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並另以獨立檔案提供您的照片 / Feng-Shiun Shie, Ph.D.
Assistant Investigator
Division of Mental Health And Substance Abuse Research
E-mail:
Education
Ph.D., University of Washington, Seattle, WA, U.S.A.,2000
M.S., Florida International University, Miami, FL, U.S.A.,1995
B.S., Fu-JenUniversity, Taipei, Taiwan,1988
Professional Experiences
2000-2005 Senior Fellow/Acting Instructor, Division of Neuropathology, Department of Pathology, University of Washington School of Medicine, Seattle, Washington.
2005-presentAssistant Investigator, Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Zhunan, Taiwan.
Research Interests
The research of Dr. Shie is focused on brain diseases with dementia especially in neurodegenerative diseases including Alzheimer's disease, Parkinson’s disease, and Niemann Pick type C disease. Dr. Shie’s research interests include the functions of microglial innate immunity and glia-neuron interactions in pathogenesis of the brain diseases. Revealing therapeutic targets and approaches for thediseases is the ultimate goal of his research.
Research Activities & Accomplishment
Dr. Shie was trained at Alzheimer’s Disease Research Center at University of Washington for researches in neurodegenerative diseases and return to home country in the end of 2005. He has established a research record on neurodegenerative diseases with 16 peer-viewed publicationand filed 2US patents in the recent 5 years. The major focus of Dr. Shie’s research in NHRI is to understand the regulatory mechanisms of the glia-neuron interactions in the pathogenesis of Alzheimer’s diseases and to gain insights into theroles of microglial activation in the functions of neuro-inflammation.
Honors & Awards
ADRD Travel Fellowship, 2004, The 9th international conference on Alzheimer's disease and related disorders.Philadelphia, PA, USA.
Poster Contest, 2004, Department of Pathology, University of Washington.
ADRC Pilot Study Award, 2002-2003, Principle investigator, Alzheimer’s Disease Research Center at University of Washington, Seattle, WA, USA.
Research Assistantship, 1995-2000,Interdisciplinary program in Nutritional Sciences, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA.
Publications/ including books , chapters, journal articles
Manuscripts (*corresponding):
  1. Feng-Shiun Shie*and Randall L. Woltjer. Manipulating microglial activation as a therapeutic strategy for Alzheimer's disease. Current Medicinal Chemistry. 2007;14(27):2865-2871. IF:5.2
  2. Feng-Shiun Shie and Zaodung Ling. Therapeutic strategy at the crossroad of neuroinflammation and oxidative stress in age-related neurodegenerative diseases. Expert Opin Ther Pat.2007;17(4):419-428. IF:1.5
  3. Jinghua Jin, Feng-Shiun Shie, Jun Liu, Yan Wang, Jeanne Davis,Aimee M Schantz, Kathleen S Montine, Thomas J Montine and Jing Zhang. Prostaglandin E2 receptor subtype 2 (EP2) regulates microglialactivation and associated neurotoxicity induced by aggregated alpha-synuclein.J Neuroinflammation. 2007;4:2:1-10. IF:4.4
  4. Randall L. Woltjer, Wendy McMahan, Dejan Milatovic, John D. Kjerulf, Feng-Shiun Shie, Lisa Rung, Kathleen S. Montine, and Thomas J. Montine Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment. Neurobiol Dis. 2007;25(2):427-437. IF:4.1
  5. Ye Xiong, Feng-Shiun Shie, Jing Zhang, Chuan Pu Lee, and Ye-Shih Ho. Prevention of mitochondrial dysfunction in post-trauma mouse brain by superoxide dismutase. J Neurochem. 2005;95(3):732-744.IF:4.3
  6. Feng-Shiun Shie, Kathleen S. Montine, and Thomas J. Montine. Microglial functions in LPS-induced neuronal cytotoxicity: the role of microglial prostaglandin E2 receptors in oxidative stress. Glia. 2005;52(1):70-77. IF:5.0
  7. Feng-Shiun Shie, Kathleen S. Montine, Richard M. Breyer, and Thomas J. Montine. Microglial EP2 as a new target to increase A-beta phagocytosis and decrease A-beta-induced damage to neurons. Brain Pathol. 2005;15 (2):134-138.IF:5.3
  8. Feng-Shiun Shie*, Richard M. Breyer, Thomas J. Montine. Microglia lacking EP2 have enhanced A-beta phagocytosis yet lack A-beta activated neurotoxicity. Am J Pathol. 2005;166(4):1163-1172.IF:5.9
  9. Jinghua Jin, Gloria E. Meredith, Leo Chen, Young Zhou, Jin Xu, Feng-Shiun Shie, Paul Lockhart, and Jing Zhang. Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson’s disease. Brain ResMol Brain Res. 2004;24;134(1):119-138.
  10. Dejan Milatovic, Snjezana Zaja-Milatovic, Kathleen S. Montine, Feng-Shiun Shie, and Thomas J. Montine. Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo. J Neuroinflammation. 2004; 21;1(1):20.IF:4.4
  11. Yong Zhou, Feng-Shiun Shie, Pedro Piccardo, Thomas J. Montine, Jing Zhang. Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson’s disease. Neuroscience. 2004;128:281-291. IF:3.4
  12. Ye Xiong, Feng-Shiun Shie, Jing Zhang, Chuan-Pu Lee, Ye-Shih Ho. The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in mouse brain. J Stroke Cerebr Dis. 2004;13:129-137.
  13. Feng-Shiun Shie, M. Diana Neely, Izumi Maezawa, Hope Wu, Sandy J. Olson, Günther Jürgens, Kathleen S. Montine and Thomas J. Montine. Oxidized Low-Density Lipoprotein Is Present in Astrocytes Surrounding Cerebral Infarcts and Stimulates Astrocyte Interleukin-6 Secretion. Am J Pathol.2004;164:1173-1181.IF:5.9.
  14. Lee-Way Jin, Feng-Shiun Shie (co-first author), Izumi Maezawa, Inez Vincent and Thomas Bird. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol.2004;164:975-985 (2004;165:1447).IF:5.9
  15. Feng-Shiun Shie, Renee C. LeBoeuf, Lee-Way Jin. Early Intraneuronal beta-amyloid deposition in the hippocampus of APP transgenic mice. NeuroReport. 2003;14:123-129. IF:2.3
  16. Jochen Brich, Feng-Shiun Shie, Brian W. Howell Renhua Li, Katalin Tus, Edward K. Wakeland, Lee-Way Jin, Marc Mumby, Gary Churchill, Joachim Herz, Jonathan A. Cooper. Genetic modulation of tau phosphorylation in the mouse. J Neurosci. 2003;23:187-192.IF:7.5
  17. Lee-Way Jin, Duy H. Hua, Feng-Shiun Shie, Izumi Maezawa, Bryce Sopher, George M Martin. Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death. J Mol Neurosci. 2002;19:57-61.IF3.0
  18. Feng-Shiun Shie, Lee-Way Jin, David G. Cook, James B Leverenz, Renee C LeBoeuf. Diet-Induced hypercholesterolemia enhance brain beta-amyloid accumulation in transgenic mice. NeuroReport. 2002;13:455-459.IF:2.3
  19. Zsica R. Dixon, Feng-Shiun Shie, Beverly A. Warden, Betty J. Burri, and Terry R. Neidlinger. The effect of a low carotenoid diet on malondialdehyde-thiobartiburic acid concentrations in women: a placebo-controlled double-blind study. J Am Coll Nutr. 1998;17:54-58.IF:2.5
Book Chapter:
Lee-Way Jin, Duy H. Hua, Feng-Shiun Shie, Izumi Maezawa, Bryce Sopher, George M. Martin. Drug discovery and development for Alzheimer’s disease 2000: Noveltricyclic pyrone compounds prevent intracellular APP C99-induced cell death. Edited by Howard M. Fillit and Alan W. O’Connel. Springer Publishing company, Inc. pp89-97.
International Conference Presentations:
  1. Poster:P-C Hsu andFeng-Shiun Shie. Modulation of microglial activation by 15d-PGJ2. Society for Neuroscience 2007.
  2. Oral presentation:Feng-Shiun Shie, Thomas J. Montine. Microglia lacking EP2 have enhanced A-beta phagocytosis yet lack A-beta activated neurotoxicity. Society for Neuroscience 2004.
  3. Poster:Feng-Shiun Shie, Dejan Milatovic, Snjezana Milatovic, Kathy Montine, Thomas J. Montine. Microglial EP2 signaling is critical to neurotoxicity from activated cerebral innate immunity. The 9th International Conference on Alzheimer's Disease and Related Disorders 2004.
  4. Poster:Lee-Way Jin, Feng-Shiun Shie, Inez Vincent, E Alvord. Cerebral A-beta accumulation in Niemann-Pick type C disease. J Neuropath Exp Neurol 2002:61:459.
5.
  1. Poster: Feng-Shiun Shie, Inez Vincent, Lee-Way Jin. Accumulation of beta-amyloid in neurons with Niemann-Pick type C defects. Society for Neuroscience 2002.
6.
  1. Poster: Feng-Shiun Shie, Lee-Way Jin, James B Leverenz, Renee C LeBoeuf. Early beta-amyloid deposition in hippocampal neurons in beta-amyloid precursor protein 695 (APP695) transgenic mice. Neurobiology of aging. 2000(21):S225
  1. .
  1. Poster: Feng-Shiun Shie, Lee-Way Jin, James B Leverenz, Renee C LeBoeuf. Effects of cholesterol feeding on histopathologic hallmarks of Alzheimer’s disease in beta-myloid precursor protein (APP) Transgenic Mice. Society for Neuroscience 1999.

Patents
Title:Methods and Compositions for Treatment of Neurological Diseases and Disorders.US-2007-0232556-A1.
Title: Novel Neuro-protective Compounds for Neurodegenerative Diseases. (US 61/049,052, May19, 2008)

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