RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
BENGALURU, KARNATAKA.
COMPLETED FOR DISSERTATION PROFORMA FOR REGISTRATION OF
SUBJECT FOR DISSERTATION
TITLE:
A PHARMACEUTICAL & ANALYTICAL STUDY OF MANIKYA BHASMA & ITS CLINICAL EVALUATION FOR SPERMATOGENIC PROPERTY.
BY:
DR. MANOJ KUMAR BHATI
M.D. (AYU.) SCHOLAR
DEPARTMENT OF RASASHASTRA, P.G.STUDIES & RESEARCH CENTRE S.J.G. AYURVEDIC MEDICAL COLLEGE AND HOSPITAL,
KOPPAL-583231, KARNATAKA.
GUIDE:
DR. P.H.C.MURTHY, M.D. (AYU)
PROFESSOR AND HEAD,
DEPARTMENT OF RASASHASTRA, P.G.STUDIES & RESEARCH CENTRE S.J.G. AYURVEDIC MEDICAL COLLEGE AND HOSPITAL,
KOPPAL-583231, KARNATAKA.
CO-GUIDE:
DR. SHASHIDHAR.J, M.D. (AYU.)
LECTURER,
DEPARTMENT OF RASASHASTRA, P.G.STUDIES & RESEARCH CENTRE S.J.G. AYURVEDIC MEDICAL COLLEGE AND HOSPITAL,
KOPPAL-583231, KARNATAKA.
2010-2011
SHREE JAGADGURU GAVISIDDHESHWAR AYURVEDIC MEDICAL COLLEGE AND HOSPITAL, GAVIMATH CAMPUS,
KOPPAL-583231, KARNATAKA.
From:
Dr. MANOJ KUMAR BHATI
Ist Year M.D., Department of Post Graduate Studies in RasaShastra
S.J.G. Ayurvedic Medical College & Hospital, Gavimath Campus
Koppal-583231, Karnataka.
To:
The Registrar,
Rajiv Gandhi University of Health Sciences
Bengaluru, Karnataka.
Through:
The Principal and the Head of the Department of RasaShastra
S.J.G. Ayurvedic Medical College & Hospital, Gavimath Campus,
Koppal-583231, Karnataka.
Respected Sir,
Sub: Regarding the submission of completed Proforma for Registration of subject
for Dissertation.
I request you to kindly register the below mentioned subject against my name for the submission of dissertation to the Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka for the partial fulfillment of M.D. (Ayurveda).
Title of the Dissertation
A PHARMACEUTICAL & ANALYTICAL STUDY OF MANIKYA BHASMA & ITS CLINICAL EVALUATION FOR SPERMATOGENIC PROPERTY.
Here with I am enclosing complete Proforma for registration of the subject for dissertation.
Thanking you,
Yours faithfully
(Dr. MANOJ KUMAR BHATI)
Place : Koppal
Date :
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
BENGALURU, KARNATAKA
Proforma for registration of subject for dissertation
1) NAME OF THE CANDIDATEADDRESS (in block letters) / Dr. MANOJ KUMAR BHATI
S/o Sh. JAGDISH SINGH BHATI
VILLAGE.- BADHPURA, P.O.- DADRI
DISTT. -GAUTAMBUDH NAGAR-203207, (U.P.)
2) NAME OF THE INSTITUTE / S.J.G.AYURVEDIC MEDICAL COLLEGE, HOSPITAL & P.G. STUDIES & RESEARCH CENTRE, GAVIMATH CAMPUS,
KOPPAL-583231, KARNATAKA.
3) COURSE OF STUDY
AND SUBJECT / AYURVEDA VACHASPATI M.D. (AYU.)
RASASHASTRA
4) DATE OF ADMISSION / 30th OCTOBER 2010
5) TITLE OF THE TOPIC / “A PHARMACEUTICAL & ANALYTICAL STUDY OF MANIKYA BHASMA & ITS CLINICAL EVALUATION FOR SPERMATOGENIC PROPERTY”.
6. Brief Review of Intended work:
6.1) Need for the study:
Rasaushadhis play an important and vital role in curing the ailments of human beings. They are well known for their minute dose, fast absorption and quick action.
Manikya (Ruby) is described as “1st Maha Ratna” in the classical texts of Rasashastra like RasaTarangini1. It is having the relation with Surya Grah(SUN). Ratna dharna or wearing of Gems has been in vogue from Vedic times for suppressing the Evil effects of Grahs and ornaments too. Rasashastra has also considered the internal administration of bhasmas prepared from the Precious Stones or Gems. Specific utility of these bhasmas has been given in the Classical Texts of Rasashastra2. Though this practice is prevalent, it could not be popularized due to the cost and the unavailability of raw material for making of bhasmas.
Since the prevalence of seminal insufficiency is growing day by day in men, which is leading to hazardous problem like infertility3. Infertility is criticized4 in the world. Manikya bhasma has been famous for alleviating Dhwajabhanga5 (erectile dysfunction). Apart from the compound preparation of Manikya Bhasma like Manikya-Mihirodya Rasa etc., on which much scientific study could not be taken up, the effect of Manikya bhasma on erectile dysfunction as an individual drug is done by Naresh P. et al at N.R.S. Government Ayurvedic College, Vijayawada in 2009. In this study apart from that an enormous development in the seminal picture like improvement in mortality, improvement in Spermatozoa count, mitigation of morbidity and abnormality was observed. Hence it is decided to take up the study individually to prepare good quality of Manikya bhasma and to see its spermatogenic effect in order to help curing Male Infertility.
6.2) Review of Literature:
Description regarding the types, Grahya Lakshanas, Shodhana, Marana, Dose, therapeutic properties & application can be observed in the Ayurvedic classical texts like RasaRatna Samuchchaya, Ras-Tarangini6, Ras Jal-Nidhi, Rasa Prakashsudhakar7 etc.
Various references regarding Manikya Bhasma and Infertility are available in different Ayurvedic classical texts.
For the present study the references of RasaTarangini are taken for Shodhana8, Marana9,10 to get the good quality of Bhasma.
6.2 a) Previous Work Done:
The effect of Manikya Bhasma on erectile dysfunction as an individual drug is done by Naresh P. et al at N.R.S. Government Ayurvedic College, Vijayawada in 2009.
6.3) Objectives of the study:
ü To analyze the Raw Manikya & Manikya Bhasma.
ü To carry out the Clinical evaluation of Manikya Bhasma for its Spermatogenic Property.
7) Materials & Methods:
i) Materials:-
Manikya Kharad
Hingula
Gandhaka
Manshila.
Relative Utensils.
ii) Method:-
· Shodhana of Manikya8.
· Marana of Manikya9,10.
(a) The patients:
The patients attending the O.P.D. and I.P.D. of the S.J.G. Ayurvedic Medical College & Hospital, Koppal will be selected for the study.
(b) The Drugs:
The formulations with their respective ingredients have been prepared in the pharmacy section of S.J.G. Ayurvedic Medical College & Hospital, Koppal.
7.1) Source of data:
1) Literary source
2) Analytical source
1) Literary source:-
A detailed review of the available literature on the drug and disease, such as classical text of Ayurveda and other compendium will be done.
Data will be also collected from various books on the field of herbo-mineral medicines, magazines, journals, periodicals and papers published in the e-journal etc.
2) Analytical source:-
Physico-chemical screening of the raw Manikya & its bhasma form by utilizing the classical and relevant Analytical methodology like AAS, NPST, XRD, SEM and CHNS etc.
7.2. Preparation of Medicine:
The raw drug is procured from the market & the processing is done in the Dept. of Rasashastra of S.J.G. Ayurvedic Medical College, Hospital & P.G. Research Centre, Koppal according to the Rastarangini8,9 and Rasashastra10 (The Mercurial Science)
7.3) Method of collection Data:
7.3. a) Sample size:
30 male patients.
7.3. b) Exclusive criteria:
· Persons aged above 45 years.
· Persons with chronic ailments like Diabetes, HIV, Cancer etc.
7.3. c) Inclusive criteria:
· Healthy individuals with oligospermia will be taken in the study.
· Healthy individuals of age group 21 yrs. To 45 yrs. Will be taken.
7.3. d) Criteria of Diagnosis:
Complete Semen Analysis.
7.3. e) Posology:
30 mg twice a day11.
7.3. f) Study duration:
Manikya Bhasma will be given for a period of 3012 days.
7.3. g) Follow up:
The patients will be followed up once in a week for a period of one month.
7.3. h) Assessment of results:
The outcome of the treatment will be recorded, analyzed analytically and assessed statically by t-test for significance.
7.3. i) Subjective Parameters:
· Erectile dysfunction like premature ejaculation, ejaculation time etc.
7.3.j) Objective Parameters:
· Improvement in seminal picture.
· Increased sperm counts.
7.3. k) Investigations:
Complete Semen Analysis
7.4) Ethical clearance:
Obtained and Certificate Enclosed.
8) List of References (Vancouver style)
1. Acharya Sdanand Sharma: 23rd Tarang, RasaTarangini, commentary by Pt. Kashinath Shastri, published by Motilal Banarsidas, office Delhi, 11th edition, 1979, reprinted in 2009, shloka no.-2, pp.-599.
2. Sri Vangbhattacharya: 4th chapter, Rasaratna Samuchchaya, commentary by Dr. Indradev Tripathi, published by Chaukhambha Sanskrit Sansthan, office Varanasi, 3rd edition, 2006, 13th shloka, pp-43 & 44.
3. D.C.Dutta: 15th chapter, Text Book of Gynecology, published by New Central Book Agency (P) Ltd., 4th edition, reprint 2006, pp-217.
4. Sri Vangbhattacharya: 50th chapter, Astang Samgraha vol-II commentary by Kaviraj Atridev Gupta, published by Krishanadas Academy, office Varanasi, reprint 1993, shloka no.-7,8, pp-421.
5. Acharya Sdanand Sharma: 23rd Tarang, RasaTarangini, commentary by Pt. Kashinath Shastri, published by Motilal Banarsidas, office Delhi, 11th edition, 1979, reprinted in 2009, shloka no.-58, pp.-611.
6. Acharya Sdanand Sharma: 23rd Tarang, RasaTarangini, commentary by Pt. Kashinath Shastri, published by Motilal Banarsidas, office Delhi, 11th edition, 1979, reprinted in 2009.
7. Acharya Yashodhar: 7th chapter, ras Prakash Sudhakar, commentary by Prof. Siddhinandan Mishr, published by Chaukhambha Orientalia, office Varanasi, 3rd edition, 2004, shloka no.-7, pp.-133.
8. Acharya Sdanand Sharma: 23rd Tarang, RasaTarangini, commentary by Pt. Kashinath Shastri, published by Motilal Banarsidas, office Delhi, 11th edition, 1979, reprinted in 2009, shloka no.-46, pp.-609.
9. Acharya Sdanand Sharma: 23rd Tarang, RasaTarangini, commentary by Pt. Kashinath Shastri, published by Motilal Banarsidas, office Delhi, 11th edition, 1979, reprinted in 2009, shloka no.-54, 55, 56, pp.-610.
10. Prof. P.H.C.Murthy: 4th chapter, Rasashastra(The Mercurial System) published by Chaukhambha Sanskrit Sansthan, office Varanasi, 1st edition, 2008, pp-367, 368.
11. Acharya Sdanand Sharma: 23rd Tarang, RasaTarangini, commentary by Pt. Kashinath Shastri, published by Motilal Banarsidas, office Delhi, 11th edition, 1979, reprinted in 2009, shloka no.-59, pp.-611.
12. Acharya Sushruta: 14th chapter, Sushrutasamhita’s Sutra sthana, commentary by Vaidya Jaadvji Trikamji Acharya, published by Chaukhamba Sanskrit Sansthan, Varanasi, reprint 2010, shloka no.-14, pp.-62.
9. Signature of the candidate :
10. Remarks of Guide :
This project facilitates the proper identification and processing of Manikya bhasma and an
effective remedy might came into lime-light for Male Infertility.
11. Name and Designation (in Block letters)
11.1. Guide : Dr. P.H.C. MURTHY M.D. (Ayu.)
11.2. Signature :
11.3. Co-Guide : Dr. SHASHIDHAR.J, M.D. (Ayu.)
11.4. Signature :
11.5. Head of the Department : Dr. P.H.C. MURTHY M.D. (Ayu.)
11.6. Signature :
12.1. Remarks of Chairman and Principal :
The above synopsis is scrutinized by the Scientific Committee post graduate studies and
research centre, of S. J. G Ayurvedic Medical College, Koppal, and submitted for registration as
subject of dissertation at R.G.U.H.S, Bengaluru, Karnataka.
Dr. B.S SAVADI
Principal / C.M.O