BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Sturtevant, Joy E / POSITION TITLE
Associate Professor
eRA COMMONS USER NAME
jsturt
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION / DEGREE
(if applicable) / YEAR(s) / FIELD OF STUDY
Colorado State University, Ft. Collins, Co. USA / B.S / 1973-1977 / Zoology
Duke University Medical School, Durham,NC / PhD / 1981-1985 / Immunology
Univ Marine Biol Station, Millport, Scotland/Uppsala Univ, Uppsala Sweden / Postdoc / 1986-1988 / Invertebrate Immunology
Institute Pasteur, Paris, France / Postdoc / 1988-1991 / Medical Mycology
Georgetown Univ Medical School, Washington DC / Postdoc / 1992-1994 / Medical Mycology
PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle):
NOTE: The Biographical Sketch may not exceed four pages. Items A and B (together) may not exceed two of the four-page limit. Follow the formats and instructions on the attached sample.
A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List any honors. Include present membership on any Federal Government public advisory committee.
Positions:
1991-1992 Visiting Scientist, University of Pierre and Marie Curie, Paris France
1994-2000 Assistant Professor on Research Track, Department of Microbiology, Georgetown University Medical School, Washington DC
2000-2002 Associate Professor on Resarch Track, Department of Microbiology, Georgetown University Medical School, Washington DC
2002 - 2005 Assistant Professor, Department of Microbiology, Center of Excellence for Oral and
Craniofacial Biology Louisiana State University Health Sciences Center, New Orleans, LA
2002 - 2005 Assistant Professor, -joint appt. Department of Periodontics, Louisiana State University School of Dentistry.
2005 - Associate Professor, Department of Microbiology, Immunology and Parasitology
Louisiana State University Health Sciences Center, New Orleans, LA
2005 - Associate Professor, -joint appt. Department of Oral Biology Louisiana State University School of Dentistry
Other Experience and Professional Memberships:
1988 - 1991: Consultant for Cassenne Pharmaceuticals, Paris, France
2001 - 2002: Ad hoc reviewer for AAR4 Study Section, NIH
2004: Member of Special emphasis panel: Mycology Research Unit Program Project Grant, NIH NIAID
2002 - 2006: Member of Aids and Related Research 4 Study Section, Association opportunistic infections
and cancer (AOIC AAR4)NIH
2000 - Ad hoc reviewer for AOIC AAR4-NIH, NIH Drug contract, Veteran Administration board,
HRB-Ireland, Scientific Foundation - Ireland
2007 - Ad hoc reviewer for AAR4 Study Section, NIH
2000 - Reviewer for Eukaryotic Cell, Infection and Immunity, Microbiology, Molecular Microbiology, Antimicrobial Agents and Chemotherapy, Genetics, Fungal Genetics and Biology, Medical Mycology, Mycoses, EMBO, Clinical Infectious Diseases, FEMS, BBRC, Nucleic Acid Research, Applied and Environmental Microbiology
Honors:
1999 Mycology Millenium Prize ($5000) awarded by ISHAM
B. Selected peer-reviewed publications (in chronological order).
Sturtevant, J.E., O. Seksek, & J. Bolard. 1992. Intracellular pH and morphological transition in Candida albicans: Laser microspectrofluorometry studies on isolated cells. J Med Mycol, 1:208-211.
Sturtevant, J.E. & J-P. Latgé. 1992. Participation of complement in the phagocytosis of the conidia of Aspergillus fumigatus by human PMN. J Infect Dis, 166:580-586.
Sturtevant, J.E. & J-P. Latgé. 1992. Interactions between the conidia of Aspergillus fumigatus and human complement component C3. Infect Immun, 60:1913-1918.
DeBernardis, F., A. Cassone, J. Sturtevant, & R. Calderone. 1995. Expression of secreted aspartyl proteinases SAP-1 and SAP-2 in experimental vaginitis caused by Candida albicans. Infect Immun. 63:1887-1892.
Sturtevant, J.E., Cihlar, R.L., and R.A. Calderone. 1998. Disruption studies of a Candida albicans gene, ELF1, A member of the ATP binding cassette family. Microbiol. 144: 2311-2321.
Sturtevant, J., F. Dixon, Wadsworth, E., J.-P. Latgé, X-J. Zhao, and R. Calderone.1999. Identification and cloning of GCA1, a gene which encodes a cell wall glucoamylase from Candida albican. .Med Myc. 37:357-366.
Sturtevant, J.E. 2000. Differential display reverse transcriptase PCR (DDRT-PCR): Its application to molecular pathogenesis and medical mycology. Clinical Reviews in Microbiology 13:408-427.
Cognetti, D., Davis, D., and J. Sturtevant. 2002. The Candida albicans 14-3-3 gene, BMH1, is essential for growth. Yeast, 19:55-67.
Sturtevant, J. 2002. Elongation factors: are they rational antifungal targets? Emerging Therapeutic Targets. Expert Opinion on Therapeutic Targets,6:545-553.
Palmer, G., Cashmore, A. and J. Sturtevant. 2003. Germtube formation in Candida albicans is dependent on vacuole function. Eukaryotic Cell, 2:411-421.
Sturtevant, J. & Cihlar, R.L. 2003. Strategies for the Study of Gene Expression in Fungi. In The Mycota Vol XII: Human Fungal Pathogens, J.E. Domer & G.S. Kobayashi, eds. Springer-Verlag, Heidelberg Germany.
Palmer, G., Cashmore, A. and J. Sturtevant. 2003. Germtube formation in Candida albicans is dependent on vacuole function. Eukaryotic Cell, 2:411-421.
Fidel, P.L., Jr., M.M. Barousse, T. Espinosa, M. Ficarra, J. Sturtevant, D.H. Martin, A.J. Quayle, K. Dunlap. 2004. New insights into the immunopathogenesis of vaginal candidiasis through a live Candida challenge in humans. Infect. Immun. 72:2939-2946.
Palmer, G.E, Johnson, K.J., Ghosh, S and Sturtevant, J. 2004.Mutant alleles of the essential 14-3-3 gene in Candida albicans distinguish between growth and filamentation. Microbiology, 150:1911-1924.
Sturtevant, J. 2004. Meeting Report: Candida and Candidiasis. Mycopathologia, 158: 141-146.
Palmer, G.E. and Sturtevant, J. 2004. Random mutagenesis of an essential C. albicans gene. Genetics 46: 343-356.
Palmer, G.E., Kelly, M. N., and J.E. Sturtevant. 2005. The Candida albicans vacuole is required for differentiation and
efficient macrophage killing. Eukaryotic Cell, 4: 1677 - 1686.
Palmer, G.E., Kelly, M.N., and J.E. Sturtevant. 2007. Autophagy in the pathogen Candida albicans. Microbiology, 153: 51 - 8.
Sturtevant, J. 2009. Reporter Gene Assays. In Candida albicans Methods and Protocols, Springer Protocols: Methods in Molecular Medicine, R.A. Calderone & R.L. Cihlar, eds. P 157-168.
Kelly, M.N., Johnston, D.A., Peel, B.A., Morgan, T.W., Palmer, G.E., and J.E. Sturtevant. 2009. Bmh1p (14-3-3) mediates pathways associated with virulence in Candida albicans. Microbiology, 155: in press
C. Research Support. List selected ongoing or completed (during the last three years) research projects (federal and non-federal support
Ongoing:
2 RO1 AI046142 Sturtevant, J P.I. Role: PI
6/15/1999-5/30/2009
NIH/NIAID
Signaling and the 14-3-3 protein in Candida.
This grant focuses on the characterization of and the role the signaling module protein, 14-3-3, plays in various in pathogenesis (growth, filamentation, invasion, drug sensitivities). The goal is to better understand the pathogenesis process and identify the signaling pathways involved in the initial steps of invasion and, potentially, targets for antifungal treatments.
P20 RR20160-01 Fidel, P., P.I. Role: Mentor
06/01/04-05/31/09
NIH/NCRR
Mentoring Oral Health Research in Louisiana
Role in this project is as a mentor to clinical investigators who are inexperienced with basic research and assist with formulation and design of research plans especially experimental approaches. Primary mentor on a Candida albicans project.
Completed:
1 R21 A106031 Sturtevant, J. P.I. Role: PI
5/31/2004 – 4/30/2008
NIH/NIAID
Vacuole expansion during filamentation in Candida.
The focus of this grant will test whether the vacuole is required for germ tube emergence and hyphal formation in Candida albicans. The goal is to better understand the role of the vacuole in pathogenesis and potentially, new targets for antifungal treatments.
1 R01 AI057804-01 Mitchell, A. P.I. Role: Consultant
NIH/NIAID
Large-scale analysis of Candida albicans gene function.
Collaboration between Mitchell lab and TIGR. Role to test mutants in our phenotypic studies when needed.
PHS 398/2590 (Rev. 09/04) Page
Continuation Format Page