheendoftheirusefullife,alongwiththebuildingmaterialstowhichtheyhavebeenapplied. Beingareactiveflameretardant,ie.onewhichisincorporatedintothepolymericmaterialbycovalentbonding,thelikelihoodofreleasetotheenvironmentthroughthismethodofdisposalislow.

Thenotifierhasoutlineddisposalproceduresasto"Complywithlocalandnationalregulations. Dispatchtheproducttoanauthorisedhazardouswasteincinerator".Duetothepossibilityofcombustionreleasingtoxicgases,landfillwouldbeapreferredoptionfortheultimatefateofwasteimportedproduct.

ThesubstancewasexaminedforbiodegradationpotentialusingEECDirective92/69,PartC.4-E(ClosedBottleTest),andOECDTestGuideline301D. Theresultswere16%biodegradationafter28days(6). Hence,thechemicalcannotbeclassifiedasreadilybiodegradable.

Thecompanystatestherearenodataforbioaccumulation. Despitethepresenceofbromines,thehighwatersolubilityandlowpartitioncoefficientofthenotifiedchemicalindicatethatitisunlikelytobioaccumulate(7).

9.EVALUATIONOFTOXICOLOGICALDATA

9.1AcuteToxicity

SummaryoftheacutetoxicityofIxolB251

Test / Species / Outcome / Reference
acute oral toxicity / rat / LD50=1337mg.kg-1 / (8)
skinirritation / rabbit / non-irritant / (9)
eye irritation / rabbit / moderateirritant / (10)
skinsensitisation / guineapig / non-sensitiser / (11)

9.1.1OralToxicity(8)

Species/strain:rat/Wistar

Number/sexofanimals:5malesperdosegroup

Observationperiod:14 days

Doses/Method of administration:

0,625,1250,2500and5000mg.kg-1by

stomachtube

Clinicalobservations:nosignswereobservedincontroland

animalstreatedwith625mg.kg-1; for 1 250mg.kg-1moderatetoseveresigns(mostly)withonsetbetween6and24hoursafterdosingwereasfor2500mg.kg-1exceptthattwitches,diminishedrightingreflexandsalivationwerenotobserved;for2500mg.kg-1moderatetoseveresignswithonsetmostlybetween1.5and6hoursafterdosingwereasfor5000mg.kg-1exceptfordispersionandopenmouthbutincludingcatatonia,salivationanddiminishedgrooming;for5000mg.kg-1, 10 to 30minutesafterdosing,mostlymoderatetoseveredispersionincage,apathy,twitches,decreasedrespirationrate,decreasedalertnessandstartleresponse,decreasedlocomotoractivity, diminishedrightingreflex,abnormalpostureandgait,piloerection,abnormaltouchresponse,paralysis,openmouth,positionalpassivity,decreasedlimbandbodytoneandhypothermiawereobserved

Mortality:

Dose / 625 / 1 250 / 2 500 / 5 000
(mg.kg-1)
Mortality / 0/5 / 3/5 / 4/5 / 5/5

Morphologicalfindings:forratsthatdiedasaresultoftreatment,

irritationofthegastro-intestinaltract,paleliver,congestedlymphnodesandredspotsonthelungs;onesurvivingratofthe

2500mg.kg-1dosegrouphadaslightlyenlargedliverandaslightlyirritatedfundus

Test method:notspecified

LD50:1337(863-2070)mg.kg-1

Result:thenotifiedchemicalwasofmoderateacuteoral toxicity in rats

DermalToxicity

not provided

9.1.2InhalationToxicity

not provided

9.1.4 / SkinIrritation(9)Species/strain: Number/sexofanimals:Observationperiod:
Methodofadministration: / rabbit/NewZealandWhite3
72hours
0.5gappliedunderocclusivepatchfor4
hours
Test method: / accordingtoOECDguidelines(12)
Result: / thenotifiedchemicalwasnotirritatingtotheskinofrabbits
9.1.5 / EyeIrritation(10)
Species/strain: / rabbit/NewZealandWhite
Number/sexofanimals: / 3males
Observationperiod: / 72hours
Methodofadministration: / 0.1mLintotheconjunctivalsacofoneeye
Draizescores(13): / Timeafterinstillation
Animal1hour / 1 day2 days3 days / 7 days
Corneaoaab / oaaboaaboaab / oaab
1114 / 242211 / 00
200 / 231211 / 00
300 / 000000 / 00

Irisnoscoresabovezero

Conjunctiva

rccdderccdderccdderccdderccdde

1 / 1 / 0 / 0 / 2 / 1 / 1 / 2 / 1 / 0 / 2 / 0 / 0 / 1 / 0 / 0
2 / 1 / 0 / 0 / 2 / 3 / 0 / 2 / 2 / 0 / 1 / 0 / 0 / 0 / 0 / 0
3 / 1 / 0 / 0 / 2 / 1 / 0 / 1 / 1 / 0 / 1 / 0 / 0 / 1 / 0 / 0
1seeAttachment1forDraizescales

a opacityb areac rednessd chemosise discharge

Freund’sCompleteAdjuvant(FCA)1:1with water;
0.25%notifiedchemicalin5%(v/v)acetoneinAlembicolD;
0.25%notifiedchemicala1:1mixtureof5%(v/v)acetoneinAlembicolDand FCA

afteroneweek,neatnotifiedchemicalwasplacedonthesameareaofskinfor48hoursunderocclusivedressing

Challengeprocedure:twoweeksfollowingtopicalinduction,

challengewasperformedwith5%(v/v)andocclusivedressingfor24hours

Challengeoutcome:

TestanimalsControlanimals

Challenge
concentratio / 24 hours* / 48 hours* / 72 hours / 24 hours / 48 hours / 72 hours
n
5% / 0/20** / 0/20 / 0/20 / 0/20 / 0/20 / 0/20
10% / 0/20 / 0/20 / 0/20 / 0/20 / 0/20 / 0/20

* timeafterpatchremoval

** numberofanimalsexhibitingpositiveresponse

Test method:accordingtoOECDguidelines(12)

Result:thenotifiedchemicalwasnotaskinsensitiseringuineapigs

9.2RepeatedDoseToxicity

not provided

9.3Genotoxicity

9.3.1MicronucleusAssayintheBoneMarrowCellsoftheMouse(14)

Species/strain:mouse/Swiss

Numberandsexofanimals:5/sex/dosegroup

Doses:0,750,1500and3000mg.kg-1Methodofadministration: gavage;vehicle:1%tragacanthTest method: similartoOECDguidelines(12)

Result:noincreaseintheproportionofmicronucleatedbonemarrowpolychromaticerythrocyteswasobservedfollowingtreatmentofmicewiththenotifiedchemical

9.4OverallAssessmentofToxicologicalData

Thenotifiedchemicalwasofmoderateacuteoraltoxicityinrats(LD50=1337mg.kg-1). Itwasnotaskinirritantinrabbitsbutwasa

moderateeyeirritantandwasnotaskinsensitiseringuineapigs. The

notifiedchemicalwasnegativeinamousemicronucleustest.

ThenotifierdidnotprovideallthedatarequiredbytheActandvariationof schedulerequirementswasrequestedforacutedermaltoxicity,repeat doseandclastogenicity. Thevariationswereallowedonthebasisthatthechemicalwouldonlybeusedatthenotifier’spremisesandthatengineeringcontrolsweresufficienttocontrolexposure.

ThenotifiedchemicalwouldbeclassifiedashazardousaccordingtotheNationalCommission’sApprovedCriteriaforClassifyingHazardousSubstances(15) in relation to acute oral toxicity.

10.ASSESSMENTOFENVIRONMENTALEFFECTS

Resultsofecotoxicitytestsaresummarisedinthetablebelow.ThetestswerecarriedouttoOECDTestMethods(12).

SpeciesTestConcentrationsa

(mg.L-1)

Result (mg.L-1)

Reference

Guppy / 96 h / 0,125,250,500,750, / LC50= 560 / (16)
(Poecilla / acute / 1000 / NOEC = 250
Reticulata)
Water Flea / 48 h / 0, 63, 125, 250, 500, / EC50= 520 / (17)
(Daphnia / acute / 1000 / NOEC = 250
magna)
Algae / 96 h / 0,125,250,500,750, / ERC50> 1000 / (18)
(Selenastrum
capricornutum) / growth / 1000 / EBC50= 880
NOEC = 250
Bacteria / 16 h / 875 / > 875 / (19)
(Pseudomonas

Putida)

aAllconcentrationsarenominalconcentrationsexceptforBacteriawhichwasestimated.

Sub-lethaleffectswereobservedinthe 96hourfishtoxicitytest. Theseeffectswerehypo-activityanduncontrolledmovements. Hypo-activitywasobservedforallfishatthetwohighestconcentrationsafter3hour. Oneortwofishexhibitedhypo-activityafterlongerperiodsatthelowerconcentrations. Uncontrolledmovementwasexhibitedbyoneortwofishatthetwohighestconcentrationsafter3hour.

Nosublethaleffectswereobservedintheothertoxicitystudies.

Thenotifiedchemicalcanbeclassifiedaspracticallynon-toxictofish,algaeandwaterfleas. WhilenoecotoxicityfigureswereprovidedforconcentrationsrequiredtoimpedereproductioninWaterFleas,itisunlikelythatIxolB251wouldbeclassedastoxicfromthefiguresprovided. Also,thechemicaldoesnotappeartoinhibittheabilityofbacteriacellmultiplication,soitshouldnoteffecttheabilityofbacteriatobiodegradeotherwastematerials.

11.ASSESSMENTOFENVIRONMENTALHAZARD

ThemajorityofthenotifiedchemicalwillbeincorporatedintoPURsorPUIRs. Theenvironmentalhazardposedbythechemicalisratedaslowwhenmanufacturedintofoamproductsasthechemicalwillbeincorporatedintothefoammatrix,whichwillbedisposedoftolandfillattheendofitusefullife.

ThecombustionofthePURsorPUIRScontainingthenotifiedchemicalmayreleasetoxicgaseswhichcanbeasourceofenvironmentalexposure. Thisisfurtherelucidatedintheenvironmentalreleasesection.

Worstcasescenarioisasfollows:withthehighestpredictedlevelofimportationof100tonnes,thisequatesto330drums(205litreseach)ayear,i.e.lessthananaverageofoneperday. With93.5%ofthenotifiedchemicalinthedrums,thisequatesto192litresofchemicalperdrum.ThereformulationsiteissituatedinSevenHills,NSW,soanyspillagewillentertheSydneysewernetwork. Withanaccidentalspillageofonedrumwhilebeingmovedtotheblendingoperation,amaximumof192litrescouldenterthesewer,whichwilldilutetoaconcentrationofapproximately64ppm(basedon300megalitresperdayoutputfromthesewer).

Thisconcentrationwouldbefurtherdilutedinreceivingwatersanddespitetherelativelyhighconcentrationthisiswellbelowtheobservedtoxiclevels(seeabove). Noaccountistakenoflossthroughvaporisationbeforeenteringthesewer.Inaddition,duetotheviscosityoftheliquid,containmentofspillagesismadeeasier. Withadequatebundingandprocedurestocontainspillages,theriskofwatercontaminationshouldbegreatlyreduced.

12.ASSESSMENTOFPUBLICANDOCCUPATIONALHEALTHANDSAFETYEFFECTS

Thenotifiedchemicalisexpectedtobeharmfulbytheoralrouteandisassumed tobeharmfulbythedermalrouteintheabsenceofotherinformation. Itisnotlikelytobeaskinirritantbutmaybeamoderateeyeirritant. Itisnotlikelytobeskinsensitiser. Anegativemousemicronucleusassaysuggestslimitedgenotoxicpotentialandaquantitativestructure-activityanalysisprovidedbythenotifiersuggestedalowgenotoxicpotential. Intheabsenceofarepeatdosestudy,itisassumedthatthenotifiedchemicalisharmfulonrepeatedorprolongedexposureonthebasisoftheacuteoraltoxicitydataandphysico-chemicalproperties.

Whenmixinganddispensingthefire-retardantblendforuseinpolyurethanefoams,exposureisnotexpectedtobehighasprecautionsaretakentoavoiddripsandspills. Theactualmixingitselfisnotexpectedtoresultinsplashingorspillsgiventhatthecomponentsareviscous,thetankislargeandbladesofthemixerturnslowly. Someexposuremaybepossibleduringcleaningofapparatusandconnectors,inwhichcasepersonalprotectiveequipmentasdescribedbelowshouldbeworn.

Duringenduseofthenotifiedchemical,precautionsaretakentominimiseexposurefrompumpresidues. However,ragsusedtominimisedripswhentransferringpumpsfromonedrumtoanothermaybeasourceofexposureunlessdisposedofcorrectly. Whensprayingfoam,precautionsarerequiredtobetaken,includingtheuseofpersonalprotectiveequipment,tominimiseexposuretoisocyanate.

Thereisariskoftoxiceffectstoworkersinvolvedinreformulationandenduseofthenotifiedchemicalfromacuteexposureorrepeatedorprolongedexposure.

Thereisalsoariskofeyeirritation.

Theriskofadversepublichealtheffectsisnegligible. Wheretheremaybeminorpublicexposuretofoamswhichhavebeendisposedof,thechemicalisboundwithinapolyurethanepolymermatrixandisnotbioavailable.

13.RECOMMENDATIONS

Tominimiseoccupationalexposuretothenotifiedchemicalthefollowingguidelinesandprecautionsshouldbeobservedduringreformulation,equipmentcleaningandenduse:

SafetygogglesshouldbeselectedandfittedinaccordancewithAustralianStandard(AS)1336(20)tocomplywithAustralian/NewZealandStandard(AS/NZS) 1337 (21);

IndustrialclothingshouldconformtothespecificationsdetailedinAS2919(22);

ImpermeableglovesormittensshouldconformtoAS2161(23);

AlloccupationalfootwearshouldconformtoAS/NZS2210(24);

Spillageofthenotifiedchemicalshouldbeavoided,spillagesshouldbecleaneduppromptlywithabsorbentswhichshouldthenbeputintocontainersforlandfilldisposal. Wastescontainingthenotifiedchemicalshouldbeconsignedtolandfillinpreferencetoincinerationduetothepotentialreleaseoftoxicgases. Duringcleanuptheabovepersonalprotectiveequipmentshouldbeworn;

Goodpersonalhygieneshouldbepractisedtominimisethepotentialforingestionparticularlyasthenotifiedchemicalisclassifiedasharmfulviatheoral route;

AcopyoftherelevantMSDSshouldbeeasilyaccessibletoemployees.

Alllabelsonformulationscontainingthenotifiedchemicalatalevelgreaterthan25%,theriskphrases:“Harmfulincontactwithskin”,“Harmfulifswallowed”and“Dangerofseriousdamagetohealthbyprolongedexposure”shouldbeused. Forformulationscontaininggreaterthan10%butlessthan25%ofthenotifiedchemical,thephrase“Dangerofseriousdamagetohealthbyprolongedexposure”isrequired.

14.MATERIALSAFETYDATASHEET

TheMSDSforthenotifiedchemicalwasprovidedinaccordancewiththeNationalCodeofPracticeforthePreparationofMaterialSafetyDataSheets(25).

ThisMSDSwasprovidedbytheapplicantaspartofthenotificationstatement. Itisreproducedhereasamatterofpublicrecord. Theaccuracyofthisinformationremainstheresponsibilityoftheapplicant.

15.REQUIREMENTSFORSECONDARYNOTIFICATION

UndertheAct,secondarynotificationofthenotifiedchemicalshallberequiredifanyofthecircumstancesstipulatedundersubsection64(2)oftheActarise. Inaddition,undersubsection64(1)oftheAct,secondarynotificationshallberequiredifreformulationofthenotifiedchemicalistooccuratotherthanthenotifier’spremises.

16.REFERENCES

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18.Jansen,W.A.J.,vanDijkN.R.M.vandenBergG.1982c,The Acute ToxicityofIxolB350totheAlgaSelenastrumcapricornutum, Project no.,56635/8/92,AgrobiologyEnvironmentalScienceUnit,EnvironmentalResearchDepartment,SolvayDupharB.V.,'s-Graveland,TheNetherlands.Jansen,W.A.J.ThusL.G.1983,TheAcuteToxicityofIxolB350totheBacteriaPseudomonasputida,Projectno.,56835/11/93,AgrobiologyEnvironmentalScienceUnit,EnvironmentalResearchDepartment,SolvayDupharB.V.,'s-Graveland,TheNetherlands.

19.StandardsAustralia1994,AustralianStandard1336-1994,EyeprotectionintheIndustrialEnvironment, StandardsAssociationofAustralia,Sydney.

20.StandardsAustralia/StandardsNewZealand1992,Australian/NewZealandStandard1337-1992,EyeProtectorsforIndustrialApplications,StandardsAssociationofAustralia/StandardsAssociationofNewZealand,Sydney/Wellington.

21.StandardsAustralia1987,AustralianStandard2919-1987,IndustrialClothing,StandardsAssociationofAustralia,Sydney.

22.StandardsAustralia1978,AustralianStandard2161-1978,IndustrialSafetyGlovesandMittens(excludingelectricalandmedicalgloves),StandardsAssociationofAustralia,Sydney.

23.StandardsAustralia/StandardsNewZealand1994,Australian/NewZealandStandard2210-1994,OccupationalProtectiveFootwear,StandardsAssociationofAustralia/StandardsAssociationofNewZealand,Sydney/Wellington.

24.NationalOccupationalHealthandSafetyCommission1994,NationalCodeof Practice for the Preparation of Material Safety Data Sheets [NOHSC:2011(1994)],AustralianGovernmentPublishingService,Canberra.

Attachment 1

TheDraizeScaleforevaluationofskinreactionsisasfollows:

ErythemaFormationRatingOedemaFormationRating

No erythema0No oedema0

Veryslighterythema(barelyperceptible)

1Veryslightoedema(barely1

perceptible)

Well-defined erythema2Slightoedema(edgesofareawell-2

definedbydefiniteraising

Moderatetosevereerythema3Moderateoedema(raisedapprox.13

mm)

Severeerythema(beetredness)4Severeoedema(raisedmorethan14

mmand extendingbeyondareaofexposure)

TheDraizescaleforevaluationofeyereactionsisasfollows:

CORNEA

OpacityRatingAreaofCorneainvolvedRating

Noopacity0 none25%orless(notzero)1

Diffusearea,detailsof irisclearlyvisible

Easilyvisibletranslucentareas,detailsofirisslightlyobscure

1slight25%to50%2

2 mild50%to75%3

Opalescentareas,nodetailsofirisvisible,sizeofpupilbarelydiscernible

moderate

Greaterthan75%4

Opaque,irisinvisible4severe

CONJUNCTIVAE
Redness / Rating / Chemosis / Rating / Discharge / Rating
Vesselsnormal / 0 none / No swelling / 0 none / No discharge / 0 none
Vesselsdefinitely / 1 / Anyswellingabove / 1slight / Anyamountdifferent / 1slight
injectedabovenormal / slight / normal / from normal
Morediffuse,deeper / 2 mod. / Obviousswelling / 2 mild / Discharge with / 2 mod.
crimsonredwith / withpartialeversion / moisteningoflids
individualvesselsnot / oflids / andadjacenthairs
easilydiscernible / Swelling with lids / 3 mod. / Discharge with / 3
Diffusebeefyred / 3 / half-closed / moisteningoflids / severe
severe / Swelling with lids / 4 / andhairsand
considerablearea
half-closedto
completelyclosed / severe / around eye

IRIS

ValuesRating

Normal0 none

Foldsabovenormal,congestion,swelling,circumcornealinjection,irisreactstolight1slightoreactiontolight,haemorrhage,grossdestruction 2severe