C.V. of Lui Chi Hang, Vincent

Curriculum Vitae

Name:Dr. Vincent Chi Hang Lui

Date of Birth: 17th Sept., 1964

Address:Department of Surgery, The University of Hong Kong. L9-56, Faculty of MedicineBuilding, 21 Sassoon Road, Pokfulam, Hong Kong.

Tel/mobile/Fax:28199607/97770545/28199621

Email:

Academic Qualifications

1987B.Sc. (First Class Honours) in Biochemistry, University of Leeds, UK

1995Ph.D. Department of Biochemistry, University of Hong Kong

Academic Appointments

  1. Associate Professor (non-clinical) at the Department of Surgery, University of Hong Kong, Hong Kong (June 2009-present)
  2. Assistant Professor (non-clinical) at the Department of Surgery, University of Hong Kong, Hong Kong (2001-June 2009)
  3. Research Assistant Professor at the Department of Surgery, University of Hong Kong, Hong Kong (1998-2000)
  4. Postdoctoral Fellow at the Department of Cell Biology and Genetics, ErasmusUniversity, Rotterdam, The Netherlands (1995-1998)
  5. Postdoctoral Fellow at the Department of Biochemistry, University of Hong Kong, Hong Kong (1994-1995)

Other Appointment/Membership:

1Honorary Research Assistant Professor, Department of Biochemistry, University of Hong Kong (1999-present)

2Associate Member of the Center of Development and Birth Defects, University of Hong Kong, Hong Kong (1999-present)

3Secretary for the Hong Kong Society for Developmental Biology (HKSDB) (2006-Aug 2013)

4Departmental Radiation Safety Representative, Department of Surgery, University of Hong Kong (2000-present)

5Member of Department Research Postgraduate Committee, Department of Surgery, University of Hong Kong (1999-present)

6Member of Department Research Committee, Department of Surgery, University of Hong Kong (1999-present)

7Chairman, Department Laboratory Management Committee, Department of Surgery, University of Hong Kong (2008-present)

8Selection Committee of the Medical Load Funds, LKS Faculty of Medicine, HKU. (January 31 2011-January 5, 2014)

9中国卫生部小儿先天畸形重点实验室学术委员会委员, 中国医科大学, 沈阳(April 2010-present)

10Department Representative for Faculty Health & Safety Committee, HKU

11Department Representativefor the University Biosafety Committee, HKU

12Member of the Committee of Management of the University of Hong Kong/China Medical Board Grants (Nov 1, 2013-Oct 31, 2016)

Journal Reviewer:

  1. Development
  2. Developmental Biology
  3. Mechanisms of Development
  4. Developmental Dynamics
  5. PLOS ONE
  6. Genesis
  7. Journal of Pediatric Surgery
  8. Pediatric Surgery International
  9. Oncogene
  10. Genesis The Journal of Genetics and Development

Award/Scholarship

1Tetley & Lupton Scholarship, University of Leeds, UK (1984-1987)

2Croucher Foundation Scholarship, Hong Kong (1988-1991)

Research Areas
  1. Development biology of neural crest cells
  2. Neural crest cell associated developmental anomalies
  3. Molecular and developmental genetics of developmental anomalies
Supervision of students

Ph.D. (Supervisor)

Fu Ming (Dept. of Surgery, Date of graduation: July 2004)

Lee King Yiu (Dept. of Surgery, Date of graduation: Feb 2005)

Cheng Wai Chun, William (Dept. of Surgery, Date of graduation: March 2008)

Poon Hiu Ching, Tracy (Dept. of Surgery, Date of graduation: Feb 2009)

Kam Ka Man, Mandy (Dept. of Surgery, Date of graduation: Dec 2011)

Ng Chun Laam, Roy (Dept. of Surgery, Date of graduation: Sept 2012)

Zhu Jiang (Dept. of Surgery, Date of graduation: Dec 2012)

Qian Chen (Dept. of Surgery, Date of registration: Sep 2013)

M.Phil. (Supervisor)

Kam Ka Man, Mandy (Dept. of Surgery, Date of graduation: Oct 2008)

Zhu Jiang (Dept. of Surgery, Date of graduation: Dec 2009)

Ho Sze Hang, Angus (Dept. of Surgery, Date of registration: Sept 2012)

Ph.D. (Co-supervisor)

Law Man Lee (Dept. of Biochemistry, Date of graduation: Dec 2006)

M.Phil. (Co-supervisor)

Li Zhao Li, Amy (Dept. of Surgery, Date of graduation: Oct 2004)

Lau Ko Chun, Danny (Dept. of Surgery, Date of graduation: Nov 2006)

Sit Yu Lam, Francesco (Dept. of Surgery, Date of graduation: Sept 2007)

MRes[Med] (Co-supervisor)

Miss TANG Wai Kiu (Dept. of Surgery, Date of graduation: 2012)

Publications (Citation: from Scopus; latest update: Nov 2011)

  1. Kimura, T., Cheah, K.S.E., Chan, S.D., Lui, V.C.H., Mattei, M.G., van der Rest, M., Ono, K., Solomon, E., Ninomiya, Y. and Olsen, B.R. (1989) The human alpha 2(XI) collagen (COL11A2) chain. Molecular cloning of cDNA and genomic DNA reveals characteristics of a fibrillar collagen with differences in genomic organization. J Biol Chem 264(23): 13910-13916. (I.F. 7.258) (Times cited: 35)
  1. Hanson, I.M., Gorman, P., Lui, V.C.H., Cheah, K.S.E., Solomon, E. and Trowsdale, J. (1989) The human alpha 2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6. Genomics 5(4): 925-931. (I.F. 3.148)(Times cited: 14)
  1. Cheah, K.S.E., Pui, M.S., Lui, V.C.H., Wong, L., Hsu, L.C.S., Pun, K.K., Priestley, L.M., and Skyes, B.C. (1990) An EcoRI RFLP in the human alpha 2 (XI) (COL11A2) gene. Nucl Acids Res 18(2): 387. (I.F. 5.396) (Times cited: 1)
  1. Cheah, K.S.E., Lui, V.C.H., Yu, E.C.L. and Hsu, L.C.S. (1990) A stuI RFLP in the human COL11A2 gene. Nucl Acids Res 18(16): 4964. (I.F. 5.396) (Times cited: 1)
  1. Stubbs, L., Lui, V.C.H., Ng, L.J. and Chean, K.S.E. (1993) The alpha 2(XI) collagen gene lies within 8 kb of Pb in the proximal portion of the murine major histocompatibility complex. Mamm Genome 4(2): 95-103. (I.F. 2.137) (Times cited: 4)
  1. Lui, V.C.H., Kong, R.Y.C., Nicholas, J., Cheung, A.N.Y. and Cheah, K.S.E. (1995) The mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: implications for homotrimeric, heterotrimeric and heterotypic collagen molecules. Biochem J 311(2): 511-516. (I.F. 4.28) (Times cited: 29)
  1. Lui, V.C.H., Ng, L.J., Nicholas, J., Tam, P.P.L. and Cheah, K.S.E. (1995) Tissue-specific and differential expression of alternatively spliced alpha 1(II) collagen mRNAs in early human embryos. Dev Dyn 203(2): 198-211. (I.F. 3.8) (Times cited: 67)
  1. Vikulla, M., Mariman, E.C.M., Lui, V.C.H., Zhidkova, N.I., Tiller, G.E., Goldring, M.B., van Beersum, S.E.C., de Waal Malefitj, M.C., van der Hoogen, F.H.J., Ropers, H-H., Mayne, R., Cheah, K.S.E. and Olsen, B.R. (1995) Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus. Cell 80(3): 431-437. (I.F. 32.44) (Times cited: 218)
  1. Lui, V.C.H., Ng, L.J., Sat, E.W.Y., Nicholas, J. and Cheah, K.S.E. (1996) Extensive alternative splicing within the amino-propeptide coding domain of alpha2(XI) procollagen mRNAs. Expression of transcripts encoding truncated pro-alpha chains. J Biol Chem 271(28): 16945-16951. (I.F. 7.258) (Times cited: 10)
  1. Lui, V.C.H., Ng, L.J., Sat, E.W. and Cheah, K.S.E. (1996) The human alpha 2(XI) collagen gene (COL11A2): completion of coding information, identification of the promoter sequence, and precise localization within the major histocompatibility complex reveal overlap with the KE5 gene. Genomics 32(3): 401-412. (I.F. 3.418) (Times cited: 14)
  1. Samy, E.T., Sham, M.H., Tam, P.K.H. and Lui, V.C.H. (2000) Identification of 3’ splicing variants of receptor kinase encoding gene RET in mouse and expression study of RET splicing variants in developing mouse embryo. Cell Biology International 24(12): 968. (I.F. 1.017)

12.Lui, V.C.H., Li, L., Sham, M.H. and Tam, P.K.H. (2001) CDX-1 and CDX-2 are expressed in human colonic mucosa and are down-regulated in patients with Hirschsprung's disease associated enterocolitis. Biochim Biophys Acta-Mol Basis Dis 1537(2): 89-100. (I.F. 3.298) (Times cited: 11)

  1. Cheng, W., Lui, V.C.H., Chen, Q.M. and Tam, P.K.H. (2001) Enteric nervous system, interstitial cells of cajal, and smooth muscle vacuolization in segmental dilatation of jejunum. J Pediatr Surg36(6): 930-935.(I.F. 1.304) (Times cited: 10)
  1. Sham, M.H., Lui, V.C.H., Fu. M., Chen, B. and Tam, P.K.H. (2001) SOX10 is abnormally expressed in aganglionic bowel of Hirschsprung's disease infants. Gut 49(2): 220-226. (I.F. 9.002) (Times cited: 13)
  1. Sham, M.H., Lui, V.C.H., Chen, B., Fu, M. and Tam, P.K.H. (2001) Novel mutations of SOX10 suggest a dominant negative role in Waardenburg-Shah syndrome. J Med Genet38(9): E30. (I.F. 7.774)(Times cited: 23)
  1. Lui V.C.H., Samy E.T., Sham M.H., Lois M. and Tam P.K.H. (2002) Glial cell line-derived neurotrophic factor family receptors are abnormally expressed in aganglionic bowel of a subpopulation of patients with Hirschsprung's disease. Lab Invest 82(6): 703-712. (I.F. 4.165) (Times cited: 8)
  1. Ho K.M., Lui, V.C.H., Lee, C.W., Tam, P.C. and Tam, P.K.H. (2002) Expression of interstitial cells of Cajal & hemeoxygenase II in human ureteropelvic junction. J Urol 167 (4), Suppl 95-96. (I.F. 2.896)
  1. Tian, L., Guo, W.H., Yuan, Z.W., Lui, V.C.H., Chan, J.K.Y., Yagita, H., Akida, H., Dallman, M. and Tam, P.K.H. (2002) Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft. Transplantation 74(1): 133-138. (I.F. 4.035) (Times cited: 7)
  1. Chen, Y., Lui, V.C.H., Sham, M.H. and Tam, P.K.H. (2002) Distribution of Carbon Monoxide-Producing Neurons in Human Colon and in Hirschsprung’s Disease Patients. Hu Pathol 33(10):1030-1036. (I.F. 3.029) (Times cited: 8)
  1. Lui, V.C.H., Tam, P.K.H., Leung, M., Lau, J., Chan, J.K.Y., Dallman, M. and Cheah, K.S.E. (2003) Mammary gland-specific secretion of biologically active immunosuppressive agent cytotoxic-T-lymphocyte antigen 4 human immunoglobulin fusion protein (CTLA4Ig) in milk by transgenesis. J Immunol Methods 227:171-183. (I.F. 2.598)(Times cited: 9)
  1. Yuan, Z.W., Lui, V.C.H. and Tam, P.K.K. (2003) Deficient motor innervation to the sphincter mechanism in fetal rats with anorectal malformation: a quantitative study by Fluorogold retrograde tracing. J Paediatr Surg 38(9):1383-1388. (I.F. 1.304)(Times cited: 14)
  1. Lee, K.Y., Tam, P.K.H., Samy, E.T., Sham, M.H. and Lui, V.C.H. (2003) Expression analysis of 3’ splicing variants of RET protooncogene in mouse embryos. Biochemica et Biophysica Acta 1627:26-38. (I.F. 2.6)(Times cited: 9)
  1. Fu, M., Lui, V.C.H., Cheung, A.N.Y., Sham, M.H. and Tam, P.K.H. (2003) HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts. Dev Dyn 228:1-10. (first two authors contribute equally to this manuscript) (I.F. 3.8)(Times cited: 31)
  1. Garcia-Barcelo, M.M., Lee, W.S., Sham, M.H., Lui, V.C.H. and Tam, P.K.H. (2003) Is there a role of the IHH gene in Hirschsprung’s disease? Neurogastroenterol Motil 15(6):663-668. (I.F. 2.083)(Times cited: 7)
  1. Garcia-Barcelo, M.M., Sham, M.H., Lui, V.C.H., Chen, B.L.S., Song, Y.Q., Lee, W.S., Yung, S.K., Romeo, G. and Tam, P.K.H. (2003) Chinese patients with sporadic Hirschsprung’s disease are predominantly represented by a single RET haplotype. J MedGenet 49(11):e122. (I.F. 7.774)(Times cited: 25)
  1. Garcia-Barcelo, M.M., Sham, M.H., Lui, V.C.H., Chan, B.L.S., Ott, J. and Tam, P.K.H. (2003) Association study of PHOX2B as a candidate gene for Hirschsprung’s disease. Gut 52(4):563-567. (I.F. 6.323)(Times cited: 32)
  1. Chan, K.K., Wong, C.K., Lui, V.C.H., Tam, P.K.H. and Sham, M.H. (2003) Analysis of SOX10 mutations identified in Waardenburg-Hirschsprung patients: Differential effects on target gene regulation. J Cell Biochem 90(3):573-585. (I.F. 2.530) (Times cited: 27)
  1. Wong E.Y., Tse J.Y., Yao K.M., Lui V.C.H., Tam P.C. and Yeung WS (2004) Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein. Biol Reprod. 70(3): 775-84. (I.F. 3.646) (Times cited: 17)
  1. Garcia-Barcelo, M.M., Sham, M.H., Lee, W.S., Lui, V.C.H., Chan, B.L.S., Wong, K.K., Wong, J.S. and Tam, P.K.H. (2004) Highly recurrent RET mutations and novel mutations in genes of the receptor tyrosine kinase and Endothelin receptor B pathways in Chinese patients with sporadic Hirschsprung’s disease. Clin Chem 50(1):93-100. (I.F. 4.788)(Times cited: 30)
  1. Fu, M., Tam, P.K.H., Sham, M.H. and Lui V.C.H. (2004) Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: A topographical study. Anat Embryology 208(1):33-41. (I.F. 1.661) (Times cited: 24)
  1. Fu, M., Lui, V.C.H., Sham, M.H., Pachnis, V. and Tam, P.K.H. (2004) Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. J Cell Biol 166(5):673-684. (I.F. 12.023) (Lui VCH is the co-first and co-corresponding author)(Times cited: 75)
  1. Chen, Y., Lui, V.C.H., Rooijen, N.V. and Tam, P.K.H. (2004) Depletion of resident macrophages prevents ischaemic reperfusion injury in gut. Gut 53(12):1772-80. (I.F. 9.002)(Times cited: 22)
  1. Cheng, W., Poon, K.H., Lui, V.C.H., Yong, J.L., Law, S., So, K.T., Tse, K. and Tam, P.K.H. (2004) Esophageal Atresia and Achalasia-like Esophageal Dysmotility. J Pediatr Surg 39:1581-1583 (I.F. 1.3042)(Times cited: 2)
  1. Ren, Y., Chan, H.M., Li, Z., Nicholls, J., Chen, C.F., Lee, P.Y., Lui, V.C.H., Bacher, M., Tam, P.K.H. (2004) Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma. OncogeneMay;23(23):4146-54. (I.F. 6.582) (Times cited: 13)
  1. Garcia-Barcelo, M.M., Ganster, R.W., Lui, V.C.H., Leon, T.Y.Y., So, M.T., Lau, A.M.F., Fu, M., Sham, M.H., Knight J., Zannini M.S., Sham P.C., Tam P.K.H. (2005) TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease.
    Hum Mol Genet 14:191-204. (I.F. 8.597)(Times cited: 35)
  1. Chan, K.K., Chen, Y.S., Yau, T.O., Fu, M., Lui, V.C.H., Tam, P.K.H., Sham, M.H. (2005) Hoxb3 vagal neural crest-specific enhancer element for controlling enteric nervous system development. Dev Dyn June;233(2):473-483. (I.F.: 3.160) (Times cited: 3)
  1. Ho, K.M., Li, A.Z., Yiu, M.K., Lee, K.C., Lui, V.C.H., Fung, P.C., Yiu, T.F., Tam, P.K.H. (2005) Altered expression of aquaporin-2 in human explants with chronic renal allograft dysfunction. BIU Int 95:1104-1108. (I.F.: 1.642)(Times cited: 1)
  1. Lui, V.C.H., Leon, T.Y.Y., Garcia-Barcelo, M.M., Ganster, R.W., Chen, B.L.S., Hutson, J.M., Tam, P.K.H. (2005) Novel RET mutation produces a truncated RET receptor lacking the intracellular signaling domain in a three generation family with Hirschsprung’s disease. Clin Chem Aug;51(8):1552-1554. (I.F.: 6.501) (Times cited: 3)
  1. Ren, Y., Lin, C.L., Li, Z., Chen, X.Y., Huang, X., Lui, V.C.H., Nicholls, J., Lam, H.Y., Tam, P.K.H. (2005) Up-regulation of macrophage migration inhibitory factor in infants with acute neonatal necrotizing enterocolitis. Histopathology Jun;46(6):659-67. (I.F. 3.216) (Times cited: 13)
  1. Lui, V.C.H., Cheng, W.W.C., Chen, Y., Sham, M.H., Tam, P.K.H. (2005) Perturbation of Hoxb5 signalling in vagal neural crest cells causes defective development of the enteric nervous system. Mechanisms of Development 122:S93. (I.F.: 3.263)
  1. Ngan, E.S.W., Lui, V.C.H., Lau, D.K.C., Garcia-Barcelo, M.M., Sham, M.H., Tam, P.K.H. (2005) Transcriptional profiling of enteric neural crest cells. Mechanisms of Development 122:S179. (I.F.: 3.263)
  1. Law, M.L., Tsang, W.H., Ngan, E., Lui, V.C.H., Sham, M.H. (2005) Abnormal enteric ganglia development in a Sox10 mouse mutant generated by gene targeting. Mechanisms ofDevelopment 122:S177. (I.F.: 3.263)
  1. Garcia-Barcelo, M.M., So, M.T., Lau, D.K.C., Leon, T.Y.Y., Yuan, Z.W., Cai, W.S., Lui, V.C.H., Fu, M., Herbrick, J.A., Gutter, E., Proud, V., Li, L., Pierre-Louis, J., Aleck, K., Van Heurn, E., Belloni, E., Scherer, S.W., Tam, P.K.H. (2006) Population differences in thepolyalanine domain and six new mutations in HLXB9 in patients with Currarino syndrome. Clin Chem 52:46-52. (I.F.: 6.501)(Times cited: 9)
  1. Garcia-Barcelo, M.M*., Miao X*., Lui, V.C.H*., So, M.T., Ngan, E.S., Leon, T.Y., Lau, D.K., Liu, T.T., Lao, X., Guo, W., Holden, W.T., Moore, J., Tam, P.K. (2007) Correlation between genetic variations in Hox clusters and Hirschsprung's disease.Ann Hum Genet.2007 Jul;71(Pt 4):526-36. (* these authors contribute equally to the work)(I.F. 2.727) (Times cited: 6)
  1. Ngan, E.S., Sit, F.Y., Lee, K., Miao, X., Yuan, Z., Wang, W., Nicholls, J.M., Wong, K.K., Garcia-Barcelo, M., Lui, V.C.H., Tam, P.K. (2007) Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression.Clin Cancer Res Feb 1;13(3):868-75. (I.F. 6.1)(Times cited: 17)
  1. Ngan, E.S., Lee, K.Y., Sit, F.Y., Poon, H.C., Chan, J.K., Sham, M.H., Lui, V.C.H., Tam, P.K. (2007) Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells.Biochim Biophys Acta-MCR Apr;1773(4):536-45. Epub 2007 Feb 2. (I.F. 6.9) (Times cited: 17)
  1. Miao, X., Garcia-Barcelo, M.M., So, M.T., Leon, T.Y., Lau, D.K., Liu, T.T., Chan, E.K., Lan, L.C., Wong, K.K., Lui, V.C.H., Tam, P.K.(2007) Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population.Gut May;56(5):736. (I.F. 9.002) (Times cited: 6)
  1. Chen, Y., Li, X., Tian, L., Lui, V.C.H., Dallman, M.J., Lamb, J.R., Tam, P.K. (2007) Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model.Transplantation May 27;83(10):1351-7. (I.F. 3.972) (Times cited: 7)
  1. Li, X., Chen, Y., Tian, L., Lui, V.C.H., Tam, P.K. (2007) Increased iNOS-expressing macrophage in long-term surviving rat small-bowel grafts.Am J Surg Aug;194(2):248-54. (I.F. 2.101) (Times cited: 2)
  1. Garcia-Barcelo, M.M., Lau, D.K., Ngan, E.S., Leon, T.Y., Liu, T.T., So, M.T., Miao, X.P., Lui, V.C.H., Wong, K.K., Ganster, R.W., Cass, D.T., Croaker, G.D., Tam, P.K. (2008) Evaluation of the Thyroid Transcription Factor-1 Gene (TITF1) as a Hirschsprung's Disease Locus.Ann Hum Genet72(Pt 2):170-7. (I.F. 2.727) (Times cited: 8)
  1. Ngan, E.S.W.,Shum, C.K.Y.,Poon, H.C., Sham, M.H., Garcia-Barcelo, M.M.,Lui, V.C.H.,Tam, P.K.H. (2008) Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest stem cells.Biochim Biophys Acta-MCR1783(3):467-478. (I.F. 6.9)(Times cited: 13)
  1. Lui, V.C.H., Cheng, W.W.C., Leon, T.Y.Y., Lau, D.K.C., Garcia-Barcelo, M.M., Miao, X.P., Kam, M.K.M., So, M.T., Chen, Y., Wall, N.A., Sham, M.H., Tam, P.K.H. (2008) Perturbation of Hoxb5 signaling in vagal neural crest cells down-regulates Ret leading to intestinal hypoganglionosis in mice. Gastroenterology Apr;134:1104-1115. (I.F. 12.457) (Times cited: 9)
  1. Chen, Y., Kam, C.S.K., Liu, F.Q., Liu, Y.,Lui, V.C.H., Lamb, J.R.,Tam, P.K.H.(2008) LPS-induced upregulation of TNF-receptor 1 is associated with TNF- expression in human monocyte derived macrophage. Journal of Leukocyte BiologyMay;83(5):1165-1173. (IF 4.572) (Times cited: 5)
  1. Liu, F.Q., Liu, Y., Lui, V.C.H., Lamb, J.R., Tam, P.K.H., Chen, Y. (2008) Hypoxia modulates lipopolysaccharide induced TNF-alpha expression in murine macrophages. Exp Cell Res Apr;314(6):1327-1336. (I.F. 3.948) (Times cited: 16)
  1. Garcia-Barcelo, M.M., Fong, P.Y., Tang, C.S., Miao, X.P., So, M.T., Yuan, Z.W., Li, L., Guo, W.H., Liu, L., Wang, B., Sun, X.B., Huang, L.M., Tou, J.F., Kak, K., Wong, Y., Ngan, E.S.W., Lui, V.C.H., Cherny, S.S., Sham, P.C., Tam, P.K.H. (2008) Mapping of a Hirschsprung’s disease locus in 3p21. Eur J Human Genetics16:833-840. (I.F. 3.697) (Times cited: 5)
  1. Garcia-Barcelo, M.M*., Lui, V.C.H*., Miao, X.P., So, M.T., Leon, T.Y.Y., Yuan, Z.W., Li, L., Liu, L., Wang, B., Sun, X.B., Huang, L.M., Tou, J.F., Ngan, E.S.W., Cherny, S.S., Chan, E.K.W., Lee, K.H., Wang, W., Wong, K.K.Y., Tam, P.K.H. (2008) Mutational analysis ofSHH and GLI3 in anorectal malformations.Birth Defects Research Part A: Clinical and Molecular TeratologySep;82(9):644-648. (I.F. 2.005) (* These authors contribute equally to this manuscript) (Times cited: 4)
  1. Garcia-Barceló, M.M., Wong, K.K., Lui, V.C.H., Yuan, Z.W., So, M.T., Ngan, E.S.W., Miao, X.P., Chung, P.H., Khong, P.L., Tam, P.K.H. (2008) Identification of a HOXD13 mutation in a VACTERL patient.Am J Med Genet A 2008 Dec 15;146A(24):3181-5. (Times cited: 15)
  1. Garcia-Barcelo, M.M., Tang, C.S., Ngan, E.S.W., Lui, V.C.H., Chen, Y., So, M.T., Leon, T.Y., Miao, X.P., Shum, C.K., Liu, F.Q., Yeung, M.Y., Yuan, Z.W., Guo, W.H., Liu, L., Sun, X.B., Huang, L.M., Tou, J.F., Song, Y.Q., Chan, D., Cheung, K.M., Wong, K.K., Cherny, S.S., Sham, P.C., Tam, P.K.H. (2009) Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.Proc Natl Acad Sci U S A Feb 24;106(8):2694-9. (I.F. 9.380) (Times cited: 19)
  1. Wang, X.Q., Lui, V.C.H., Poon, R.T., Lu, P., Poon, R.Y.. (2009) DNA damage mediated S and G(2) checkpoints in human embryonal carcinoma cells.Stem Cells Mar;27(3):568-76. (I.F. 7.741) (Times cited: 4)
  1. Garcia-Barceló, M.M.*, Lui, V.C.H.*, So, M.T., Miao, X.P., Leon, T.Y., Yuan, Z.W., Ngan, E.S.W., Ehsan, T., Chung, P.H., Khong, P.L., Wong, K.K., Tam, P.K.H. (2009) MNX1 (HLXB9) mutations in Currarino patients.J Pediatr Surg Oct;44(10):1892-8. (I.F.: 1.557) (* These authors contribute equally to this manuscript) (Times cited: 4)
  1. Leon, T.Y., Ngan, E.S., Poon, H.C., So, M.T., Lui, V.C.H., Tam, P.K.H., Garcia-Barcelo, M.M. (2009) Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3. J Pediatr Surg Oct;44(10):1904-12. (I.F. 1.557) (Times cited: 3)
  1. Kam, K.M.M., Lui, V.C.H., Cheung, M.C.H., Tam, P.K.H. (2009) Expression of engrailed-Hoxb5 transcriptional repressor by Wnt1-Cre produces hydrocephalus and neuro-cristopathies in mice.Mechanism of Development126:S133. (I.F. 2.827)
  1. Ng, R.C.L., Lui, V.C.H. (2009) Wnt antagonists regulate urethra tubercularization and cloaca septation. Mechanism of Development126:S134. (I.F. 2.827)
  1. Miao, X., Garcia-Barceló, M.M., So, M.T., Tang, W.K., Dong, X., Wang, B., Mao, J., Ngan, E.S., Chen, Y., Lui, V.C., Wong, K.K., Liu, L., Tam, P.K. (2010)Lack of association between nNOS -84G>A polymorphism and risk of infantile hypertrophic pyloric stenosis in a Chinese population. J Pediatr Surg. Apr;45(4):709-13. (I.F. 1.557) (Times cited: 2)
  1. Miao, X., Leon, T.Y., Ngan, E.S., So, M.T., Yuan, Z.W., Lui, V.C., Chen, Y., Wong, K.K., Tam, P.K., Garcia-Barceló, M. (2010) Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease. Hum Mol Genet. Apr 15;19(8):1461-7. (I.F. 7.386) (Times cited: 3)
  1. Garcia-Barceló, M.M., Yeung, M.Y., Miao, X.P., Tang, C.S., Chen, G., So, M.T., Ngan, E.S., Lui, V.C., Chen, Y., Liu, X.L., Hui, K.J., Li, L., Guo, W.H., Sun, X.B., Tou, J.F., Chan, K.W., Wu, X.Z., Song, Y.Q., Chan, D., Cheung, K., Chung, P.H., Wong, K.K., Sham, P.C., Cherny, S.S., Tam, P.K. (2010) Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. Hum Mol Genet. Jul 15;19(14):2917-25. Epub May 11. (I.F. 7.386) (Times cited: 3)
  1. Liu, X., Lee, P.Y., Ho, C.M., Lui, V.C., Chen, Y., Che, C.M., Tam, P.K., Wong, K.K. (2010) Silver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healing. ChemMedChem. Mar 1;5(3):468-75. (Times cited: 10)
  1. Lui, V.C.H., Lung, S.S.S., Hung, K.N., Leung, G.K.K. (2010) Invasion of Human Glioma Cells is Regulated by Multiple Chloride Channels Including ClC-3. Anticancer Res. Nov;30(11):4515-24. (I.F. 1.428) (Times cited: 1)
  1. Tang, C.S., Tang, W.K., So, M.T., Miao, X.P., Leung, B.M., Yip, B.H., Leon, T.Y., Ngan, E.S., Lui, V.C., Chen, Y., Chan, I.H., Chung, P.H., Liu, X.L., Wu, X.Z., Wong, K.K., Sham, P.C., Cherny, S.S., Tam, P.K., Garcia-Barceló, M.M. (2011) Fine Mapping of the NRG1 Hirschsprung's Disease Locus. PLoS One. Jan 20;6(1):e16181. (I.F. 4.351)
  1. Zhu, J., Garcia-Barceló, M.M., Tam, P.K.,Lui, V.C.H. (2011) HOXB5 Cooperates with NKX2-1 in the Transcription of Human RET. PLoS One. June 3;6(6):e20815. (I.F. 4.351)
  1. Chen, Y., Li, D, Tsang, J.Y., Niu, N., Peng, J., Zhu, J., Hui, K., Xu, A., Lui, V.C., Lamb, J.R., Tam, P.K. (2011) PPAR-γ signaling and IL-5 inhibition together prevent chronic rejection of MHC Class II-mismatched cardiac grafts. J Heart Lung Transplant. Jun;30(6):698-706. Epub 2011 Mar 23. (I.F. 3.426)
  1. Ngan, E.S.W., Garcia-Barcelo, M.M., Yip, B.H.K., Poon, P.C., Lau, C.S.T., Kwok, K.M., Sat, E.W.Y., Sham, M.H., Wong, K.K.Y., Wainwright, B.J., Cherny, S.S., Hui, C.C., Sham, P.C., Lui, V.C.H., Tam, P.K.H. (2011) Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung’s disease in mice and humans. J Clin Invest. 2011 Sep 1;121(9):3467-78. (I.F.14.152)
  1. Cheung, P.F., Cheng, C.K., Wong, N.C., Ho, J.C., Yip, C.W., Lui, V.C., Cheung, A.N., Fan, S.T., Cheung, S.T. (2011) Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells. PLoS ONE6(12): e28246. doi:10.1371/journal.pone.0028246 (I.F. 4.351)
  1. So, M.T., Leon, T.Y.Y., Cheng, G., Tang, C.S.M., Miao, X.P., Cornes, B.K., Ngo, D.N., Cui, L., Ngan, E.S.W., Lui, V.C.H., Wu, X.Z., Wang, B., Wang, H., Yuan, Z.W., Huang, L.M., Li, L., Xia, H., Zhu, D., Liu, J., Nguyen, T.L., Chan, I.H.Y., Chung, P.H.Y., Liu, X.L., Zhang, R., Wong, K.K.Y., Sham, P.C., Cherny, S.S., Tam, P.K.H., Garcia-Barcelo, M.M. (2011) RET mutational spectrum in Hirschsprung disease: evaluation of 601 Chinese patients. PLoS ONE6(12):e28986. Epub 2011 Dec 9(I.F. 4.351)
  1. Tang, C.S., Ngan, E.S., Tang, W.K., So, M.T., Cheng, G., Miao, X.P., Leon, T.Y., Leung, B.M., Hui, K.J., Lui, V.C.H., Chen, Y., Chan, I.H., Chung, P.H., Liu, X.L., Wong, K.K., Sham, P.C., Cherny, S.S., Tam, P.K., Garcia-Barcelo, M.M. (2012) Mutations in the NRG1 gene are associated with Hirschsprung disease. Hum Genet.Jan;131(1):67-76. Epub 2011 Jun 25. (I.F. 5.047)
  1. Li, H., Gao, F, Ma, L., Jiang, J., Miao, J., Jiang, M., Fan, Y., Wang, L., Wu, D., Liu, B., Wang, W., Lui, V.C., Yuan, Z. (2012) Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat fetuses with spina bifida aperta. J Cell Mol Med. Jul;16(7):1606-17. doi: 10.1111/j.1582-4934.2011.01470.x. [Epub ahead of print] (I.F. 4.608)
  1. Leon,T.Y.Y.,So, M.T.,Lui, V.C.H.,Hofstra,R.M.W.,Tam,P.K.H.,Ngan,E.S.W., Garcia-Barcelo,M.M. (2012) Functional analyses of RET mutations in Chinese Hirschsprung disease patients. Birth Defects Research Part A: Clinical and Molecular Teratology. Jan;94(1):47-51. doi: 10.1002/bdra.22863. Epub 2011 Dec 1 (I.F. 2.482)
  1. Kam,M.K.M., Lee,K.Y., Tam,P.K.H., Lui,V.C.H. (2012) Generation of NSE-MerCreMer transgenic mice with tamoxifen inducible Cre activity in neurons. PLoS ONE2012;7(5):e35799. Epub 2012 May 7 (I.F. 4.351)
  1. Tang, C.S., Cheng, G., So, M.T., Yip, B.H.K., Miao, X.P., Wong, E.H.M., Ngan, E.S., Lui,V.C.H.,Song, Y.Q., Chan,D., Cheung,K., Yuan, Z.W., Lei, L., Chung, H.Y., Liu, X.L., Wong, K.K.Y., Marshall, C.R., Scherer, S., Cherny, S.S., Sham, P.C., Tam, P.K.H., Garcia-Barceló, M.M. (2012) Genome-wide copy number analysis uncovers a new HSCR gene: NRG3. PLoS Genetics2012;8(5):e1002687. Epub 2012 May 10 (I.F.: 9.8)
  1. Li, D., Tsang, J.Y., Peng, J., Ho, D.H., Chan, Y.K., Zhu, J., Lui, V.C., Xu, A., Lamb, J.R., Tam, P.K., Chen, Y. (2012) Adiponectin mediated MHC class II mismatched cardiac graft rejection in mice is IL-4 dependent. PLoS One. 7(11):e48893. doi: 10.1371/journal.pone.0048893. Epub 2012 Nov 14.(I.F. 4.351)
  1. Wong, E.H.,* Cui, L.,* Ng, C.L.,* Tang, C.S., Liu, X.L., So, M.T., Yip, B.H., Cheng, G., Zhang, R., Tang, W.K., Yang, W., Lau, Y.L., Baum, L., Kwan, P., Sun, L.D., Zuo, X.B., Ren, Y.Q., Yin, X.Y., Miao, X.P., Liu, J., Lui, V.C., Ngan, E.S., Yuan, Z.W., Zhang, S.W., Xia, J., Wang, H., Sun, X.B., Wang, R., Chang, T., Chan, I.H., Chung, P.H., Zhang, X.J., Wong, K.K., Cherny, S.S., Sham, P.C., Tam, P.K., Garcia-Barcelo, M.M. (2013) Genome-wide copy number variation study in anorectal malformations. Hum Mol Genet. 2012 Nov 7. [Epub ahead of print] (*: Co-first author)
  1. Peng, J., Chen, Y., Tsang, J.Y., Li, D., Niu, N., Ho, D.H., Lau, K.F., Lui, V.C., Lamb, J.R., Tam, P.K. (2013) Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages. Cancer Lett. Jan 11. doi:pii: S0304-3835(13)00004-9. 10.1016/j.canlet.2013.01.001. [Epub ahead of print] (I.F. 4.238)
  1. Wong, E.H., Ng, C.L., Lui, V.C., So, M.T., Cherny, S.S., Sham, P.C., Tam, P.K., Garcia-Barceló, M.M. (2013) Gene network analysis of candidate Loci for human anorectal malformations. PLoS One. 8(8):e69142. doi: 10.1371/journal.pone.0069142. Print 2013. (I.F. 4.351)
  1. Cheng, G., Tang, C.S., Wong, E.H., Cheng, W.W., So, M.T., Miao, X., Zhang, R., Cui, L., Liu, X., Ngan, E.S., Lui, V.C., Chung, P.H., Chan, I.H., Liu, J., Zhong, W., Xia, H., Yu, J., Qiu, X., Wu, X.Z., Wang, B., Dong, X., Tou, J., Huang, L., Yi, B., Ren, H., Chan, E.K., Ye, K., O Reilly, P.F., Wong, K.K., Sham, P.C., Cherny, S.S., Tam, P.K., Garcia-Barceló, M.M. (2013) Common genetic variants regulating ADD3 gene expression alter biliary atresia risk. J Hepatol. 2013 Jul 19. doi:pii: S0168-8278(13)00532-1. 10.1016/j.jhep.2013.07.021. [Epub ahead of print] (I.F. 9.858)
  1. Kam, M.K.M., Cheung, M.C.H., Zhu, J.J., Cheung, W.W.C., Sat, E.W.Y., Tam, P.K.H., Lui, V.C.H. (2013) Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in mice. Cell Death Differ. 2013 Oct 18. doi: 10.1038/cdd.2013.142. [Epub ahead of print] (I.F. 8.371)
  1. Ng, R.C.L., Matsumaru, D., Ho, A.S.H., Garcia-Barceló, M.M., Yuan, Z.W., Smith, D., Kodjabachian, L., Tam, P.K.H., Yamada, G., Lui, V.C.H. (2014) Dysregulation of Wnt Inhibitory Factor 1 (Wif1) expression resulted in aberrantWnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectalmalformations.Cell Death Differ. (In Press) (I.F. 8.371)
  1. Miyagawa, S., Harada, M., Matsumaru, D., Tanaka, K., Inoue, C., Nakahara, C., Haraguchi, R., Matsushita, S., Suzuki, S., Nakagata, N., Ng, R.C.L., Akita, K., Lui, V.C.H., Yamada G. (2014) Disruption of the Temporally Regulated Cloaca Endoderm β-catenin Signaling Causes Anorectal Malformations. Cell Death Differ. (In Press) (I.F. 8.371)

  1. Invited Lecture at international conferences:
  1. Lui, V.C.H., Fu, M., Poon, H.C., Sham, M.H., Pachnis, V., Hui, C.C., Tam, P.K.H. (2006) Conditional knockout of Ptc1 gene in vagal neural crest cells causes defective ENS development in mice. Development of the Enteric Nervous System: Cells, Signals & Genes. New YorkAcademy of Medicine, New York, USA, 26-29 March 2006.
  1. Poon, T.H.C., Ngan, E.S.W., Sit, F.Y.L., Hui, C.C., Wainwright, B.J., Sham, M.H., Tam, P.K.H., Lui, V.C.H. (2009) Conditional Ptc1 knockout in vagal neural crest cells causes intestinal hypoganglinosis. 2nd International Symposium Development of the Enteric Nervous System: cells, signals and genes, UCL Institute of Child Health, London, UK. Feb 22-25, 2009.
  1. Lui, V.C.H. (2010) HOXB5 and Hirschsprung’s Disease. Symposium of Pediatric Experimental Surgery and Perinatology in Sheng Jing Hospital of China Medical University, Shenyang. 6-9 May 2010, 2010.

Presentations at international conferences (2000-present):