cv for Satin, Jonathan
Curriculum Vitae
Jonathan Satin, Ph.D.
01Dec 2013
Home:
2172 Island Drive
Lexington, KY40502
Work:
Department of Physiology, MS-508
University of Kentucky
Lexington, KY40536-0298
phone: 859.323.5356
FAX: 859.323.1070
e-mail:
Education
1983A.B. The University of Chicago
1989Ph.D.EmoryUniversity
1989-92Postdoctoral FellowThe University of Chicago
Faculty Appointments
1992-1994Research Associate (Instructor), Department of Medicine, Section of Cardiology, The University of Chicago
1995-2001 Assistant Professor, Department of Physiology, College of Medicine, University of Kentucky
2001-2010 Associate Professor, Department of Physiology, College of Medicine, University of Kentucky
2010Professor, Department of Physiology, College of Medicine, University of Kentucky
Educational Interests (1)Teaching methods, flipped classroom; hybrid instruction
(2)Cardiovascular physiology
Research Interests(1)Electrophysiological function of the heart with emphasis on
voltage-gated ion channel contributions to hypertrophic state, and to embryonic development of cardiac excitability.
(2)Voltage-gated ion channel structure-function relationships and
molecular biophysics of ion channel function.
(3)Cardiac development/maturation and the relationship between excitable function and developmental signaling
Current Research Grant Support
(Annual Direct costs)
NIH-NHLBIMechanisms of Long-term Regulation of Cardiac Ion Channel
P.I. (RO1-HL74091-06)($250,000)
7/01/03 – 5/30/15
NIH-NHLBIRegulation of Calcium Function by the Rem GTPase
PI of multi-PI (RO1-HL72936-06)($257,500)
4/15/03 – 3/31/2015
Submitted
NIH - HLRO1HL124384-01Novel Inotropic Support By Targeting Rad GTPase
P.I.
07.01.2014 – 06.30.2019
The goal of this grant is to test the hypothesis that modulation of Rad GTPase offers inotropic support to the heart.
NIH F32 award
Sponsor/mentor
04.01.2014 – 3.31.2017To be reviewed Fall 2013
Previous Research Grant Support
AHA –National Embryonic Cardiomyocyte Plasma Membrane Calcium Handling
P.I. (Established Investigator Award - #0340127)
1/01/2003 – 12/31/2007($500,000)
NIH-NHLBI Modulation of T-type Calcium Channels
P.I. (RO1-HL63416-05)
4/01/2000 – 3/31/2005$725,000
NIH-NHLBI “Adaptive Heterogeneity of Embryonic Chick Myocardium”
co-investigator (1RO1-HL64626)
4/01/2001 – 8/31/2002$250,000
National Science Foundation, “Molecular Basis of Modulation of Neuronal Sodium Channels
P.I. (IBN-9977920)
3/1/1999 – 6/1/2000$42,515
NIH-NHLBIPulmonary C-Neuron Hypersensitivity: Cellular Mechanisms
Collaborating investigator (RO1 – HL67379)
4/01/02 - 3/31/2006
American Heart Association - National, "Structural Determinants of the Cardiac Sodium Channel Voltage Sensor"
P.I. (96009560)
7/01/1996 – 4/30/2000$120,000
American Heart Association - Kentucky Affiliate, "Structural Determinants of the Cardiac Sodium Channel Voltage Sensor,"
P.I.
7/01/1996 – 6/30/1998 $40,000; declined due to overlap
UKMCRF, AActivity Dependence of Muscle Function In a Novel Neuromuscular Disease Model System,"
P.I.
7/01/1997 – 6/30/1998 $15,000
UKMCRF, "Mechanism for Isoform Specific Parameters of Sodium Channel Gating,"
P.I.
7/1/1995 – 6/30/1996$15,000
American Heart Assoc. of Metro. Chicago Grant-in-Aid, "Structure/Function Study of the Cloned Cardiac Sodium Channel"
P.I.
7/1/1993 – 6/30/1995$40,000
Teaching Responsibilities
University of Chicago
Lecturer, 1st year Medical Physiology Course, 1993, 1994.
University of Kentucky
PGY 604, April 1995 Pathophysiology, Lecturer
PGY 590, Spring 1996 (Cell Physiology), Lecturer
PGY 502, Fall 1996-2003, 2007-2013 (Cell, Molecular & Integrative Physiology), Lecturer
PGY 602, Fall 1996-99, 07-13 (ReadingsCell, Molecular & Integrative Phys), Lecturer
PGY 640, Spring 1997, 1999, 2001, 2003 (Advanced Cardiovascular Physiology),Lecturer
PGY 690, Spring 1997 (Readings in Cell Physiology), Lecturer
PGY 560, Pathophysiology, Fall 1997, Spring 1999, Lecturer
PGY 774 Fall & Spring 1998-99, Graduate Pro-seminar, Course Director
PGY 630 (Advanced PGY Topic- Ion Channels) Spring 1999, Course Director
IBS 604 Cell Signaling, Spring 2003-08, Lecturer
PGY 412G Physiology, Fall 2004, Spring 2005, Fall 2005, Spring 2006
PGY 604, Spring 2005-2013, Advanced Cardiovascular Physiology,Course Director
OBI 814 Spring 2008-2013, Dental School Physiology
IBSSummer 2009-2010, Mechanism of Human Disease
Students Directed
The University of Chicago
Steven Y. Chang, MD, PhD, June 1995 (currently attending physician, Dept. of
Pulm. & Critical Care, U. Chicago
Thomas Hauser, summer medical student
University of Kentucky
Graduate, Ph.D. Dissertation director:
Yi Zhang, Ph.D. awarded August 1999, (currently research associate, Baylor)
Brian Delisle, Ph.D. awarded 2001 (currently Asst. Prof, U. Ky. Dept Physiol.)
Miranda Byse (2005 – 2010)
William C. Lester (2006- 2012)
Shawn Crump (2006 – 2012)
Carmen Kiper (2007 – 2011)
Graduate, Ph.D. committee
Runze Wu (Biomedical Engineering), 2002- 2005
Rebecca Scotland (Pharmacology), 2003-2007
Robert N. Correll (Biochemistry), 2004 - 2008
Dan Ni (Phsyiology) 2005- 2008
Chunyan Pang (Chemistry/Biochemistry) 2005 – 2008
Randall Hulshizer (Pharmacology)
Letitia Richardson (Bioengineering, outside examiner, 2006)
Kalyani Bharadwaj (Pharmaceutical Science, outside examiner, 2006)
Himachandra Chebrolu (Bioengineering, outside examiner, 2007)
Dusan Jeftinija (Pharmacology, 2007- 2008)
Manisha Gupta (Nutritional Science, 2010)
Dan Bartos (Physiology, 2011-13 )
Katherine Kaminski (Biochemistry 2012 - )
Ahmed Abdel-Latif (Micro – 2012)
Chontida Yarana (Toxicology 2013 - )
Graduate, Medical School – Summer Research Fellow
John Penn, 2012
Graduate, Masters Thesis Director
John Penn, 2011
Ayman Haroun, 2012-2013
Faisal A. Hassan, 2012-
Graduate, IBS – rotations
Xinyu Qu, Fall II 2012
Graduate, Masters Program mentor
John Penn (Graduate School Masters of Medical Science, 2011)
Ellyn Velasco (Graduate Masters of Science, 2012)
Wil Lester (2012)
Ayman Haroun 2012-2013
Faisal Hassan2013
Post-graduate – Don Burgess, Ph.D., Res. Assoc/P-doc on RO1-HL63416
Mentor for Yidong Wei, M.D., post-doctoral scholar
Co-sponsor for Elizabeth Schroder, Ph.D., NHLBI -NRSA fellowship
Sponsor for Ju Lun Hong, MD, AHA fellowship entitled, "Cardiopulmonary Effects
of Adenosine: Role of Pulmonary C-Fibers"
Sponsor for Qihai Gu, MD, Frances Parker Foundation Fellowship
Undergraduate: Brian Delisle (recipient: HHMI Fellowship), Heather Gregory (Outreach
Center Scholar; Bio395 honors student), Shardon (Dean) Ramash, Karl Strand, Thomas Bell, Joe Broudy, Curtis, Swanson, Jennifer Osterhage (Bio395 Honors student), Kedar Oak, Carmen Kiper, Adam Baylor (UKURP); Yang Sheng (Bio395); Zahra
Rashmitha Edem (Bio 395)
Technicians trained & now attending medical school or physicians:
Heather Gregory, Scott Fraser, Eva Sum, Alison Nemes, Lindsay Fox-Burns (Chief Resident, Pediatrics, UKy Healthcare), Joe Hill
IBS Graduate Student Rotations:
Josh Arnold, Jeff Yates, Miranda Byse, Paul Mueller
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Cosultant for HHMI sponsored Outreach Program in Grant Writing
Mentor for Dr. H. L. Martinez, UC – Santa Barbara
Past and Current Trainees
NameTenureCurrent Position
Steven Y. Chang, M.D., Ph.D.1992-1995Associate Professor, Pulmonary/Crit Care
UMNDJ, NewarkNJ
Yi Zhang, M.D., Ph.D.1995-1999Post-doctoral fellow Baylor
Univ., Dept of Neurology
Brian Delisle, Ph.D.1997-2001Assistant Professor, Univ. of
Kentucky, Department of Physiology
Don Burgess, Ph.D.1999-2008Professor, Asbury College,
Wilmore, KY
Elizabeth Schroder, Ph.D.1999-2010Research Assistant Professor
Univ. Kentucky, Dept. Physiol.
Yidong Wei, M.D.2002-2004Associate Professor
TongjiUniversity, Shanghai, China
Miranda Byse2005 – 2010Course Coordinator, APS,
Bethesda, MD
Wil Lester, MS2006 – 2012Student, UKy Pharmacy
Shawn Crump, Ph.D.2006 – 2012Post-doc, UC-Irvine
Carmen Kiper, Ph.D.(2011)2007 – 2013U. Louisville, Ped. internship
Janet Manning, Ph.D.2012 – presentpost-doc, Satin lab
Guo Yin, MS2012 – presentpost-MS fellow
Ayman Haroun2013- presentpost-MS fellow; Dental student
Faisal Hassan2013- presentpost-MS fellow
Undergraduate Students
Jennifer Osterhage2001Physician
Heather Gregory 1995-1998Physician
Alison Nemes1998-1999?
Eva Sum1997-1998?
Mentored Trainee Fellowships
TraineeFellowship
Miranda ByseNIH NHLBI T32 Cardiovascular Sciences Training Grant
Miranda ByseAmerican Heart Association Predoctoral Fellowship
Wil LesterNIH-NHLBI T32 Cardiovascular Sciences Training Grant
Wil LesterNIH – NHLBI F31 Individual Predoctoral Fellowship
Carmen KiperNIH NHLBI T32 Muscle Biology Training Grant
Shawn CrumpNIH – NHLBI T32 Cardiovascular Sciences Training Grant
Janet ManningNIH- NHLBI F32 - pending
Awards
1986Grass Foundation Fellowship, Hopkins Marine Station, Stanford University
1989-1992 Postdoctoral Traineeship, Multidisciplinary Cardiac Sciences Training
Grant, NIH/NHLBI HL07381-12-14
2001- 2012Wethington Research Award, University of Kentucky
2010Holsinger Award – Excellence in Teaching, U. of Ky
2003 AHA – Established Investigator Award Recipient
2004 Lady Davis Fellow
2006 AHA Volunteer Recognition Award – Research Administration
2012Mentor to Janet Manning recipient of Stew Whitman Memorial 1st Place Award
2013Mentor to Janet Manning recipient of Post-doctoral fellow 1st Place Award, UKy
2013Mentor to Janet Manning recipient of AHA travel award, BCVS 2013
Activities and Professional Societies
1993 Ad-Hoc Grant Reviewer for the Austrian Science Foundation (FWF)
1994Joint Peer Review Committee, American Heart Assoc. of Metro. Chicago
1994Platform Session Chair, Na Channels: Structure & Function, Biophys. Soc.
Meeting
1999Ad-hoc reviewer for American Cancer Society small grant program
2001Platform Session Chair, Ion Channel Permeation, Biophys. Soc. Ann. Meeting
2001- 02, Children’s Miracle Network Grant Review Panelist
2001Session Moderator, Calcium Regulation in Disease, AHA-Scientific Session 2001
2001- 06 Wethington Research Award, University of Kentucky
2002Faculty, ISHR 2002, Translational Approaches to Cardiovascular Diseases
2002ad hoc reviewer for NSF
2002-05, 2007-09American Heart Association (AHA) -National Peer Review Committee, Basic Cell and Molecular Biology
2010AHA – National Peer Review - Electrophysiology
2003-2013AHA- Scientific sessions abstract review committee
2006 ad hoc reviewer for Israel National Science Foundation
2006/08ad hoc reviewer for U.S. – Israel Binational Science Foundation
2006 - 2008 NIH grant review group, CCHF (Cardiovascular Sciences IRG)
2006 Platform Moderator, American Heart Association – Scientific Sessions
2008 -09grant review NIH, NHLBI, Program Project (PO1) review
2009NIH - NHLBI grant review, Special Emphasis Panel
2009NIH – ZRG1 CVRS-B Challenge Grants Panel 19
2010NIH - HLBP1 – Workgroup 013
2010Israel Science Foundation
2011-14NIH – grant review – F10A Panel
2010-11NIH – grant review CVS IRG, ESTA
2011NIH – grant review CVS IRG, CCHF
2012MarchNIH – grant review - Physiology and Pathobiology of Cardiovascular and
Respiratory Systems
2012JuneNIH – grant review - Physiology and Pathobiology of Cardiovascular and
Respiratory Systems
2012NovNIH – grant review - Physiology and Pathobiology of Cardiovascular and
Respiratory Systems
2012 OctAHA, National – grant review – Established Investigator Award Review
2013Agence Nationale de la Recherche (French Natl Sci) ad hoc grant review
2012-13AHA, National – grant review – Innovative Research Grant Review
2013-14AHA, National member Committee on Scientific Sessions Planning
Memberships: Biophysical Society, Society of General Physiology, American Heart Association, Basic Science Council
Reviewer for: Biophysical Journal; American Journal of Physiology : Cell Physiology
American Journal of Physiology : Heart Physiology; Gerontology, Life Sciences; Journal of Biological Chemistry; Circulation Research
Journal of Neuroscience; Journal of Pharmacological & Experimental Therapeutics; Journal of Clinical Investigation; Journal of Physiology (London); Journal of General Physiology, Cardiovascular Research, Stem Cells
Editorial Board
Channels
University Service
2012- presentCollege of Medicine, International Affairs Committee
2012- present University of Kentucky International Affairs, Mideast & North Africa Region
2009- 2012Physiology Department, Research Committee
2012Physiology Department, Flipped Classroom
2007 6-year review committee for Department of Obstetrics & Gynecology
2006 Animal Transport Sub-committee
2002-2004 Member, Institutional Animal Care and Use Committee (IACUC)
2002-2003 Member, Post-doctoral scholar Committee
2003 Member, Physiology Department faculty search committee
Invited Talks toNational / International Conferences
199819th Annual Meeting of The Southeast Pharmacological Society, Voltage-Gated Ion Channel Session, Modulation of Cloned Voltage-Gated Sodium and T-type Calcium Channels: Structure-Function Implications
2000ASPET/ASBMB Annual meeting, Symposium Speaker, “EETs and Cardiac T-type Calcium Channels”
July 2002, International Society for Heart Research – North American Section Annual Meeting, Faculty, Ion Channel Symposium, T-type Ca channels in the heart.
November 2004, Great Wall International Cardiology Conference, Beijing, China
April 2006, 4th Annual Fairberg International Workshop on Interactive and Integrative Cardiology, Charleston, SC, USA
May 2010Heart Rhythm 2010, the 31st Annual Scientific Sessions of the Heart Rhythm Society
June 2010Cardiac Regulatory Mechanisms, Gordon Research Conference
Nov 2010American Heart Assoc – Sci Sessions – Moderator
May 2011Heart Rhythm 2011, the 32ndAnnual Scientific Sessions of the Heart Rhythm Society
Feb 2013Cardiac Arrhythmias, Gordon Research Conference
June 2014Cardiac Regulatory Gordon Research Conference
Invited Seminars
1994Dept. of Physiology; LoyolaUniv.StrictchSchool of Medicine
1994Dept. of Physiology, ChicagoMedicalSchool, North Chicago, IL
1995Dept. of Physiology and Section of Cardiology, Univ. of Utah, Salt Lake City, UT
1996Center for Biomedical Engineering, Univ. of Kentucky, Lexington, KY
1996Dept. of Physiology, University of CincinnatiMedicalSchool, Cincinnati, OH
1999Dept. of Pharmacology, University of Kentucky, Lexington, KY
1999Gill Heart Institute, University of Kentucky, Lexington, KY
2000 Cardiovascular Research Institute, LoyolaUniversity, Maywood, IL
2000MedicalUniversity of South Carolina, Gazes Heart Institute, Charleston, SC
2000NE OhioUnivCollege of Medicine, Dept of Physiology, Rootstown, Oh
2000University of Tennessee, Dept of Physiology, Memphis, TN
2000Masonic Medical Research Laboratories, Utica, NY
2001Dept. of Medicine, The University of Chicago, Chicago, IL
2002Gill Heart Institute, Lexington, Ky
2003Technion – IsraelInstitute of Technology, Haifa, Israel
2004Dept. of Physiology, EmoryUniversity, Atlanta, GA
2005Dept. of Physiology & Pharmacology, Columbia University, New York, NY
2005Cardiology/Dept of Medicine, Northwestern University, Chicago, IL
2007Dept. of Pharmacology, University of Kentucky, Lexington, KY
2008Dept. of Physiology, LoyolaUniversity, Maywood, IL
2008Dept. of Physiology/Biophysics & Stem Cell Institute, Univ. of Washington, Seattle, WA
2009Cardiovascular Research Center & Dept Physiology, Temple Univ., Philadelphia, PA
2012Dept of Pharmacology, University of Vermont, Burlington, VT
Book Reviews, Chapters
1. Oxygen Regulation of Ion Channels and Gene Expression, The Physiologist 42: 221-2 (1999)
2. DeHaan, R.L. and Satin, J. (1990) The local cues in physiological differentiation of the
embryonic heart: Ion channel development. In Molecular Biology of the Cardiovascular System. UCLA Symposia on Molecular and Cellular Biology. Vol 132 (eds., R.Roberts and J. Sambrook) Alan R. Liss Inc, New York, pp.73-98.
3. Schroder, E.A., Satin, J., Tsyvian, P.B., Routkevitch, S., and B.B. Keller (2002) T-type and L-type Calcium Currents Modulate Force in Embryonic Chick Myocardium. In Cardiac Development, eds. B. Ostadal, M. Nagano, and N.S. Dhalla, Kluwer Academic Publishers.
4. J. Satin and E.A. Schroder (2009) Auto-regulation of Cardiac L-type Calcium Channels. Trends in Cardiovascular Medicine, 19(8):268-71. PMID: 20447569
5. J. Satin (2013) Cardiac L-type Calcium Channel Gating, in Cardiac Electrophysiology: From Bench to Bedside. Editors: J. Jalife & D. Zipes, 6th edition. Publ. Saunders (Elsevier)
Articles in Refereed Journals
1. Satin, J, Fujii, S., and DeHaan, R.L. (1988) Development of cardiac beat rate in early chick embryos is regulated by extracellular cues. Develop. Biol.129: 103-113.
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2. DeHaan, R.L., Fujii, S., and Satin, J. (1990) Cell Interactions in Cardiac Development. Develop. Growth & Diff.32: 233-241.
3. Cribbs, L.L., Satin, J., Fozzard, H.A., and Rogart, R.B. (1990) Functional expression of the rat heart I Na channel isoform. Febs. ltt.275: 195-200.
4. Satin, J., Kyle, J.W., Chen, M., Bell, P., Cribbs, L.L., Fozzard, H.A., and Rogart, R.B. (1992) A mutant of TTX-Resistant cardiac Na channels with STX-Sensitive properties. Science.256: 1202-1205.
5. Satin, J., Kyle, J.W., Chen, M., Rogart, R.B., and Fozzard, H.A. (1992) The cloned cardiac Na channel -subunits expressed in Xenopus oocytes show gating and blocking properties of native channels. J. Membr. Biol., 130: 11-22.
6. Doyle, D.D., Guo, Y., Lustig, S.L., Satin, J., Rogart, R., and Fozzard, H.A. (1993) Divalent cation competition with 3H-Saxitoxin binding to tetrodotoxin-resistant and sensitive sodium channnels. A Two-site structural model of ion/toxin interaction. J. Gen. Physiol.101: 153-182.
7. Kyle, J.W., Chang, S.Y., Satin, J., Fang, J.M., Fozzard, H.A., and R.B. Rogart (1993) Rat brain ß1 Na channel subunit interacts with rat brain IIa, skeletal muscle (I), and rat heart (RH1) -subunits. Biophysical J.,64: a88.
8. Makielski, J.C., Satin, J., and Z. Fan (1993) Post-repolarization block of cardiac sodium channels by saxitoxin. Biophysical J. 65: 790-798.
9. Satin, J., Kyle, J.W., Fan, Z., Rogart, R.B., Fozzard, H.A., and J.C. Makielski (1994) Post-repolarization block of cloned Na channels by saxitoxin: The contribution of pore-region amino acids. Biophysical J.66: 1353-1363.
10. Satin, J., Limberis, J., Kyle, J.W., Rogart, R.B., and H.A. Fozzard (1994) Saxitoxin block of the Rat Brain IIa Sodium Channel is in the Electrical Field. Biophysical J., 67: 1007-1014.
11. Chang, S., Satin, J., and H.A. Fozzard (1996) Modal Behavior of the 1 Na Channel and Effects of Coexpression of the ß1 Subunit.Biophys. J.70: 2581-2592.
12. Cribbs, L.L., Lee, J.-H., Satin, J., Zhang, Y., Daud, A., Barclay, J., Williamson, M.P., Fox, M., Rees, M., and E. Perez-Reyes (1998) Cloning and Characterization of a1H from Human Heart, A Member of the T-type Calcium Channel Gene Family. Circ. Res. 83:103-109.
13. Zhang, Y., Hartmann, H.A., and J. Satin (1999) Glycosylation Influences Voltage-dependent Gating of Cardiac and Skeletal Muscle Sodium Channels. J. Membr. Biol. 171: 195-207.
14. Zhang, Y., Cribbs, L.L., and J. Satin (2000) Arachidonic Acid Modulation of 1H, A Cloned Human T-type Calcium Channel. Am. J. Physiol: Heart & Circ. 278: H184-H193.
15. Satin, J. and L.L. Cribbs (2000) Molecular Identification and Functional Characterization of A Splice Variant of T-type Calcium Channel in Atrial Myocytes. Circ. Res., 86: 636-642.
16. Delisle, B.P., and J. Satin (2000) pH Modification of Human T-type Calcium Gating. Biophys. J. 78: 1895-1905.
17. Cribbs, L.L., Martin, B.L., Schroder, E.A., Keller, B.B. and J. Satin (2001) Identification of the CaV3.1d Gene Product and T-type Ca Current in Developing Mouse Heart. Circ Res. 88: 403-407.
18. Delisle, B.P. andJ. Satin (2003) Calcium Channel Permeation is Regulated by Internal Monovalent Cations. J. Membr. Biol. 103: 185-192
19. Burgess, D., Crawford, O., Delisle, B.P., Cribbs, L.L. and J. Satin (2002) Mechanism of Inactivation Gating of Human Low-Voltage Activated (T-type) Calcium Channels. Biophys. J. 82: 1894-1906.
20. Finlin, B.S., Crump, S., Satin, J., and D.A. Andres (2003) Regulation of Voltage-gated Calcium Channel Activity by the Rem GTPase. P.N.A.S. 100: 14469-14474.
21. Satin, J., Kehat, I., Caspi, O., Huber, I., Arbel, G., Itzhaki, I., Magyar, J., Schroder, E.A., Perlman, I., and L. Gepstein (2004) Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes
J Physiol (Lond)559: 479-496
22. Magyar, J., Kiper, C.E., Dumaine, R., Burgess, D.E., Banyasz, T., J. Satin (2004) Divergent Action Potential Morphologies Reveal Nonequilibrium Properties of Human Cardiac Sodium Channels. Cardiovasc. Res 64: 477-487.
23. Kehat, I., Khimovich, L., Caspi, O., Gepstein, A., Shofti, R., Arbel, G., Huber, I., Satin, J., Itskovitz-Eldor, J., and L. Gepstein (2004) Electromechanical Integration of Human Embryonic Stem Cell Derived Cardiomyocytes. Nature Biotechnology. 22: 1282-1289.
24. Finlin BS, Mosley AL, Crump SM, Correll RN, Ozcan S, Satin J, Andres DA. (2005)
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.
J. Biol. Chem. 280:41864-71.
25. Crump, S.M., Correll, R.N., Lester, W., Finlin, B.S., Andres, D.A., and J. Satin. 2006. Phosphorylation Status of Calcium Channel -subunit Modulates RGK-Calcium Channel -Subunit Regulation of L-type Current. AJP: Heart & Circ., 291: H1959-71; PMID 16648185.
26. Andres DA, Crump SM, Correll RN, Satin J, Finlin BS. (2006) Analyses of Rem/RGK Signaling and Biological Activity. Methods Enzymol. 2005;407:484-98.
27. Finlin BS, Correll RN, Pang C, Crump SM, Satin J, Andres DA. (2006) Analysis of the complex between Ca2+ channel beta-subunit and the Rem GTPase.J Biol Chem. 281:23557-66.
28. Shroder EA, Wei Y, and J Satin (2006) The Developing Cardiac Myocyte: Maturation of Excitation and Excitation-Contraction Coupling. Ann. NYAS, 1080: 63-75.
29. Itzhaki I, Schiller J, Beyar R, Satin J and L Gepstein. (2006) Calcium Handling in embryonic stem cell derived cardiac myocytes. Ann. NYAS, 1080: 207-215.
30. Schroder, EA, Magyar, J, and J Satin. (2007) Calcium channel block remodels Calcium channel current (ICa,L). AJP: Heart, 292: H1906-1916
31. Correll, RN, Pang, C, Finlin BS, Dailey, AM, Satin J, and DA Andres (2007) Plasma Membrane Targeting Is Essential for Rem-mediated Calcium Channel Inhibition. J. Biol. Chem., 282(39):28431-40
32. Correll, RN, Botzet, GJ, Satin J, Andres, DA, and BS Finlin (2008) Analysis of the Rem2 – voltage dependent calcium channel b subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids. Cell Signal., 20: 400-408.
33. Correll, RN, Pang, C, Niedowicz DM, Satin J, and DA Andres (2008) Calmodulin binding is dispensable for Rem-mediated calcium channel inhibition. Mol. Cell. Biochem., 310: 103-110.
34. Lester WC, Schroder EA, Burgess DE, Yozwiak D, Andres DA, and J Satin. (2008) Coupling of Plasma Membrane Calcium Entry to Extrusion Revealed by Novel L-type Calcium Channel Block. Cell Calcium. 44:353-2 PMID: 19230140.
35. Satin J, Izhaki I,Schiller J, Izu L, Balke CW, Beyar R, and L Gepstein. (2008) Calcium Handling in Human Embryonic Stem Derived Cardiac Myocytes. Stem Cells. 26: 1961-1972.
36. Caspi O, Itzhaki I, Arbel G, Kehat I, Gepstien A, Huber I, Satin J, Gepstein L.(2008)In Vitro Electrophysiological Drug Testing using Human Embryonic Stem Cell Derived Cardiomyocytes. Stem Cells Dev. 18: 161-172. PMID: 18510453
37.Schroder EA, Byse MB, and J Satin (2009) The L-Type Calcium Channel C-terminus Auto-regulates Transcription. Circ. Res. 104(12): 1373-1381. PMID: 19461046
***Paper selected for Faculty of 1000***
38. Satin, J, and EA Schroder. 2009. Autoregulation of cardiac l-type calcium channels. Trends Cardiovasc Med Nov;19(8):268-71. PMID: 20447569
39. Pang C, Correll RN, Finlin BS, Satin J, and DA Andres (2010) Rem GTPase Interacts with the Proximal Cav1.2 C-terminus and Modulates Calcium-dependent Channel Inactivation. Channels 4:192-202. PMID: 20458179
40. Satin J, Schroder EA, Crump SM. (2011) L-type calcium channel auto-regulation of transcription. Cell Calcium. 2011 Feb 2. 49:306-313. PMID:21295347