Table S1. Gene ontology (GO) clusters correlated with specific turnover rate ranges (bins). GO terms were identified that were significantly (p<0.001) enriched for proteins in one or more rate bins as described in the text. Groups of GO terms were combined into clusters based on significant overlap of constituent proteins using criteria described in the text. GO terms comprising each cluster are listed below. Proteins within our dataset that are shared among all GO terms within the cluster (“Shared Proteins”) along with their turnover rates (in parentheses, log d-1) are also listed. Note that these proteins constitute all the proteins in the cluster as it is possible for proteins to belong to a subset of GO terms within a cluster. The ordering of the list is based on Figure 5.
Blood: Response to oxidative stress
GO Biological Process:
GO:0006979response to oxidative stress
Shared Proteins:
P11352glutathione peroxidase 1(-1.4)
Q61171peroxiredoxin 2(-1.4)
O55234proteasome (prosome, macropain) subunit, beta type 5(-1.2)
P08228superoxide dismutase 1, soluble(-1.1)
P35700peroxiredoxin 1(-1.1)
Q8BYC6TAO kinase 3(-1.0)
Q99LX0Parkinson disease (autosomal recessive, early onset) 7(-1.0)
Blood: Ubiquitin cycle
GO Cellular Component:
GO:0005634nucleus
GO Biological Process:
GO:0043285biopolymer catabolic process
GO:0006511ubiquitin-dependent protein catabolic process
GO:0019941modification-dependent protein catabolic process
GO:0030163protein catabolic process
GO:0043632modification-dependent macromolecule catabolic process
GO:0044257cellular protein catabolic process
GO:0051603proteolysis involved in cellular protein catabolic process
GO:0006512ubiquitin cycle
GO:0043283biopolymer metabolic process
Shared Proteins:
P61089ubiquitin-conjugating enzyme E2N(-1.0)
Q01853valosin containing protein(-0.9)
Blood: RAS oncogene family
GO Molecular Function:
GO:0000166nucleotide binding
GO:0016462pyrophosphatase activity
GO:0016817hydrolase activity, acting on acid anhydrides
GO:0016818hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0017111nucleoside-triphosphatase activity
GO:0017076purine nucleotide binding
GO:0032553ribonucleotide binding
GO:0032555purine ribonucleotide binding
Shared Proteins:
P32883v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(-1.2)
P62827RAN, member RAS oncogene family(-1.2)
Q01853valosin containing protein(-0.9)
Q9CQD1RAB5A, member RAS oncogene family(-0.9)
P08752guanine nucleotide binding protein (G protein), alpha inhibiting 2(-0.8)
P35278RAB5C, member RAS oncogene family(-0.8)
P62331ADP-ribosylation factor 6(-0.8)
P63017Null(-0.8)
P62746ras homolog gene family, member B(-0.7)
P62821RAB1, member RAS oncogene family(-0.7)
P63001RAS-related C3 botulinum substrate 1(-0.7)
Q9D1G1RAB1B, member RAS oncogene family(-0.7)
P39054dynamin 2(-0.6)
P56480ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit(-0.6)
P60766cell division cycle 42 homolog (S. cerevisiae)(-0.6)
P99024tubulin, beta 5(-0.6)
Q03265ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1(-0.6)
Q64518ATPase, Ca++ transporting, ubiquitous(-0.6)
Q8VDD5myosin, heavy polypeptide 9, non-muscle(-0.6)
Q9QUI0ras homolog gene family, member A(-0.6)
P68368tubulin, alpha 4A(-0.5)
Q9D6F9tubulin, beta 4(-0.4)
Blood: Serine protease inhibitor
GO Molecular Function:
GO:0004867serine-type endopeptidase inhibitor activity
Shared Proteins:
Q61838pregnancy zone protein(-0.4)
P28665murinoglobulin 1(-0.3)
Q00896serine (or cysteine) peptidase inhibitor, clade A, member 1C(-0.2)
Q03734serine (or cysteine) peptidase inhibitor, clade A, member 3M(-0.2)
P07759serine (or cysteine) peptidase inhibitor, clade A, member 3K(-0.1)
P22599serine (or cysteine) preptidase inhibitor, clade A, member 1B(-0.1)
Q61702inter-alpha trypsin inhibitor, heavy chain 1(-0.1)
Q61247serine (or cysteine) peptidase inhibitor, clade F, member 2(0.0)
Q07456alpha 1 microglobulin/bikunin(0.1)
Q61703inter-alpha trypsin inhibitor, heavy chain 2(0.2)
Blood: Blood coagulation
GO Biological Process:
GO:0030193regulation of blood coagulation
Shared Proteins:
P20918plasminogen(0.3)
P26262kallikrein B, plasma 1(0.4)
Q01339apolipoprotein H(0.6)
Blood: Extracellular region / Complement activation
GO Cellular Component:
GO:0005615extracellular space
GO:0044421extracellular region part
GO:0005576extracellular region
GO Molecular Function:
GO:0004252serine-type endopeptidase activity
GO:0008236serine-type peptidase activity
GO:0017171serine hydrolase activity
GO Biological Process:
GO:0045087innate immune response
GO:0002250adaptive immune response
GO:0002443leukocyte mediated immunity
GO:0002449lymphocyte mediated immunity
GO:0002455humoral immune response mediated by circulating immunoglobulin
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0016064immunoglobulin mediated immune response
GO:0019724B cell mediated immunity
GO:0002682regulation of immune system process
GO:0050776regulation of immune response
GO:0006959humoral immune response
GO:0002526acute inflammatory response
GO:0002252immune effector process
GO:0002253activation of immune response
GO:0002684positive regulation of immune system process
GO:0050778positive regulation of immune response
GO:0051240positive regulation of multicellular organismal process
GO:0006955immune response
GO:0006958complement activation, classical pathway
GO:0002541activation of plasma proteins during acute inflammatory response
GO:0006956complement activation
GO:0006954inflammatory response
GO:0051239regulation of multicellular organismal process
GO:0006952defense response
GO:0002376immune system process
GO:0009611response to wounding
GO:0009605response to external stimulus
GO:0050896response to stimulus
GO:0006957complement activation, alternative pathway
GO:0006508proteolysis
GO:0048518positive regulation of biological process
GO:0006950response to stress
GO:0044267cellular protein metabolic process
GO:0044260cellular macromolecule metabolic process
GO:0032501multicellular organismal process
GO:0019538protein metabolic process
GO:0043170macromolecule metabolic process
GO:0030193regulation of blood coagulation
Liver: Nucleosome
GO Cellular Component:
GO:0000786nucleosome
GO:0000785chromatin
GO:0044427chromosomal part
GO:0005694chromosome
GO Biological Process:
GO:0006333chromatin assembly or disassembly
GO:0006334nucleosome assembly
GO:0031497chromatin assembly
GO:0065004protein-DNA complex assembly
GO:0006325establishment and/or maintenance of chromatin architecture
GO:0051276chromosome organization and biogenesis
GO:0006323DNA packaging
GO:0006259DNA metabolic process
Shared Proteins:
P62806histone cluster 1, H4a(-1.8)
P10853histone cluster 1, H2bf(-1.6)
P10922H1 histone family, member 0(-1.3)
P43274histone cluster 1, H1e(-1.3)
Liver: Hemoglobin
GO Cellular Component:
GO:0005833hemoglobin complex
GO Molecular Function:
GO:0005344oxygen transporter activity
GO:0019825oxygen binding
GO Biological Process:
GO:0015671oxygen transport
GO:0015669gas transport
Shared Proteins:
P01942hemoglobin alpha, adult chain 1(-1.4)
P02088hemoglobin, beta adult major chain(-1.4)
P02089hemoglobin, beta adult minor chain(-1.4)
Liver: Ribosome (large subunit)
GO Cellular Component:
GO:0015934large ribosomal subunit
Shared Proteins:
P61255Null(-1.0)
P62911ribosomal protein L32(-1.0)
P14148ribosomal protein L7(-0.9)
P19253ribosomal protein L13A(-0.9)
P41105ribosomal protein L28(-0.9)
Q9CXW4ribosomal protein L11(-0.9)
P84099ribosomal protein L19(-0.8)
Q9CPR4ribosomal protein L17(-0.8)
Liver: ATP synthase
GO Cellular Component:
GO:0016469proton-transporting two-sector ATPase complex
GO:0045259proton-transporting ATP synthase complex
GO:0005746mitochondrial respiratory chain
GO:0044455mitochondrial membrane part
GO:0005743mitochondrial inner membrane
GO:0005740mitochondrial envelope
GO:0031966mitochondrial membrane
GO:0019866organelle inner membrane
GO:0031967organelle envelope
GO:0031975envelope
GO Molecular Function:
GO:0046933hydrogen ion transporting ATP synthase activity, rotational mechanism
GO:0046961hydrogen ion transporting ATPase activity, rotational mechanism
GO:0015078hydrogen ion transmembrane transporter activity
GO:0015077monovalent inorganic cation transmembrane transporter activity
GO:0042625ATPase activity, coupled to transmembrane movement of ions
GO:0008324cation transmembrane transporter activity
GO:0022890inorganic cation transmembrane transporter activity
GO:0015075ion transmembrane transporter activity
GO:0022891substrate-specific transmembrane transporter activity
GO:0022857transmembrane transporter activity
GO Biological Process:
GO:0015986ATP synthesis coupled proton transport
GO:0006119oxidative phosphorylation
GO:0015672monovalent inorganic cation transport
Liver: NADH dehydrogenase
GO Molecular Function:
GO:0003954NADH dehydrogenase activity
GO:0008137NADH dehydrogenase (ubiquinone) activity
GO:0050136NADH dehydrogenase (quinone) activity
GO:0016655oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
GO:0016651oxidoreductase activity, acting on NADH or NADPH
GO:0009055electron carrier activity
Shared Proteins:
P03888Null(-1.0)
Q9CPU2NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2(-1.0)
Q9CQ54NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2(-1.0)
P03893Null(-0.9)
P03921Null(-0.9)
Q3UIU2NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6(-0.9)
Q99LY9Null(-0.9)
Q9CQC7NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4(-0.9)
Q9CQH3NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5(-0.9)
Q9CR61NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7(-0.9)
Q9D6J5NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8(-0.9)
Q9DCJ5NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8(-0.9)
Q9DCS9NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10(-0.9)
Q9ERS2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13(-0.9)
O09111NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11(-0.8)
Q8K3J1NADH dehydrogenase (ubiquinone) Fe-S protein 8(-0.8)
Q91VD9NADH dehydrogenase (ubiquinone) Fe-S protein 1(-0.8)
Q9CPP6NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5(-0.8)
Q9CQ91NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3(-0.8)
Q9CQZ5NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14)(-0.8)
Q9DC70NADH dehydrogenase (ubiquinone) Fe-S protein 7(-0.8)
Q91WD5NADH dehydrogenase (ubiquinone) Fe-S protein 2(-0.7)
Q91YT0NADH dehydrogenase (ubiquinone) flavoprotein 1(-0.7)
Q99LC3NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10(-0.7)
Q9CQ75NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2(-0.7)
Q9CQZ6NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3(-0.7)
Q9CXZ1NADH dehydrogenase (ubiquinone) Fe-S protein 4(-0.7)
Q9DC69NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9(-0.7)
Q7TMF3NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12(-0.6)
Q9D6J6NADH dehydrogenase (ubiquinone) flavoprotein 2(-0.6)
P52503NADH dehydrogenase (ubiquinone) Fe-S protein 6(-0.5)
Q62425NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4(-0.5)
Liver: Cellular respiration
GO Biological Process:
GO:0045333cellular respiration
Shared Proteins:
Q9CZB0succinate dehydrogenase complex, subunit C, integral membrane protein(-1.0)
P08249malate dehydrogenase 2, NAD (mitochondrial)(-0.9)
P54071isocitrate dehydrogenase 2 (NADP+), mitochondrial(-0.9)
Q9CXV1succinate dehydrogenase complex, subunit D, integral membrane protein(-0.9)
Q9WUM5succinate-CoA ligase, GDP-forming, alpha subunit(-0.9)
P97807fumarate hydratase 1(-0.8)
Q99KI0aconitase 2, mitochondrial(-0.8)
Q9CQA3succinate dehydrogenase complex, subunit B, iron sulfur (Ip)(-0.8)
Q9CZU6citrate synthase(-0.8)
Q9D2G2dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)(-0.8)
Q9Z2I9succinate-Coenzyme A ligase, ADP-forming, beta subunit(-0.8)
P00397mitochondrially encoded cytochrome c oxidase I(-0.7)
P06151lactate dehydrogenase A(-0.7)
P14152malate dehydrogenase 1, NAD (soluble)(-0.7)
Q8K2B3succinate dehydrogenase complex, subunit A, flavoprotein (Fp)(-0.7)
Q9Z2I8succinate-Coenzyme A ligase, GDP-forming, beta subunit(-0.7)
O88844isocitrate dehydrogenase 1 (NADP+), soluble(-0.6)
P28271aconitase 1(-0.6)
Q9CQB5CDGSH iron sulfur domain 2(-0.6)
Liver: Carbonic anhydrase / one-carbon metabolic process
GO Biological Process:
GO:0006730one-carbon compound metabolic process
Shared Proteins:
O35490betaine-homocysteine methyltransferase(-0.7)
P13634carbonic anhydrase 1(-0.7)
P16015carbonic anhydrase 3(-0.7)
P50247S-adenosylhomocysteine hydrolase(-0.7)
P00375dihydrofolate reductase(-0.6)
P50431serine hydroxymethyltransferase 1 (soluble)(-0.6)
Q8R0Y6aldehyde dehydrogenase 1 family, member L1(-0.6)
Q922D8methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase(-0.6)
P00920carbonic anhydrase 2(-0.5)
Q99JI6RAS related protein 1b(-0.5)
Q91X83methionine adenosyltransferase I, alpha(-0.3)
Liver: Protein transport
GO Biological Process:
GO:0015031protein transport
GO:0045184establishment of protein localization
GO:0033036macromolecule localization
Shared Proteins:
O08547SEC22 vesicle trafficking protein homolog B (S. cerevisiae)(-0.7)
O35643adaptor protein complex AP-1, beta 1 subunit(-0.7)
P17427adaptor protein complex AP-2, alpha 2 subunit(-0.7)
P17563selenium binding protein 1(-0.7)
P62075Null(-0.7)
P62077translocase of inner mitochondrial membrane 8 homolog b (yeast)(-0.7)
Q6PDM2splicing factor, arginine/serine-rich 1 (ASF/SF2)(-0.7)
Q8BUV3gephyrin(-0.7)
Q91X44glucokinase regulatory protein(-0.7)
Q99KF1transmembrane emp24 protein transport domain containing 9(-0.7)
Q9CPQ3translocase of outer mitochondrial membrane 22 homolog (yeast)(-0.7)
Q9D1M0SEC13 homolog (S. cerevisiae)(-0.7)
Q9DCM2glutathione S-transferase kappa 1(-0.7)
Q9QZ88vacuolar protein sorting 29 (S. pombe)(-0.7)
Q9WV98translocase of inner mitochondrial membrane 9 homolog (yeast)(-0.7)
P14211calreticulin(-0.6)
P17426adaptor protein complex AP-2, alpha 1 subunit(-0.6)
P61620Sec61 alpha 1 subunit (S. cerevisiae)(-0.6)
P61967adaptor protein complex AP-1, sigma 1(-0.6)
Q01405SEC23A (S. cerevisiae)(-0.6)
Q61937nucleophosmin 1(-0.6)
Q8CIE6coatomer protein complex subunit alpha(-0.6)
Q9CQS8Sec61 beta subunit(-0.6)
Q9DCW4electron transferring flavoprotein, beta polypeptide(-0.6)
Q9R0Q3transmembrane emp24 domain trafficking protein 2(-0.6)
Q9Z1Z0USO1 homolog, vesicle docking protein (yeast)(-0.6)
O89079coatomer protein complex, subunit epsilon(-0.5)
P35278RAB5C, member RAS oncogene family(-0.5)
P35700peroxiredoxin 1(-0.5)
P38647heat shock protein 9(-0.5)
P51150RAB7, member RAS oncogene family(-0.5)
P61205ADP-ribosylation factor 3(-0.5)
P61924coatomer protein complex, subunit zeta 1(-0.5)
P62259tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide(-0.5)
P70670nascent polypeptide-associated complex alpha polypeptide(-0.5)
Q61335B-cell receptor-associated protein 31(-0.5)
Q8VDD5myosin, heavy polypeptide 9, non-muscle(-0.5)
Q99PL5ribosome binding protein 1(-0.5)
Q9CQV7DnaJ (Hsp40) homolog, subfamily C, member 19(-0.5)
Q9D1D4transmembrane emp24-like trafficking protein 10 (yeast)(-0.5)
O55029coatomer protein complex, subunit beta 2 (beta prime)(-0.4)
P62746ras homolog gene family, member B(-0.4)
P70168karyopherin (importin) beta 1(-0.4)
Q01853valosin containing protein(-0.4)
Q3UPL0Sec31 homolog A (S. cerevisiae)(-0.4)
Q62261spectrin beta 2(-0.4)
Q9CQC9SAR1 gene homolog B (S. cerevisiae)(-0.4)
Q9JIF7coatomer protein complex, subunit beta 1(-0.4)
Q9QZE5coatomer protein complex, subunit gamma(-0.4)
O70492sorting nexin 3(-0.3)
P22892adaptor protein complex AP-1, gamma 1 subunit(-0.3)
P51660hydroxysteroid (17-beta) dehydrogenase 4(-0.3)
P53994RAB2A, member RAS oncogene family(-0.3)
Q3U2P1Sec24 related gene family, member A (S. cerevisiae)(-0.3)
Q61598guanosine diphosphate (GDP) dissociation inhibitor 2(-0.3)
Q91V41RAB14, member RAS oncogene family(-0.3)
Q9DBH5lectin, mannose-binding 2(-0.3)
Q9WU78programmed cell death 6 interacting protein(-0.3)
Liver: RAS oncogene family
GO Biological Process:
GO:0007264small GTPase mediated signal transduction
Shared Proteins:
P14685proteasome (prosome, macropain) 26S subunit, non-ATPase, 3(-0.5)
P35278RAB5C, member RAS oncogene family(-0.5)
P61205ADP-ribosylation factor 3(-0.5)
Q99JI6RAS related protein 1b(-0.5)
Q9CQW2ADP-ribosylation factor-like 8B(-0.5)
P32883v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(-0.4)
P62746ras homolog gene family, member B(-0.4)
Q9CQC9SAR1 gene homolog B (S. cerevisiae)(-0.4)
P53994RAB2A, member RAS oncogene family(-0.3)
P60766cell division cycle 42 homolog (S. cerevisiae)(-0.3)
Q61598guanosine diphosphate (GDP) dissociation inhibitor 2(-0.3)
Q91V41RAB14, member RAS oncogene family(-0.3)
Q9QUI0ras homolog gene family, member A(-0.3)
P61211ADP-ribosylation factor-like 1(-0.2)
P61750ADP-ribosylation factor 4(-0.2)
Q8CG50RAB43, member RAS oncogene family(-0.2)
Q9D1G1RAB1B, member RAS oncogene family(-0.2)
Liver: Peroxisome
GO Cellular Component:
GO:0005777peroxisome
GO:0042579microbody
Shared Proteins:
O35459enoyl coenzyme A hydratase 1, peroxisomal(-0.5)
O35488solute carrier family 27 (fatty acid transporter), member 2(-0.5)
P55096ATP-binding cassette, sub-family D (ALD), member 3(-0.5)
Q9QXE02-hydroxyacyl-CoA lyase 1(-0.5)
Q9WV682-4-dienoyl-Coenzyme A reductase 2, peroxisomal(-0.5)
Q9Z211peroxisomal biogenesis factor 11 alpha(-0.5)
P25688urate oxidase(-0.4)
Q80XL6acyl-Coenzyme A dehydrogenase family, member 11(-0.4)
Q921H8acetyl-Coenzyme A acyltransferase 1A(-0.4)
Q99LC9peroxisomal biogenesis factor 6(-0.4)
Q9D826pipecolic acid oxidase(-0.4)
Q9DBM2enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase(-0.4)
Q9QXD1acyl-Coenzyme A oxidase 2, branched chain(-0.4)
P51660hydroxysteroid (17-beta) dehydrogenase 4(-0.3)
Q8JZR0acyl-CoA synthetase long-chain family member 5(-0.3)
Q91X34bile acid-Coenzyme A: amino acid N-acyltransferase(-0.3)
Q99P30nudix (nucleoside diphosphate linked moiety X)-type motif 7(-0.3)
Q9WU19hydroxyacid oxidase 1, liver(-0.3)
P32020sterol carrier protein 2, liver(-0.2)
Q8VCH0Null(-0.2)
P24270catalase(-0.1)
Q9DC50carnitine O-octanoyltransferase(0.0)
Liver: Endoplasmic reticulum
GO Cellular Component:
GO:0005783endoplasmic reticulum
Shared Proteins:
O08547SEC22 vesicle trafficking protein homolog B (S. cerevisiae)(-0.7)
Q91VS7microsomal glutathione S-transferase 1(-0.7)
Q922R8protein disulfide isomerase associated 6(-0.7)
Q99KF1transmembrane emp24 protein transport domain containing 9(-0.7)
Q9Z247FK506 binding protein 9(-0.7)
O88962cytochrome P450, family 8, subfamily b, polypeptide 1(-0.6)
P11714cytochrome P450, family 2, subfamily d, polypeptide 9(-0.6)
P14211calreticulin(-0.6)
P24369peptidylprolyl isomerase B(-0.6)
P56395cytochrome b-5(-0.6)
P61620Sec61 alpha 1 subunit (S. cerevisiae)(-0.6)
Q01405SEC23A (S. cerevisiae)(-0.6)
Q62452UDP glucuronosyltransferase 1 family, polypeptide A9(-0.6)
Q64435UDP glucuronosyltransferase 1 family, polypeptide A6A(-0.6)
Q6P5E4UDP-glucose glycoprotein glucosyltransferase 1(-0.6)
Q8BHN3alpha glucosidase 2 alpha neutral subunit(-0.6)
Q8BSY0aspartate-beta-hydroxylase(-0.6)
Q8CIE6coatomer protein complex subunit alpha(-0.6)
Q924Z4LAG1 homolog, ceramide synthase 2(-0.6)
Q9CQS8Sec61 beta subunit(-0.6)
Q9CRC0vitamin K epoxide reductase complex, subunit 1(-0.6)
Q9QXT0canopy 2 homolog (zebrafish)(-0.6)
O08601microsomal triglyceride transfer protein(-0.5)
O08795protein kinase C substrate 80K-H(-0.5)
O35488solute carrier family 27 (fatty acid transporter), member 2(-0.5)
O54749cytochrome P450, family 2, subfamily j, polypeptide 5(-0.5)
O88451retinol dehydrogenase 7(-0.5)
O89079coatomer protein complex, subunit epsilon(-0.5)
P08003protein disulfide isomerase associated 4(-0.5)
P08113heat shock protein 90, beta (Grp94), member 1(-0.5)
P09103prolyl 4-hydroxylase, beta polypeptide(-0.5)
P20029heat shock protein 5(-0.5)
P27773protein disulfide isomerase associated 3(-0.5)
P35576glucose-6-phosphatase, catalytic(-0.5)
P37040P450 (cytochrome) oxidoreductase(-0.5)
P41216acyl-CoA synthetase long-chain family member 1(-0.5)
P47740aldehyde dehydrogenase family 3, subfamily A2(-0.5)
P50172hydroxysteroid 11-beta dehydrogenase 1(-0.5)
P50285flavin containing monooxygenase 1(-0.5)
P61924coatomer protein complex, subunit zeta 1(-0.5)
P97872flavin containing monooxygenase 5(-0.5)
Q60991cytochrome P450, family 7, subfamily b, polypeptide 1(-0.5)
Q61335B-cell receptor-associated protein 31(-0.5)
Q63886UDP glucuronosyltransferase 1 family, polypeptide A1(-0.5)
Q8VCC2carboxylesterase 1(-0.5)
Q8VCT4carboxylesterase 3(-0.5)
Q8VCU1predicted gene 4738(-0.5)
Q99P27phospholipase A2, group XIIB(-0.5)
Q99PL5ribosome binding protein 1(-0.5)
Q9CXE7transmembrane emp24 protein transport domain containing 5(-0.5)
Q9DCN2cytochrome b5 reductase 3(-0.5)
Q9JIZ0camello-like 1(-0.5)
Q9JKR6hypoxia up-regulated 1(-0.5)
O08914fatty acid amide hydrolase(-0.4)
O55022progesterone receptor membrane component 1(-0.4)
O55029coatomer protein complex, subunit beta 2 (beta prime)(-0.4)
O55143ATPase, Ca++ transporting, cardiac muscle, slow twitch 2(-0.4)
O55242sigma non-opioid intracellular receptor 1(-0.4)
O70503hydroxysteroid (17-beta) dehydrogenase 12(-0.4)
P17717UDP glucuronosyltransferase 2 family, polypeptide B5(-0.4)
P35564calnexin(-0.4)
P56565S100 calcium binding protein A1(-0.4)
Q01853valosin containing protein(-0.4)
Q3UPL0Sec31 homolog A (S. cerevisiae)(-0.4)
Q63880esterase 31(-0.4)
Q64310surfeit gene 4(-0.4)
Q6XVG2cytochrome P450, family 2, subfamily c, polypeptide 54(-0.4)
Q8CFX1hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)(-0.4)
Q8K3K71-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)(-0.4)
Q91WL5cytochrome P450, family 4, subfamily a, polypeptide 12a(-0.4)
Q99L04dehydrogenase/reductase (SDR family) member 1(-0.4)
Q99PG0arylacetamide deacetylase (esterase)(-0.4)
Q9CQC9SAR1 gene homolog B (S. cerevisiae)(-0.4)
Q9D1Q6endoplasmic reticulum protein 44(-0.4)
Q9D379epoxide hydrolase 1, microsomal(-0.4)
Q9EQH2endoplasmic reticulum aminopeptidase 1(-0.4)
Q9EQU5SET translocation(-0.4)
Q9ES97reticulon 3(-0.4)
Q9JIF7coatomer protein complex, subunit beta 1(-0.4)
Q9QZE5coatomer protein complex, subunit gamma(-0.4)
Q9R092hydroxysteroid (17-beta) dehydrogenase 6(-0.4)
Q9WUU7cathepsin Z(-0.4)
P45878FK506 binding protein 2(-0.3)
P494294-hydroxyphenylpyruvic acid dioxygenase(-0.3)
P53994RAB2A, member RAS oncogene family(-0.3)
Q3U2P1Sec24 related gene family, member A (S. cerevisiae)(-0.3)
Q4LDG0solute carrier family 27 (fatty acid transporter), member 5(-0.3)
Q8JZR0acyl-CoA synthetase long-chain family member 5(-0.3)
Q91W90thioredoxin domain containing 5(-0.3)
Q9CY27trans-2,3-enoyl-CoA reductase(-0.3)
P12815programmed cell death 6(-0.2)
P24456cytochrome P450, family 2, subfamily d, polypeptide 10(-0.2)
P56654cytochrome P450, family 2. subfamily c, polypeptide 37(-0.2)
P58710gulonolactone (L-) oxidase(-0.2)
Q64176esterase 22(-0.2)
Q64458cytochrome P450, family 2, subfamily c, polypeptide 29(-0.2)
Q8CHQ9camello-like 2(-0.2)
Q9JLJ4elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2(-0.2)
P33267cytochrome P450, family 2, subfamily f, polypeptide 2(-0.1)
P56593cytochrome P450, family 2, subfamily a, polypeptide 12(-0.1)
P56656cytochrome P450, family 2, subfamily c, polypeptide 39(-0.1)
Q5YD48APOBEC1 complementation factor(-0.1)
Q8K5B2multiple coagulation factor deficiency 2(-0.1)
Q8CIM7cytochrome P450, family 2, subfamily d, polypeptide 26(0.0)
Q921L3transmembrane and coiled-coil domains 1(0.0)
Liver: Serine peptidase inhibitors (SERPINA)
GO Molecular Function:
GO:0004866endopeptidase inhibitor activity
GO:0030414protease inhibitor activity
GO Biological Process:
GO:0002526acute inflammatory response
GO:0009611response to wounding
GO:0009605response to external stimulus
Shared Proteins:
P01027complement component 3(-0.2)
P01029Null(-0.1)
P22599serine (or cysteine) peptidase inhibitor, clade A, member 1B(-0.1)
Q00896serine (or cysteine) peptidase inhibitor, clade A, member 1C(0.0)
Liver: Lipid transport
GO Biological Process:
GO:0006869lipid transport
Shared Proteins:
P32020sterol carrier protein 2, liver(-0.2)
Q8VDJ3high density lipoprotein (HDL) binding protein(-0.2)
Q00623apolipoprotein A-I(0.0)
Q9DC50carnitine O-octanoyltransferase(0.0)
Q5QNQ6oxysterol binding protein 2(0.1)
Q9EPQ7StAR-related lipid transfer (START) domain containing 5(0.2)
P09813apolipoprotein A-II(0.4)
Liver: Extracellular region
GO Cellular Component:
GO:0005576extracellular region
Shared Proteins:
P01027complement component 3(-0.2)
Q11011aminopeptidase puromycin sensitive(-0.2)
Q64176esterase 22(-0.2)
Q64458cytochrome P450, family 2, subfamily c, polypeptide 29(-0.2)
Q8CHQ9camello-like 2(-0.2)
Q9CQN1TNF receptor-associated protein 1(-0.2)
P01029Null(-0.1)
P15116cadherin 2(-0.1)
P28665murinoglobulin 1(-0.1)
P33267cytochrome P450, family 2, subfamily f, polypeptide 2(-0.1)
P56593cytochrome P450, family 2, subfamily a, polypeptide 12(-0.1)
P63028tumor protein, translationally-controlled 1(-0.1)
Q61207prosaposin(-0.1)
Q8K5B2multiple coagulation factor deficiency 2(-0.1)
P11276fibronectin 1(0.0)
Q00623apolipoprotein A-I(0.0)
Q8K0E8fibrinogen beta chain(0.0)
Q921I1transferrin(0.0)
P00186cytochrome P450, family 1, subfamily a, polypeptide 2(0.1)
P04186complement factor B(0.1)
P56657cytochrome P450, family 2, subfamily c, polypeptide 40(0.1)
Q61147ceruloplasmin(0.1)
P23953esterase 1(0.2)
Q8VCM7fibrinogen gamma chain(0.2)
P39039mannose-binding lectin (protein A) 1(0.3)
P09813apolipoprotein A-II(0.4)
P01887beta-2 microglobulin(0.5)
P20918plasminogen(0.5)
Q9EP75cytochrome P450, family 4, subfamily f, polypeptide 14(0.5)
Liver: MHC proteins
GO Cellular Component:
GO:0042611MHC protein complex
GO:0042612MHC class I protein complex
Shared Proteins:
P01897histocompatibility 2, D region(0.4)
P01887beta-2 microglobulin(0.5)
Liver: Chylomicron
GO Cellular Component:
GO:0042627chylomicron
Shared Proteins:
P33622apolipoprotein C-III(0.6)
P06728apolipoprotein A-IV(1.0)
Liver: Enzyme linked receptors
GO Biological Process:
GO:0007167enzyme linked receptor protein signaling pathway
Shared Proteins:
Q01279epidermal growth factor receptor(0.6)
P29699alpha-2-HS-glycoprotein(0.7)
Q8VCC1hydroxyprostaglandin dehydrogenase 15 (NAD)(0.9)
Brain: Myelin Sheath
GO Cellular Component:
GO:0043209myelin sheath
GO Biological Process:
GO:0007272ensheathment of neurons
GO:0008366axon ensheathment
GO:0042552myelination
GO:0001508regulation of action potential
Shared Proteins:
P04370myelin basic protein(-2.6)
P60202proteolipid protein (myelin) 1(-2.6)
Brain: Nucleosome
GO Cellular Component:
GO:0000786nucleosome
GO Biological Process:
GO:0006334nucleosome assembly
Shared Proteins:
P10853histone cluster 1, H2bf(-2.5)
P62806histone cluster 1, H4a(-2.5)
Brain: Neurofilament
GO Cellular Component:
GO:0005883neurofilament
Shared Proteins:
P08551neurofilament, light polypeptide(-2.0)
P08553neurofilament, medium polypeptide(-2.0)
P46660internexin neuronal intermediate filament protein, alpha(-1.9)
P19246neurofilament, heavy polypeptide(-1.7)
Brain: ATP synthase
GO Cellular Component:
GO:0045259proton-transporting ATP synthase complex
GO Molecular Function:
GO:0017111nucleoside-triphosphatase activity
Shared Proteins:
Q91VR2ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1(-1.9)
P56480ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit(-1.8)
Q9CQQ7ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1(-1.8)
Q03265ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1(-1.7)
Q9CPQ8ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g(-1.7)
Q9DB20ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit(-1.7)
Q9DCX2ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d(-1.5)
Brain: Mitochondrial porin
GO Molecular Function:
GO:0015288porin activity
GO:0022829wide pore channel activity
Shared Proteins:
Q60931voltage-dependent anion channel 3(-1.8)
Q60932voltage-dependent anion channel 1(-1.8)
Q60930voltage-dependent anion channel 2(-1.7)
P55088aquaporin 4(-1.5)
Brain: Cytochrome C oxidase
GO Molecular Function:
GO:0004129cytochrome-c oxidase activity
GO:0015002heme-copper terminal oxidase activity
GO:0016675oxidoreductase activity, acting on heme group of donors
GO:0016676oxidoreductase activity, acting on heme group of donors, oxygen as acceptor
Shared Proteins:
P19536cytochrome c oxidase, subunit Vb(-1.7)
P19783cytochrome c oxidase subunit IV isoform 1(-1.7)
P12787cytochrome c oxidase, subunit Va(-1.6)
Q9CPQ1cytochrome c oxidase, subunit VIc(-1.6)
P00405mitochondrially encoded cytochrome c oxidase II(-1.5)
P43024cytochrome c oxidase, subunit VI a, polypeptide 1(-1.5)
Brain: NADH dehydrogenase
GO Molecular Function:
GO:0051536iron-sulfur cluster binding
GO:0051540metal cluster binding
GO:00515394 iron, 4 sulfur cluster binding
Shared Proteins:
Q8K3J1NADH dehydrogenase (ubiquinone) Fe-S protein 8(-1.7)
Q99KI0aconitase 2, mitochondrial(-1.6)
Q91VD9NADH dehydrogenase (ubiquinone) Fe-S protein 1(-1.5)
Q91YT0NADH dehydrogenase (ubiquinone) flavoprotein 1(-1.5)
Q9CQA3succinate dehydrogenase complex, subunit B, iron sulfur (Ip)(-1.5)
Q91WD5NADH dehydrogenase (ubiquinone) Fe-S protein 2(-1.3)
Q9DC70NADH dehydrogenase (ubiquinone) Fe-S protein 7(-1.3)
Brain: Ribosome
GO Cellular Component:
GO:0015935small ribosomal subunit
GO:0005830cytosolic ribosome (sensu Eukaryota)
GO:0033279ribosomal subunit
GO:0005840ribosome
GO:0044445cytosolic part
GO:0030529ribonucleoprotein complex
GO Molecular Function:
GO:0003735structural constituent of ribosome
GO:0005198structural molecule activity
GO Biological Process:
GO:0042254ribosome biogenesis and assembly
Shared Proteins:
P62702ribosomal protein S4, X-linked(-1.4)
P14131ribosomal protein S16(-1.3)
P62849ribosomal protein S24(-1.3)
Q9CZX8ribosomal protein S19(-1.3)
P62264ribosomal protein S14(-1.2)
P97461ribosomal protein S5(-1.2)
P62082ribosomal protein S7(-1.1)
P62843ribosomal protein S15(-1.1)
Brain: Actin cytoskeleton
GO Biological Process:
GO:0030036actin cytoskeleton organization and biogenesis
Shared Proteins:
P63001RAS-related C3 botulinum substrate 1(-1.5)
Q7TPR4actinin, alpha 1(-1.5)
Q9D898actin related protein 2/3 complex, subunit 5-like(-1.5)
P16546spectrin alpha 2(-1.4)
P59999actin related protein 2/3 complex, subunit 4(-1.4)
P63260actin, gamma, cytoplasmic 1(-1.4)
P13020gelsolin(-1.3)
P62331ADP-ribosylation factor 6(-1.3)
Q62261spectrin beta 2(-1.3)
Q9CVB6actin related protein 2/3 complex, subunit 2(-1.3)
Q9QUI0ras homolog gene family, member A(-1.3)
P15508spectrin beta 1(-1.2)
P26039talin 1(-1.2)
P60766cell division cycle 42 homolog (S. cerevisiae)(-1.2)
P62962profilin 1(-1.2)
Q811D0discs, large homolog 1 (Drosophila)(-1.2)
Q9JJV2profilin 2(-1.2)
Q9JM76actin related protein 2/3 complex, subunit 3(-1.2)
Q9QXS6drebrin 1(-1.2)
Q9R0Q6actin related protein 2/3 complex, subunit 1A(-1.2)
Q9Z2H5erythrocyte protein band 4.1-like 1(-1.2)
O70318erythrocyte protein band 4.1-like 2(-1.1)
P28660NCK-associated protein 1(-1.1)
P40124CAP, adenylate cyclase-associated protein 1 (yeast)(-1.1)
P57780actinin alpha 4(-1.1)
P70336Rho-associated coiled-coil containing protein kinase 2(-1.1)
Q9R0P5destrin(-1.1)
P47754capping protein (actin filament) muscle Z-line, alpha 2(-1.0)
Q61879myosin, heavy polypeptide 10, non-muscle(-1.0)
Brain: Membrane organization and biogenesis
GO Biological Process:
GO:0016044membrane organization and biogenesis
Shared Proteins:
P63001RAS-related C3 botulinum substrate 1(-1.5)
Q61548synaptosomal-associated protein 91(-1.5)
Q62277synaptophysin(-1.5)
O08539bridging integrator 1(-1.4)
P08228superoxide dismutase 1, soluble(-1.4)
Q62420SH3-domain GRB2-like 2(-1.4)
Q7TQF7amphiphysin(-1.4)
P17426adaptor protein complex AP-2, alpha 1 subunit(-1.3)
P17427adaptor protein complex AP-2, alpha 2 subunit(-1.3)
P39054dynamin 2(-1.3)
P63044vesicle-associated membrane protein 2(-1.3)
Q61644protein kinase C and casein kinase substrate in neurons 1(-1.3)
Q62108discs, large homolog 4 (Drosophila)(-1.3)
Q9CQD1RAB5A, member RAS oncogene family(-1.3)
P22892adaptor protein complex AP-1, gamma 1 subunit(-1.2)
P63011RAB3A, member RAS oncogene family(-1.2)
Q03157amyloid beta (A4) precursor-like protein 1(-1.2)
O35643adaptor protein complex AP-1, beta 1 subunit(-1.1)
P39053dynamin 1(-1.1)
P40124CAP, adenylate cyclase-associated protein 1 (yeast)(-1.1)
P57780actinin alpha 4(-1.1)
P58281optic atrophy 1 homolog (human)(-1.1)
P61021RAB5B, member RAS oncogene family(-1.1)
Q8BVE3ATPase, H+ transporting, lysosomal V1 subunit H(-1.1)
Q8CHC4synaptojanin 1(-1.1)
O88531palmitoyl-protein thioesterase 1(-1.0)
P84086complexin 2(-1.0)
Q4KUS2unc-13 homolog A (C. elegans)(-1.0)
Q61879myosin, heavy polypeptide 10, non-muscle(-1.0)
Brain: Proteasome
GO Cellular Component:
GO:0005839proteasome core complex (sensu Eukaryota)
GO:0000502proteasome complex (sensu Eukaryota)
GO:0005829cytosol
GO Molecular Function:
GO:0004298threonine endopeptidase activity
Shared Proteins:
Q9R1P4proteasome (prosome, macropain) subunit, alpha type 1(-1.2)
O55234proteasome (prosome, macropain) subunit, beta type 5(-1.1)
Q60692proteasome (prosome, macropain) subunit, beta type 6(-1.1)
Q9R1P0proteasome (prosome, macropain) subunit, alpha type 4(-1.1)
Q9Z2U0proteasome (prosome, macropain) subunit, alpha type 7(-1.1)
O09061proteasome (prosome, macropain) subunit, beta type 1(-1.0)
O70435proteasome (prosome, macropain) subunit, alpha type 3(-1.0)
P49722proteasome (prosome, macropain) subunit, alpha type 2(-1.0)
P70195proteasome (prosome, macropain) subunit, beta type 7(-1.0)
P99026proteasome (prosome, macropain) subunit, beta type 4(-1.0)
Q9R1P3proteasome (prosome, macropain) subunit, beta type 2(-1.0)
Q9Z2U1proteasome (prosome, macropain) subunit, alpha type 5(-1.0)
Brain: Cell cycle process
GO Biological Process:
GO:0022402cell cycle process
Shared Proteins:
P42669purine rich element binding protein A(-1.2)
P62746ras homolog gene family, member B(-1.2)
Q811D0discs, large homolog 1 (Drosophila)(-1.2)
P11798calcium/calmodulin-dependent protein kinase II alpha(-1.1)
P34022RAN binding protein 1(-1.1)
P62827RAN, member RAS oncogene family(-1.1)
P63328protein phosphatase 3, catalytic subunit, alpha isoform(-1.1)
Q6PER3microtubule-associated protein, RP/EB family, member 3(-1.1)
Q8R5M8cell adhesion molecule 1(-1.1)
Q9R0Y5adenylate kinase 1(-1.1)
P28652calcium/calmodulin-dependent protein kinase II, beta(-1.0)
P63005platelet-activating factor acetylhydrolase, isoform 1b, subunit 1(-1.0)
P63017Null(-1.0)
Q61879myosin, heavy polypeptide 10, non-muscle(-1.0)
Q80TV8CLIP associating protein 1(-1.0)
Q80U28MAP-kinase activating death domain(-1.0)
Q8R001microtubule-associated protein, RP/EB family, member 2(-1.0)
Q8VDD5myosin, heavy polypeptide 9, non-muscle(-1.0)
Q923T9calcium/calmodulin-dependent protein kinase II gamma(-1.0)
P14211calreticulin(-0.9)
Q8R464cell adhesion molecule 4(-0.9)
Q8VDM4proteasome (prosome, macropain) 26S subunit, non-ATPase, 2(-0.9)
Q9QXZ0microtubule-actin crosslinking factor 1(-0.9)
Q9WV60glycogen synthase kinase 3 beta(-0.9)
P54227stathmin 1(-0.8)
P63330protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform(-0.8)
P68510tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide(-0.8)