Table S2. Mollivirus predicted proteins associated to a function or a domain
Gene # / General function / Best match to / Annotation / In virion1ml_57 / actin cross-linking / Pithovirus / Fascin-likedomain / 171
ml_237 / actin cross-linking / Pandoravirus / Fascin-likedomain / no
ml_324 / Apoptose / OtherEukaryote / Programmed cell death protein 2-like / no
ml_476 / Apoptose / A. castellanii / Autophagyprotein / 52
ml_336 / Carbohydrate processing / Pandoravirus / GlcNactransferase / 100
ml_353 / Carbohydrate processing / Pandoravirus / Glycosyltransferase / 46
ml_254 / Diverse / A. castellanii / Ankyrinrepeatprotein / no
ml_235 / Diverse / A. castellanii / Ankyrinrepeatprotein / no
ml_154 / Diverse / Archaea / Ankyrinrepeatprotein / no
ml_217 / Diverse / Archaea / Ankyrinrepeatprotein / no
ml_220 / Diverse / Archaea / Ankyrinrepeatprotein / no
ml_141 / Diverse / Bacteria / Ankyrinrepeatprotein / 89
ml_153 / Diverse / Bacteria / Ankyrinrepeatprotein / no
ml_155 / Diverse / Bacteria / Ankyrinrepeatprotein / no
ml_151 / Diverse / OtherEukaryote / Ankyrinrepeatprotein / 22
ml_221 / Diverse / OtherEukaryote / Ankyrinrepeatprotein / no
ml_238 / Diverse / OtherEukaryote / Fugue: Ankyrinrepeat / no
ml_464 / Diverse / OtherEukaryote / Fugue: Ankyrinrepeat / no
ml_500 / Diverse / OtherEukaryote / Ankyrinrepeatprotein / no
ml_502 / Diverse / OtherEukaryote / Fugue: Ankyrinrepeat / no
ml_252 / Diverse / Pandoravirus / Ankyrinrepeatprotein / no
ml_253 / Diverse / Pandoravirus / Ankyrinrepeatprotein / no
ml_453 / Diverse / Pandoravirus / Ankyrinrepeatprotein / no
ml_506 / Diverse / Pandoravirus / Ankyrinrepeatprotein / no
ml_441 / Diverse / No match / CDD: Ankyrinrepeatprotein / 88
ml_166 / Diverse / Mimiviridae / EGF-likedomain / no
ml_379 / Diverse / No match / CDD: Cupin domain motif-containing / 181
ml_411 / Diverse / No match / CDD: GRF zinc finger motif-containing / no
ml_294 / Diverse / No match / CDD: Small proline-rich 2 domain motif-containing / 26
ml_126 / Diverse / OtherEukaryote / Fugue: Sterile alpha motif / no
ml_132 / Diverse / Pandoravirus / BTB/POZ domain / no
ml_134 / Diverse / Pandoravirus / BTB/POZ domain / no
ml_228 / Diverse / Pandoravirus / BTB/POZ domain / no
ml_325 / Diverse / OtherEukaryote / MYND-type zinc finger-containing / no
ml_207 / Diverse / Pandoravirus / Zinc finger / no
ml_312 / Diverse / Pandoravirus / MYM-type zinc finger-containing / no
ml_71 / Diverse / Pandoravirus / Von willebrand factor type A domain / no
ml_79 / Diverse / Pandoravirus / Endoribonuclease L-PSP/chorismate mutase-like / 11
ml_215 / Diverse / Pandoravirus / Putative membrane protein / no
ml_25 / DNA metabolism / A. castellanii / Endonuclease/exonuclease/phosphatase family protein / no
ml_382 / DNA metabolism / A. castellanii / Flap Endonuclease-1 / no
ml_135 / DNA metabolism / Bacteria / DNA methylase N-4/N-6 domain-containingprotein / no
ml_18 / DNA metabolism / OtherEukaryote / DNA cross-link repair protein SNM1-like / no
ml_143 / DNA metabolism / OtherEukaryote / GIY-YIG endonuclease / no
ml_343 / DNA metabolism / OtherEukaryote / DNA-3-methyladenine glycosylase / no
ml_216 / DNA metabolism / Pithovirus / DNA-cytosine methyltransferase / no
ml_240 / DNA metabolism / Pandoravirus / DEDDy 3'-5' exonuclease domain-containing / no
ml_318 / DNA metabolism / Pandoravirus / B-family DNA polymerase / no
ml_432 / DNA metabolism / Pandoravirus / Eukaryotic DNA primase small subunit / no
ml_498 / DNA metabolism / Pandoravirus / N6-N4 DNA methylase / no
ml_385 / DNA processing / A. castellanii / PFI-1 likehelicase / 229
ml_327 / DNA processing / Iridovirus / Putative helicase 172L / 194
ml_36 / DNA processing / OtherEukaryote / Fugue: ds-DNA binding / no
ml_266 / DNA processing / OtherEukaryote / Putative SWI2/SNF2 helicase / no
ml_322 / DNA processing / Pandoravirus / Contains a C-terminal VV A18-like helicase domain / no
ml_334 / DNA processing / Pandoravirus / YqaJ-like viral recombinase / no
ml_339 / DNA processing / Pandoravirus / VV A32-like virion packaging ATPase / no
ml_359 / DNA processing / Pandoravirus / Helicasesuperfamily 3 / no
ml_37 / Enzymaticactivity / Bacteria / Dihydrofolatereductase / 167
ml_348 / Enzymaticactivity / Marseilleviridae / HD motif metaldependentphosphohydrolase / no
ml_425 / Enzymaticactivity / No match / CDD: AAA+ ATPase motif-containing / no
ml_369 / Enzymaticactivity / OtherEukaryote / Fugue: RNAse H1 / no
ml_164 / Enzymaticactivity / Pandoravirus / Pyrroloquinoline quinone-dependentalcoholdehydrogenase / no
ml_422 / Enzymaticactivity / Pandoravirus / NAD-dependent amine oxidase / 38
ml_499 / Enzymaticactivity / Pandoravirus / Fugue: ketosteroidisomerase / 29
ml_196 / Enzymaticactivity / Pithovirus / Alpha/beta hydrolase / 48
ml_201 / Lipase / Pandoravirus / Carboxylesterase / 102
ml_401 / Lipase / Pandoravirus / Patatin-like phospholipase / 80
ml_262 / Lipidprocessing / Bacteria / Acyl-coA-binding protein, ACB / no
ml_287 / Lipid transport / Bacteria / Lipocalin / 12
ml_496 / Nucleotidemetabolism / A. castellanii / dCMPdeaminase / no
ml_103 / Nucleotidemetabolism / Bacteria / Guanylate kinase / no
ml_233 / Nucleotidemetabolism / Bacteria / Nucleosidediphosphate kinase / 85
ml_270 / Nucleotidemetabolism / Bacteria / Nucleosidediphosphate kinase / no
ml_87 / Nucleotidemetabolism / Bacteria / Phosphoribosylaminoimidazole-succinocarboxamide synthase / 162
ml_387 / Nucleotidemetabolism / No match / Nudix hydrolase motif-containing / 132
ml_88 / Nucleotidemetabolism / OtherEukaryote / Amidophosphoribosyltransferase / no
ml_29 / Nucleotidemetabolism / OtherEukaryote / Deoxyuridine 5'-triphosphate nucleotidohydrolase / no
ml_214 / Nucleotidemetabolism / Pandoravirus / Dihydrofolatereductase motif-containing / no
ml_188 / Proteasome / Pandoravirus / Kua-ubiquitinconjugating enzyme motif-containing / no
ml_395 / Redox activity / A. castellanii / Dyptypeperoxidase / no
ml_39 / Redox activity / Bacteria / Short-chainalcoholdehydrogenase / 54
ml_434 / Redox activity / No match / Erv1 / Alrsulphydryloxidase motif / 35
ml_208 / Redox activity / OtherEukaryote / Thioredoxin-1 / 37
ml_435 / Redox activity / OtherEukaryote / Fugue: Sulfhydryloxidase / 49
ml_41 / Redox activity / Pandoravirus / Thioredoxinreductase / 43
ml_186 / Redox activity / Pandoravirus / Cytochrome P450 / no
ml_414 / Redox activity / Pandoravirus / Fugue: Proteindisulfideisomerase / 20
ml_352 / Signal transduction / A. castellanii / Protein kinase / no
ml_191 / Signal transduction / Bacteria / Fugue: Serine/Threonine protein kinase / 190
ml_278 / Signal transduction / OtherEukaryote / Protein kinase / 90
ml_377 / Signal transduction / OtherEukaryote / Protein kinase / no
ml_398 / Signal transduction / OtherEukaryote / Serine/Threonineprotein kinase / 183
ml_505 / Signal transduction / Pandoravirus / Dual specificityprotein phosphatase / no
ml_114 / Signal transduction / Pandoravirus / Serine/Threonineprotein kinase / no
ml_200 / Signal transduction / Pandoravirus / Serine/Threonineprotein kinase / no
ml_297 / Signal transduction / Pandoravirus / Serine/threonine phosphatase 2c / 33
ml_416 / Transcription / A. castellanii / mRNAcapping enzyme / no
ml_310 / Transcription / OtherEukaryote / DNA-dependent RNA polymerase II subunitRPB1 / no
ml_473 / Transcription / OtherEukaryote / Transcription regulator SNF5-like / no
ml_332 / Transcription / Pandoravirus / Vltf3-like transcription factor / no
ml_371 / Transcription / Pandoravirus / DNA-directed RNA polymerase II subunit RPB2 / no
ml_427 / Transcription / Pandoravirus / DNA-directed RNA polymerase II subunit RPB10/N / no
ml_431 / Transcription / Pandoravirus / Transcription elongation factor S-II / no
ml_363 / Translation / Pandoravirus / Eukaryotic translation initiation factor 4E, mRNA cap-binding / 110
ml_89 / Transport / A. castellanii / Transporter, major facilitator subfamily protein / no
ml_156 / Transport / A. castellanii / Fugue: Molybdenum carrier / 78
ml_148 / Transport / No match / CDD: ATP-binding cassette domain of PrtD motif-containing / no
ml_218 / Vesicletrafficking / OtherEukaryote / Tankyrase-2-like / no
ml_347 / Virion / A. castellanii / NCLDV major capsid protein-like / 4
1: Abundance rank is indicated when detected