Supplemental Table 1. Proteins modified by drugs of abuse
Gene Symbol / Protein Name / Alcohol / Amphetamine/ Methamphetamine / Cocaine / Marijuana / Morphine/Heroin/ Butorphanol / NicotineAmino acid and protein metabolism
BCAT1 / Branched-chain aminotransferase 1 / +
DDX3X / ATP-dependent RNA helicase DDX3X / +
DDX48 / Probable ATP-dependent RNA helicase DDX48 / +
DPP3 / Dipeptidylpeptidase 3 / +
EEF1A1 / Eukaryotic translation elongation factor 1, alpha-1 / + / +
EEF1G / Elongation factor 1-gamma / + / + / +
EEF2 / Elongation factor 2 / + / +
EEFTU / Elongation factor Tu / + / +
GLN1 / Gln synthetase / + / +
GOT1 / Glutamate oxaloacetate transaminase 1 / + / +
GOT2 / Aspartate aminotransferase, mitochondrial / +
LAMR1 / Laminin receptor 1 / +
LAP3 / Leucine aminopeptidase 3 / + / +
LONM / Lon protease / +
PPP2CA / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / +
PPP2CB / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform / +
PPP3CA / Protein phosphatase 3, catalytic subunit, alpha isoform / + / +
Ppp3r1 / Protein phosphatase 3, catalytic subunit, alpha isoform / + / +
PPP5C / Serine/threonine-protein phosphatase / +
SCRN1 / Secernin-1 / +
TUFM / Elongation factor Tu, mitochondrial / +
Apoptosis
BCLAF1 / Bcl-2-Associated transcription factor 1 / +
BID / BH3-interacting domain death agonist / +
BTBD14B / BTB/POZ domain-containing protein / +
CARD10 / Caspase recruitment domain family, member 10 / +
CD40 / Tumor necrosis factor receptor superfamily, member 5
CSTB / Cystatin-B / + / +
DEDD / Death effector domain-containing protein / +
DNASE1L3 / Deoxyribonuclease 1-like 3 / +
EMAPII / Endothelial monocyte-activating polypeptide 2 / +
GLO1 / Glyoxalase 1 / + / +
GSN / Gelsolin / +
KNG1 / T-kininogen / +
LMNA / Lamin-A / +
MTCH1 / Mitochondrial carrier homolog 1 / +
PEA15 / Astrocytic phosphoprotein PEA-15 / +
SON / DNA binding protein Son / +
TPT1 / Translationally-controlled tumor protein / +
Cell cycle
CDKN1B / Cyclin-dependent kinase inhibitor 1b / +
DCTN2 / Dynactin 2 / +
DYNC1H1 / Dynein, cytoplasmic 1, heavy chain 1 / +
MDC1 / Mediator of DNA damage checkpoint protein 1 / +
MYC / V-myc avian myelocytomatosis viral oncogene homolog / +
SKP1A / S-phase kinase-associated protein 1 / +
Cell structure and organization
ACTB / Beta actin / + / + / + / + / +
ACTG1 / Gamma-actin / + / +
ACTR2 / Actin-related protein 2 / + / +
ACTZ / Alpha-centractin (Centractin) / +
ARGBP2 / Arg/Abl-interacting protein ArgBP2 / +
BRAL1 / Brain-specific hyaluronan-binding protein / +
CAP1 / Adenylyl cyclase-associated protein 1 / +
CAPZB / F-actin-capping protein subunit beta / + / +
CBX1 / Chromobox homolog 1 / +
CDH13 / Cadherin 13 / +
CFL1 / Cofilin 1 / +
CTNNA1 / Catenin, alpha / +
CTNNB1 / Catenin, beta / +
CTNND1 / Similar to Catenin delta-1 / +
EPB41 / Erythrocyte membrane protein band 4.1 / +
FSCN1 / Fascin / + / +
H2AFZ / H2a histone family, member z / +
H3F3B / H3 histone, family 3b / +
HAPLN1 / Hyaluronan and proteoglycan link protein 1 precursor / +
HIST1H1C / Histone gene cluster 1, h1 histone family, member c / +
INA / Internexin, alpha / +
MAP1A / Microtubule-associated protein 1A / +
MAP1LC3A / Microtubule-associated proteins 1A/1B light chain 3A / +
MAP2 / Microtubule-associated protein 2 / +
PACSIN1 / Protein kinase C and casein kinase substrate in neurons protein 1 / + / +
PFN2 / Profilin-2 / +
RANBP1 / RAN binding protein 1 / +
RBBP4 / Histone-binding protein RBBP4, chromatin assembly factor I p48 subunit / +
TBA3 / Tubulin a-3 chain / +
TMSB4X / Thymosin, beta-4 / +
TPM1 / Tropomyosin 1 / + / +
TPM2 / Tropomyosin 2 / +
TPM3 / Tropomyosin 3 / + / +
TUBA1 / Tubulin A / + / + / +
TUBA1A / Tubulin, alpha-1a / + / + / +
TUBA1B / Tubulin, alpha-1b / +
TUBA2 / Tubulin, alpha-2 / + / +
TUBA4A / Tubulin, alpha-4a / +
TUBA6 / Tubulin alpha 6 / +
TUBB2 / Tubulin b-2 chain / +
TUBB3 / Tubulin b-3 chain / + / +
TUBB4 / Tubulin b-4 chain / +
TUBB5 / Tubulin b-5 chain / +
VCL / Vinculin / +
VIM / Vimentin / +
WASF1 / Wiskott-aldrich syndrome protein family, member 1 / +
Energy metabolism
ACO1 / Aconitase 1, soluble / +
Aco2 / Aconitase 2, mitochondrial / + / + / + / + / +
ACOT2 / Acyl-coenzyme A thioesterase 2 / +
AK1 / Adenylate kinase 1 / +
AK5 / Adenylate kinase 5 / +
AKR1A1 / Alcohol dehydrogenase [NADP+] / +
AKR1B4 / Aldo-keto reductase family 1, member B4 / + / +
AKR7A2 / Aldo-keto reductase family 7, member A2 / +
ALBU / Serum albumin precursor / +
ALDH2 / Aldehyde dehydrogenase, mitochondrial / +
ALDH5A1 / Succinate-semialdehyde dehydrogenase, mitochondrial / + / +
ALDH6A1 / Aldehyde dehydrogenase 6 family, member a1 / + / +
ALDOA / Aldolase, fructose-bisphosphate / + / + / + / + / + / +
ALDOC / Aldolase C, fructose-bisphosphate / + / + / + / +
ALDR1 / Alcohol dehydrogenase / +
ATP12A / ATPase, H+/K+ transporting, nongastric, alpha polypeptide / +
ATP1A1 / ATPase, Na+/K+ transporting, alpha-1 polypeptide / + / +
ATP1A2 / ATPase, Na+/K+ transporting, alpha-2 polypeptide / +
ATP1A3 / ATPase, Na+/K+ transporting, alpha-3 polypeptide / + / +
ATP5A1 / ATP synthase subunit alpha, mitochondrial / + / + / + / +
ATP5B / Mitochondrial atp synthase, beta subunit / + / + / + / +
ATP5D / Mitochondrial atp synthase, delta subunit / +
ATP5F1 / Mitochondrial atp synthase, beta subunit / +
Atp5g1 / ATP synthase, H+ transporting, mitochondrial F0 complex, alpha subunit, isoform 1 / + / + / + / + / +
Atp5g3 / ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 / +
ATP5H / ATP synthase subunit d, mitochondrial / +
Atp6v1a1 / Similar to ATPase, H+ transporting, V1 subunit A, isoform 1 / + / + / +
Atp6v1B2 / Similar to ATPase, H+ transporting, V1 subunit B, isoform 2 / + / + / +
ATP6V1D / ATPase, H+ transporting, lysosomal V1 subunit D / +
ATP6V1H / ATPase, H+ transporting, lysosomal, 50/57-kd, v1 subunit H / + / +
CA1 / Carbonic anhydrase I / +
CA8 / Carbonic anhydrase 8 / +
CAH2 / Carbonic anhydrase 2 / +
CBR1 / Carbonyl reductase / +
CKB / Creatine kinase B chain / + / + / + / + / +
CKMT1 / Creatine kinase, mitochondrial 1, ubiquitous / + / +
CKMT2 / Creatine kinase, mitochondrial 2 / +
CNDP2 / Cytosolic non-specific dipeptidase / + / +
CoII / Cytochrome c oxidase, subunit 2 / +
Cox5a / Cytochrome c oxidase polypeptide Va / +
Cox5b / Cytochrome c oxidase polypeptide Vb / + / +
Cox6c / Cytochrome c oxidase polypeptide VIc-2 / +
CS / Citrate synthase, mitochondrial / + / +
CYB5R3 / Cytochrome b5 reductase 3 / +
DDAH1 / Dimethylarginine dimethylaminohydrolase 1 / + / + / +
DDAH2 / Dimethylarginine dimethylaminohydrolase 2 / + / +
DDT / D-Dopachrome tautomerase / +
DHPR / Dihydropteridine reductase / +
DLAT / Dihydrolipoamide acetyltransferase / + / + / +
DLD / Dihydrolipoamide dehydrogenase / + / + / + / +
DLST / Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex / +
ENO1 / Enolase 1, alpha / + / + / + / + / + / +
Eno2 / Enolase 2, gamma / + / + / + / +
ENOA / Alpha-enolase / + / +
ETFB / Electron transfer flavoprotein, beta polypeptide / +
FABP1 / Fatty acid binding protein / +
FABP5 / Fatty acid-binding protein, epidermal / +
FABP7 / Fatty acid-binding protein 7 / + / + / +
FAHD2A / Fumarylacetoacetate hydrolase domain-containing protein 2A / +
FH / Fumarate hydratase, mitochondrial / +
G6PD / Glucose-6-phosphate 1-dehydrogenase / +
G6PI / Glucose-6-phosphate 1-isomerase / +
GALK1 / Galactokinase 1 / +
GALM / Galactose mutarotase / +
GAPDH / Glyceraldehyde 3-phosphate-dehydrogenase / + / + / + / +
GCP1 / Glutamate carboxypeptidase I / +
GLUD1 / Glutamate dehydrogenase 1 / + / + / + / +
GPDH / Glycerol-3-phosphate dehydrogenase / +
GPI / Glucose-6-phosphate isomerase / + / +
GRP58 / Glucose regulated protein, 58 kDa / +
GRP78 / Glucose regulated protein, 78 kDa / +
GSTA1 / Glutathione s-transferase, alpha-1 / +
HIOMT / Hydroxyindole O-methyltransferase / +
HK1 / Hexokinase 1 / + / +
HPRT1 / Hypoxanthine-guanine phosphoribosyltransferase / +
IDH / Isocitrate dehydrogenase / +
Idh3a / Isocitrate dehydrogenase 3 (NAD+) alpha / + / + / + / + / +
Idh3B / Isocitrate dehydrogenase 3 (NAD+) beta / +
IMPA1 / Inositol-monophosphatase / +
IMPDH2 / Inosine-5'-monophosphate dehydrogenase 2 / +
IVD / Isovaleryl-CoA dehydrogenase, mitochondrial / +
LDHA / L-lactate dehydrogenase A chain / + / +
LDHB / L-lactate dehydrogenase B chain / + / + / + / + / + / +
MCCC2 / Methylcrotonoyl-coa carboxylase beta chain, mitochondrial / +
MDH1 / Malate dehydrogenase, mitochondrial / + / + / + / +
MDH2 / Malate dehydrogenase, mitochondrial / +
Mor1 / Malate dehydrogenase, mitochondrial / + / + / +
MPI / Mannose-6-phosphate isomerase / +
MPST / 3-mercaptopyruvate sulfurtransferase / +
MTHFD1 / Methylenetetrahydrofolate dehydrogenase / +
NDPK / Nucleoside-diphosphate kinase / +
NDPKB / Nucleoside diphosphate kinase B / + / +
NDUA9 / NADH dehydrogenase (ubiquinone) 1 a subcomplex subunit 9 / +
NDUFA10 / NADH dehydrogenase 1 alpha subcomplex 10-like protein / + / + / + / + / +
NDUFA12 / Similar to NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 / +
NDUFA5 / NADH-ubiquinone oxidoreductase 13 kDa-B subunit / + / +
NDUFA6 / NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 / +
Ndufs1 / NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial / +
Ndufs2 / NADH dehydrogenase (ubiquinone) Fe-S protein 2 / + / + / + / +
NDUFV2 / NADH-ubiquinone oxidoreductase 24 kDa subunit / + / + / +
NDUFV3 / NADH-ubiquinone oxidoreductase flavoprotein 3 / +
NIT2 / Nitrilase family, member 2 / +
NUKM / NADH-Ubiquinone oxidoreductase 20 kDa subunit / +
PdhA / Pyruvate dehydrogenase (lipoamide) alpha / + / +
Pdhb / Pyruvate dehydrogenase (lipoamide) beta / + / + / +
PDK3 / Pyruvate dehydrogenase kinase isozyme 3, mitochondrial / +
PFKM / 6-Phosphofructokinase (phosphofructokinase 1) / +
PFKP / Phosphofructokinase, platelet type / + / +
PGAM1 / Phosphoglycerate mutase 1 / + / + / +
PGK1 / Phosphoglycerate kinase 1 / + / + / + / +
PGLS / 6-phosphogluconolactonase
/ +
PGM1 / Phosphoglucomutase 1 / + / +
PHGDH / D-3-Phosphoglycerate dehydrogenase / + / + / +
PKLR / Pyruvate kinase, liver and red blood cell / +
PKM2 / M2 pyruvate kinase / + / + / + / + / +
PLIN1 / Perilipin-1 / +
PRPS1 / Phosphoribosyl pyrophosphate synthetase 1 / +
PYGM / Glycogen phosphorylase, muscle form / +
PYK1 / Pyruvate kinase 1 / +
RGS10 / Regulator of G protein signaling 10 / +
SAMM50 / SAM50-like protein CGI-51 homologue / +
SCOT / Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial / +
SDHA / Succinate dehydrogenase complex, subunit A, flavoprotein variant / + / +
SIRT2 / NAD-dependent deacetylase sirtuin-2 / + / + / +
SLC25A11 / Solute carrier family 25 (mitochondrial carrier, oxoglutarate carrier), member 11 / +
SSDH / Succinate-semialdehyde dehydrogenase, mitochondrial / +
ST2a1 / Alcohol sulfotransferase / +
TALDO1 / Transaldolase / +
Tkt / Transketolase / + / + / + / +
Tpi1 / Triosephosphate isomerase 1 / + / + / + / + / + / +
TXNL1 / Thioredoxin-like protein 1 / +
Uqcrc1 / Ubiquinol-cytochrome c reductase core protein I / + / + / + / + / + / +
Uqcrc2 / Ubiquinol-cytochrome c reductase core protein II / + / +
UQCRH / Cytochrome b-c1 complex subunit 6, mitochondrial / +
Neuronal function
BDNF / Brain-derived neurotrophic factor / +
DCX / Neuronal migration protein doublecortin / +
DPYL3 / Dihydropyrimidinase-related protein 3 / +
DPYSL1 / Dihydropyrimidinase-related protein 1 / + / + / +
DPYSL2 / Dihydropyrimidinase-related protein 2 / + / + / + / +
DPYSL4 / Dihydropyrimidinase-related protein 4 / +
DPYSL5 / Dihydropyrimidinase-related protein 5 / + / +
DRP2 / Dystrophin related protein 2 / + / +
GAP43 / Neuromodulin (axonal membrane protein GAP-43) / +
GDA / Guanine deaminase / + / +
GMFB / Glia maturation factor, beta / +
GPM6A / Glycoprotein m6a / +
GPRIN1 / Similar to G protein-regulated inducer of neurite outgrowth 1 / +
HPCA / Neuron-specific calcium-binding protein hippocalcin / +
HPCAL1 / Hippocalcin-like protein 1 / +
IGSF8 / Immunoglobulin superfamily, member 8 / +
LY6H / Similar to lymphocyte antigen 6 complex, locus H / +
MTPN / Myotrophin / +
NCDN / Neurochondrin / +
NDRG2 / Nmyc downstream-regulated gene 2 / +
NEFH / Neurofilament protein, heavy polypeptide / +
NEFL / Neurofilament light polypeptide / + / + / + / +
NEFM / Neurofilament triplet M protein / +
NP22 / Neuronal protein 22 / +
PCP4 / Purkinje cell protein 4 / +
SEPT2 / Septin 2 / +
SEPT3 / Septin 3 / +
SEPT4 / Septin 4 / +
SEPT5 / Septin 5 / + / + / +
SEPT6 / Septin 6 / +
SEPT7 / Septin 7 / +
SEPT8 / Septin 8 / +
SEPT9 / Septin 9 / +
SH3GL2 / Endophilin-1 / +
STIP1 / Stress-induced-phosphoprotein 1 / + / + / +
STMN1 / Stathmin / + / +
SYNPO / Synaptopodin / +
TAGLN2 / Transgelin 2 / +
TAGLN3 / Transgelin 3 / + / + / +
TMOD2 / Tropomodulin 2 / + / +
VSNL1 / Visinin-like protein 1 / +
Oxidative stress response
GPX1 / Glutathione peroxidase 1 / + / +
GSTM1 / Glutathione S-transferase Mu 1 / + / +
GSTM3 / Glutathione S-transferase Yb-3 / + / +
GSTO1 / Glutathione S-transferase omega 1 / + / + / + / +
Gstp1 / Glutathione S-transferase, pi 1 / + / + / + / +
HP / Haptoglobin / +
PARK7 / Parkinson disease protein 7 / + / +
PDIA1 / Protein disulfide isomerase / + / +
PDIA3 / Protein disulfide isomerase 3 / + / +
PEBP / Phosphatidylethanolamine-binding protein 1 / + / + / + / +
PRDX1 / Peroxiredoxin-1 / + / +
PRDX2 / Peroxiredoxin 2 / + / + / + / + / +
PRDX5 / Peroxiredoxin 5 / + / + / +
PRDX6 / Peroxiredoxin 6 / + / + / +
SOD1 / Superoxide dismutase / + / + / +
SOD2 / Superoxide dismutase [Mn], mitochondrial / + / +
Protein modification and degradation
CCT2 / Chaperonin containing tcp1, subunit 2 / + / +
CCT3 / Chaperonin containing tcp1, subunit 3 / + / + / +
CCT5 / Chaperonin containing tcp1, subunit 5 / + / + / +
CCT6A / Chaperonin containing tcp1, zeta subunit / +
COPS4 / COP9 signalosome complex subunit 4 / +
CTSD / Cathepsin D / + / + / + / +
HIP / Hsc70-interacting protein / +
HSBP1 / Heat shock factor binding protein 1 / +
HsC70-ps1 / Heat shock 70 kDa protein 8, pseudogene 1 / + / + / +
HSP60 / Heat-shock 60 kD protein 1 / + / + / +
HSP7C / Heat-shock 71 kD protein 1 / + / +
HSP90AB1 / Heat shock protein HSP 90-beta / + / +
Hspa2 / Heat shock 70 kDa protein 2 / + / + / + / + / +
HSPA5 / Heat-shock 70-kd protein 5 / +
Hspa8 / Heat shock 70 kDa protein 8 / + / + / + / + / + / +
Hspa9 / Heat shock 70 kDa protein 9 / + / + / +
HSPB1 / Heat-shock protein beta-1 / +
HSPD1 / Heat shock 60 kDa protein 1 / + / + / + / + / +
OTUB1 / OUT domain, ubiquitin aldehyde binding 1 / +
PCMT1 / Protein L-isoaspartyl/D-aspartyl methyltransferase / +
PFDN5 / Prefoldin 5 / +
PPIA / Peptidylprolyl isomerase A / + / +
PSMA1 / Proteasome subunit, alpha-type, 1 / +
PSMA2 / Proteasome subunit, alpha-type, 2 / +
PSMA3 / Proteasome subunit, alpha-type, 3 / +
PSMB3 / Proteasome subunit beta type-3 / +
PSMB4 / Proteasome subunit beta type-4 / +
PSMB7 / Proteasome subunit beta type-7 / +
PSMC2 / Proteasome 26s subunit, ATPase, 2 / +
PSMC3 / Proteasome subunit, alpha-type, 6 / +
PSMF1 / Proteasome inhibitor PI31 subunit / +
RPLP1 / Ribosomal phosphoprotein, large, P1 / +
RPS3 / 40S ribosomal protein S3 / +
RPS4 / Ribosomal protein S4 / +
RPSA / 40S ribosomal protein SA / +
UBB / Ubiquitin b / +
UBE2N / Ubiquitin-conjugating enzyme E2N / + / +
UBE2V2 / Ubiquitin-conjugating enzyme E2 variant 2 / +
UBP12 / Ubiquitin C-terminal hydroxylase 12 / +
Uchl1 / Ubiquitin carboxy-terminal hydrolase L1 / + / + / + / + / +
UCHL3 / Ubiquitin carboxyl-terminal hydrolase isozyme L3 / +
Response to stimulus
Aif1 / Allograft inflammatory factor 1 / +
BLMH / Bleomycin hydrolase / +
CD81 / Cd81 / +
COL1A1 / Collagen alpha-1(I) chain / +
CRYAB / Alpha-crystallin B chain / +
CRYGA / Gamma-crystallin A chain / +
Crym / Crystallin, mu / + / + / + / + / +
GFAP / Glial fibrillary acidic protein / + / + / +
LXN / Latexin / +
LZIC / Protein LZIC / +
NPM1 / Nucleolar phosphoprotein b23 / +
OPA1 / Optic atrophy 1-like protein / +
WDR1 / WD repeat-containing protein 1 / + / +
Signal transduction
ADCY10 / Adenylate cyclase type 10 / +
ANXA1 / Annexin A1 / +
ANXA11 / Annexin A11 / +
ANXA3 / Annexin A3 / + / + / +
ANXA4 / Annexin A4 / +
ANXA5 / Annexin A5 / + / + / + / +
APOA1 / Apolipoprotein A-I / +
ARF1 / ADP-ribosylation factor 1 / + / +
ARF3 / ADP-ribosylation factor 3 / +
ARHGDIA / Rho GDP-dissociation inhibitor 1 / +
ARHGDIB / Rho gdp-dissociation inhibitor beta / +
CALM / Calmodulin (CaM) / + / +
CALML3 / Calmodulin like 3 / +
CALNA1 / Calcineurin A / +
CALNA2 / Calcineurin A2 / +
CAMK2A / Calcium/calmodulin-dependent protein kinase II alpha / + / +
CAMK2B / Calcium/calmodulin-dependent protein kinase II beta / + / +
CAMK2D / Calcium/Calmodulin-dependent protein kinase II-delta / +
CAMK2G / Calcium/Calmodulin-dependent protein kinase II-gamma / +
CENTA1 / Centaurin alpha / +
CNTN1 / Contactin-1 / +
CNTN2 / Contactin-2 / +
CRK / Adapter molecule crk / +
FBN1 / Fibrillin 1 / +
FGB / Fibrinogen beta chain precursor / +
GDI1 / Rab GDP dissociation inhibitor alpha / + / + / +
GNA11 / Guanine nucleotide-binding protein, alpha-11 / +
GNA12 / Guanine nucleotide-binding protein, alpha-12 / +
GNA13 / Guanine nucleotide-binding protein, alpha-13 / +
GNAI1 / Guanine nucleotide-binding protein Gi, alpha-1 subunit / + / +
GNAI2 / Guanine nucleotide-binding protein, alpha-inhibiting activity polypeptide 2 / +
GNAO / GTP-binding protein alpha o / + / + / + / +
GNAQ / GTP-binding protein alpha q / +
GNAS / Guanine nucleotide-binding protein Gs subunit alpha isoforms short / +
GNB1 / Guanine nucleotide-binding protein, beta-1 subunit / + / + / + / +
GNB2 / Guanine nucleotide-binding protein, beta-2 subunit / + / + / +
GNB2L1 / Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 / +
GNB3 / Guanine nucleotide-binding protein, beta-3 subunit / +
GNB4 / Guanine nucleotide-binding protein, beta-4 subunit / + / +
GNB5 / Guanine nucleotide-binding protein, beta-5 subunit / +
GUCY1B3 / Soluble guanylyl cyclase beta 1 subunit / +
HDGF / Hepatoma-derived growth factor / +
INPP4B / Inositol polyphosphate-4-phosphatase, / +
INPP5A / Inositol polyphosphate-5-phosphatase, 40kda / +
LGALS1 / Galectin-1 / +
MADD / MAP kinase-activating death domain protein / +
MAP2K1 / ERK activator kinase 1 / + / +
MAPK12 / Mitogen-activator protein kinase-12 / +
MAPK8 / Mitogen-activated protein kinase 8 / +
MAPK9 / Mitogen-activator protein kinase-9 / +
MESDC2 / Mesoderm development candidate 2 / +
PDE2A / Phosphodiesterase 2a, cGMP-stimulated / +
PHB / Prohibitin / + / + / + / +
PHB2 / Prohibitin 2 / +
PLCB1 / 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 / +
PLD1 / Phospholipase D1 / +
PLD2 / Phospholipase D2 / +
PPP1R1B / Protein phosphatase 1, regulatory subunit 1b / +
PRKACB / cAMP-dependent protein kinase, beta-catalytic subunit (PKA Cb) / +
PRKAR2B / Type II cAMP-dependent protein kinase regulatory subunit, Type IIb / +
PRKCA / Protein kinase C alpha type / +
PRKCE / PKC, epsilon type / +
PRKCG / Protein kinase c, gamma / +
RAB1 / Ras-related protein Rab-1A / + / + / +
RAB10 / RAS-associated protein rab10 / +
RAB11A / Ras-related protein Rab-11A / +
RAB3A / Ras-related protein Rab-3A / +
RAB3B / RAS-associated protein rab3b / +
RAB3C / RAS-associated protein rab3c / +
RAB3D / RAS-associated protein rab 3d / +
RAB4B / RAS-related protein Rab-4b / +
RABEP1 / RAB GTPase-binding effector protein 1 / +
RABGDIA / RAB GDP-dissociation inhibitor, alpha / +
RABGDIB / RAB GDP-dissociation inhibitor, beta / +
RABIF / Rab-interacting factor / +
RALA / Ras-related protein Ral-A / +
RAN / Ras-related nuclear protein / +
RAP1A / RAS-related protein 1a / +
S100A13 / S100 calcium-binding protein a13 / +
STRAP / Serine-threonine kinase receptor-associated protein / +
YWHAE / 14-3-3 protein eps / + / + / +
YWHAG / 14-3-3 protein gamma / +
YWHAH / Tyrosine 3-monooxygenase / +
YWHAZ / 14-3-3 protein isoform zeta / + / + / + / + / +
Synaptic function
ABAT / 4-aminobutyrate aminotransferase / + / +
AP2A2 / Adaptor-related protein complex 2, alpha 2 subunit / +
AP2B1 / AP-2 complex subunit beta / +
BCAN / Brevican core protein precursor / +
CACNB4 / Calcium channel beta-4 subunit / +
CALB1 / Calbindin 1 / + / +
CALB2 / Calbindin 2 / + / +
CLTC / Clathrin, heavy polypeptide / + / +
CNP / Cyclic nucleotide phosphodiesterase / + / +
CNRIP1 / CB1 cannabinoid receptor-interacting protein 1 / +
CPLX1 / Complexin I / +
CPLX2 / Complexin II / +
DBN1 / Drebrin E / +
DNM1 / Dynamin 1 / + / + / +
DNM1L / Dynamin-1-like protein / + / +
DNM2 / Dynamin 2 / +
GABARAP / Gaba-a receptor-associated protein / +
GAD2 / Glutamate decarboxylase 2 / +
GLUL / Glutamate-ammonia ligase / + / + / + / +
GRIP1 / Glutamate receptor interacting protein / + / +
HOMER1 / Homer homolog 1 / +
KCNMB3 / Calcium-activated potassium channel subunit beta-3 / +
MBP / Myelin a1 protein, basic / + / +
MUNC18 / Unc-18 protein homolog / +
NAPA / N-ethylmaleimide sensitive fusion protein attachment protein alpha / + / +
NAPB / Similar to Beta-soluble NSF attachment protein (SNAP-beta) / + / + / +
NCALD / Neurocalcin, delta / +
NSF / N-ethylmaleimide sensitive fusion protein / + / + / + / +
NSFL1C / P47 protein [NSFL1 (p97) cofactor (p47)] / +
SLC1A2 / Solute carrier family 1 (glial high affinity glutamate transporter), member 2 / +
SLC1A3 / Solute carrier family 1 (glial high affinity glutamate transporter), member 3 / +
SNAP25 / Synaptosomal-associated protein 25 kDa / + / +
SNAP29 / Synaptosomal-associated protein 29 kDa / +
SNCA / Alpha synuclein (phosphoneuroprotein 14) / + / + / +
SNCB / Beta synuclein (phosphoneuroprotein 14) / + / +
STX1A / Syntaxin 1a / +
STX1B2 / Syntaxin 1b2 / +
Stxbp1 / Syntaxin binding protein 1 / + / + / + / +
Stxbp3 / Syntaxin binding protein 3 / +
SV2A / Synaptic vesicle glycoprotein 2a / +
SYN1 / Synapsin I / +
Syn2 / Synapsin IIb / + / + / + / +
SYNGAP1 / Synaptic ras-GTPase-activating protein 1 / +
VAT1 / Vesicle amine transport protein 1 / +
VCP / Valosin-containing protein / +
Transport
ARCN1 / Archain 1 / +
BIN1 / Bridging integrator 1 / +
CLCN1 / Chloride channel, muscle / +
CLIC1 / Chloride intracellular channel protein 1 / +
ERP29 / Endoplasmic reticulum protein, 29-kd / + / +
GJA1 / Gap junction alpha-1 protein (Connexin 43) / +
HNRNPA1 / Heterogeneous nuclear ribonucleoprotein A1 / + / +
HNRNPA2B1 / Heterogeneous nuclear ribonucleoproteins A2/B1 / +
HNRNPF / Heterogeneous nuclear ribonucleoprotein f / +
HNRPH / Heterogeneous nuclear ribonucleoprotein H / +
HNRPH2 / Heterogeneous nuclear ribonucleoprotein H2 / + / +
HNRPK / Heterogeneous nuclear ribonucleoprotein K / +
HNRPL / Heterogeneous nuclear ribonucleoprotein L / +
NU107 / Nuclear pore complex protein Nup107 / +
RBP1 / Retinol-binding protein 1 / +
SLC25A12 / Solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 12 / +
SLC25A4 / Solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 / +
SLC25A5 / Solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 / +
SNX5 / Sorting nexin-5 / +
THIK2 / Tandem pore domain halothane-inhibited potassium channel 2 / +
TIMM10 / Mitochondrial import inner membrane translocase subunit Tim10 / +
TOMM70A / Mitochondrial import receptor subunit TOM70 / +
VDAC1 / Voltage-dependent anion channel 1 / + / + / + / +
VDAC2 / Voltage-dependent anion channel 2 / + / +
VPS29 / Vacuolar protein sorting-associated protein 29 / +
Other
ELAV1 / Elav-like generic protein 1 (Hu-antigen R) / +
IMMT / Inner membrane protein, mitochondrial / +
NONO / non-POU domain containing, octamer-binding / +
PCBP1 / Poly(rC) binding protein 1 / +
RUBV2 / RuvB-like 2 / +
SPG3A / Atlastin like protein / +
TPD54 / Tumor protein D54 / +
ZBP-89 / Zinc-finger binding protein-89 / +
*Note: ‘+’ indicates the protein has been reported to be modulated by the drugs of abuse shown in the same columns.
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