ORDINANCES
Examinations for 2016-17 & 2017-18 sessions
M.Sc. (PHARMACEUTICAL CHEMISTRY)
Course of Examination
Notwithstanding the integrated nature of a course spread over more than one academic year, the Ordinances in force at the time a student joins a course shall hold good only for the examination held during or at the end of the Semester. Nothing in these Ordinances shall be deemed to debar the University from amending the Ordinances subsequently and the amended ordinances, if any, shall apply to all students whether old or new.
1.The course for M.Sc. Pharmaceutical Chemistry shall be spread over two academic years
and four semesters to be called M.Sc. Previous consisting of Semester I and II, and M.Sc.
Final consisting of Semester III and IV. The examination for the I and III Semesters shall
be held in the month of December and for the II and IV semesters in the month of May or
on such other dates as may be fixed by the Academic Council.
2.The outlines of tests and syllabi shall be such as prescribed by the Academic Council from
time to time.
3.(a) The last date by which admission forms and fees must reach the Registrar shall be
as follows:
Examination WithoutWith lateWith late
Feelate fee fee of fee of
Rs. 100/- Rs. 300/-
Semester I & IIISept. 30Oct.15Oct.31
(Regular and Reappear)
Semester II & IVFeb.28March 15March 31
(Regular and Reappear)
A late fee of Rs. 500/- will be charged for submission of forms 21 days before the
commencement of Semester examinations practical or theory which ever is earlier.
A late fee of Rs. 1000/- will be charged for submission of forms 10 days before the
commencement of Semester examination only practical or theory which ever is
earlier and with prior permission of Vice- chancellor.
(b)Incomplete form or forms of candidates who have not cleared his/her all dues will
not be accepted.
(c)The amount of examination fee to be paid by a candidate for each semester shall
be as prescribed by the University from time to time.
(d) The I, II and III semester examinations shall consist of four theory papers
each and two practical papers each as specified in the syllabus.
(e)The IV semester examination shall consist of three theory papers and one practical
paper. In addition, candidates will undertake a research project work. The project
work shall be of 200 marks. The project work shall be evaluated as follows:
100 marks-To be evaluated by internal examiner/guide on the basis of day-to-day
work.
50 marks –To be evaluated by external examiner for the project report.
50 marks-To be evaluated by external examiner on the basis of viva-voce/
presentation of project report by the candidate.
(f) Each theory paper shall be of 100 marks of which 70 marks shall be allocated to the
theory papers set by the external examiner. The internal assessment in each paper
shall be of 30 marks i.e. two assignments or seminar of 12 marks, I test of 12 marks (average of two shall be taken) and 6 marks for attendance.
4(a)The admission to Semester I in the course is based on merit in qualifying exam and
entrance test.
The candidates who have passed the Bachelor’s degree in Science with subjects in
the faculty of Life Sciences/ Biological /Medical/Engineering are eligible to appear
in the entrance test conducted by the Department.
Besides, the candidates who have passed the Bachelor’s degree in the sciences with
any three of the following subjects are also eligible: Mathematics/Statistics/Physics/
Chemistry.
(b)The candidates should have obtained a minimum of 50% marks (including optional
subject) in the qualifying examination for all courses. The candidates who are
awarded grades shall be required to produce the conversion formula of converting
the scored grade in to percentage of marks.
(c)(i) Schedule Castes and Schedule Tribes.
(ii)Physically handicapped candidates.
(Produce medical certificate showing at least 35% disability)
Details about entrance test will be given in hand Book of Information.
(d)A candidate who has passed the first Semester examination of M. Sc.
Pharmaceutical Chemistry shall be eligible to join the second Semester.
(e)A candidate who has passed the second Semester examination of M.Sc.
Pharmaceutical Chemistry shall be eligible to join the third Semester.
(f)The final examination shall be open to any person who has passed in the subject
offered in the previous examination in full or in part and satisfies the following
requirements :
i.Has been on the rolls of the University throughout the academic year preceeding
the Semester examination.
ii.Has not discontinued his/her studies for more than two continuous years after
passing M.Sc. Previous examination.
iii.Has his/her name submitted to the Registrar by the Head of the Department that
he/she attended 75% lectures of the full courses of theory and practicals provided
that deficiency in the number of theory lectures or practicals may be condoned for
special reasons by the Academic Council.
OR
Has completed the prescribed course of instruction for the examination but has not
appeared or having repeated has failed and has been recommended by the head of
the Department for admission to such examination as a late University student
without attending a fresh course of instruction (theory and practicals) within a
period of two years from the date of completion of course.
(g)A candidate who has passed the Third Semester examination of M.Sc.
Pharmaceutical Chemistry shall be eligible to join the IV Semester.
(h)The candidate shall have attended not less than 75% of the full course of the
lectures and practicals in each of the course /paper. A deficiency in the number of
lectures and practicals may be condoned as per University rules.
(i).A candidate who having attended the prescribed number of lectures and practicals
fails or does not appear in the examination held for relevant Semester shall be
allowed to appear in the next examination held for that Semester.
M.Sc. PHARMACEUTICAL CHEMISTRY
PART- I
Examinations for 2016-17 & 2017-18 sessions
OUTLINES OF THE TEST
- The examination will consist of two semesters i.e. semester I and II
- Each semester shall be of maximum 600 marks.
- In each semester there shall be four theory papers and two practical papers.
- Each theory paper shall be of 100 marks of which 70 marks shall be allocated to the theory papers set by external examiner. The internal assessment in each paper shall be of 30 marks i.e. Assignments /seminar of 12 marks, internal test of 12 marks (average of two shall be taken) and 6 marks for attendance.
SEMESTER-I (November/December)
Paper Title of paperMarks
Theory IQuantitative analytical methods100
IIBiochemistry100
IIIStereochemistry and Chemistry of heterocyclic compounds100
IVPharmacology100
Practical IQuantitative analytical methods & Biochemistry 100
IIStereochemistry and Chemistry of heterocyclic compounds100
Total600
SEMESTER – II (April/May)
PaperTitle of paperMarks
Theory VModern analytical methods100
VIPhysical Pharmacy100
VIIChemistry of natural products100
VIIIBioinformatics and Biostatistics 100
Practical IIIModern analytical methods & physical Pharmacy 100
IVChemistry of natural products & Bioinformatics100
Total600
M.Sc. PHARMACEUTICAL CHEMISTRY (SEMESTER-I)
Examinations for 2016-17 & 2017-18 sessions
PAPER-I: QUANTITATIVE ANALYTICAL METHODS
Maximum Mark : 100 Time: 3 hours
i)Theory Paper : 70 Pass Marks : 35% ii)Internal Assessment : 30 Lectures to be delivered:60
INSTRUCTIONS FOR THE PAPER SETTERS:
The question paper will consist of three sections A, Band C. Section Aand B will have four questions from the respective sections of the syllabus and will carry 07 marks each. Section C will consist of a short answer / objective type questions,which will cover the entire syllabus uniformly and will carry 28 marks (2 marks each).
INSTRUCTIONS FOR THE CANDIDATES:
1.Candidates are required to attempt three questions each from sections A and B of the question paper and the entire section C.
2.The use of scientific calculators is allowed.
SECTION-A
Introduction: Computation of analytical results, significant figures, concept of error, precision and accuracy, standard deviation, rejection of doubtful values with special reference to volumetric and gravimetric analysis, calibration of analytical equipments.
Quantitative chemical analysis I:
- Fundamentals of volumetric analysis: Solubility product, effect of temperature, pH and solvent on solubility of precipitates, common ion effect, Buffers, Hydrolysis of salts. Methods of expressing concentrations, primary and secondary standards.
- Neutralization reactions: Theory of indicators and neutralization indicators.
- Oxidation-reduction titrations: Principles of oxidation reduction titrations, redox indicators, Iodimetric and Iodometric titrations.
- Precipitation titration: Theory of precipitation titrations, Methods of determining end point.
SECTION-B
Quantitative chemical analysis II:-
- Gravimetric analysis: Methods of gravimetric analysis, co-precipitation, post-precipitation, digestion, thermogravimetry.
- Complexometric titrations: Principles of complexometric titrations, chelating agents, Complexometric methods using EDTA, indicators, and titrations with disodium edetate.
- Non-aqueous titrations: General discussion and principles of titrations in non-aqueous medium, aprotic, Protophillic, Protogenic and amphiprotic solvents. Titrations with perchloric acid,and sodium methoxide.
Chromatographic analysis:- Classification of chromatographic processes, Basic principles and theory of adsorption chromatography, partition chromatography, TLC, HPLC, Gas Chromatography and ion-exchange chromatography.Pharmaceutical applications.
Books recommended:-
- A.H Becket and J.B Stenlake, Practical Pharmaceutical Chemistry, Part1,4th edition,CBS Publishers and Distributors, New Delhi,1997.
- G.H Jeffery, J.Bassett, J.Mendham and R.C Denney Vogel’s Text Book of Quantitative Chemical Analysis 5th edition, ELBS, U.K, 1989.
- A.Keneth and A. Connors, A Text Book of Pharmaceutical Analysis, 3rd edition Wiley Interscience Singapore, 1982.
- H.H. Willard, L.L. Merriet & J.A. Dean, Instrumental methods of Analysis, 5th Edition, 1974.(Van Nostrand Reinfold, New York, USA)
M.Sc. PHARMACEUTICAL CHEMISTRY (SEMESTER-1)
Examinations for 2016-17 & 2017-18 sessions
PAPER-II: BIOCHEMISTRY
Maximum Mark : 100 Time: 3 hours
i)Theory Paper : 70 Pass Marks : 35% ii)Internal Assessment : 30 Lectures to be delivered : 60
INSTRUCTIONS FOR THE PAPER SETTERS:
The question paper will consist of three sections A, Band C. Section A and B will have four questions from the respective sections of the syllabus and will carry 07 marks each. Section C will consist of a short answers / objective type questions,which will cover the entire syllabus uniformly and will carry 28 marks (2 marks each).
INSTRUCTIONS FOR THE CANDIDATES:
1.Candidates are required to attempt three questions each from sections A and B of the question paper and the entire section C.
2.The use of scientific calculators is allowed.
SECTION-A
Introduction to bio-molecules: Biological properties of water, pH, ionisation, biological buffers, titration of amino acids, amino acids, proteins and their three dimensional structure, weak and strong interactions.
Structure and function of carbohydrates: Monosaccharides, disaccharides, polysaccharides, homopolysaccharides (starch, cellulose, chitin), heteropolysaccharides, mucopolysaccharides. Structure and function of nucleic acids: Purines, pyrimidines, nucleosides, nucleotides, internucleotide bonding, tautomerism.Structure and function of lipids, neutral lipids, phospholipids, isoprenoids, phosphotidylinositol ( intracellular messenger), Biological effectors.
Vitamins: Water soluble and fat soluble.Hormones, their structure and functions.
Enzymes: General properties of enzymes and co-enzymes, their nature, classification and nomenclature of enzymes, fundamentals of steady state kinetics, enzyme inhibition, isozymes.
Biological membrane and cell wall: Properties of lipid aggregates, micelles, liposomes, structure and
properties; membrane proteins and their function, fluid mosaic model, membrane mediated transport,
membrane equilibrium and permeability, chemical, physical composition and biosynthesis of cell wall
components.
SECTION-B
Carbohydrate metabolism: Glycolysis, biochemistry of alcoholic and lactic acid fermentation , citric acid cycle and pentose phosphate pathway, EDP pathway, disaccharide and polysaccharide metabolism, gluconeogensis, regulation of carbohydrate metabolism.
Oxidative phosphorylation/Respiration:Electron transport chain, photorespiration, cyanide resistant bacterial respiration,. Microtonal electron transport.
Biochemistry of lipid metabolism: Biosynthesis and catabolism of fatty acids, neutral lipids, phospholipids and cholesterol, glyoxylate cycle, regulation of fatty acid metabolism.
Amino acid metabolism:Biosynthesis and catabolism of amino acids, urea cycle, regulation of amino acids, nitrogen fixation and nitrogenase complex.
Nucleotide metabolism:Biosynthesis and catabolism of nucleotides, regulation of nucleotide metabolism.
Books recommended
- Biochemistry, Voet, D and Voet, J.G, John Wiley and Co. 1990.
- Biochemistry: Principle of cell structure and function, by Lehninger A.L. CBS Publishers, New Delhi,2005.
- Steyer Lubert, Berg Jeremy M. Biochemistry, 5th edition W.H Freeman & company. New York 2002.
- M.C. Pant, Essentials of Biochemistry, 8th edition Kedar and Ram Nath & co. Publishers. Meerut, 1996.
M.Sc PHARMACEUTICAL CHEMISTRY (SEMESTER-I)
Examinations for 2016-17 & 2017-18 sessions
PAPER-III: STEREOCHEMISTRY AND CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Maximum Mark : 100 Time: 3 hours
i)Theory Paper : 70 Pass Marks : 35%
ii)Internal Assessment : 30 Lectures to be delivered : 60
INSTRUCTIONS FOR THE PAPER SETTERS:
The question paper will consist of three sections A, Band C. Section A and B will have four questions from the respective sections of the syllabus and will carry 07 marks each. Section C will consist of a short answers/ objective type questions,which will cover the entire syllabus uniformly and will carry 28 marks (2 marks each).
INSTRUCTIONS FOR THE CANDIDATES:
1.Candidates are required to attempt three questions each from sections A and B of the question paper and the entire section C.
SECTION-A
Stereoisomerism: Optical isomerism, Chirality & Compounds showing optical activity (olefins, allenes & trivalent atoms), configuration, Assignment & determination of configuration (D,L,&R,S systems), Conformation (acyclic & cyclic system) . Stereoselective & stereospecific reactions.
Asymmetric synthesis- Cram’s rules, Cram’s chelate rule, Felkin & Anti-felkin rules (1,2- Induction ), Prelogs generalization (1,3-Induction), Amino acid synthesis (Strecker).
Organic reactions and mechanism: Substitution reactions; bimolecular and unimolecular nucleophilic substitutions, aromatic electrophilicand nucleophilic substitutions. Elimination reactions; bimolecular and unimolecular 1, 2- elimination, synelimination, 1, 3- elimination reactions. Addition reactions; nucleophilic addition to carbonyl group, addition involving bridged intermediates. Pericyclic reactions [cyclo addition(2+2, 2+4)], Electrocyclic reactions, Sigmatropic rearrangement.[1,3;1,5].
SECTION-B
Selective organic name reactions & rearrangements: Aldol, Perkin, Dieckmann condensation, Cannizaro Reaction, Hoffman, Schmidt, Curtius, Reimer- Tiemann, Reformastsky and Grignard Reactions, Friedel craft Reaction, Oppenauer Oxidation, Michael Addition, Mannich reaction, Sharpless asymmetric epoxidation, Hoffman rearrangements and Hoffman degradation, Beckmann and Fries rearrangement, Claisen rearrangements, benzylic acid rearrangement, Bayer- Villiger reaction, Pinacol rearrangement , dienone-phenol rearrangement.
Heterocyclic compounds:- Nomenclature of heterocyclic compounds, heterocyclic ring systems with one heteroatom: Structure, synthesis and reaction of aziridine, azirines, oxiranes, thiranes, pyrrole, furan, thiophene, -lactam and pyridine.
Heterocyclic ring systems with two, three & four heteroatoms: Structure, synthesis and reactions of imidazole, oxazole, thiazole, pyrazole, pyramidine , pyrazines, triazole & triazines.
Fused heterocyclic systems up to two heteroatoms: Chemistry and Reactions of indole (Fisher’s synthesis),Quinolines, Isoquinolines,quinagoline, cinnoline, quinoxaline.
Books recommended:
- I.L. Finner: Organic chemistry, Vol. II, 1stIndian edn. PearsonEducation Pvt. Ltd. Indian Branch, Delhi. 2002.
- O.P. Agarwal: Chemistry of Natural Products, Vol. I and II, 7th edn., Goel Publishing House, Meerut, 1983.
- D.C. Gautam: Heterocyclic chemistry, RBSA Publisher, Jaiput, 2004.
- E.L. Eliel Stereochemistry of carbon compounds, Tata Mc Graw Hill publishing Company, New Delhi, 1975.
- Jerry March, Advance Organic chemistry 4th edition, A Wiley- Interscience Publication, 1999.
- P.S. Kalsi, Stereochemistry Conformation and Mechanism 6th edition. New Age International Pvt, Limited Publishers, 2005.
M.Sc PHARMACEUTICAL CHEMISTRY (SEMESTER-I)
Examinations for 2016-17 & 2017-18 sessions
PAPER-IV: PHARMACOLOGY
Maximum Mark : 100 Time: 3 hours
i)Theory Paper : 70 Pass Marks : 35% ii)Internal Assessment : 30 Lectures to be delivered : 60
INSTRUCTIONS FOR THE PAPER SETTERS:
The question paper will consist of three sections A, Band C. Section A and B will have four questions from the respective sections of the syllabus and will carry 07 marks each. Section C will consist of a short answers/ objective type questions,which will cover the entire syllabus uniformly and will carry 28 marks (2 marks each).
INSTRUCTIONS FOR THE CANDIDATES:
1.Candidates are required to attempt three questions each from sections A and B of the question paper and the entire section C.
SECTION-A
Routes of drug administration, pharmacokinetics; absorption, distribution, metabolism and excretion of drugs.
Pharmacodynamics: mechanism of action, site of drug action, concept of receptors and theories of drug action.
Chemotherapy: Classification, mechanism of action of drugs in following classes.
* Sulfonamides
* Amino – glycosides
* Macrolides
* Fluoroquinolones
-lactam antibiotics
* Antiviral
* Anti-neoplastics
* Anti-tubercular
* Anti-malarial
SECTION-B
Classification of drugs and pharmacology of prototype drugs in followings:-
- CNS – Psychosis, Anxiety, Depression, Mania.
- Autonomic-nervous system – Cholinergic drugs, Anticholinergic drugs, sympathomimetic drugs, sympatholytic drugs.
- Gastro – intestinal system – Peptic ulcers.
- Drugs for management of pain and inflammation-NSAID,opioid analgesics.
- Cardiovascular system – Hypertension, Congestive Heart disease, Angina, Myocardial Infarction.
- Respiratory system – Bronchial Asthma
- Endocrine system – Anti- thyroid drugs, corticosteroids, oral contraceptives, Anti – diabetic agents.
Books recommended:
- K.D. Tripathi: Essentials of Medical Pharmacology, 5thedition. Jaypee Brothers, 2004.
- S.K. Kulkarni: Experimental Pharmacology, Vallabh Prakashan, New Delhi,Edn., 1991.
- Goodman Gilman’s: The pharmacological Basis of Therapeutics, 11th edition.
Mc Graw Hill, New York. USA, 1996.
M. Sc. PHARMACEUTICAL CHEMISTRY (SEMESTER-I)
Examinations for 2016-17 & 2017-18 sessions
Practical Paper-I: Quantitative analytical methods & Biochemistry
M. marks: 100
Time: 4 hoursTotal practical hours: 60
Suggested Experiments
- Identification of amino acid using paper chromatography techniques.
- Identification of different organic compounds using thin layer chromatographic techniques.
- Neutralization titrations: Assay of sodium bicarbonate, borax, boric acid, aspirin.
- Iodimetric and iodometric titrations: Assay of iodine, copper sulphate.
- Nonaquous titrations: Assay of Ephedrine HCl tablets.
- Preparation and standardization of Disodium EDTA solution.
- Qualitative and quantitative analysis of reducing and total sugars by biochemical and biophysical techniques.
- Determination of acid value of a fat/oil.
- Determination of cholesterol: total, free and esterified.
- Isolation, qualitative and quantitative analysis of lipids.
- Qualitative and quantitative analysis of protein by biochemical and biophysical techniques.
- Immobilization of enzymes.
- Purification of enzyme by affinity chromatography and ion exchange chromatography.
- Factors affecting enzyme activity.
- Titration curve for amino acids.
- Estimation of DNA and RNAs.
Note: Any other experiment(s) may be included in support of the theoretical aspect of the course.