Stephan C. Jahn, Ph.D.Curriculum Vitae

Home Address: 1627 NE 40th PL

Gainesville, FL 32609

Cell Phone: (352) 246-0292

Email:

Professional Website: stephan.jahnphd.com

EDUCATION

Doctorate of Philosophy inMedical Sciences 2013

Physiology and Pharmacology Concentration

Dissertation: Overactive Cdk2 in the Progression and Treatment of Cancer

University of Florida College of Medicine, Gainesville, FL

Certificate in Teaching with Technology 2012

University of Florida Graduate School, Gainesville, FL

Certificate in Pedagogy 2011

University of Florida Graduate School, Gainesville, FL

Certificate in European Studies 2008

Lille Catholic University, Lille, France

Bachelor of Science in Biochemistry 2008

Summa Cum Laude, Honors Program

Thesis: Completing the Cycle: Formation of Cloud Point Depressants from Glycerin Obtained in the Production of Biodiesel

Saginaw Valley State University, University Center, MI

RESEARCH POSITIONS

Research Associate2017 – Present

Department of Medicinal Chemistry

College of Pharmacy

University of Florida, Gainesville, FL

Supervisor: Dr. Margaret O. James

Studied the role of miRNAs in the regulation of glutathione transferase Z1 (GSTZ1) in human development

Postdoctoral Associate 2016 – 2017

Department of Pathology

College of Medicine

University of Florida, Gainesville, FL

Mentor: Dr. Petr Starostik, Director of Molecular Pathology

Used next-generation sequencing to identify mutational signatures in lymphoma
Utilized CRISPR gene editing to discover mechanisms behind differing patient outcomes based on FLT3 and NPM1 mutational status

Postdoctoral Associate 2013 – 2016

Department of Medicinal Chemistry

College of Pharmacy

University of Florida, Gainesville, FL

Mentor: Dr. Margaret O. James, Department Chair

Researched the drug resistance provided by the metabolism of dichloroacetate by glutathione transferase Z1 (GSTZ1) in tumors
Developed assay to measure chloride concentrations in normal and tumor tissues
Characterized dichloroactetate metabolism by GSTZ1 in secondary, extra-hepatic sites of rats

Graduate Research Assistant 2008 – 2013

Department of Pharmacology and Therapeutics

University of Florida, Gainesville, FL

Mentor: Dr. Brian K. Law

Examined the role of Cdk2 in the chromosomal instability of cancer using various biochemical, cell biology, and molecular biological techniques
Identified novel drug candidates for multiple signaling pathways through computer-aided drug design

Laboratory Technician and Formulation Specialist2006 – 2008 2008

The Dow Chemical Company

Midland, MI, USA

Developed personal care emulsions to match customer needs
Expanded and maintained rigorous product analytics and quality control program

TEACHING POSITIONS

Adjunct Assistant Professor 2014 – Present

Sciences for Health Programs Department

Santa Fe College, Gainesville, FL

Created and taught lecture and laboratory sections to a diverse group of students
Developed common departmental curricula as part of a team of instructors

TEACHING EXPERIENCE

Course Instructor

Elements of Chemistry 1Fall 2014– Present

Santa Fe College, Gainesville, FL

Integrated health science topics and experiences with general chemistry principles
Utilized technological teaching methods in the classroom and online to more effectively deliver information and to stimulate student interest

Center for Precollegiate Education and TrainingSummers 2010 – 2015, 2017

Student Science Training Program

University of Florida, Gainesville, FL

Created a summer course on Cancer Biology and Therapeutics
Designed activities and lectures to teach and assess students

Lecturer and Lesson Development

Principles of Drug Action Spring 2011 / 2015 / 2016 / 2017

Interdisciplinary Graduate Program in Biomedical Science

University of Florida College of Medicine, Gainesville, FL

Delivered lectures on dose response and occupancy theory

Advanced Signal TransductionFall 2013 – 2016

Interdisciplinary Graduate Program in Biomedical Science

University of Florida College of Medicine, Gainesville, FL

Presented a lecture highlighting the history, mechanics, and function of TGF-β signaling followed by student examination

Career and Life Span Planning 2015

University of Florida College of Education, Gainesville, FL

Gave a brief talk about retirement basics

Fundamentals of Biomedical Science Fall 2012

Interdisciplinary Graduate Program in Biomedical Science

University of Florida College of Medicine, Gainesville, FL

Developed and implemented a Computer-Based Learning series in structure-based drug design

Teaching Assistant

Undergraduate Science for Life Seminar Fall 2012

University of Florida Honors Program, Gainesville, FL

Maintained attendance record for large class
Evaluated student achievement through writing assignments

Discussion Leader

Fundamentals of Biomedical Science 2011 / 2012

Interdisciplinary Graduate Program in Biomedical Science

University of Florida College of Medicine, Gainesville, FL

Facilitated student conversation regarding select research articles

Personal Tutor2006 / 2013

Tailored lessons to individual students’ needs
Experience in high school and college-level general chemistry

EDITORIAL EXPERIENCE

Advisory Board Member2017 - Present

Editor In Chief2014 – 2017

Journal of Postdoctoral Research

Reviewer

BMC Cell Biology (1 Manuscript)2016

Molecular Biotechnology (1 Manuscript)2015

Contributing Editor2013 – 2014

Journal of Postdoctoral Research

HONORS

First Place, College of Pharmacy Postdoc Poster Competition2014 & 2015

University of Florida College of Pharmacy, Gainesville, FL

College-wide research poster competition

Participant, Postdoctoral Preparation Institute: Career Transitions2014

Federation of American Societies for Experimental Biology and the NIH, Bethesda, MD

Two-day career development workshop given by NIH leaders

Finalist, University of Florida Postdoc Symposium Oral Competition2014

University of Florida, Gainesville, FL

University-wide oral research presentation competition

First Place, University of Florida Medical Guild Research Competition2013

University of Florida College of Medicine, Gainesville, FL

College-wide graduate student competition of oral research presentations

First Place, Physiology and Pharmacology Concentration Research Competition2013

University of Florida College of Medicine, Gainesville, FL

Intra-division graduate student competition of oral research presentations

Alumni Graduate Fellowship 2008 – 2012

University of Florida College of Medicine, Gainesville, FL

Competitive fellowship awarded to a small number of incoming Ph.D. students

Analytical Chemistry Student of the Year 2007

Department of Chemistry, Saginaw Valley State University, University Center, MI

Organic Chemistry Student of the Year 2006

Department of Chemistry, Saginaw Valley State University, University Center, MI

UNIVERSITY SERVICE

Life Coach2014 – 2015

Machen Florida Opportunity Scholars Program

University of Florida, Gainesville, FL

Adjudicator

Florida Junior Science, Engineering, and Humanities Symposium2015– 2016

University of Florida, Gainesville, FL

Graduate Student Research Day2013 – 2017

University of Florida, Gainesville, FL

Presentation Facilitator2014 / 2017

Florida Junior Science, Engineering, and Humanities Symposium

University of Florida, Gainesville, FL

Peer Review Panel2011

University of Florida Medical Guild Research Incentive Award

University of Florida, Gainesville, FL

PROFESSIONAL MEMBERSHIPS

Association of Florida Colleges2014 – Present

Florida Society of Clinical Oncology2013 – Present

American Association for Cancer Research 2010 – 2017

National Postdoctoral Association 2014 – 2017

American Association for the Advancement of Science2009 – 2010

American Chemical Society 2005 – 2008

RESEARCH PUBLICATIONS AND REVIEWS

James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW. Therapeutic Applications of Dichloroacetate and the Role of Glutathione Transferase Zeta-1. Pharmacol Ther 170:166-80 (2017)

Jahn SC, Solaymen MH, Lorenzo JL‡, Langaee T, Stacpoole PW, James MO. GSTZ1 Expression and Chloride Concentrations Modulate Sensitivity of Cancer Cells to Dichloroacetate. Biochim Biophys Acta 1860(6):1202-10 (2016) [‡ denotes undergraduate]

Jahn SC, Biel MB, Sudhan DR, Wiggins JM, Hughes VS. A Summer Course in Cancer for High School Students – Lessons Taught and Lessons Learned. J Postdoctoral Res 3(11):15-23 (2015)

Jahn SC, Rowland-Faux L, Stacpoole PW, James MO. Chloride Concentrations in Human Hepatic Cytosol and Mitochondria Are a Function of Age. Biochem Biophys Res Commun 459(3):463-8 (2015)

Ferreira RB, Law ME, Jahn SC, Davis BJ, Heldermon CD, Reinhard MK, Castellano RK, Law BK. Novel Agents that Downregulate EGFR, HER2, and HER3 in Parallel. Oncotarget 6(12):10445-59(2015)

Jahn SC, Law ME, Corsino PE, Davis BJ, Harrison JK, Law BK. Signaling Mechanisms that Suppress the Cytostatic Actions of Rapamycin. PLOS ONE 9(6):e99927 (2014)

Jahn SC. Vetting the Internet’s Favorite Cancer Cures. J Postdoctoral Res. 2(5):24-36 (2014) [Review Article]

Jahn SC, Law ME, Corsino PE, Rowe TC, Davis BJ, Law BK. Assembly, Activation, and Substrate Specificity of Cyclin D1/Cdk2 Complexes. Biochemistry 52(20):3489-501 (2013)

Yang H, Pinello CE, Luo J, Li D, Wang Y, Zhao LY, Jahn SC, Saldanha SA, Planck J, Geary KR, Ma H, Law BK, Roush WR, Hodder P, Liao D. Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening are Potent Anticancer Agents. Mol. Cancer Ther. 12(5):610-20 (2013)

Jahn SC, Corsino PE, Davis BJ, Law ME, Norgaard P, Law BK. Constitutive Cdk2 Activation Promotes Aneuploidy While Altering the Spindle Assembly and Tetraploidy Checkpoints. J Cell Sci.126(Pt 5):1207-17 (2013)

Jahn SC*, Law ME*, Corsino PE, Parker NN, Pham K, Davis BJ, Lu J, Law BK. An In Vivo Model of Epithelial to Mesenchymal Transition Reveals a Mitogenic Switch. Cancer Letters. 326(2):183-90 (2012) [* denotes co-first authors]

Law M, Corsino P, Jahn S, Davis B, Chen S, Patel B, Pham K, Lu J, Sheppard B, Norgaard P, Hong J, Higgins P, Kim J, Luesch H, Law B. Glucocorticoids and Histone Deacetylase Inhibitors Cooperate to Block the Invasiveness of Basal-like Breast Cancer Cells through Novel Mechanisms. Oncogene 32(10):1316-29 (2012)

Jahn S, Law M, Corsino P, Law B. TGF-beta Antiproliferative Effects in Tumor Suppression. Front Biosci. 4:749-66 (2012) [Review Article]

Jayandharan G, Aslanidi G, Martino A, Jahn S, Perrin G, Herzog R, Srivastava A. Activation of the NF-{kappa}B Pathway by Adeno-Associated Virus (AAV) Vectors and its Implications in Immune Response and Gene Therapy. PNAS 108(9):3743-8 (2010)

Book Chapters

Jahn SC, Starostik P. Clinical Lung Cancer Mutation Detection. A Global Scientific Vision - Prevention, Diagnosis, and Treatment of Lung Cancer, In Tech Publishing (2017)

Jahn S. Spindle Assembly Checkpoint. Encyclopedia of Cancer, 4th edition, Springer Publishing (2012)

Jahn S, Law B. CDCP1. Encyclopedia of Cancer, 4th edition, Springer Publishing (2012)

PEER-REVIEWED EDITORIALS

Lorenzo RJ‡, Jahn SC. Palbociclib – A Novel Therapy for Hormone-Receptor-Positive Breast Cancer. J Postdoctoral Res 3(8):66-68 (2015) [‡ denotes undergraduate]

Lorenzo RJ‡, Jahn SC. Dicloroacetate – Phase 1 Trial in Adults with Malignant Brain Tumors. J Postdoctoral Res 3(2):33-4 (2015) [‡ denotes undergraduate]

Jahn SC. Assessing the Negativity around Negative Results. J Postdoctoral Res 2(11):56-7 (2014)

Jahn SC. Supporting the NIH: The Original Crowdfunding of Medical Research. J Postdoctoral Res. 2(6):33-5 (2014)

Jahn SC. Let There Be Light Activated Drug Release. J Postdoctoral Res. 2(3):38-40 (2014)

Jahn SC. Tumor Cells Are the Dip on This Chip. J Postdoctoral Res. 2(1):59-60 (2014)

Jahn SC. Antidepressants Give Cancer Cells the Blues. J Postdoctoral Res. 1(12):43-5 (2013)

INVITED SPEAKER

Graduate School: A General Discussion 2014
and a Look at the Biomedical Research Field

University of North Florida, ACS Chemistry Club, Jacksonville, FL

The Basics of Cancer Biology and Therapy2013

Lutherans in Fellowship Together, University Lutheran Church, Gainesville, FL

PLATFORM TALKS GIVEN

The Roles of Chloride and GSTZ1 in the Metabolism of Dichloroacetate2014

Experimental Biology Conference, San Diego, CA

POSTERS PRESENTED AT MEETINGS

Jahn SC, Smonskey M, Starostik P, FLT3 ITD Mutations Downregulate MLLT3 in Acute Myeloid Leukemia, University of Florida Postdoc Research Symposium, Gainesville, FL 2017

Jahn SC, Smonskey M, Starostik P, FLT3 ITD Mutations Downregulate MLLT3 in Acute Myeloid Leukemia, University of Florida College of Medicine Celebration of Research, Gainesville, FL 2017

Kim JT, Jahn SC, Newsome K, Wang H, Chamala S, Starostik P, NGS-Based Evaluation of Enteropathy-Associated T-Cell Lymphoma Mutation Profile, University of Florida College of Medicine Celebration of Research, Gainesville, FL 2017

Jahn SC, Solaymen MH, Gay LA, Lorenzo JL‡, Langaee T, Stacpoole PW, James MO, GSTZ1 Expression is Variable in Breast & Liver Cancer & Modulates the Potency of Dichloroacetate, University of Florida College of Pharmacy Annual Research Showcase, Gainesville, FL 2016
[‡ denotes undergraduate]

Jahn SC, Solaymen MH, Lorenzo JL‡, Langaee T, Stacpoole PW, James MO, Chemoresistance Through the Intratumoral Metabolism of Dichloroacetate, AACR Metabolism in Cancer Conference, Bellevue,WA 2015
[‡ denotes undergraduate]

Smeltz M, Zhong G, Jahn S, Rowland-Faux L, Hu Z, Stacpoole P, James M. Glutathione Transferase Z1 (GSTZ1) Inactivation by Dichloroacetate Differs in Rat Liver Cytosol and Mitochondria, Experimental Biology Conference, Boston, MA 2015

Lorenzo JL‡, Jahn SC, Solaymen MH, Langaee T, Stacpoole PW, James MO, Dichloroacetate metabolism varies between tumor types, University of Florida Undergraduate Research symposium, Gainesville, FL 2015
[‡ denotes undergraduate]

Jahn SC, Solaymen MH, Lorenzo JL‡, Langaee T, Stacpoole PW, James MO, Chemoresistance Through the Intratumoral Metabolism of Dichloroacetate, University of Florida College of Pharmacy Annual Research Showcase, Gainesville, FL 2015
[‡ denotes undergraduate]

Zhong G, Smeltz MG, Jahn SC, Langaee T, Stacpoole PW, James MO. Age-Related Changes in Expression and Activity of Human Mitochondrial Glutathione Transferase Zeta1,University of Florida College of Pharmacy Annual Research Showcase, Gainesville, FL 2015

Zhong G, Smeltz MG, Jahn SC, Langaee T, Stacpoole PW, James MO. Age-Related Changes in Expression and Activity of Human Mitochondrial Glutathione Transferase Zeta1, International Society for the Study of Xenobiotics meeting, San Francisco, CA 2014

Jahn SC, Zhong G, Smeltz M, Rowland-Faux L, Stacpoole P*, James M. The Roles of Chloride and GSTZ1 in the Metabolism of Dichloroacetate. Mitochondrial Medicine, Pittsburgh, PA 2014 [* denotes presenting author]

Virstyuk S, Lu Z, Habibi S, Cho SH, Leong R, Jahn S, Xing H, Soti F, Kem W. Benzylidene-Anabaseine Binding within the Torpedo Muscle Nicotinic Receptor Ion Channel. University of Colorado Denver Silvio O. Conte Center Annual Meeting, Aurora, CO 2014

Jahn SC, Zhong G, Smeltz M, Rowland-Faux L, Stacpoole P, James M. The Roles of Chloride and GSTZ1 in the Metabolism of Dichloroacetate. Experimental Biology Conference, San Diego, CA 2014

Jahn SC, Zhong G, Smeltz M, Rowland-Faux , Stacpoole P, James M. The Roles of Chloride and GSTZ1 in the Metabolism of Dichloroacetate. UF Health Cancer Center Research Poster Day, Gainesville, FL 2014

Yang H, Pinello C, Luo J, Li D, Wang Y, Zhao LY, Jahn SC, Saldanha SA, Chase P, Planck J, Geary KR, Ma H, Law BK, Roush WR, Hodder P, Liao D. Identification and Anticancer Activity of a Novel Class of KAT Inhibitors. UF Health Cancer Center Research Poster Day, Gainesville, FL 2014

Jahn SC, Zhong G, Smeltz M, Rowland-Faux L, Stacpoole P, James M. The Roles of Chloride and GSTZ1 in the Metabolism of Dichloroacetate. University of Florida College of Pharmacy Annual Research Showcase, Gainesville, FL 2014

Jahn S, Corsino P, Law M, Davis B, Law B. Overactive Cdk2 Permits Polyploidy by Overwhelming the Tetraploidy Checkpoint. AACR National Meeting, Washington, D.C. 2013

Jahn S, Corsino P, Law M, Davis B, Law B. Overactive Cdk2 Permits Polyploidy by Overwhelming the Tetraploidy Checkpoint. UF&Shands Cancer Center Research Poster Day, Gainesville, FL 2013

Yang H, Pinello C, Luo J, Zhao L, Saldanha A, Jahn S, Law B, Roush W, Hodder P, Liao D. Targeting p300 for Inhibiting Triple Negative Breast Cancer. University of Florida College of Medicine Celebration of Research, Gainesville, FL 2013

Jahn S, Corsino P, Law M, Davis B, Law B. Constitutive Cdk2 Activation Results in Endoreduplication, Failed Cytokinesis, and Chromosomal Instability. UF&Shands Cancer Center Research Poster Day, Gainesville, FL 2012

Yang H, Pinello C, Luo J, Zhao L, Saldanha A, Jahn S, Law B, Roush W, Hodder P, Liao D. Targeting p300 for Inhibiting Triple Negative Breast Cancer. UF&Shands Cancer Center Research Poster Day, Gainesville, FL 2012

Jahn S, Corsino P, Law M, Davis B, Law B. Cdk2, Mad2, and the Tetraploidy Checkpoint in Paclitaxel Induced Endoreduplication. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, San Francisco, CA 2011

Jahn S, Corsino P, Law M, Davis B, Law B. Constitutive Cdk2 Activation Results in Endoreduplication, Failed Cytokinesis, and Chromosomal Instability. AACR National Meeting, Orlando, FL 2011

Law B, Corsino P, Law M, Jahn S, Davis B. Regulation of E2F-Dependent Transcription by the mTORC1 Pathway. AACR National Meeting, Orlando, FL 2011

Corsino P, Law M, Jahn S, Davis B, Law, B. The Epithelial to Mesenchymal Transition is Associated with Alterations in the Mitogenic Signaling Pathways that Drive Cancer Cell Proliferation. AACR National Meeting, Orlando 2011

Law B, Corsino P, Law M, Davis B, Parker N, Jahn S. A Novel Class of Structure-Based Cyclin-Dependent Kinase Inhibitors. AACR National Meeting, Washington D.C. 2010

Jahn S, Fojtik M, Karpovich D. Evaluating a Biodiesel Cloud Point Reduction Additive Synthesized from Waste Glycerin. ACS National Meeting, New Orleans, LA 2008

PATENTS

Novel Small Molecule Anticancer Agents2017, Pending

Application number: 15/519,433

COMPLETED RESEARCH FUNDING

Misregulation of glutathione transferase Z1 in 2015

liver and breast cancers, $1,000

Clinical and Translational Science Institute Service Voucher

University of Florida, Gainesville, FL

The control of GSTZ1 expression through DNA methylation, $1,0002014

Clinical and Translational Science Institute Service Voucher

University of Florida, Gainesville, FL

Inducing HSET aggregation with small molecules identified2010
through in-silico docking, $700

University of Florida Medical Guild Research Incentive Award

University of Florida, Gainesville, FL

TRAVEL FUNDING

Federation of American Societies for Experimental Biology, $1,2502014

Office of Research, University of Florida, $4002013

Graduate Student Council, University of Florida, $2502013

Department of Pharmacology and Therapeutics, University of Florida; $2002013

Interdisciplinary Program in Biomedical Science, University of Florida; $1,000 2013

Department of Pharmacology and Therapeutics, University of Florida; $2002011

Interdisciplinary Program in Biomedical Science, University of Florida; $1,000 2011