RI2 Application - Format for Submission

RI2 proposals should be a maximum of 4 pages long (page limit excludes the title page, budget, and any citations) and must contain and answer the following questions:

1.  Title page

·  Project title, Caltech PI name, and budget requested

2.  What is the ultimate product or service?

·  If your RI2 proposal is successful and you start a company or the technology is licensed, what is the product? What would be sold?

·  Example: Cancer therapeutic; imaging chip for cell phones

3.  What is the commercialization path? What milestones must be completed in order for your technology to become a product or service?

·  Example: Step 1) in vitro studies, 2) in vivo studies, 3) animal studies/pre-clinical, 4) human trials

4.  Which of the above milestones do you intend to achieve using your RI2 funds?

·  Example: Milestone 1: complete in vitro studies, Milestone 2: complete in vivo studies in one animal model

5.  What is the unmet need in the marketplace? What are the current competing technologies? What is the advantage over the competition?

·  Example: Current gene sequencer takes 2 hours, but ours can be completed in 5 minutes

6.  In addition to the advantages cited above, will your technology have a cost advantage or at least be competitive with the market?

7.  Can you manufacture your technology on a mass scale? What are hurdles to scalability?

·  We understand that this may be very difficult to predict for some technologies, speculate as best you can

·  Example: Feasibility to manufacture 1mg of a chemical versus 1kg

8.  What is the funding status for this project?

·  How much funding has your lab received for this project and from what sources?

·  Example: 250K from the DOD; 500K from the Parkinson’s Foundation

9.  What is the current IP status of your project?

·  Example: 4 provisional applications filed and 1 issued patent

10.  As best you can, please provide a rough estimate of the market size.

·  Example: The US non-small-cell lung cancer drug market is currently estimated at 35 billion, it is expected to double by 2016; all cell phone manufacturers

11.  A succinct annual budget

·  List direct costs only, up to $125K. A second year projection can be included for a total of $250k direct costs; second year of funding is not guaranteed and will be evaluated the following along with new proposals