Research outputs
Listing of Research outputs
Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach
Bereczki, E., Branca, R. M., Francis, P. T., Pereira, J. B., Baek, J-H., Hortobágyi, T., Winblad, B., Ballard, C., Lehtiö, J. & Aarsland, D. 1 Feb 2018 In : Brain. 141, 2, p. 582-595 14 p.
Research output: Contribution to journal › Article
Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study
Gatt, A., Ekonomou, A., Somani, A., Thuret, S., Howlett, D., Corbett, A., Johnson, M., Perry, E., Attems, J., Francis, P., Aarsland, D. & Ballard, C. 27 Jan 2018 In : Dementia and Geriatric Cognitive Disorders. 44, 5-6, p. 283-293 11 p.
Research output: Contribution to journal › Article
Mitochondrial Translocase of the Outer Membrane Alterations May Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer's Disease
Chai, Y. L., Xing, H., Chong, J. R., Francis, P. T., Ballard, C. G., Chen, C. P. & Lai, M. K. P. 19 Dec 2017 In : JOURNAL OF ALZHEIMERS DISEASE. 61, 2, p. 793-801 9 p.
Research output: Contribution to journal › Article
RELATIONSHIP BETWEEN PATHOLOGY SCORES, CLINICAL DATA AND EXPRESSION LEVELS OF PROTEASOME SUB-UNITS IN ALZHEIMER’S DISEASE AND LEWY BODY DEMENTIAS: 2017 Abstract Supplement
Hortobagyi, T., Alghamdi, A., Vallortigara, J., Whitfield, D., Howlett, D. R., Broadstock, M., Ballard, C., Attems, J., Aarsland, D. & Francis, P. T. 20 Oct 2017 In : Alzheimer's & Dementia. 13, 7, Supplement, p. P333-P334
Research output: Contribution to journal › Article
Increased Levels of Brain Adrenomedullin in the Neuropathology of Alzheimer’s Disease
Ferrero, H., Larrayoz, I. M., Martisova, E., Solas, M., Howlett, D. R., Francis, P., Gil-Bea, F. J., Martínez, A. & Ramírez, M. J. 2 Sep 2017 In : Molecular Neurobiology. p. 1-7 7 p.
Research output: Contribution to journal › Article
Glucocerebrosidase mutations and neuropsychiatric phenotypes in Parkinson's disease and Lewy body dementias: Review and meta-analyses
Creese, B., Bell, E., Johar, I., Francis, P., Ballard, C. & Aarsland, D. 26 May 2017 In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics.
Research output: Contribution to journal › Article
Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia
Alghamdi, A., Vallortigara, J., Howlett, D. R., Broadstock, M., Hortobágyi, T., Ballard, C., Thomas, A. J., O'Brien, J. T., Aarsland, D., Attems, J., Francis, P. T. & Whitfield, D. R. 21 Mar 2017 In : JOURNAL OF ALZHEIMERS DISEASE. 57, 2, p. 373-386 14 p.
Research output: Contribution to journal › Article
Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease
Kassaar, O., Morais, M. P., Xu, S., Adam, E. L., Chamberlain, R. C., Jenkins, B., James, T., Francis, P. T., Ward, S., Williams, R. J. & Van Den Elsen, J. 23 Feb 2017 In : Scientific Reports. 7, 42874
Research output: Contribution to journal › Article
Disturbed Matrix Metalloproteinase Pathway in Both Age-Related Macular Degeneration and Alzheimer's Disease
Hussain, A. A., Lee, Y., Zhang, J. J., Francis, P. T. & Marshall, J. 18 Jan 2017 In : Journal of Neurodegenerative Diseases. 2017, 4810232
Research output: Contribution to journal › Article
Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia
Whitfield, D. R. E., Vallortigara, J., Broadstock, M., Aarsland, D., Hortobagyi, T., Ballard, C. G. & Francis, P. T. 17 Jan 2017 In : Journal of Alzheimer's Disease. 57 (2017) , p. 373–386 DOI 10.3233/JAD-160946
Research output: Contribution to journal › Article
Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load
Chong, J. R., Chai, Y. L., Lee, J. H., Howlett, D. R., Attems, J., Ballard, C. G., Aarsland, D., Francis, P. T., Chen, C. P. & Lai, M. K. P. 12 Jan 2017 In : JOURNAL OF ALZHEIMERS DISEASE. 56, 1, p. 157-166
Research output: Contribution to journal › Article
Serotonin 5-HT6 Receptor Antagonists in Alzheimer’s Disease: Therapeutic Rationale and Current Development Status
Ferrero, H., Solas, M., Francis, P. & Ramirez, M. J. 3 Dec 2016 In : CNS Drugs. p. 1-14 14 p.
Research output: Contribution to journal › Article
Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia
Lee, J. H., Francis, P. T., Ballard, C. G., Aarsland, D., Kalaria, R. N., Wong, P. T-H., Chen, C. P. & Lai, M. K. P. 19 Oct 2016 In : Journal of Parkinson's disease. 6, 4, p. 733-739
Research output: Contribution to journal › Article
A pilot study of potential brain donor satisfaction and attitudes towards telephone assessment
Costello, H., Hayes, G. M., Highton-Williamson, E., Nurock, S., Hanbury, D. & Francis, P. T. 7 Oct 2016 In : International Journal of Geriatric Psychiatry.
Research output: Contribution to journal › Article
Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias
Xing, H., Lim, Y-A., Chong, J. R., Lee, J. H., Aarsland, D., Ballard, C. G., Francis, P. T., Chen, C. P. & Lai, M. K. P. 8 Sep 2016 In : Molecular Brain Research. 9, 1, p. 84
Research output: Contribution to journal › Article
Apathy associated with neurocognitive disorders: recent progress and future directions
Lanctôt, K. L., Agüera-Ortiz, L., Brodaty, H., Francis, P. T., Geda, Y. E., Ismail, Z., Marshall, G. A., Mortby, M. E., Onyike, C. U., Padala, P. R., Politis, A. M., Rosenberg, P. B., Siegel, E., Sultzer, D. L. & Abraham, E. H. 27 Jun 2016 In : Alzheimer's & Dementia.
Research output: Contribution to journal › Article
Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease
Tajeddinn, W., Persson, T., Calvo-Garrido, J., Seed Ahmed, M., Maioli, S., Vijayaraghavan, S., Kazokoglu, M. S., Parrado-Fernández, C., Yoshitake, T., Kehr, J., Francis, P., Winblad, B., Höglund, K., Cedazo-Minguez, A. & Aarsland, D. 22 Jun 2016 In : JOURNAL OF ALZHEIMERS DISEASE. 53, 1, p. 349-361 13 p., JAD160046
Research output: Contribution to journal › Article
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia
Bereczki, E., Francis, P. T., Howlett, D., Pereira, J. B., Höglund, K., Bogstedt, A., Cedazo-Minguez, A., Baek, J-H., Hortobágyi, T., Attems, J., Ballard, C. & Aarsland, D. 21 May 2016 In : Alzheimer's & Dementia.
Research output: Contribution to journal › Article
Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency
Gatt, A. P., Duncan, O. F., Attems, J., Francis, P. T., Ballard, C. G. & Bateman, J. M. 8 Feb 2016 In : Movement disorders : official journal of the Movement Disorder Society.
Research output: Contribution to journal › Article
Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients
Lee, J. H., Koh, S. Q., Guadagna, S., Francis, P. T., Esiri, M. M., Chen, C. P., Wong, P. T. H., Dawe, G. S. & Lai, M. K. P. 1 Feb 2016 In : Psychopharmacology. 233, 4, p. 591-598 8 p.
Research output: Contribution to journal › Article
An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease
Lee, C., Low, C. Y. B., Francis, P. T., Attems, J., Wong, P. T. H., Lai, M. K. P. & Tan, M. G. K. 1 Feb 2016 In : Journal of Neurochemistry. 136, 3, p. 637-650 14 p.
Research output: Contribution to journal › Article
Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia
Vallortigara, J., Whitfield, D., Quelch, W., Alghamdi, A., Howlett, D., Hortobágyi, T., Johnson, M., Attems, J., O'Brien, J. T., Thomas, A., Ballard, C. G., Aarsland, D. & Francis, P. T. 30 Nov 2015 In : JOURNAL OF ALZHEIMERS DISEASE. 50, 1, p. 101-110 10 p.
Research output: Contribution to journal › Article
Unfolded protein response is activated in Lewy body dementias
Baek, J. H., Whitfield, D., Howlett, D., Francis, P., Bereczki, E., Ballard, C., Hortobágyi, T., Attems, J. & Aarsland, D. 17 Aug 2015 In : Neuropathology and Applied Neurobiology. 14 p.
Research output: Contribution to journal › Article
5-HT1B and other related serotonergic proteins are altered in APPswe mutation
Tajeddinn, W., Persson, T., Maioli, S., Calvo-Garrido, J., Parrado-Fernandez, C., Yoshitake, T., Kehr, J., Francis, P., Winblad, B., Höglund, K., Cedazo-Minguez, A. & Aarsland, D. 6 May 2015 In : Neuroscience Letters. 594, p. 137-143 7 p.
Research output: Contribution to journal › Article
Spreading pathologies precede cognitive decline in Alzheimer's disease
Howlett, D. R., Attems, J. & Francis, P. T. 15 Apr 2015 In : Biological Psychiatry. 77, 8, p. 678-679 2 p.
Research output: Contribution to journal › Comment/debate
Stage-Specific Changes in Neurogenic and Glial Markers in Alzheimer's Disease
Ekonomou, A., Savva, G. M., Brayne, C., Forster, G., Francis, P. T., Johnson, M., Perry, E. K., Attems, J., Somani, A., Minger, S. L., Ballard, C. G. & The Medical Research Council Cognitive Function and Ageing Neuropathology Study 15 Apr 2015 In : Biological Psychiatry. 77, 8, p. 711-719 9 p.
Research output: Contribution to journal › Article
Depression and Synaptic Zinc Regulation in Alzheimer Disease, Dementia with Lewy Bodies, and Parkinson Disease Dementia
Whitfield, D. R., Vallortigara, J., Alghamdi, A., Hortobágyi, T., Ballard, C., Thomas, A. J., O'Brien, J. T., Aarsland, D. & Francis, P. T. Feb 2015 In : The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 23, 2, p. 141-148 8 p.
Research output: Contribution to journal › Article
Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing
Cox, C. J., Choudhry, F., Peacey, E., Perkinton, M. S., Richardson, J. C., Howlett, D. R., Lichtenthaler, S. F., Francis, P. T. & Williams, R. J. 1 Jan 2015 In : Neurobiology of Aging. 36, 1, p. 178-187 10 p.
Research output: Contribution to journal › Article
Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease
Mohamed, N. E., Lee, J. H., Francis, P. T., Esiri, M. M., Chen, C. P. & Lai, M. K. P. 2015 In : JOURNAL OF ALZHEIMERS DISEASE. 44, 2, p. 431-437 7 p.
Research output: Contribution to journal › Article
Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment
Whitfield, D. R., Vallortigara, J., Alghamdi, A., Howlett, D., Hortobágyi, T., Johnson, M., Attems, J., Newhouse, S., Ballard, C., Thomas, A. J., O'Brien, J. T., Aarsland, D. & Francis, P. T. Dec 2014 In : Neurobiology of Aging. 35, 12, p. 2836-2844 9 p.
Research output: Contribution to journal › Article
Erratum to: Neuropsychiatric Symptoms in Patients with Dementias Associated with Cortical Lewy Bodies: Pathophysiology, Clinical Features, and Pharmacological Management.
Ballard, C. G., Aarsland, D., Francis, P. T. & Corbett, A. M. J. 1 Aug 2014 In : Drugs and Aging. 31, 8, p. 651 1 p.
Research output: Contribution to journal › Article
Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia
Vallortigara, J., Rangarajan, S., Whitfield, D., Alghamdi, A., Howlett, D., Hortobágyi, T., Johnson, M., Attems, J., Ballard, C., Thomas, A., O'Brien, J., Aarsland, D. & Francis, P. 13 May 2014 In : F1000Research. 3, 11 p., 108
Research output: Contribution to journal › Article
Serotonergic therapies for cognitive symptoms in Alzheimer's disease: Rationale and current status
Ramirez, M. J., Lai, M. K. P., Tordera, R. M. & Francis, P. T. 1 May 2014 In : Drugs. 74, 7, p. 729-736 8 p.
Research output: Contribution to journal › Article
Corrigendum to "Association of a polymorphism in mitochondrial transcription factor A (TFAM) with Parkinson's disease dementia but not dementia with Lewy bodies" [Neurosci. Lett., 557, (2013), 177-180]
Gatt, A. P., Jones, E., Francis, P. T., Ballard, C. & Bateman, J. M. 20 Mar 2014 In : Neuroscience Letters. 563, p. 44 1 p.
Research output: Contribution to journal › Article
Dynamin protein in stroke and vascular dementia
Mulugeta, E., Vallortigara, J., Francis, P. T., Hye, A., Kalaria, R. N., Perry, E. K., Lovestone, S. & Ballard, C. G. 20 Mar 2014 In : Neuroscience Letters. 563, N/A, p. 118-122 5 p., N/A
Research output: Contribution to journal › Article
Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia
Datta, A., Qian, J., Chong, R., Kalaria, R. N., Francis, P., Lai, M. K. P., Chen, C. P. & Sze, S. K. 17 Mar 2014 In : Journal Of Proteomics. 99, p. 54-67 14 p.
Research output: Contribution to journal › Article
Decreased immunoreactivities of neocortical AMPA receptor subunits correlate with motor disability in Lewy body dementias
Mohamed, N-E., Howlett, D. R., Ma, L., Francis, P. T., Aarsland, D., Ballard, C. G., McKeith, I. G., Chen, C. P. & Lai, M. K. P. Jan 2014 In : Journal of Neural Transmission. 121, 1, p. 71-78 8 p.
Research output: Contribution to journal › Article
Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden
Tan, M. G. K., Lee, C., Lee, J. H., Francis, P. T., Williams, R. J., Ramirez, M. J., Chen, C. P., Wong, P. T. -H. & Lai, M. K. P. Jan 2014 In : Neurochemistry International. 64, p. 29-36 8 p.
Research output: Contribution to journal › Article
Regional Multiple Pathology Scores are Associated with Cognitive Decline in Lewy Body Dementias
Howlett, D. R., Whitfield, D., Johnson, M., Attems, J., O'Brien, J. T., Aarsland, D., Lai, M. K., Lee, J. H., Chen, C., Ballard, C., Hortobágyi, T. & Francis, P. T. 2014 In : Brain pathology (Zurich, Switzerland).
Research output: Contribution to journal › Article
Association of a polymorphism in mitochondrial transcription factor A (TFAM) with Parkinson’s disease dementia but not dementia with Lewy bodies
Gatt, A., Jones, E., Francis, P., Ballard, C. & Bateman, J. 17 Dec 2013 In : Neuroscience Letters. 557, Part B, p. 177-180 4 p.
Research output: Contribution to journal › Article
Clusterin Associates Specifically with A beta 40 in Alzheimer's Disease Brain Tissue
Howlett, D. R., Hortobagyi, T. & Francis, P. T. Nov 2013 In : Brain Pathology. 23, 6, p. 623-632 10 p.