Supplemental TablesIs the type of GnRH…STYLE REVISION SUBMISSIONLondra
Supplemental Table 1- Characteristics of fresh autologous embryo transfer cycles that resulted in a clinical pregnancy, by type of ovarian hyperstimulation protocol.
Total / Luteal GnRH agonist / GnRH agonist flare / GnRH antagonist / P*n / % / % / % / %
Age / <35 years / 62,002 / 45 / 54 / 25 / 39 / <0.001
35-39 years / 50,917 / 37 / 36 / 41 / 39
≥40 years / 23,686 / 17 / 11 / 33 / 23
Race/ethnicity / Caucasian / 64,275 / 47 / 49 / 45 / 45 / <0.001
Black / 5,415 / 4 / 4 / 4 / 4
Hispanic / 7,307 / 5 / 5 / 5 / 6
Asian / 9,565 / 7 / 7 / 7 / 7
Other / 642 / 0 / 0 / 1 / 0
Missing / 49,401 / 36 / 35 / 39 / 37
Region / Northeast / 45,888 / 34 / 31 / 31 / 38 / <0.001
South / 39,010 / 29 / 29 / 33 / 27
Midwest / 24,910 / 18 / 21 / 13 / 16
West / 26,768 / 20 / 19 / 23 / 19
Missing / 29 / 0 / 0 / 0 / 0
Body mass index / <30 / 94,376 / 69 / 69 / 65 / 70 / <0.001
≥30 / 19,133 / 14 / 14 / 14 / 14
Unknown / 23,096 / 17 / 16 / 22 / 17
Smoking / Yes / 6579 / 5 / 5 / 4 / 5 / <0.001
No / 110,8789 / 81 / 81 / 83 / 81
Missing / 19,237 / 14 / 14 / 13 / 15
Prior full term births / 0 / 99,518 / 73 / 74 / 69 / 72 / <0.001
1 / 27,956 / 20 / 20 / 24 / 21
2 / 8,267 / 6 / 6 / 7 / 6
Missing / 864 / 1 / 1 / 1 / 1
Prior preterm births / 0 / 130,640 / 96 / 96 / 94 / 96 / <0.001
1 / 3712 / 3 / 3 / 3 / 3
≥2 / 433 / 0 / 0 / 0 / 0
Missing / 1819 / 1 / 1 / 2 / 1
Prior miscarriages / 0 / 95,455 / 70 / 72 / 64 / 68 / <0.001
1 / 26,370 / 19 / 18 / 22 / 20
2 / 8,761 / 6 / 6 / 8 / 7
3 / 4,897 / 4 / 3 / 4 / 4
Missing / 1,122 / 1 / 1 / 1 / 1
Tubal infertility / 18,340 / 13 / 14 / 14 / 13 / 0.003
Tubal ligation / 3075 / 2 / 2 / 2 / 2 / <0.001
Endometriosis / 15,286 / 11 / 11 / 12 / 11 / <0.001
Uterine / 5523 / 4 / 4 / 5 / 5 / <0.001
Polycystic ovary / 23,844 / 17 / 20 / 9 / 16 / <0.001
Diminished ovarian reserve / 20,083 / 15 / 7 / 35 / 20 / <0.001
Male infertility / 55,163 / 40 / 42 / 37 / 39 / <0.001
Unexplained infertility / 20,368 / 15 / 15 / 13 / 15 / <0.001
Prior IVF cycles / None / 83,270 / 62 / 66 / 47 / 57 / <0.001
Frozen cycles only / 163 / 0 / 0 / 0 / 0
Fresh cycles / 53,172 / 37 / 34 / 53 / 43
Number of oocytes / 1 to 10 / 51,608 / 38 / 30 / 58 / 43 / <0.001
11 to 15 / 37,642 / 28 / 29 / 23 / 27
16-20 / 24,467 / 18 / 21 / 10 / 16
>20 / 22,888 / 17 / 20 / 8 / 14
Use of ICSI / All mature / 91,039 / 67 / 65 / 71 / 68 / <0.001
Some / 8,580 / 6 / 7 / 4 / 6
None / 36,839 / 27 / 28 / 24 / 26
Missing / 147 / 0 / 0 / 0 / 0
Use of assisted hatching / All embryos / 45,276 / 33 / 27 / 51 / 38 / <0.001
Some embryos / 3,436 / 3 / 2 / 3 / 3
None / 87,872 / 64 / 71 / 47 / 60
Blastocyst stage transfer / 56,805 / 42 / 44 / 30 / 41 / <0.001
Number of embryos transferred / 1 / 13,980 / 10 / 10 / 8 / 10 / <0.001
2 / 82,128 / 60 / 66 / 44 / 56
3 / 28,128 / 21 / 17 / 30 / 23
≥4 / 12,369 / 9 / 6 / 18 / 11
Surplus embryos cryopreserved / 0 / 71,312 / 52 / 47 / 70 / 55 / <0.001
1 to 4 / 44,213 / 32 / 35 / 24 / 31
>4 / 21,043 / 15 / 18 / 6 / 14
Use of ultrasound for embryo transfer / Yes / 88,026 / 64 / 60 / 65 / 70 / <0.001
*P values represent difference between agonist vs. antagonist cycles.
Supplemental Table 2: Proportionof EP by maternal and treatment characteristics, within each type of ovarian hyperstimulation protocol.
Luteal GnRH agonist / GnRH agonist flare / GnRH antagonist% EP / P* / % EP / P* / % EP / P*
1.6 / 2.1 / 2.4
Age / <35 years / 1.4 / 0.000 / 1.4 / 0.006 / 2.3 / 0.14
35-39 years / 1.6 / 2.3 / 2.5
≥40 years / 2.0 / 2.4 / 2.6
Race/ethnicity / Caucasian / 1.5 / <0.001 / 1.9 / 0.09 / 2.3 / <0.001
Black / 2.1 / 3.3 / 2.9
Hispanic / 1.5 / 2.5 / 2.2
Asian / 2.5 / 3.1 / 3.8
Other / 2.5 / 1.4 / 5.2
Missing / 1.5 / 2.0 / 2.3
Body mass index / <30 / 1.6 / 0.000 / 2.1 / 0.09 / 2.4 / 0.002
≥30 / 2.1 / 2.7 / 3.0
Missing / 1.1 / 2.0 / 2.2
Smoking / Yes / 1.4 / 0.72 / 1.9 / 0.92 / 3.0 / 0.07
No / 1.6 / 2.1 / 2.5
Missing / 1.5 / 2.2 / 2.1
Prior full term births / 0 / 1.7 / 0.000 / 2.1 / 0.94 / 2.6 / 0.009
1 / 1.3 / 2.1 / 2.2
2 / 1.0 / 2.00 / 1.7
Missing / 2.1 / 1.4 / 1.8
Prior preterm births / 0 / 1.6 / 0.42 / 2.1 / 0.19 / 2.4 / 0.66
1 / 1.2 / 2.4 / 2.8
≥2 / 1.2 / 6.5 / 1.5
Missing / 1.8 / 1.8 / 2.1
Prior miscarriages / 0 / 1.5 / 0.49 / 2.1 / 0.99 / 2.4 / 0.90
1 / 1.6 / 2.1 / 2.5
2 / 1.6 / 2.1 / 2.4
3 / 1.9 / 2.4 / 2.7
Missing / 1.9 / 2.2 / 2.4
Tubal infertility / Yes / 2.0 / 0.000 / 3.2 / 0.001 / 2.9 / 0.01
No / 1.5 / 1.9 / 2.4
Tubal ligation / Yes / 0.7 / 0.002 / 0.7 / 0.07 / 1.0 / 0.004
No / 1.6 / 2.1 / 2.5
Endometriosis / Yes / 1.9 / 0.004 / 2.2 / 0.67 / 2.7 / 0.17
No / 1.5 / 2.9 / 2.4
Uterine / Yes / 1.8 / 0.27 / 2.9 / 0.19 / 2.8 / 0.29
No / 1.6 / 2.1 / 2.4
Polycystic ovary / Yes / 1.4 / 0.12 / 2.5 / 0.32 / 2.5 / 0.87
No / 1.6 / 2.1 / 2.4
Diminished ovarian reserve / Yes / 2.1 / 0.001 / 2.3 / 0.31 / 2.4 / 0.91
No / 1.5 / 2.0 / 2.4
Male infertility / Yes / 1.4 / 0.03 / 2.1 / 0.67 / 2.2 / 0.003
No / 1.7 / 2.1 / 2.6
Unexplained infertility / Yes / 1.7 / 0.34 / 1.4 / 0.03 / 2.8 / 0.03
No / 1.5 / 2.2 / 2.4
Prior IVF cycles / None / 1.5 / 0.006 / 2.1 / 0.80 / 2.2 / 0.004
Frozen cycles only / 0.0 / 0.0 / 4.7
Fresh cycles / 1.8 / 2.1 / 2.7
Number of oocytes / 1 to 10 / 1.5 / 0.64 / 2.1 / 0.59 / 2.3 / 0.01
11 to 15 / 1.6 / 2.3 / 2.3
16-20 / 1.6 / 1.9 / 2.5
>20 / 1.6 / 1.6 / 3.0
Use of ICSI / All mature oocytes / 1.6 / 0.42 / 2. / 0.88 / 2.2 / 0.001
Some / 1.5 / 2.4 / 3.1
None / 1.5 / 2.1 / 2.9
Unknown / 0.0 / 0.0 / 3.3
Use of assisted hatching / All embryos / 1.7 / 0.03 / 2.1 / 0.95 / 2.4 / 0.66
Some embryos / 1.9 / 1.9 / 2.8
None / 1.5 / 2.1 / 2.4
Blastocyst stage transfer / Yes / 1.4 / 0.004 / 2.3 / 0.23 / 2.2 / 0.02
No / 1.7 / 2.0 / 2.6
Number of embryos transferred / 1 / 1.5 / <0.001 / 1.2 / <0.001 / 1.9 / 0.01
2 / 1.4 / 1.8 / 2.4
3 / 1.8 / 2.2 / 2.6
≥4 / 2.2 / 3.1 / 3.0
Surplus embryos cryopreserved / 0 / 1.6 / 0.11 / 2.2 / 0.20 / 2.6 / 0.07
1 to 4 / 1.6 / 1.7 / 2.2
>4 / 1.4 / 2.0 / 2.4
Use of ultrasound for embryo transfer / Yes / 1.6 / 0.99 / 1.9 / 0.04 / 2.5 / 0.05
No / 1.6 / 2.4 / 2.2
*P values represent difference in frequency of EP by maternal and IVF procedure characteristics
Supplemental Table 3- Odds of EP by maternal and treatment characteristics: results of generalized estimated equation regression models.
Ref. = reference category.
aOR= adjusted odds ratio.
All cyclesaOR / 95% Confidence Interval / P
Type of ovarian hyperstimulation protocol / Luteal GnRH agonist (Ref.) / 1
GnRH agonistflare / 1.25 / 1.09-1.44
GnRH antagonist / 1.52 / 1.39-1.65 / <0.001
Age / <35 years (Ref.) / 1 / 0.06
35-39 years / 1.10 / 1.00-1.21
≥40 years / 1.14 / 1.00-1.30
Race/ethnicity / Caucasian (Ref.) / 1 / <0.001
Black / 1.31 / 1.09-1.58
Hispanic / 1.10 / 0.91-1.32
Asian / 1.72 / 1.51-1.97
Other / 1.84 / 1.18-2.87
Unknown / 1.00 / 0.92-1.10
Body mass index / <30 (Ref.) / 1 / <0.001
>=30 / 1.33 / 1.19-1.47
Unknown / 0.84 / 0.75-0.94
Full termbirths / 0 (Ref.) / 1 / 0.001
1 / 0.83 / 0.75-0.92
≥2 / 0.74 / 0.60-0.91
Unexplainedinfertility / No (Ref.) / 1
Yes / 1.13 / 0.99-1.28 / 0.06
Male infertility / No (Ref.) / 1
0.92 / 0.84-1.00 / 0.06
Endometriosis / No (Ref.) / 1
Yes / 1.22 / 1.08-1.38 / 0.001
Tubalinfertility / No (Ref.) / 1
Yes / 1.26 / 1.13-1.41 / <0.001
Diminishedovarianreserve / No (Ref.) / 1
Yes / 1.08 / 0.96-1.22 / 0.19
Tuballigation / No (Ref.) / 1
Yes / 0.51 / 0.33-0.78 / 0.002
Prior fresh cycles / No (Ref.)
Yes / 1.08 / 0.99-1.17 / 0.07
Number of oocytes / 1 to 10 (Ref.) / 1
11 to 15 / 1.13 / 1.02-1.25
16-20 / 1.18 / 1.04-1.33
>20 / 1.37 / 1.21-1.56 / <0.001
Number of embryoscryopreserved / 0 (Ref.) / 1
1 to 4 / 0.92 / 0.84-1.02
>4 / 0.86 / 0.75-0.98 / 0.06
Number of embryostransferred / 1 (Ref.) / 1
2 / 1.08 / 0.93-1.24
3 / 1.17 / 1.00-1.38
≥4 / 1.38 / 1.14-1.67 / 0.004
Blastocysttransfer / No (Ref.)
Yes / 0.93 / 0.84-1.01 / 0.10
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