Agenda Item VIII
OVERVIEW OF RECERTIFICATION FOR MUSC
RESEARCH UNIVERSITY INFRASTRUCTURE PROJECT
This document is a part of the on-going development of the Research Infrastructure Project as defined in Section 11-51-30 (4) of the South Carolina Code, to be developed primarily on the Medical University of South Carolina campus. The background for the Charleston Translational Research Initiative has been presented to the SC Centers of Economic Excellence Review Board on two occasions. It was first presented on May 11, 2005, at which time MUSC was recommended for matching funds of $36,071,822. The Board at that meeting enthusiastically endorsed the overall concept of the Charleston Translational research Initiative.
Following that, a second presentation was done to the COEE Board on September 15, 2005. This presentation further defined the Initiative and presented additional documentation on the buildings themselves and scope of these projects.
The current document addresses some of the changes to the Initiative that have come as a result of several factors. First and foremost, building costs have skyrocketed such that original project cost estimates are no longer tenable. These costs increased so much that the third phase of the project, the Patient Oriented Research Tower (PORT), has been deferred as a RUIA-funded project. MUSC is still engaged in developing the PORT and is working with Federal, State, and City officials to find alternate funding to bring about this element of the Initiative.
Another significant change was the site of the Drug Discovery Building. City of Charleston height and scale restrictions, as well as logistical problems with the original Sabin Street site, forced MUSC to consider an alternate site. A parcel of land adjacent to the proposed Bioengineering building site in MUSC's G Parking Lot was selected as the new site for the Drug Discovery Building. This turned out to be a positive move as it allowed for the buildings to share engineering and mechanical space, loading docks, lab animal space, and additional “utilities” for the buildings.
Both the Drug Discovery and Bioengineering buildings will maintain their same approximate size (~110,000 sq.ft.), scope, and scientific themes as presented previously. The Drug Discovery Building will house programs for three of our Center of Excellence Endowed Chairs: Drs. Kenneth Tew, John J. Lemasters, and Charles D. Smith. The Bioengineering building will house interdisciplinary research from all three senior research universities. Center of Economic Excellence chair in Regenerative Medicine, Richard Swaja, will be housed in this facility and will continue to lead the successful Clemson-MUSC Bioengineering program within this space. A University of South Carolina CoEE endowed chair candidate, who is under recruitment and has an offer letter in hand, is being offered space in this building as well.
The information that follows outlines the revised program costs associated with the Charleston Translational Research Initiative. Also summarized are the matching components that are part of MUSC’s request for recertification of its Research University Infrastructure Act funds.
SUMMARY OF BUILDING AND PROGRAM EXPENSES
Charleston Phase
Drug Discovery Program
· Construction $40,888,400
· Site Prep $2,112,000
· MRE Upgrades $2,079,000
· 10% Contingency $4,550,000
· Professional Services $5,400,000
· Plaza/Landscape $2,800,000
· Equipment $7,550,000
· After construction costs $1,225,000
o Furnishings
o Signage
o Security
o Audio/Visual
· 3rd and 4th Floor Basic Science Building renovation $7,700,000
· Pharmacology -3rd and 4th floor Clinical Science Building $250,000
Hot Water upgrade
· Animal Imaging MRI facility/7T Installation $300,000
· Hollings Marine Lab
o Equipment (purchased 2003-2007) $2,477,527
o Construction (2003-2007) $5,000,000
o Facility Operations support $250,000
o Other Facility support $330,000
· GCRC Clean Room Renovation $210,000
TOTAL $ 83,121,927
Bioengineering Program
· Construction $53,600,000
· Site $11,800,000
· 10% Contingency $5,400,000
· Professional Services $6,400,000
· Equipment $8,800,000
· After Construction Cost (noted above) $1,500,000
· Plaza/Landscape $3,300,000
TOTAL$79,000,000
Charleston Translational Research Initiative $162,121,927
Greenville Phase[1]
Translational Research program - REII Building
· Interior build-out/Furniture/Fixtures $2,519,000
TOTAL $2,519,000
TOTAL TRANSLATIONAL RESEARCH COST $164,640,927
Summary of matching funds – Previously described
1. NMR instrumentation/construction grant $4,201,479 awarded**
(NIST 60NANB0D0073) National Institute of Standards and Technology 08/23/2003
Description- This competitive federal infrastructure grant to the Hollings Cancer Center funded
research-related renovations and the purchase of scientific equipment for the cancer drug discovery
program. This program will be housed in the Drug Discovery Building. The state of the art
instrumentation will benefit the project directly.
2. NMR instrumentation/construction grant $1,000,000 awarded**
(NIST 60NANB0D0073) National Institute of Standards and Technology 08/23/2003
Description- This competitive federal infrastructure grant to the Hollings Cancer Center funded
research-related renovations and the purchase of scientific equipment for the cancer drug discovery
program. This program will be housed in the Drug Discovery Building. The state of the art
instrumentation will benefit the project directly.
3. NMR instrumentation grant $500,000 awarded
(3 P20 RR017677-02S1) NIH National Center for Research Resources 09/08/2003
Description- This competitive federal infrastructure grant funded the research-related purchase of
scientific equipment (NMR spectroscopy) for the drug discovery and structural biology programs.
These programs will be housed in the Drug Discovery Building. The state of the art instrumentation
will benefit the project directly.
4. Animal imaging instruments $2,952,479*[(] awarded
(HRSA 1-C76HF03130-01-00) Health Resources and Services Administration 12/23/2004
Description- This competitive federal infrastructure grant funded animal research laboratory
construction and equipment in Hollings Cancer Center supporting the cancer drug discovery
program. This program will be housed in the Drug Discovery Building. The state of the art
instrumentation will benefit the project directly.
5. NMR instrumentation grant (accessories) $485,000 awarded
(DE-FG02-02ER63385) Department of Energy 02/03/2005
Description- This competitive federal infrastructure grant funded the research-related purchase of
scientific equipment (accessories for NMR spectroscopy) for the drug discovery and structural biology programs. These programs will be housed in the Drug Discovery Building. The state of the art
instrumentation will benefit the project directly.
6. NMR/structural biology instrumentation $800,000 awarded
(NSF EPS-0132573) National Science Foundation 06/01/2005
Description- This competitive federal infrastructure grant funded the research-related purchase of
scientific equipment (NMR spectroscopy) for the drug discovery and structural biology programs.
These programs will be housed in the Drug Discovery Building. The state of the art instrumentation
will benefit the project directly.
7. Federal road work enhancement appropriation $3,200,000 awarded
The Safe, Accountable, Flexible, Efficient Transportation Equity Act 08/10/2005
(SAFETEA-LU), enacted August 10, 2005. H.R.3-152, item 995
This federal infrastructure appropriation will provide funds to improve MUSC campus access,
which will make feasible construction, occupancy and operation of the Drug Discovery and
Bioengineering Buildings in the MUSC G-lot. The improved access for commuters and employees to
our core campus will benefit the project directly.
8. Federal road work appropriation, MUSC- Charleston match $3,240,000 matched
Required match associated with SAFETEA-LU award noted above
Description - This is the local infrastructure match for #7 (SAFETEA-LU), funded by local sales tax
increase.
9. Construction grant – Bioengineering and Cancer $9,820,650 awarded
(HRSA 1 C76HF06131-01-00) Health Resources and Services Administration 09/01/2005
Description- This competitive federal infrastructure grant will provide funds for the construction
of the Bioengineering Building. These construction funds will benefit the project directly.
10. Federal parking appropriation $3,887,113 awarded
(Federal Register 70/ No. 175/ Monday, September 12,2005/ 53880) 09/12/2005
Department of Transportation/Federal Transit Authority
Description- This federal infrastructure appropriation will provide funds to improve MUSC campus
parking, which will be necessary to replace XXX parking spaces lost in order to site the Drug
Discovery and Bioengineering Buildings in the MUSC G-lot. This will make feasible the construction,
occupancy and operation of the Drug Discovery and Bioengineering Buildings in the MUSC G-lot.
The parking improvements will directly benefit the project.
11. Federal parking intermodal facility appropriation $3,883,494 awarded
(Federal Register 70/ No. 175/ Monday, September 12,2005/ 53880) 09/12/2005
Department of Transportation/Federal Transit Authority
Description- This federal infrastructure appropriation will provide funds to improve MUSC campus
access, which will be necessary to deal with the loss of XXX parking spaces lost in order to site the
Drug Discovery and Bioengineering Buildings in the MUSC G-lot. This will make feasible the
construction, occupancy and operation of the Drug Discovery and Bioengineering Buildings in the
MUSC G-lot, directly benefiting the project.
12. MRI equipment grant $1,500,000 awarded (NSF EPS-0447660) National Institute of Standards and Technology
(NSF EPS-0447660- MUSC component) National Science Foundation 09/14/2005
Description- This competitive federal infrastructure grant was funded to establish a statewide animal
imaging resource through the purchase of a 7 Tesla MRI instrument. The animal imaging program
will be housed in the Drug Discovery Building, benefiting the project directly. The state of the art
instrumentation will benefit the project directly.
13. College of Pharmacy construction gifts $250,000 awarded
Philanthropy- one donor 09/14/2005
Description- This gift is from CVS, for construction of facilities related to drug discovery and
Development, specifically for the CVS Pharmacy practice Laboratory, which will be housed on the
first floor of the Drug Discovery Building. These construction funds will benefit the project directly.
14. Drug Discovery Building construction grant $19,732,864 awarded (NIST 60NANB5D1246) National Institute of Standards and Technology 10/01/2005
Description- This competitive federal infrastructure grant will provide funds for the construction
of the Drug Discovery Drug Discovery Building. These construction funds will benefit the project
directly.
______
Total previous match, items 1-14: $55,453,079
Summary of matching funds – New Matches in Hand
15. Animal Support Facilities and Development Grant $2,000,000 awarded
(C06 RR015455-01A1) NIH National Center for Research Resources 02/01/2002[**]
Description- This competitive federal infrastructure grant to MUSC funded research-related
renovations to develop new animal care facilities that will support drug discovery, bioengineering
and cancer genomics programs to be housed in the drug Discovery and Bioengineering
Buildings. These funds allow for more laboratory space and smaller animal facilities in both
of those buildings, and thus directly benefit the project.
16. NIH/NCRR Biosafety Lab Level 3 $631,352 awarded
(1 G20 RR019721-0) NIH National Center for Research Resources 06/01/2004
Description- This competitive federal infrastructure grant to MUSC funded research-related
renovations to develop a bio-containment level 3 facility that will enable our drug discovery
program to develop new treatments for infectious diseases, directly benefiting the project.
17. Oral Health Research Infrastructure Development Grant $2,883,206 awarded
(NIDCR-U24 DE016508) NIH National Institute of Dental and Craniofacial Research 09/27/2004
Description- This competitive federal infrastructure grant provided funds for the enhancement
of bioengineering, materials science, regenerative medicine and other related programs in
the MUSC College of Dental Medicine, which will be housed in the Bioengineering Building.
These infrastructure funds provide a direct benefit to the project.
18. NSF EPSCOR Equipment and Infrastructure grant $2,302,966 awarded (NSF EPS-0447660) National Institute of Standards and Technology
(NSF EPS-0447660- USC component) National Science Foundation 06/06/2005
Description- This competitive federal equipment and infrastructure grant was funded to
enhance the bioengineering program at USC, in collaboration with MUSC and Clemson.
These funds directly benefit the project in that this program, including USC faculty
members, students and fellows will be housed in the Bioengineering Building.
19. NSF EPSCOR Equipment and Infrastructure grant $1,774,000 awarded (NSF EPS-0447660) National Institute of Standards and Technology
(NSF EPS-0447660- Clemson component) National Science Foundation 06/06/2005
Description- This competitive federal equipment and infrastructure grant was funded to
enhance the bioengineering program at Clemson, in collaboration with MUSC and USC.
These funds directly benefit the project in that this program, including USC faculty
members, students and fellows will be housed in the Bioengineering Building.
20. Shared Instrumentation Grant $140,205 awarded
(1 S10 RR021096-01A1) NIH National Institute of Dental and Craniofacial Research 04/01/2006
Description- This competitive federal infrastructure grant provided funds for the purchase of State of the art instrumentation that will be enhance the drug discovery and bioengineering programs. The gene scanner and accessories for analysis of gene expression through the use of DNA
microarray technology will benefit the project directly.
21. Animal Support facilities and Development Grant $529,000 awarded
(G20 RR021351) NIH National Center for Research Resources 06/01/2006
Description- This competitive federal infrastructure grant to MUSC funded research-related
renovations and equipment to develop new animal care facilities that will support drug discovery,
bioengineering and cancer genomics programs to be housed in the drug Discovery and
Bioengineering Buildings. These funds allow for more laboratory space and smaller animal facilities in both of those buildings, and thus directly benefit the project.
22. Construction grant - Center for Bioengineering $7,897,824 awarded
and Cancer Genomics 08/22/2006
(NIST 60NANB6D6150) National Institute of Standards and Technology
Description- This competitive federal infrastructure grant will provide funds for the construction
of the Bioengineering Building. These construction funds will benefit the project directly.
23. Department of Pharmacology, MUSC $3,700,000 in process
(Renovations of Drug Discovery laboratory space in the Basic Science Building) under construction
Description- These renovations were proposed in our original proposal to be funded by a competitive
federal C06 infrastructure construction grant, for which an outstanding score was received. Congress
de-funded the C06 program of the National Center for Research Resources of the NIH, so we
pursued alternative sources of funding for these critical renovations of Department of Pharmacology
drug discovery program space. Fortunately the University Medical Associates has funded this project
from non-state revenues generated by the physician practice. These renovations directly benefit the
project as was described in our original presentation.
24. Stem Cell/Regenerative Medicine Core Facility $187,792[***] awarded
(P20 RR016461) NIH National Institute of Dental and Craniofacial Research 09/30/2005
Description- This competitive federal infrastructure grant provided funds for equipment to develop a statewide bioengineering core facility. This award directly benefits the project in that this program will be housed in the Bioengineering Building.