DDDs FOR COMBINED PRODUCTS January 2008
The DDDs assigned for combination products are based on the main principle of counting the combination as one daily dose, regardless of the number of active ingredients included in the combination. If a treatment schedule for a patient includes e.g. two single ingredient products, then the consumption will be measured by counting the DDDs of each single ingredient product separately. If , however, a treatment schedule includes a combination product containing two active ingredients, then the calculated consumption measured in DDDs will normally be lower since the DDD for the combination will be counted.
Principles for assigning DDDs to combination products are described in the Guidelines for ATC classification and DDD assignment or see website (the ATC/DDD system):
For combination products or products where a DDD for various reasons cannot be given in amount of active ingredient, the unit UD (unit dose) is used:
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-Tablets, suppositories, pessaries, etc:
1 UD equals 1 tablet, 1 suppository, 1 pessary etc.
-Powder for oral use:
1 UD equals 1 gram of powder.
-Powder in single dose units for oral use:
1 UD equals 1 unit dose powder.
-Powder for injection:
1 UD equals 1 gram of powder.
-Powder for inhalation:
1 UD equals 1 unit dose powder, e.g. 1 capsule.
-Liquid preparations for oral use (mixtures, syrups etc.):
1 UD equals 5 ml of the preparation.
-Liquid preparations for parenteral use (injections):
1 UD equals 1 ml of the preparation.
-Liquid preparations for rectal use:
1 UD equals 1 ml of the preparation.
-Liquid preparations for inhalation:
1 UD equals 1 ml of the preparation.
-Liquid preparations for inhalation in single dose units (unit dose):
1 UD equals 1 unit dose inhal.sol
-Enemas:
1 UD equals 1 enema.
-Plaster for transdermal application:
1 UD equals 1 plaster.
-Vaginal cream:
1 UD equals 1 dose, 1 application.
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List of combination products were the DDD deviates from the general rules (the ATC/DDD system):
ATC Code / Brand name / Dosage form / Active ingredients per unit dose (UD) / DDD comb.A03AX58 * / Meteospasmyl / Caps / Alverine 60 mg/ Simethicone 0.3 g / 2 UD (=2 caps)
A06AB58 / Pico-salax / Powder, single dose sachets / Sodium picosulfate 5 mg/Magnesium oxide 3.5 g / 2 UD (=2 sachets)
A06AD61 / Milaxulose / Oral paste / 0.35 g lactulose/ Liquid and soft paraffin 0.64 g / 2 UD (=10 ml)
A06AD65 / Movicol / Powder, single dose sachets / Polyetylenglycol 13.125 g/Sodiumbicarbonate 178.5 mg / 2 UD (=2 sachets)
A07DA53 / Imodium plus / Chew.tab / Loperamide 2 mg/Simeticone 0.125 g / 4 UD (=4 tab)
A09AA02 / Combizym / Tab / Multienzymes (lipase, protease etc.) / 4 UD (=4 tab)
A09AA02 / Creon / Enterocaps / Multienzymes (lipase, protease etc.) / 6 UD (=6 caps)
A09AA02 / Creon forte / Enterocaps / Multienzymes (lipase, protease etc.) / 4 UD (=4 tab)
A09AA02 / Pancrease / Enterocaps / Multienzymes (lipase, protease etc.) / 6 UD (=6 tab)
A10BD02 / Glucovance / Tab / Metformin 0.5 g/Glibenclamide 2.5 mg / 2 UD (=2 tab)
A10BD02 / Glucovance / Tab / Metformin 0.5 g/Glibenclamide 5 mg / 2 UD (=2 tab)
A10BD03 / Avandamet / Tab / Metformin 0.5 g/Rosiglitazone 1 mg / 2 UD (=2 tab)
A10BD03 / Avandamet / Tab / Metformin 0.5 g/Rosiglitazone 2 mg / 2 UD (=2 tab)
A10BD03 / Avandamet / Tab / Metformin 0.5 g/Rosiglitazone 4 mg / 2 UD (=2 tab)
A10BD03 / Avandamet / Tab / Metformin 1 g/Rosiglitazone 2 mg / 2 UD (=2 tab)
A10BD03 / Avandamet / Tab / Metformin 1 g/Rosiglitazone 4 mg / 2 UD (=2 tab)
A10BD04 / Avandaryl / Tab / Glimepiride 1 mg/Rosiglitazone 4 mg / 1 UD (=1 tab)
A10BD04 / Avandaryl / Tab / Glimepiride 2 mg/Rosiglitazone 4 mg / 1 UD (=1 tab)
A10BD04 / Avandaryl / Tab / Glimepiride 4 mg/Rosiglitazone 4 mg / 1 UD (=1 tab)
A10BD04 / Avandaryl / Tab / Glimepiride 1 mg/Rosiglitazone 8 mg / 1 UD (=1 tab)
A10BD04 / Avandaryl / Tab / Glimepiride 2 mg/Rosiglitazone 8 mg / 1 UD (=1 tab)
A10BD04 / Avandaryl / Tab / Glimepiride 4 mg/Rosiglitazone 8 mg / 1 UD (=1 tab)
A10BD05 / Actoplus met / Tab / Metformin 500 mg/Pioglitazone 15 mg / 2 UD (=2 tab)
A10BD05 / Actoplus met / Tab / Metformin 850 mg/Pioglitazone 15 mg / 2 UD (=2 tab)
A10BD05 / Competact / Tab / Metformin 850 mg/Pioglitazone 15 mg / 2 UD (=2 tab)
A10BD06 / Duetact / Tab / Glimepiride 2 mg/ Pioglitazone 30 mg / 1 UD (=1 tab)
A10BD06 / Duetact / Tab / Glimepiride 4 mg/ Pioglitazone 30 mg / 1 UD (=1 tab)
A10BD08 / Eucreas / Tab / Metformin 850 mg/ Vildagliptin 50 mg / 2 UD (=2 tab)
A10BD08 / Eucreas / Tab / Metformin 1000 mg/ Vildagliptin 50 mg / 2 UD (=2 tab)
B01AC30 / Asasantin Retard / Caps / Dipyridamole 0.2 g/ Acetylsalicylic acid 25 mg / 2 UD (=2 tab)
C10BA02 / Inegy / Tab / Simvastatin 20 mg/ Ezetimibe 10 mg / 1 UD (=1 tab)
C10BA02 / Inegy / Tab / Simvastatin 40 mg/ Ezetimibe 10 mg / 1 UD (=1 tab)
C10BA02 / Inegy / Tab / Simvastatin 80 mg/ Ezetimibe 10 mg / 1 UD (=1 tab)
G03GA30 / Pergoveris / Inj / Follitropin alfa150 IU / Lutropin alfa75 IU / 1 UD (= 1 ml)
G03HB01 / Diane / Tab / Cyproterone 2 mg/Ethinylestradiol 35 mcg / 0.75 UD (=0.75 tab)
G04BE30 / Androskat / Inj / Papaverine 15 mg/Phentolamine 0.5 mg / 1 UD (= 1 ml)
J01AA20 / Deteclo / Tab / Tetracycline 115.4 mg/Chlortetracycline 115.4 mg/Demeclocycline 69.2 mg / 2 UD (=2 tab)
J01CA20 / Miraxid / Tab / Pivampicillin 0.25 g/Pivmecillinam 0.2 g / 3 UD (=3 tab)
J01CA20 / Miraxid mite / Tab / Pivampicillin 0.125 g/Pivmecillinam 0.1 g / 6 UD (=6 tab)
J01CE30 / Bicillin C-R, Bicillin A-P, Bicillin / Powder for inj / Comb. of Benzylpenicillin/Procain-benzylpenicillin/Benzathine benzylpenicillin / 3.6 g expressed as benzylpenicillin
J01CR50 / Ampiclox / Tab / Ampicillin 0.25 g/Cloxacillin 0.25 g / 4 UD (=4 tab)
J01CR50 / Ampoxium / Powder for inj / Ampicillin 0.66 g/Oxacillin 0.33 g / 2 UD (= 2 g)
J01CR50 / Ampoxium / Caps / Ampicillin 0.125g/Oxacillin 0.125 g / 8 UD (= 8 caps)
J01CR50 / Co-fluampicil / Tab / Ampicillin 0.25 g/Flucloxacillin 0.25 g / 4 UD (=4 tab)
J01EC20 / Trisulfamid / Tab / Sulfacarbamide 0.167 g/Sulfadiazine 0.167 g/
Sulfadimidine 0.167 g / 4 UD (=4 tab)
J01EE01 / Bactrim, Eusaprim, Trimetoprim-sulfa / Inf.conc / Sulfamethoxazole 80 mg/ Trimethoprim 16 mg / 20 UD (=20 ml)
J01EE01 / Bactrim, Eusaprim, Trimetoprim-sulfa / Mixt / Sulfamethoxazole 0.2 g/ Trimethoprim 40 mg / 8 UD (= 40 ml)
J01EE01 / Bactrim, Eusaprim Trimetoprim-sulfa / Tab / Sulfamethoxazole 0.4 g / Trimethoprim 80 mg / 4 UD (=4 tab)
J01EE02 / Triglobe, Trimin Sulfa / Mixt / Sulfadiazine 0.205 g/ Trimethoprim 45 mg / 4 UD (=20 ml)
J01EE02 / Triglobe, Trimin Sulfa / Tab / Sulfadiazine 0.41 g/ Trimethoprim 90 mg / 2 UD (=2 tab)
J01EE03 / Lidaprim / Tab / Sulfametrole 0.8 g/ Trimethoprim 0.16 g / 2 UD (=2 tab)
J01EE03 / Lidaprim / Powder for inj / Sulfametrole 0.8 g/ Trimethoprim 0.16 g per vial / 2 UD (defined as 2 vials)
J01EE06 / Sterinor / Tab / Sulfadiazin 0.25 g/Tetroxoprim 0.1 g / 2 UD (=2 tab)
J01EE07 / Berlocombin / Tab / Sulfamerazin 0.12 g/ Trimethoprim 80 mg / 4UD (=4 tab)
J04AM02 / Rifinah / Tab / Rifampicin 0.3 g/ Isoniazid 0.15 g / 2 UD (=2 tab)
J04AM02 / Rifinah / Tab / Rifampicin 0.15 g/ Isoniazid 0.1 g / 4UD (=4 tab)
J04AM02 / Rimactazid / Tab / Rifampicin 0.15 g/ Isoniazid 75 mg / 4UD (=4 tab)
J04AM05 / Rifater / Tab / Rifampicin 0.12 g/ Isoniazid 50 mg/
Pyrazinamide 0.3 g / 6UD (=6 tab)
J04AM05 / Rimcure / Tab / Rifampicin 0.15 g/ Isoniazid 75 mg/
Pyrazinamide 0.4 g / 4UD (=4 tab)
J04AM06 / Rimstar / Tab / Rifampicin 0.15 g/ Ethambutol 0.275 g / Isoniazid 75 mg/ Pyrazinamide 0.4 g / 4UD (=4 tab)
J05AR01 / Combivir / Tab / Lamivudine 0.15 g/ Zidovudine 0.3 g / 2 UD (=2 tab)
J05AR02 / Kivexa / Tab / Abacavir 0.6 g/ Lamivudine 0.3 g / 1 UD (=1 tab)
J05AR03 / Truvada / Tab / Emtricitabine 0.2 g/Tenofovir disoproxil 0.245 g / 1 UD (=1 tab)
J05AR04 / Trizivir / Tab / Zidovudine0.3 g/Lamivudine 0.15 g/
Abacavir0.3 g / 2 UD (=2 tab)
J05AR06 / Atripla / Tab / Emtricitabine 0.2 g/Tenofovir disoproxil 0.245 g/ Efavirenz 0.6 g / 1 UD (=1tab)
M03BA52 / Somadril comp / Tab / Carisoprodol 0.2 g/Paracetamol 0.16 g/
Caffeine 32 mg / 4 UD (=4 tab)
M03BB52 / Lobac / Tab / Chlormezanone 0.1 g/ Paracetamol 0.45 g / 4 UD (=4 tab)
M03BB53 / Paraflex Comp / Tab / Chorzoxazone 0.125 g/Acetylsalicylic acid 0.5 g/
Dextropropoxifene (napsylate) 45 mg / 4 UD (=4 tab)
M03BC51 / Norgesic / Tab / Orphenadrine 35 mg/ Paracetamol 0.45 g / 4 UD (=4 tab)
N02AA59 / Codeine/ paracetamol / supp / Codeine 20 mg/Paracetamol 1.0 g / 3 UD (=3 supp)
N02AA59 / Paralgin forte / Tab / Codeine 30 mg/Paracetamol 0.4 g / 4 UD (=4 tab)
N02AA59 / Paralgin forte / Supp / Codeine 30 mg/Paracetamol 0.4 g / 4 UD (=4 supp)
N02AA59 / Citodon, Parkodin forte, Panocod, Pinex forte / Tab / Codeine 30 mg/Paracetamol 0.5 g / 3 UD (=3 tab)
N02AA59 / Citodon / Supp / Codeine 30 mg/ Paracetamol 0.5 g / 3 UD (=3 supp)
N02AA59 / Codeine/ paracetamol / supp / Codeine 40 mg/ Paracetamol 0.5 g / 3 UD (=3 supp)
N02AA59 / Codeine/ paracetamol / Tab / Codeine 50 mg/ Paracetamol 0.5 g / 3 UD (=3 tab)
N02AA59 / Citodon forte / Supp / Codeine 60 mg/ Paracetamol 1 g / 1.5 UD (=1.5 supp)
N02AC54 / Aporex / Tab / Dextropropoxyphene 70 mg/ Paracetamol 0.4 g / 2 UD (=2 tab)
N02AG01 / Morfin-skopolamin / Inj / Morphine 10 mg/ Scopolamine 0.4 mg / 1 UD (=1 ml)
N02AG02 / Ketogan / Supp / Ketobemidone 10 mg/ Dimethylaminodiphenylbutene50 mg / 2.5 UD (=2.5 supp)
N02AX52 / Ultracet/Zaldiar / Tab / Tramadol 37.5 mg/ Paracetamol 0.325 g / 4 UD (=4 tab)
N02BA51 / Migrafin / Powder, single dose sachets / Acetylsalicylic acid 0.9 g/Metoclopramide 10 mg / 3 UD (=3 sachets)
N06CA02 / Deanxit / Tab / Melitracen 10 mg/ Flupentixol 0.5 mg / 1 UD (=1 tab)
N07AA51 / Robinul-Neostigmine / Inj / Glycopyrronium 0.5 mg/ Neostigmine 2.5 mg / 1 UD (=1ml)
P01BB51 / Malarone / Tab / Atovaquone 0.25 g/ Proguanil hydrochloride0.1 g / 4 UD (=4 tab)
P01BB51 / Malarone junior / Tab / Atovaquone 62.5 mg/
Proguanilhydrochloride 25 mg / 16 UD (=16 tab)
R03AK03 / Berodual / Inhal.aer / Fenoterol 50 mcg/ Ipratropium bromide 20 mcg / 6 UD (=6 doses inhal.aer)
R03AK04 / Combivent / Inhal.aer / Salbutamol 0.12 mg/ Ipratropium bromide 20 mcg / 6 UD (=6 doses inhal.aer)
R03AK04 / Combivent Unit Dose / Inhal.sol / Salbutamol 2.5 mg/ Ipratropium bromide 0.5 mg/ vial:2.5 ml / 3 UD (=3 vials inhal.sol)
R03AK06 / Seretide / Inhal.powd / Salmeterol 50 mcg/ Fluticasone 0.1 mg (metered dose) / 2 UD (=2 inhal.powd)
R03AK06 / Seretide / Inhal.powd / Salmeterol 50 mcg/ Fluticasone 0.25 mg (metered dose) / 2 UD (=2 inhal.powd)
R03AK06 / Seretide / Inhal.powd / Salmeterol 50 mcg/ Fluticasone 0.5 mg (metered dose) / 2 UD (=2 inhal.powd)
R03AK06 / Seretide / Inhal.aer / Salmeterol 25 mcg/ Fluticasone 50 mcg (metered dose) / 4 UD (=4 doses inhal.aer)
R03AK06 / Seretide / Inhal.aer / Salmeterol 25 mcg/ Fluticasone 0.125 mg (metered dose) / 4 UD (=4 doses inhal.aer)
R03AK06 / Seretide / Inhal.aer / Salmeterol 25 mcg/ Fluticasone 0.25 mg (metered dose) / 4 UD (=4 doses inhal.aer)
R03AK07 / Foster / Inhal.aer / Formoterol 6 mcg/ Beclometasone 0.1 mg (metered dose) / 4 UD (=4 doses inhal.aer)
R03AK07 / Symbicort mite / Inhal.powd Turbohaler / Formoterol 4.5 mcg / Budesonide 80 mcg (delivered dose) / 4 UD (=4 inhal.powd)
R03AK07 / Symbicort / Inhal.powd Turbohaler / Formoterol 4.5 mcg / Budesonide 0.16 mg (delivered dose) / 4 UD (=4 inhal.powd)
R03AK07 / Symbicort forte / Inhal.powd Turbohaler / Formoterol 9 mcg/ Budesonide 0.32 mg (delivered dose) / 2 UD (=2 inhal.powd)
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