Texts for Biomedical Tracers, Biology 685, Spring 2009

It is probably advisable to obtain these via Amazon.com, Barnes & Noble.com, Biblio.com, or similar sites. In several instances the book is several years old and is available as a new remainder book or as a used volume at a considerably reduced price.

1) Introduction to the Principles of Medical Imaging (Hardcover)

by Chris Guy (Author), Dominic Ffytche (Author)
Key Phrases: freewaterdensity, nuclearmagnetisation, rotatingmagnetisation, KeyConcepts (more...),

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[United States] / Hardcover, ISBN1860945023
Publisher: World Scientific Pub Co Inc, 2005
Extra $5.2 discount available for B&N members / $52.00
  • Hardcover: 420 pages
  • Publisher: Imperial College Press; Revised edition (June 2005)
  • Language: English
  • ISBN-10: 1860945023
  • ISBN-13: 978-1860945021

Review
"This book manages to cover a wide range of subjects in a relatively compact way and could form a useful introductory text ... It is full of many historical details and these are interesting. There are lots of useful technical details in this book and the authors frequently illustrate the formulae they provide with specific numerical examples which helps to put them in context." - Medical Engineering & Physics
Product Description
The introduction of X-ray computed tomography (CT) 25 years ago revolutionized medical imaging; X-ray CT itself provided the first clear cross-sectional images of the human body, with substantial contrast between different types of soft tissue. The enduring legacy of CT is, however, the spur that it gave to the subsequent introduction of tomographic imaging techniques into diagnostic nuclear medicine and the extraordinarily rapid development of magnetic resonance imaging (MRI) over this period.

This book is a non-mathematical introduction to the principles underlying modern medical imaging, taking tomography as its central theme. The first three chapters cover the general principles of tomography, a survey of the atomic and nuclear physics which underpins modern imaging, and a review of the key issues involved in radiation protection. The subsequent chapters deal in turn with X-ray radiography, gamma imaging, MRI and ultrasound. The clinical role of diagnostic imaging is illustrated in the final chapter through the use of fictional clinical histories. Three appendices provide a more mathematical background to the tomographic method, the principles of mathematical Fourier methods, and the mathematics of MRI.

This revised edition includes new introductory sections on the relevant physics of molecules in general, and water, in particular. Every chapter now has a table of key points with cross-references to other sections. Several figures have also been revised.

The book is intended to provide a broad introductory background to tomographic imaging for two groups of readers: the physics or engineering undergraduate thinking of specializing in medical physics, and the medical student or clinician using tomographic techniques in research and clinical practice.

2) Bioanalytical Chemistry (Paperback)

by Andreas Manz (Author), Nicole Pamme (Author), Dimitri Iossifidis (Author) "Amino acids are the building blocks for peptides and proteins and play an important part in metabolism..."(more)
Key Phrases: bioanalyticalchemistry, sulfidebridges, performicacid, OxfordUniversityPress, PracticalApproach, AffymetrixCorp (more...) (1 customer review), $29.00 & this item ships for FREE with Super Saver Shipping. Details, 9newfrom$24.942usedfrom$17.40

  • Paperback: 201 pages
  • Publisher:ImperialCollege Press (November 2004)
  • Language: English
  • ISBN-10: 1860943713
  • ISBN-13: 978-1860943713

Review
"The book is well written and easy to read ... It will complement any lecture courses on modern analytical chemistry as it focuses on one of the most topical areas in the field of analysis -- that of bioanalysis ... this first edition is an excellent foundation from which to build as the new techniques become accepted. I would highly recommend it to any student (or indeed other scientists) with interest in bioanalysis." Chemistry World "It will be useful to chemists interested in bioanalysis who have little experience with biochemistry, and to biologists interested in the range of analytical techniques for studying protein and nucleic acid samples." Choice
Product Description
Interdisciplinary knowledge is becoming more and more important to the modern scientist. This invaluable textbook covers bioanalytical chemistry (mainly the analysis of proteins and DNA) and explains everything for the nonbiologist. Electrophoresis, mass spectrometry, biosensors, bioassays, DNA and protein sequencing are not necessarily all included in conventional analytical chemistry textbooks. The book describes the basic principles and the applications of instrumental and molecular methods. It is particularly useful to chemistry and engineering students who already have some basic knowledge about analytical chemistry.

3) Nonradioactive Analysis of Biomolecules (Springer Lab Manuals) (Paperback)

by Christoph Kessler (Editor),$160.00 & this item ships for FREE with Super Saver Shipping. Details, 8newfrom$25.705usedfrom$47.99

  • Paperback: 750 pages
  • Publisher: Springer; 2nd edition (April 2000)
  • Language: English
  • ISBN-10: 3540646019
  • ISBN-13: 978-3540646013

Product Description
New techniques and updated protocols for the detection and analysis of biomolecules - proteins, glycoproteins and nucleic acids - are presented in the second edition of this successful laboratory manual. Highly sensitive systems which are widely used in molecular biological and biomedical laboratories, such as colorimetric, luminescence, fluorescence measuring using antibody/antigen binding or hybridisation, as well as PCR amplification are described in detail. The clearly structured step-by-step protocols with practical hints and a troubleshooting guide are complemented by chapters on the theoretical background and the application of the techniques. Thus the manual will enable scientists to plan, design and conduct the appropriate procedures which fulfill their particular requirements.

4) Bioimaging: Current Techniques in Light & Electron Microscopy (Hardcover)

by Douglas Chandler (Author), Robert W. Roberson (Author)
Key Phrases: cryogenictechniques, videomicroscopy, rotaryplatinumshadowing, NewYork, AcademicPress, OxfordUniversityPress (more...) $120.95 & this item ships for FREE with Super Saver Shipping. Details, 17newfrom$56.197usedfrom$56.24

  • Hardcover: 456 pages
  • Publisher: Jones & Bartlett Publishers; 1 edition (September 16, 2008)
  • Language: English
  • ISBN-10: 0763738743
  • ISBN-13: 978-0763738747
  • Product Dimensions: 10.1 x 7.1 x 0.8 inches
  • Shipping Weight: 2.2 pounds (View shipping rates and policies)

Product Description
The development of microscopy revolutionized the world of cell and molecular biology as we once knew it and will continue to play an important role in future discoveries. Bioimaging: Current Concepts in Light and Electron Microscopy is the optimal text for any undergraduate or graduate bioimaging course, and will serve as an important reference tool for the research scientist. This unique text covers, in great depth, both light and electron microscopy, as well as other structure and imaging techniques like x-ray crystallography and atomic force microscopy. Written in a user-friendly style and covering a broad range of topics, Bioimaging describes the state-of-the-art technologies that have powered the field to the forefront of cellular and molecular biological research.

5) Nonisotopic DNA Probe Techniques (Paperback)

by Larry J. Kricka (Editor) , Available from these sellers (check link to alibris, massbookstore, et al.), 1newfrom$73.809usedfrom$13.72

  • Paperback: 358 pages
  • Publisher: Academic Pr (March 1992)
  • Language: English
  • ISBN-10: 0124262961
  • ISBN-13: 978-0124262966

Other/alternative volumes of interest or use, arranged roughly according to topical coverage. Some of these are classic, but many are dated, these may be of particular use to individuals within the class. They are only recommendations beyond the suggested books list:

1) Biomedical Photonics Handbook (Hardcover)

by Tuan Vo-Dinh (Editor),$158.36 & this item ships for FREE with Super Saver Shipping; 11newfrom$153.155usedfrom$179.90

  • Hardcover: 1872 pages
  • Publisher: CRC; 1 edition (March 26, 2003)
  • Language: English
  • ISBN-10: 0849311160
  • ISBN-13: 978-0849311161

Review
New optical technologies, many involving lasers or nanotechnologies providing sensitive and compact electronic-like devices, are revolutionizing many fields. Applications of new optical technologies to biology and medicine might be described as in an adolescent stage, where their power and potential can be recognized but are still developing rapidly, and much is yet to come. The Biomedical Photonics Handbook provides outstanding coverage of basic ideas, present applications of these new technologies, and future potentials. The manifold aspects of the field are discussed by a remarkable selection of experts. This handbook can be expected to be a much used and standard reference during the inevitably rapid development of biological and medical photonics.
-Charles H. Townes, Nobel Prize in Physics, 1964, Co-inventor of the Laser
This straightforward, well-organized book is an excellent reference that consolidates a wealth of information of interest to anyone involved in biophotonics research, teaching, learning or practice.
- Optics and Photonics News, Vol. 15, No. 12, December 2004
Product Description
A wide variety of biomedical photonic technologies have been developed recently for clinical monitoring of early disease states; molecular diagnostics and imaging of physiological parameters; molecular and genetic biomarkers; and detection of the presence of pathological organisms or biochemical species of clinical importance. However, available information on this rapidly growing field is fragmented among a variety of journals and specialized books.Now researchers and medical practitioners have an authoritative and comprehensive source for the latest research and applications in biomedical photonics. Over 150 leading scientists, engineers, and physicians discuss state-of-the-art instrumentation, methods, and protocols in the Biomedical Photonics Handbook. Editor-in-Chief Tuan Vo-Dinh and an advisory board of distinguished scientists and medical experts ensure that each of the 65 chapters represents the latest and most accurate information currently available.

2) Principles of Medical Imaging (Hardcover)

by K. Kirk Shung (Author), Michael B. Smith (Author), Benjamin M. W. Tsui (Author) "X-ray was discovered accidentally by a German physicist, W. K. Roentgen, in 1895..."(more)
Key Phrases: NewYork, JohnWiley, AcademicPress (more...), 7usedfrom$23.99

  • Hardcover: 289 pages
  • Publisher: Academic Press (August 1992)
  • Language: English
  • ISBN-10: 0126409706
  • ISBN-13: 978-0126409703

Product Description
Since the early 1960's, the field of medical imaging has experienced explosive growth due to the development of three new imaging modalities-radionuclide imaging, ultrasound, and magnetic resonance imaging. Along with X-ray, they are among the most important clinical diagnostic tools in medicine today. Additionally, the digital revolution has played a major role in this growth, with advances in computer and digital technology and in electronics making fast data acquisition and mass data storage possible. This text provides an introduction to the physics and instrumentation of the four most often used medical imaging techniques.
Each chapter includes a discussion of recent technological developments and the biological effects of the imaging modality. End-of-chapter problem sets, lists of relevant references, and suggested further reading are presented for each technique.
Key Features
* X-ray imaging, including CT and digital radiography
* Radionuclide imaging, including SPECT and PET
* Ultrasound imaging
* Magnetic resonance imaging

3) Medical Imaging Signals and Systems (Hardcover)

by Jerry L. Prince (Author), Jonathan Links (Author), $89.25 & this item ships for FREE with Super Saver Shipping. Details, 27newfrom$60.9320usedfrom$50.00

  • Hardcover: 496 pages
  • Publisher: Prentice Hall; 1 edition (April 25, 2005)
  • Language: English
  • ISBN-10: 0130653535
  • ISBN-13: 978-0130653536

Product Description
For courses in medical imaging systems. With signal processing as its foundation, this text covers the most important imaging modalities in radiology: projection radiography, x-ray computed tomography, nuclear medicine, ultrasound imaging, and magnetic resonance imaging. Organized into parts to emphasize key overall conceptual divisions, Medical Imaging is most appropriate for engineering students who have taken the prerequisite signals and systems courses as well as elementary probability.
Excerpt. © Reprinted by permission. All rights reserved.

This book has developed over the past 14 years, during which time we have taught a course on medical imaging systems at JohnsHopkinsUniversity. This course started out as a survey course, and then evolved according to our mutual interests and inclinations into a course that emphasizes the signals and systems aspects—or more precisely, the signal processing aspects—of medical imaging.

With signal processing as the fundamental viewpoint, this book covers the most important imaging modalities in radiology: projection radiography, x-ray computed tomography, nuclear medicine, ultrasound imaging, and magnetic resonance imaging. The authors expect the reader to be familiar with signals and systems, which are usually covered in the sophomore year of most engineering curricula, and with elementary probability. Freshman courses in physics, chemistry, and calculus are also assumed.

The book is organized into parts emphasizing key overall conceptual divisions, as follows. Part I introduces basic imaging principles, including an introduction to medical imaging systems in Chapter 1, a review of signal processing in Chapter 2 (with emphasis on two-dimensional signals), and a discussion of image quality in Chapter 3. Our presentation of the theory of medical imaging systems is strongly based on continuous signals; however, a development of discrete signals is included to permit discussions on sampling and implementation. Issues of image quality, including resolution, noise, contrast, geometric distortion, and artifacts are described in general context here, but revisited within each modality in subsequent chapters.

Part II describes key modalities in radiographic imaging. It begins in Chapter 4 with a brief presentation of the physics of radiography, including the generation and detection of ionizing radiation and its effect on the human body. Chapter 5 describes projection radiography systems, including chest x-ray and fluoroscopy systems. As in all subsequent chapters, coverage focuses on signals, including only enough physics and biology to motivate the modality and provide a model for the analysis. Chapter 5 also presents the mathematics of projection imaging, a very fundamental idea in medical imaging. Chapters 6 covers x-ray computed tomography, expanding on the instrumentation and mathematics of projection imaging and introducing the concept of image reconstruction in medical imaging. Computed tomography produces true tomograms (images of cross sections of the body) rather than projections of the body.

Part IV presents the physics and modalities of nuclear medicine imaging. Chapter 7 describes the physics of nuclear medicine, focusing primarily on the concept of radioactivity. The major modalities in nuclear medicine imaging are described in Chapter 8, which covers planar scintigraphy, and Chapter 9, which covers emission computed tomography.

Part IV covers ultrasound imaging. It begins in Chapter 10 with a brief presentation of the physics of sound, and continues in Chapter 11 with the various imaging modes offered within this rich modality. Part V covers magnetic resonance imaging. Chapter 11 presents the physics of nuclear magnetic resonance, and Chapter 12 continues with a presentation of various magnetic resonance imaging techniques.

We have used drafts of this book for a one-semester upper-level/graduate course on medical imaging systems. In order to cover the material in one semester, we routinely skip some material in the book and we move at a very brisk pace. We feel that this book could be used in a two-semester course as well, perhaps by covering Parts I-III in the first semester and Parts IV-V in the second semester. A two-semester approach would allow instructors to use supplementary materials for additional depth or to present current research topics.

Medical imaging is very visual—just ask any radiologist. Although the formalism of signals and systems is mathematical, we understand the advantages offered through visualization. Therefore, the book contains many images and diagrams. Some are strictly pedagogical, offered in conjunction with the exposition or an example problem. Others are motivational, 'revealing interesting features for discussion or study. Special emphasis is made to provide biologically relevant examples including images, so that the important context of medical imaging can be appreciated by students.

4) Introduction to Health Physics: Fourth Edition (Paperback)

by Herman Cember (Author), Thomas Johnson (Author) "Health physics, or radiological health, as it is frequently called, is the area of environmental health engineering that deals with the protection of the individual..."(more)
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  • Paperback: 864 pages
  • Publisher: McGraw-Hill Medical; 4 edition (July 25, 2008)
  • Language: English
  • ISBN-10: 0071423087
  • ISBN-13: 978-0071423083

Review
"Overall, this is a good introductory health physics book for students in health and medical physics and could be used as a study guide and reference by health and medical physicists. The fourth edition has improvements and updates over the third edition, including the addition of NCRP 147 shielding methodology and ICRP 66 respiratory tract dosimetric model, the discussion of machine sources of radiation, and a revamped chapter on non-ionizing radiation."--Doody's Review Service. (Doody's )

5) Biomedical Optics: Principles and Imaging (Hardcover)

by Lihong V. Wang (Author), Hsin-i Wu (Author)
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  • Hardcover: 376 pages
  • Publisher: Wiley-Interscience; 1 edition (May 29, 2007)
  • Language: English
  • ISBN-10: 0471743046
  • ISBN-13: 978-0471743040

Product Description
This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at TexasA&MUniversity. After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. The imaging modalities include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging. The basic physics and engineering of each imaging technique are emphasized.

A solutions manual is available for instructors; to obtain a copy please email the editorial department at .

…It covers:

  • The fundamentals of photon transport in biological tissues, including explanations of Rayleigh and Mie scattering, Monte Carlo simulations, the radiative transport equation, and more
  • Various optical imaging techniques for biological tissues, including ballistic or quasi-ballistic imaging (such as confocal microscopy, two-photon microscopy, and optical coherence tomography), diffuse imaging (such as DC, time-domain techniques, and frequency-domain techniques), and ultrasound-aided hybrid imaging (including photoacoustic tomography and ultrasound-modulated optical tomography)
  • The basic physics and engineering of each imaging modality
  • Complete with equation derivations, examples, and case studies plus a constantly updated Web site featuring an established Monte Carlo program, other sample programs, tables and figures, and more, this is a great reference for practitioners. With an instructor's solutions manual and problems for students to complete, it's an excellent textbook for upper-level undergraduates or graduate students.

6) Optical Methods: A Guide to the "-escences" (Paperback)