European Society of Cardiology
ARTERIAL HAEMODYNAMICS AND WAVE INTENSITY –
Concepts, controversies, and clinical applications
Sir Alexander Fleming Building,
Imperial College, London
1st-3rd April 2004
Reduced compliance of central arteries and increased reflections from peripheral arteries are major causes of left ventricular disease, through their deleterious effects on ventriculo-vascular coupling. Much treatment in heart failure and hypertension is intended to ameliorate these effects, but the precise mechanisms of drugs acting on the vasculature and their consequences for the heart are difficult to study in clinical practice. Recent developments suggest that comprehensive non-invasive assessment of interactions between vascular and ventricular function may now be possible.
This international symposium on arterial function and wave intensity will be a forum for an ‘in depth’ review of recent research, involvingfluid dynamicists, engineers, experimental physiologists, clinical investigators, and cardiologists and vascular physicians. Topics to be discussed will includephysical principles and measurement techniques, new methods of assessing large arterial function and ventriculo-arterial coupling, clinical applications, and the results of early clinical studies of wave intensity. The atmosphere will be informal, to promote as much discussion as possible and to allow time for consideration of directions for future research.
Scientific Committee
Dr Alan Fraser, Cardiff
Professor Kim Parker, London
Dr Frank Schön, Düsseldorf
Professor Motoaki Sugawara, Tokyo
Professor John Tyberg, Calgary
Dr Chris Jones, Cardiff
Local host
Professor Kim Parker,
Physiological Flow Studies Group,
Department of Bioengineering,
Imperial College for Science, Technology and Medicine,
London, UK.
Sponsors
Aloka, Tokyo, Japan
PROGRAMME
Thursday 1st April 2004
Registration : 10.00 – 14.00
Lunch :13.00 – 14.00
Session 1: Basic concepts and applications of wave intensity
Chairmen:Chris Jones, Cardiff
John Tyberg, Calgary
14.00 – 14.30 :Fundamental concepts of wave intensity
Kim Parker, London
14.30 – 15.00 :Non-invasive implementation for clinical measurement
Motoaki Sugawara, Tokyo
15.00 – 15.15 :Comparison of wave intensity with catheter-derived indices
Nobuyuki Ohte, Nagoya
15.15 – 15.45 :Discussion
15.45 :Tea
Session 2: Arterial disease and ventriculo-vascular coupling
Chairmen:Kim Parker, London
Alan Fraser, Cardiff
16.15 – 16.45 :Translating the biology of vascular disease into clinical research
Tudor Griffith, Cardiff
16.45 – 17.15 :Pathophysiological insights from wave intensity in animal models
John Tyberg, Calgary
17.15 – 17.45 : Discussion
Friday 2nd April 2004
Session 3: Are measurements of wave intensity and arterial stiffness
ready for clinical use?
Chairmen:Motoaki Sugawara, Tokyo
Henryk Siniawski, Berlin
09.00 – 09.15 :Relationships between flow, diameter and pressure
Victoria Franke, London
09.15 – 09.30 :Regional variations in wave intensity and sources of error
Andrew Zambanini, London
09.30 – 09.45 :Reproducibility – Tokyo studies
Kiyomi Niki, Tokyo
09.45 – 10.00 :Reproducibility – Cardiff studies
Dragos Vinereanu, Bucharest
10.00 – 10.15 :Discussion
10.15 :Coffee break
Session 4: Non-invasive diagnosis of circulatory health –
Alternative techniques and clinical utility
Chairmen:John Goodfellow, Cardiff
Tony Dart, Melbourne
10.45 – 11.10 :Using flow-mediated dilatation to assess endothelial function
John Deanfield, Londont.b.c.
11.10 – 11.35 :Using applanation tonometry for pulse wave analysis in hypertension and diabetes
Ian Wilkinson, Cambridget.b.c.
11.35 – 12.00 :Using wave speed and separation of waves
Ashraf Khir, London
12.00 – 12.25 :Using wave speed as a clinical tool
Jim Cameron, Melbourne
12.25 – 12.45 :Using pulse wave velocity
Katarina Naka, Ioanninat.b.c.
12.45Discussion
13.00Lunch
Session 5: Clinical studies of arterial wave intensity
Chairmen:Frank Schön, Dusseldorf
Alun Hughes, London
14.00 – 14.25 :Hypertension and heart failure
Simon Thom, London
14.25 – 14.50 :Heart valve disease and cardiomyopathy
Kiyomi Niki, Tokyo
14.50 – 15.15 :Stratification of treatment for left heart failure
Henryk Siniawski, Berlin
15.15 – 15.30 :Discussion
15.30Tea
16.00Clinical demonstration – Dr K Niki and Dr H Siniawski
Session 6: Wave intensity at other sites – recent insights and new questions
Chairmen:Simon Gibbs, London
Michael Frenneaux, Cardiff
16.30 – 16.50 :In the coronary circulation
Jos Spaan, Amsterdamt.b.c.
16.50 – 17.10 :In the left ventricle
Juin-Jr Wang, Calgary
17.10 – 17.30 :In the pulmonary circulation
Aoife O’Brien, Cork
17.30 – 18.00 : Discussion
Saturday 3rd April 2004
Session 7: Targeting risk factors for cardiovascular disease
Chairmen:Tudor Griffith, Cardiff
John Deanfield, London t.b.c.
09.00 – 09.30 :Risk factors and conduit arterial function
Tony Dart, Melbourne
09.30 – 10.00 :The genetics of conduit arterial function
Stephane Laurent, Paris
10.00 – 10.30 :Vascular disease, subclinical left ventricular dysfunction,
and heart failure
Alan Fraser, Cardiff
10.30 – 11.00 :Discussion
11.00 :Coffee break
Session 8: Priorities for research
Chairmen:Kim Parker, London
Alan Fraser, Cardiff
11.30 – 11.55 :Developments in engineering
Akimitsu Harada, Tokyo
11.55 – 12.20 :An integrated approach to vascular and cardiac disease
Chris Jones, Cardiff
12.20 – 13.00 :General discussion
Summing-up
13.00Lunch
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