MOLECULAR
PHARMACOLOGY
July 2008Volume 74Number 1 0026-895X
ACCELERATED COMMUNICATION
Atrial Natriuretic Peptide Protects against Histamine-Induced Endothelial Barrier Dysfunction in Vivo Robert Fiirst, Martin F. Bubik, Peter Bihari, Bettina A. Mayer, Alexander G. Khandoga,
Florian Hoffmann, Markus Rehberg, Fritz Krombach, Stefan Zahler, and Angelika M. Vollmar1
ARTICLES
Identification of Regions Required for Apical Membrane Localization of Human Multidrug Resistance Protein 2
Paul E. Bandler, Christopher J. Westlake, Caroline E. Grant, Susan P. C. Cole, and
Roger G. Deeley9
Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells
Venkatesh L. Hegde, Shweta Hegde, Benjamin F. Cravatt, Lome J. Hofseth, Mitzi Nagarkatti, and
Prakash S. Nagarkatti20
Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L
Parag P. Shah, Michael C. Myers, Mary Pat Beavers, Jeremy E. Purvis, Huiyan Jing,
Heather J. Grieser, Elizabeth R. Shadow, Andrew D. Napper, Donna M. Huryn,
Barry S. Cooperman, Amos B. Smith III, and Scott L. Diamond34
Niemann-Pick Cl-Like 1 Mediates a-Tocopherol Transport
Kazuya Narushima, Tappei Takada, Yoshihide Yamanashi, and Hiroshi Suzuki42
Molecular Determinants for the Activating/Blocking Actions of the 2/7-1,4-Benzoxazine Derivatives, a Class of Potassium Channel Modulators Targeting the Skeletal Muscle KATP Channels Domenico Tricarico, Antonietta Mele, Giulia Maria Camerino, Antonio Laghezza, d Giuseppe Carbonara, Giuseppe Fracchiolla, Paolo Tortorella, Fulvio Loiodice, and
Diana Conte Camerino50
Reciprocal Regulation of Dopamine Dl and D3 Receptor Function and Trafficking by
Heterodimerization
Chiara Fiorentini, Chiara Busi, Emanuela Gorruso, Cecilia Gotti, PierFranco Spano, and
Cristina Missale59
Baicalein Induces Functional Hypoxia-Inducible Factor-la and Angiogenesis
Hyunju Cho, Ho-Youl Lee, Dae-Ro Ahn, Sang Yoon Kim, Sunyun Kim, Keun Byeol Lee,
You Mie Lee, Hyunsung Park, and Eun Gyeong Yang70
Carmustine-Resistant Cancer Cells Are Sensitized to Temozolomide As A Result of Enhanced
Mismatch Repair during the Development of Carmustine Resistance
Takahiro Yamauchi, Masami Ogawa, and Takanori Veda82
Activation of 9-[(i?)-2-[[(S)-[[(S)-l~(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-
methoxy]propyl]adenine (GS-7340) and Other Tenofovir Phosphonoamidate Prodrugs by
Human Proteases
Gabriel Birkus, Nilima Kutty, Gong-Xin He, Andrew Mulato, William Lee, Martin McDermott, and
Tomas Cihlar92
RNA Interference-Mediated Knockdown of Dynamin 2 Reduces Endocannabinoid Uptake into Neuronal dCAD Cells
Matthew J. McFarland, Tamera K. Bardell, Maria L. Yates, Ekaterina A. Placzek, and
Eric L. Barker101
Histone Deacetylase Inhibitors Exert Time-Dependent Effects on Nuclear Factor-KB but Consistently
Suppress the Expression of Proinflammatory Genes in Human Myometrial Cells
Tamsin M. Lindstrbm, Aarthi R. Mohan, Mark R. Johnson, and Phillip R. Bennett109
Organic Anion Transporter 3 (0&t3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion
Increases Systemic Exposure to Ciprofloxacin
Adam L. VanWert, Chutima Srimaroeng, and Douglas H. Sweet122
Roles of Accessory Subunits in a4j32* Nicotinic Receptors
Alexandre Kuryatov, Jennifer Onksen, and Jon Lindstrom132
Fluvastatin Synergistically Improves the Antiproliferative Effect of Everolimus on Rat Smooth Muscle
Cells by Altering p27ffipi/Cyclin E Expression
N. Ferri, A. Granata, C. Pirola, F. Torti, P. J. Pfister, R. Dorent, and A. Corsini144
Molecular Mechanisms of Topical Anti-Inflammatory Effects of Lipoxin A4 in Endotoxin-Induced
Uveitis
Rodrigo Medeiros, Gustavo Buchele Rodrigues, Claudia Pinto Figueiredo,
Eduardo Buchele Rodrigues, Astor Grumman, Jr., Octavio Menezes-de-Lima, Jr.,
Giselle Fazzioni Passos, and Jodo Batista Calixto154
Conformational Rearrangements and Signaling Cascades Involved in Ligand-Biased Mitogen-Activated Protein Kinase Signaling through the j31-Adrenergic Receptor
Segolene Galandrin, Genevieve Oligny-Longpre, Helene Bonin, Koji Ogawa, Celine Gales, and
Michel Bouvier162
AKT Is Activated in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner in Response to Temozolomide and Confers Protection against Drug-Induced Cell Growth Inhibition
Simona Caporali, Lauretta Levati, Giuseppe Starace, Gianluca Ragone, Enzo Bonmassar,
Ester Alvino, and Stefania D'Atri173
Formaldehyde-Activated Pixantrone Is a Monofunctional DNA Alkylator That Binds Selectively to CpG
and CpA Doublets
Benny J. Evison, Francis Chiu, Gabriella Pezzoni, Don R. Phillips, and Suzanne M. Cutts184
Arrestin Binds to Different Phosphorylated Regions of the Thyrotropin-Releasing Hormone Receptor
with Distinct Functional Consequences
Brian W. Jones and Patricia M. Hinkle195
Individually Monitoring Ligand-Induced Changes in the Structure of the GABAA Receptor at
Benzodiazepine Binding Site and Non-Binding-Site Interfaces
L. M. Sharkey and C. Czajkowski203
JV-Palmitoyl Glycine, a Novel Endogenous Lipid That Acts As a Modulator of Calcium Influx and Nitric Oxide Production in Sensory Neurons
Neta Rimmerman, Heather B. Bradshaw, H. Velocity Hughes, Jay Shih-Chieh Chen,
Sherry Shu-Jung Hu, Douglas McHugh, Eivind Vefring, Jan A. Jahnsen, Eric L. Thompson,
Kim Masuda, Benjamin F. Cravatt, Sumner Burstein, Michael R. Vasko, Anne L. Prieto,
David K. O'Dell, and J. Michael Walker213
Protection against Hydrogen Peroxide-Mediated Cytotoxicity in Friedreich's Ataxia Fibroblasts Using
Novel Iron Chelators of the 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone Class
C. K. him, D. S. Kalinowski, and D. R. Richardson225
Nitric Oxide Donor, (±)-S-Nitroso-iV-acetylpenicillamine, Stabilizes Transactive Hypoxia-Inducible
Factor-la by Inhibiting von Hippel-Lindau Recruitment and Asparagine Hydroxylation
Young-Kwon Park, Dae-Ro Ahn, Myoungsuk Oh, Taekyoung Lee, Eun Gyeong Yang, Miwon Son,
and Hyunsung Park236
Disruption of Signaling through SEK1 and MKK7 Yields Differential Responses in Hypoxic Colon Cancer Cells Treated with Oxaliplatin
Irina A. Vasilevskaya, Muthu Selvakumaran, and Peter J. O'Dwyer246
Roles of Cytosolic Phospholipase A2 and Src Kinase in the Early Action of 2,3,7,8-Tetrachlorodibenzo-p-
dioxin through a Nongenomic Pathway in MCF10A Cells
Bin Dong and Fumio Matsumura255
Characterization of mENTlAll, a Novel Alternative Splice Variant of the Mouse Equilibrative
Nucleoside Transporter 1
Kevin R. Robillard, Derek B. J. Bone, Jamie S. Park, and James R. Hammond264
Inhibition of Nod2 Signaling and Target Gene Expression by Curcumin
Shurong Huang, Ling Zhao, Kihoon Kim, Dong Seok Lee, and Daniel H. Hwang274
(2i?)-[(4-Biphenylylsulfonyl)amino]-Ar-hydroxy-3-phenylpropionamide (BiPS), a Matrix Metalloprotease
Inhibitor, Is a Novel and Potent Activator of Hypoxia-Inducible Factors
Marie-Claude Lauzier, Genevieve A. Robitaille, Denise A. Chan, Amato J. Giaccia, and
Darren E. Richard282
Selective Killing of Smad4-Negative Tumor Cells via a Designed Repressor Strategy
Viduja Dixit and Rudy L. Juliano289
33 Integrin-Mediated Drug Resistance in Human Laryngeal Carcinoma Cells Is Caused by
Glutathione-Dependent Elimination of Drug-Induced Reactive Oxidative Species
Anamaria Brozovic, Dragomira Majhen, Vibor Roje, Nevenka Mikac, Sanjica Jakopec,
Gerhard Fritz, Maja Osmak, and Andreja Ambriovic-Ristov298
ERRATUM
Correction to Table of Contents (Volume 73, Number 6, June 2008)307