MCB 7200 Reading List - Fall 2016

MCB 7200 Reading List - Fall 2016

Frank Horodyski

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Chromatin Structure

Lodish Ch. 8, pp. 301-302, 327-347

Ch. 9, pp. 373-374

Zhou, V.W., Goren, A. and Bernstein, B.E. (2011). Charting histone modifications and the functional organization of mammalian genomes. Nature Rev.Genet.12,7-18.

Venkatesh,S. and Workman,J.W. (2015). Histone exchange, chromatin structure and the regulation of transcription. Nature Rev.Mol.Cell Biol. 16, 178-189.

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Heterochromatin

Lodish, Ch. 9, pp. 390-395, 404-405

Grewal, S.I.S.and Jia, S. (2007). Heterochromatin revisited. Nature Rev.Genet.8, 35-46.

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Epigenetics

Lodish Ch. 9, pp. 406-411

Johnstone, S.E. and Baylin, S.B. (2010). Stress and the epigenetic landscape: a link to the pathobiology of human diseases? Nature Rev.Genet.11, 806-812.

Margueron, R. and Reinberg, D. (2010). Chromatin structure and the inheritance of epigenetic information. Nature Rev.Genet.11, 285-296.

Bantignies, F. and Cavalli, G. (2011). Polycomb group proteins: repression in 3D. Trends Genet.27, 454-464.

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Imprinting and Dosage Compensation

Lee, J.T. (2012). Epigenetic regulation by long noncoding RNAs. Science338, 1435-1539.

Paters, J. (2015). The role of genomic imprinting in biology and disease: an expanding view. Nature Rev.Genet. 15, 517-530.

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DNA Replication

Lodish Ch. 5, pp.167-176, 197-203

Ch. 8, pp. 347-349

Ch. 19, pp. 892-895

Ch. 24, pp.1139-1140

Alabert, C. and Groth, A. (2012). Chromatin replication and epigenome maintenance. Nature Rev.Mol.Cell Biol.13, 153-167.

Martinez, P. and Blasco, M.A. (2015). Replicating through telomeres: a means to an end. Trends Biochem.Sci.40, 504-515.

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Mutation-DNA Repair

Lodish Ch. 5, pp. 203-212

Ch. 24, pp.1143-1145, 1166-1168

Lindahl, T. (1993). Instability and decay of the primary structure of DNA. Nature362, 709-715.

Marteijn, J.A., Lans, H., Vermeulen, W. and Hoeijmakers, J.H.J.(2014). Understanding nucleotide excision repair and its roles in cancer and ageing. Nature Rev.Mol.Cell Biol.15, 465-481.

Panier, S. and Boulton, S.J. (2014). Double-strand break repair: 53BP1 comes into focus. Nature Rev.Mol.Cell Biol.15, 7-18.

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Posttranscriptional Gene Silencing/Biological Roles of microRNAs

Lodish Ch. 6, pp. 264-268

Ch. 10, pp. 447-451

Ch. 21, pp. 981-984

Ch. 24, pp. 1155-1156

Huntzinger, E. and Izaurralde, E. (2011).Gene silencing by microRNAs: contributions of translational repression and mRNA decay.Nature Rev.Genet.12,99-110.

Thornton, J.E. and Gregory, R.I. (2012). How does Lin28 let-7 control development and disease? Trends Cell Biol.22, 474-482

tenOever, B.R. (2013). RNA viruses and the host microRNA machinery. Nature Rev.Microbiol. 11, 169-180.

Barrangou, R. and Marraffini, L.A. (2014). CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity. Mol.Cell54, 234-244.

Gantz, V.M. and Bier, E. (2015). The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations. Science348, 442-444.

Komor, A.C., Kim, Y.B., Packer, M.S., Zuris, J.A. and Liu, D.R. (2016). Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 533, 420-424.(student presentation) (1)

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Recombination and Transposition (student presentations)

Lodish Ch. 8, pp. 312-323

Ch. 23, pp. 1095-1103

Student Presentations:

Mechanism of Homologous Recombination (2)

Immunoglobulin Gene Rearrangement (3)

Transposons and Mechanisms of Transposition (4)