PRUDHVI K MUMMANENI

720 C Blake St 214-435-4125

Indianapolis, IN-46202

  • Bioinformatics programming / analysis and IT infrastructure management for high performance computational biology efforts.
  • Understanding scientific user needs, translating them into technical requirements, implementing efficient IT/application/data management solutions.
  • Statistical analysis of next generation sequencing data (RNA, miRNA, ChIP-seq) and microarray data.
  • Provide full IT support (scientific programming, databases, and technical) to PIs at IU Center for Systems Biology and Personalized Medicine.
  • Two years of research experience in bioinformatics.
  • Skilled analytical problem-solver with the ability to quickly learn new technologies.
  • Polished communication, presentation, training, and client relations skills.

OBJECTIVE

Seeking a challenging full-time position in the field of Bioinformatics

ACADEMIC DETAILS

Master of Science, Bioinformatics Expected Nov 2010 Indiana School of Informatics, Indianapolis, IN GPA: (3.8/4.0), Dean’s List

Thesis Advisor - Prof.Jake Chen

Bachelor of Science, BiotechnologyMay 2008

Sathyabama University, Chennai, India GPA – (3.6/4.0)

TECHNICAL SKILLS

  • Languages/Scripts: Perl, BioPerl, Java, HTML, C++, SAS, R, PHP, VBA. Database Applications: SQL, PL/SQL, Access, Database Design and Architecture, Oracle/SQL.
  • Platforms: UNIX, Win XP/2000/Vista, Macintosh, Oracle 10G/11.
  • Tools: MATLAB, Blast, Clustal W, Minitab, SPSS, Spdbv, Spotfire, BioMAP, Genome Browser, Ensembl, Consed.
  • Networking tools: Pathway studio, Cytoscape, MetaCore.

RESEARCH EXPERIENCE

Bioinformatics Analyst– (IUPUI, IN, 2009-2010):

  • Designed and analyzed gene expression and genotyping using microarray data.
  • Designed and developed data mining algorithms to process, analyze and interpret high volumes of data in predicting the toxicology profiles of drugs based on functional activities of ADME data using PERL, MATLAB, and JAVA.
  • Worked with various teams as an expert to support programs from different therapeutic areas.
  • Assisted in QA/QC and maintaining the disease specific connectivity maps database using Oracle/SQL.
  • Currently working on designing, implementation and administration of IT infrastructure and data management for Next Generation Sequencing data from Illumina platform.

Application Usability Programmer – (IUPUI, IN, 2008-2009):

  • Developed and coded web based applications and application interface.
  • Provided informatics support to integrate data from biological databases using PERL, SQL.
  • Worked with various teams in developing database, data search, and retrieval applications using SQL, PHP, and HTML.
  • Provided expertise to analyze multidimensional data generated by genomic technologies, included microarrays and SNPs.

ACADEMIC COURSE PROJECTS

  • Connectivity maps - (IUPUI, IN, 2009): Worked on a project supervised by Prof.Jake Chen and developed a novel computational framework to build biologically significant C-Maps for disease-specific studies which will serve as a brand new platform for multi-dimensional disease theradiagnostic research.Used ADME associated proteins in order to explain the disease consistency and the pharmacokinetic parameters for disease specific drugs.
  • Understanding P53_HUMAN interaction network – (IUPUI, IN, 2009):Designed a new algorithm using the concepts of MCODE and GN and applied to P53_HUMAN interaction network. The algorithm finds the interacting sites between the proteins in a network using the concept of Edgebetweenness.
  • Human Pathway Database – (IUPUI, IN, 2009): Designed and semantically integrated a comprehensive human pathway database which facilitates a semantic level integration of human signaling pathways, regulatory networks, and protein-protein interactions (in-info-web4.informatic.iupui.edu/~gkkilaru/p1.html).
  • Data mining approaches to predict protein-protein interactions-(IUPUI, IN 2009): Used WEKA tool for classifying large datasets and adopted various classifiers to train and predict the protein-protein interactions using their patch scores. The approach proved random forest as the best classifier to predict the protein-protein interactions.
  • Gene Expression profiling of murine embryonic gonad development – (IUPUI, IN, 2009): Analyzed the development of murine embryonic gonad using R/Bioconductor and MATLAB. Statistical analysis produced 3693 transcripts exhibiting differential expression during male and/or female gonad development which helped understanding mammalian organogenesis.
  • Understanding the Neu5Ac bio-synthesis of sialic acid in Bos Taurus– (IUPUI, IN, 2008): Designed a primer for predicting sequence alignment and homology of candidate genesusing Perl programming and found four sequences to be the putative candidate genes which could have the specific linkage ability to attach sialic acid to GalNAc.
  • Effect of Soybean Trypsin Inhibitor on Protease Assay – (CLRI, India, 2007-2008): Developed a general protease substrate consisting of cross-linked albumin, azoalbumin, and gelatin. The substrate is susceptible to proteolysis by a wide range of enzymes including: collagenase, papain, bromelain, trypsin, chymotrypsin, proteinase K, and pronase. The time course of the hydrolysis for collagenase (25µg) and proteinase K (25µg) is greater than for papain and chymotrypsin (50 µg of both in assays).

WORK EXPERIENCE

  • Teaching Assistant – (IUPUI, IN, 2009-2010): Worked as a teaching assistant providing instructional and clerical support for Introduction to Bioinformatics and Computational Systems Biology courses. Participated in the instructional, advising and evaluation of students.
  • Webmaster - (IUPUI, IN, 2009): Developed the website for Indian Students Advisory Council.
  • Math Grader – (IUPUI, IN, 2008-2009): Assisted students in their exams and conducting tests and managed many students in their class activities conducting classes.
  • Student Body President – (Department of Biotechnology, Sathayabama University, India, 2004-2008): Acted as bridge between the administration and staff, and organizing the conferences.

PAPER PUBLICATIONS

  • A paper under the title “Extending Connectivity maps for disease specific theradiagnostic research” is being prepared for submission to BIBM workshop 2010.

PRACTICAL TRAINING

  • Underwent inplant training in manufacturing facility at Pharman Laboratories Limited, A.P, India.
  • Underwent inplant training on “Various immunological Techniques” at Sterile Specialties India Limited, Vijayawada, A.P, India.

WORKSHOP

  • Participated in a workshop held by Indian Institute of Technology, Chennai ,TN, on

“Nanotechnology”.

  • Participated in a CSI workshop held by Indian Institute of Technology, Chennai, TN, India.

ACTIVITIES

  • Member of Heifer International, a volunteer organization.

LANGUAGES

  • Fluent in English, Hindi, Tamil, Telugu

REFERENCES

  • Dr. Jake Y. Chen

Professor of Informatics and Computer Science

Walker Plaza Building (WK), Suite #190

719 N. Indiana Ave, Indianapolis, IN 46202

Phone: (317) 278-7604

E-mail:

  • Dr. Karl Mac Dorman

Associate Professor of Informatics

Walker Plaza Building (WK), Suite #190

719 N. Indiana Ave, Indianapolis, IN 46202

Phone: (202) 303-3723

E-mail:

  • Dr. Narayan Perumal

Assistant Professor of Informatics

Walker Plaza Building (WK), Suite #190

719 N. Indiana Ave, Indianapolis, IN 46202

E-mail: