Supplementary material3Top 100 Up- and downregulated genes in patients with complex seizures due torotavirus infection
Top 100 Up-regulated genes
Probe ID / Gene symbol / Gene title / Fold change / p value205984_at / CRHBP / corticotropin releasing hormone binding protein / 13.474 / 0.0444
243209_at / KCNQ4 / potassium voltage-gated channel, KQT-like subfamily, member 4 / 12.042 / 0.0470
239636_at / MCF2L / MCF.2 cell line derived transforming sequence-like / 11.883 / 0.0032
229073_at / PRTG / Protogenin / 11.332 / 0.0180
230658_at / SLC7A2 / solute carrier family 7, member 2 / 11.317 / 0.0041
205492_s_at / DPYSL4 / dihydropyrimidinase-like 4 / 11.288 / 0.0205
1570471_at / ARHGEF12 / Rho guanine nucleotide exchange factor 12 / 10.181 / 0.0398
1557349_at / RERE / arginine-glutamic acid dipeptide repeats / 10.116 / 0.0129
203936_s_at / MMP9 / matrix metallopeptidase 9 / 9.732 / 0.0288
1570470_at / CATSPERB / cation channel, sperm-associated, beta / 9.463 / 0.0320
1556986_at / OR2H1 / olfactory receptor, family 2, subfamily H, member 1 / 9.068 / 0.0197
207379_at / EDIL3 / EGF-like repeats and discoidin I-like domains 3 / 9.061 / 0.0375
232904_at / SLC7A14 / solute carrier family 7, member 14 / 8.863 / 0.0128
209400_at / SLC12A4 / Solute carrier family 12, member 4 / 8.856 / 0.0022
224208_at / PLEKHA8 / pleckstrin homology domain containing, family A member 8 / 8.296 / 0.0281
211372_s_at / IL1R2 / interleukin 1 receptor, type II / 8.192 / 0.0426
229755_x_at / DLL3 / Delta-like 3 / 8.041 / 0.0225
224178_s_at / SOX6 / SRY-box 6 / 8.022 / 0.0297
220737_at / RPS6KA6 / ribosomal protein S6 kinase, 90kDa, polypeptide 6 / 7.961 / 0.0496
1554163_at / TWIST2 / twist homolog 2 / 7.801 / 0.0431
228648_at / LRG1 / leucine-rich alpha-2-glycoprotein 1 / 7.746 / 0.0453
205574_x_at / BMP1 / bone morphogenetic protein 1 / 7.735 / 0.0484
206252_s_at / AVPR1A / arginine vasopressin receptor 1A / 7.626 / 0.0467
223508_at / NOTCH1 / notch 1 / 7.572 / 0.0161
1557218_s_at / FANCB / Fanconi anemia, complementation group B / 7.312 / 0.0378
220475_at / SLC28A3 / solute carrier family 28, member 3 / 7.282 / 0.0385
210961_s_at / ADRA1D / adrenergic, alpha-1D-, receptor / 7.098 / 0.0061
220528_at / VNN3 / vanin 3 / 6.714 / 0.0003
217071_s_at / MTHFR / methylenetetrahydrofolate reductase / 6.654 / 0.0461
206350_at / APCS / amyloid P component, serum / 6.640 / 0.0066
203473_at / SLCO2B1 / solute carrier organic anion transporter family, member 2B1 / 6.517 / 0.0448
206733_at / TULP2 / tubby like protein 2 / 6.251 / 0.0330
1554969_x_at / DIP2A / DIP2 disco-interacting protein 2 homolog A / 6.210 / 0.0231
221541_at / CRISPLD2 / cysteine-rich secretory protein LCCL domain containing 2 / 6.052 / 0.0035
229324_x_at / ISYNA1 / inositol-3-phosphate synthase 1 / 6.006 / 0.0100
1560854_s_at / ZNF107 / zinc finger protein 107 / 5.978 / 0.0489
220263_at / SMAD5OS / SMAD family member 5 opposite strand / 5.923 / 0.0492
217462_at / C11orf9 / chromosome 11 open reading frame 9 / 5.910 / 0.0068
210689_at / CLDN14 / claudin 14 / 5.866 / 0.0079
228758_at / BCL6 / B-cell CLL/lymphoma 6 / 5.858 / 0.0165
233030_at / PNPLA3 / patatin-like phospholipase domain containing 3 / 5.686 / 0.0069
206691_s_at / PDIA2 / protein disulfide isomerase family A, member 2 / 5.482 / 0.0237
203779_s_at / MPZL2 / myelin protein zero-like 2 / 5.320 / 0.0187
207653_at / FOXD2 / forkhead box D2 / 5.060 / 0.0339
203815_at / GSTT1 / glutathione S-transferase theta 1 / 5.043 / 0.0286
217518_at / MYOF / Myoferlin / 5.032 / 0.0456
1554384_at / PADI2 / peptidyl arginine deiminase, type II / 4.824 / 0.0329
205991_s_at / PRRX1 / paired related homeobox 1 / 4.782 / 0.0430
205199_at / CA9 / carbonic anhydrase IX / 4.782 / 0.0258
207094_at / CXCR1 / chemokine receptor 1 / 4.773 / 0.0322
206765_at / KCNJ2 / potassium inwardly-rectifying channel, subfamily J,
member 2 / 4.746 / 0.0416
206515_at / CYP4F3 / cytochrome P450, family 4, subfamily F, polypeptide 3 / 4.663 / 0.0005
1555236_a_at / PGC / Progastricsin / 4.555 / 0.0235
210994_x_at / TRIM23 / tripartite motif-containing 23 / 4.540 / 0.0012
203167_at / TIMP2 / TIMP metallopeptidase inhibitor 2 / 4.479 / 0.0378
236811_at / DMRTC2 / DMRT-like family C2 / 4.436 / 0.0409
211123_at / SLC5A5 / solute carrier family 5, member 5 / 4.386 / 0.0409
206209_s_at / CA4 / carbonic anhydrase IV / 4.378 / 0.0321
214438_at / HLX / H2.0-like homeobox / 4.333 / 0.0357
216217_at / PLCL2 / phospholipase C-like 2 / 4.298 / 0.0147
209791_at / PADI2 / peptidyl arginine deiminase, type II / 4.294 / 0.0134
237799_at / SLC22A12 / solute carrier family 22, member 12 / 4.265 / 0.0433
210119_at / KCNJ15 / potassium inwardly-rectifying channel, subfamily J,
member 15 / 4.164 / 0.0424
1557136_at / ATP13A4 / ATPase type 13A4 / 4.099 / 0.0393
204174_at / ALOX5AP / arachidonate 5-lipoxygenase-activating protein / 4.081 / 0.0182
220910_at / FRAS1 / Fraser syndrome 1 / 4.061 / 0.0188
220777_at / KIF13A / kinesin family member 13A / 3.991 / 0.0099
206508_at / CD70 / CD70 molecule / 3.968 / 0.0264
216010_x_at / FUT3 / fucosyltransferase 3 / 3.956 / 0.0130
1559561_at / FBXO18 / F-box protein, helicase, 18 / 3.939 / 0.0104
221386_at / OR3A2 / olfactory receptor, family 3, subfamily A, member 2 / 3.933 / 0.0381
239058_at / FOXC2 / Forkhead box C2 / 3.932 / 0.0152
210357_s_at / SMOX / spermine oxidase / 3.914 / 0.0004
226275_at / MXD1 / MAX dimerization protein 1 / 3.888 / 0.0494
224327_s_at / DGAT2 / diacylglycerol O-acyltransferase 2 / 3.886 / 0.0379
209962_at / EPOR / erythropoietin receptor / 3.886 / 0.0173
213478_at / KAZ / Kazrin / 3.880 / 0.0005
240440_at / NPL / N-acetylneuraminate pyruvate lyase / 3.869 / 0.0302
203505_at / ABCA1 / ATP-binding cassette, sub-family A, member 1 / 3.857 / 0.0443
217977_at / SEPX1 / selenoprotein X, 1 / 3.836 / 0.0481
232555_at / CREB5 / CAMP responsive element binding protein 5 / 3.834 / 0.0173
226064_s_at / DGAT2 / diacylglycerol O-acyltransferase 2 / 3.829 / 0.0485
219969_at / TXLNG / taxilin gamma / 3.824 / 0.0480
228846_at / MXD1 / MAX dimerization protein 1 / 3.816 / 0.0142
203435_s_at / MME / membrane metallo-endopeptidase / 3.749 / 0.0093
205935_at / FOXF1 / forkhead box F1 / 3.745 / 0.0495
238600_at / JAKMIP1 / janus kinase and microtubule interacting protein 1 / 3.738 / 0.0253
224576_at / ERGIC1 / endoplasmic reticulum-golgi intermediate compartment 1 / 3.725 / 0.0012
205119_s_at / FPR1 / formyl peptide receptor 1 / 3.720 / 0.0453
1553047_at / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase, type II, beta / 3.716 / 0.0175
1554710_at / KCNMB1 / potassium large conductance calcium-activated channel, subfamily M, beta member 1 / 3.693 / 0.0316
221051_s_at / ITGB1BP3 / integrin beta 1 binding protein 3 / 3.658 / 0.0136
208401_s_at / GLP1R / glucagon-like peptide 1 receptor / 3.624 / 0.0106
232193_at / GSTT1 / Glutathione S-transferase theta 1 / 3.592 / 0.0098
218739_at / ABHD5 / abhydrolase domain containing 5 / 3.571 / 0.0130
228950_s_at / WLS / wntless homolog / 3.554 / 0.0273
211429_s_at / SERPINA1 / serpin peptidase inhibitor, clade A, member 1 / 3.535 / 0.0099
209863_s_at / TP63 / tumor protein p63 / 3.520 / 0.0171
1554624_a_at / SIRPB1 / signal-regulatory protein beta 1 / 3.514 / 0.0375
219516_at / TRPV4 / transient receptor potential cation channel, subfamily V, member 4 / 3.501 / 0.0341
Top 100 Down-regulated genes
Probe ID / Gene symbol / Gene title / Fold change / p value1552897_a_at / KCNG3 / potassium voltage-gated channel, subfamily G, member 3 / 0.069 / 0.0341
1562245_a_at / ZNF578 / Zinc finger protein 578 / 0.073 / 0.0364
1558887_at / ZNF321 / zinc finger protein 321 / 0.075 / 0.0253
216468_s_at / ZNF682 / zinc finger protein 682 / 0.079 / 0.0081
1554345_a_at / GIN1 / gypsy retrotransposon integrase 1 / 0.083 / 0.0229
1569283_at / ZNF891 / zinc finger protein 891 / 0.086 / 0.0343
1552794_a_at / ZNF547 / zinc finger protein 547 / 0.113 / 0.0307
205727_at / TEP1 / telomerase-associated protein 1 / 0.113 / 0.0128
241141_at / BMP6 / Bone morphogenetic protein 6 / 0.113 / 0.0080
206831_s_at / ARSD / arylsulfatase D / 0.116 / 0.0353
217915_s_at / RSL24D1 / ribosomal L24 domain containing 1 / 0.116 / 0.0440
1555842_at / CYTH2 / cytohesin 2 / 0.128 / 0.0287
1555120_at / CD96 / CD96 molecule / 0.129 / 0.0428
221248_s_at / WHSC1L1 / Wolf-Hirschhorn syndrome candidate 1-like 1 / 0.130 / 0.0392
1554047_at / TXNDC9 / thioredoxin domain containing 9 / 0.132 / 0.0012
203881_s_at / DMD / dystrophin / 0.137 / 0.0213
209662_at / CETN3 / centrin, EF-hand protein, 3 / 0.145 / 0.0233
220907_at / GPR110 / G protein-coupled receptor 110 / 0.146 / 0.0060
240846_at / PCBD2 / pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2 / 0.147 / 0.0046
232751_at / RBBP9 / retinoblastoma binding protein 9 / 0.148 / 0.0352
203759_at / ST3GAL4 / ST3 beta-galactoside alpha-2,3-sialyltransferase 4 / 0.149 / 0.0042
238526_at / RAB3IP / RAB3A interacting protein / 0.153 / 0.0379
211525_s_at / GP5 / glycoprotein V / 0.153 / 0.0062
222465_at / RSL24D1 / ribosomal L24 domain containing 1 / 0.159 / 0.0283
211279_at / NRF1 / nuclear respiratory factor 1 / 0.160 / 0.0057
214990_at / PIGO / phosphatidylinositol glycan anchor biosynthesis, class O / 0.161 / 0.0235
223036_at / FARSB / phenylalanyl-tRNA synthetase, beta subunit / 0.168 / 0.0276
1553140_at / PELO / pelota homolog / 0.168 / 0.0356
210457_x_at / HMGA1 / high mobility group AT-hook 1 / 0.170 / 0.0229
1559513_a_at / FANCC / Fanconi anemia, complementation group C / 0.170 / 0.0346
1554906_a_at / MPHOSPH6 / M-phase phosphoprotein 6 / 0.173 / 0.0016
1554491_a_at / SERPINC1 / serpin peptidase inhibitor, clade C, member 1 / 0.177 / 0.0423
218886_at / PAK1IP1 / PAK1 interacting protein 1 / 0.194 / 0.0484
204013_s_at / LCMT2 / leucine carboxyl methyltransferase 2 / 0.194 / 0.0231
218234_at / ING4 / inhibitor of growth family, member 4 / 0.196 / 0.0148
207191_s_at / ISLR / immunoglobulin superfamily containing leucine-rich repeat / 0.196 / 0.0435
212325_at / LIMCH1 / LIM and calponin homology domains 1 / 0.196 / 0.0313
1569272_at / PIK3C3 / phosphoinositide-3-kinase, class 3 / 0.196 / 0.0247
216574_s_at / RPE / ribulose-5-phosphate-3-epimerase / 0.200 / 0.0374
223374_s_at / B3GALNT1 / beta-1,3-N-acetylgalactosaminyltransferase 1 / 0.200 / 0.0438
211210_x_at / SH2D1A / SH2 domain containing 1A / 0.206 / 0.0289
233899_x_at / ZBTB10 / zinc finger and BTB domain containing 10 / 0.207 / 0.0483
206734_at / JRKL / jerky homolog-like / 0.211 / 0.0182
216627_s_at / B4GALT1 / UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 / 0.213 / 0.0155
211079_s_at / DYRK1A / dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A / 0.217 / 0.0329
220867_s_at / SLC24A2 / solute carrier family 24, member 2 / 0.218 / 0.0494
230719_at / ING3 / inhibitor of growth family, member 3 / 0.218 / 0.0238
237061_at / ZNF347 / zinc finger protein 347 / 0.220 / 0.0041
228029_at / ZNF721 / zinc finger protein 721 / 0.227 / 0.0045
216850_at / SNRPN / small nuclear ribonucleoprotein polypeptide N / 0.227 / 0.0063
202351_at / ITGAV / integrin, alpha V / 0.229 / 0.0156
223323_x_at / TRPM7 / transient receptor potential cation channel, subfamily M, member 7 / 0.230 / 0.0030
220338_at / RALGPS2 / Ral GEF with PH domain and SH3 binding motif 2 / 0.233 / 0.0290
210801_at / DIMT1L / DIM1 dimethyladenosine transferase 1-like / 0.233 / 0.0447
200099_s_at / RPS3A / ribosomal protein S3A / 0.233 / 0.0253
219532_at / ELOVL4 / elongation of very long chain fatty acids-like 4 / 0.234 / 0.0243
217353_at / HNRNPA1 / heterogeneous nuclear ribonucleoprotein A1 / 0.236 / 0.0241
240078_at / SFSWAP / splicing factor, suppressor of white-apricot homolog / 0.240 / 0.0401
236128_at / ZNF91 / zinc finger protein 91 / 0.246 / 0.0167
206785_s_at / KLRC / killer cell lectin-like receptor subfamily C / 0.246 / 0.0081
202684_s_at / RNMT / RNA methyltransferase / 0.248 / 0.0040
214470_at / KLRB1 / killer cell lectin-like receptor subfamily B, member 1 / 0.252 / 0.0487
1552716_at / SPEF2 / sperm flagellar 2 / 0.255 / 0.0051
201304_at / NDUFA5 / NADH dehydrogenase 1 alpha subcomplex, 5, 13kDa / 0.257 / 0.0142
234742_at / SIRPG / signal-regulatory protein gamma / 0.258 / 0.0454
230556_at / IMMP1L / IMP1 inner mitochondrial membrane peptidase-like / 0.260 / 0.0250
239482_x_at / ZNF708 / zinc finger protein 708 / 0.268 / 0.0447
226279_at / PRSS23 / protease, serine, 23 / 0.269 / 0.0489
238821_at / CSTF2 / cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa / 0.270 / 0.0475
204291_at / ZNF518A / zinc finger protein 518A / 0.277 / 0.0317
238756_at / GAS2L3 / Growth arrest-specific 2 like 3 / 0.278 / 0.0424
228053_s_at / TOMM5 / translocase of outer mitochondrial membrane 5 homolog / 0.279 / 0.0189
201699_at / PSMC6 / proteasome 26S subunit, ATPase, 6 / 0.279 / 0.0130
223154_at / MRPL1 / mitochondrial ribosomal protein L1 / 0.283 / 0.0187
218128_at / NFYB / nuclear transcription factor Y, beta / 0.286 / 0.0113
208442_s_at / ATM / ataxia telangiectasia mutated / 0.289 / 0.0313
224484_s_at / BRMS1L / breast cancer metastasis-suppressor 1-like / 0.293 / 0.0297
204286_s_at / PMAIP1 / phorbol-12-myristate-13-acetate-induced protein 1 / 0.293 / 0.0395
222808_at / ALG13 / asparagine-linked glycosylation 13 homolog / 0.296 / 0.0168
213452_at / ZNF184 / zinc finger protein 184 / 0.298 / 0.0288
214700_x_at / RIF1 / RAP1 interacting factor homolog / 0.303 / 0.0048
239229_at / PHEX / phosphate regulating endopeptidase homolog, X-linked / 0.304 / 0.0473
204105_s_at / NRCAM / neuronal cell adhesion molecule / 0.304 / 0.0170
200032_s_at / RPL9 / ribosomal protein L9 / 0.309 / 0.0238
203341_at / CEBPZ / CCAAT/enhancer binding protein, zeta / 0.316 / 0.0272
228303_at / GALNT6 / UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 / 0.317 / 0.0034
228829_at / ATF7 / activating transcription factor 7 / 0.319 / 0.0040
202918_s_at / MOBKL3 / MOB1, Mps One Binder kinase activator-like 3 / 0.319 / 0.0117
226350_at / CHML / choroideremia-like / 0.327 / 0.0137
1555325_s_at / ZNF26 / zinc finger protein 26 / 0.328 / 0.0049
1553113_s_at / CDK8 / cyclin-dependent kinase 8 / 0.329 / 0.0054
218645_at / ZNF277 / zinc finger protein 277 / 0.330 / 0.0306
223416_at / SF3B14 / splicing factor 3B, 14 kDa subunit / 0.332 / 0.0089
215519_x_at / SGSM3 / small G protein signaling modulator 3 / 0.334 / 0.0203
212391_x_at / RPS3A / ribosomal protein S3A / 0.334 / 0.0438
209865_at / SLC35A3 / solute carrier family 35, member A3 / 0.336 / 0.0171
209389_x_at / DBI / diazepam binding inhibitor / 0.338 / 0.0061
212918_at / RECQL / RecQ protein-like / 0.339 / 0.0068
224714_at / MKI67IP / MKI67 interacting nucleolar phosphoprotein / 0.340 / 0.0314
224587_at / SUB1 / SUB1 homolog / 0.341 / 0.0053