9

CURRICULUM VITAE

Daniel J. Frey, M.D., FACS

Title: Vice Chairman – Department of Surgery

Professor of Surgery

Chief, Division of Transplantation

Office Address: Department of Surgery

LSUHSC

University Medical Center

2390 West Congress Ave

Lafayette, La 70506

Office Telephone Number: 337-261-8500

Office Fax Number: 337-261-8505

E-Mail

Education: B.S.: Louisiana State University

Biochemistry/Pre-Med, 1978

M.D.: Louisiana State University

School of Medicine, 1982

Surgical Resident, Charity Hospital

L.S.U. Division

New Orleans, Louisiana, 1982-1985

Surgical Resident, Lahey Medical Clinic

Burlington, Massachusetts, January 1986--June 1986

Chief Resident, Department of Surgery

L.S.U. School of Medicine

New Orleans, Louisiana, July 1986--June 1987

Fellowship in Transplantation

University of Minnesota Hospitals, 1989-1990


Academic Positions/Appointments

Clinical Instructor Department of Surgery, Louisiana State University Medical Center,

New Orleans, Louisiana July 1984--July 1989

Teaching Resident in Surgery, Louisiana State University Medical Center,

New Orleans, Louisiana July 1986--December 1986

Clinical Assistant Professor of Surgery, Louisiana State University Medical Center,

New Orleans, Louisiana July 1989--July 1990

Assistant Professor of Surgery, Louisiana State University Medical Center,

New Orleans, Louisiana July 1990--July 1995

Associate Professor of Surgery, Louisiana State University Medical Center,

New Orleans, Louisiana July 1995--2003

Professor of Surgery, Louisiana State University Medical Center,

New Orleans, Louisiana July 2003--present

Interim Chairman, Louisiana State University Medical Center

New Orleans, Louisiana October 2002--February 2004

Vice Chairman of Surgery, Louisiana State University Medical Center

New Orleans, Louisiana July 2002-present

Other Professional Appointments

Louisiana Organ Procurement Agency:

President 2009-2011

Board of Directors 1990- present

Secretary 1993-1994

Vice President 1992

Medical Director 1999-2001

Hotel Dieu Hospital Committees:

Pharmacy & Therapeutics, ICU 1992-1993

National Kidney Foundation:

Board of Directors 1993-2004

American Association of Kidney Patients

Board of Directors 1993-1999

Memorial Medical Center - ICU Committee 1997-2000

Pharmacy and Therapeutics 2000-2005

Other Professional Appointments (Cont’d)

University Medical Center-Lafayette, La

Pharmacy and Therapeutics committee 2008

Infection Control Committee (chair) 2008

LSU PPA:

Board of Directors 1994-1995

LSU Department of Surgery Compliance Officer 1998-2003

LSU School of Medicine

Faculty Assemby alternate 1999-2003

Ethics Curriculum Committee 1999-2003

IPE committee 2004

Supplemental compensation committee (chair) 2008

Self Study committee on Faculty 2008

LSUHN

Executive committee 2008-present

Attending Surgeon:

Medical Center of Louisiana, New Orleans 1990-2006

Memorial Medical Center 1993-2006

Children’s Hospital of New Orleans 1993-2006

University Medical Center-Lafayette, La 2005-present

American College of Surgeon – Louisiana Chapter

President 2009

Board of Governors 2008

Council Member 2001-2003

Secretary 2004-2006

Vice President 2007

Young Surgeon 2000

President-elect 2008

Program Chairman-Louisiana Chapter American College

of Surgeons/Surgical Association of Louisiana,

Annual Meeting 2001 and 2002

Board Certifications

American Board of Surgery: February 1988

Recertifications October 1996/ October 2006

Speciality Certificate in Surgical Critical Care, 1995

Recertified 2003

Medical Licensure

Louisiana July 1982, No. 016612

Minnesota, 1989, No. 032461 (Inactive)

Awards/Honors

Alpha Omega Alpha, 1982

Phi Kappa Phi, 1977

Top Doctor of New Orleans, Louisiana, and US

Professional Society Memberships

Southern Surgical Society

American College of Surgeons

American Medical Association

American Society of Transplant Surgeons

Association for Academic Surgery

Gulf Coast Vascular Society

James D. Rives Surgical Society (executive committee) President 2010

Louisiana State Medical Society (House of Delegates 2007-2008)

New Orleans Surgical Society (secretary)

Lafayette Parish Medical Society (executive committee)

Society of Critical Care Medicine

Southeastern Surgical Society

Editorial & Advisory Boards – None

Publications -- Refereed:

1. Sottiurai, V. S.; Sue, S. L.; Batson, R. C.; Frey, D. J.; Khaw, H. (1985). Effects of Papaverine on Smooth Muscle Cells; Morphology and vein graft preparation. Journal of Vascular Surgery, 2, 834-42.

2. Remine S. G.; Frey, D. J.; & Rossi, R. (1987). Cystic neoplasms of the pancreas. Archives of Surgery, 122, 442-447.

3. Najarian, J. S.; Frey, D. J.; & Matas, A. J (1990). Renal transplantation in infants. Annals of Surgery 212, 353-367.

4. Matas, A. J.; Frey, D. J.; Gillingham, K. J.; & Noreen, H. J. ( 1990 ). The impact of HLA matching on graft survival and on sensitization after a failed transplant: Failure of “poor” matched renal transplants does not result increased sensitization. Transplantation.,50.589- 607.

5. Frey, D. J.; & Matas, A. J. (1991). Allocation of cadaver kidneys: A survey of the American Society of Transplant Surgeons. Clinical Transplantation; 5, 1-2.

6. Chappuis, C. W.; Frey, D. J.; Dietzen, C. D.; Panetta, T. R.; Buechter, K. J.; & Cohn, I., Jr. (1992). Management of penetrating colon Injuries: A prospective randomized trial. Annals of Surgery, 213, 493-498.

7. Matas, A. J.; & Frey, D. J. (1992). Sequential therapy : A prospective randomized trial of MALG vs OKT3 for prophylactic immunosuppression in cadaver renal allograft recipients. Transplantation, 54; 50-56.

8. Kumar, P.; Frey, D. J.; Ahuja, A.; Shahane, A.; Sander, M.; Elston, R.; Thompson, J.; Nelson, D.; & Elston, R. (1992). The influence of donor-recipient race on cadaveric renal allograft survival. Clinical Research, 40, 862 A.

9. Frey, D. J.; Matas, A. J.; Gillingham, K. J.; Canafax, D.; Payne, W. D.; Dunn, D. L.; Sutherland, D. E.; & Najarian, J. S. (1992). Sequential therapy: A prospective randomized trial of MALG versus OKT3 for prophylactic immunosuppression in cadaver renal allograft recipients. Transplantation, 54, 50-56.

10. Kaku, D. A.; Malamut, R. I.; Frey, D. J.; & Parry, G. J. (1993 ). Conduction block as an early sign of reversible injury in ischemic monomelic neuropathy. Neurology, 43,

1126- 1130.

11. Jacobbi, L. M.; McBride, V. ; Etheredge, E. E.; McDonald, J. C.; Cooper, E. S.; Frey, D. J.; Boudreaux, J. P.; Gonzalez, F.; Van Meter, C.; & McMillan, R. (1995). The risks, benefits, and costs of expanding donor criteria: A collaborative prospective three-year study. Transplantation, 60, 149-196.

12. Kumar, P.; Thompson, J. J.; Frey, D. J.; Vira, M. A.; Shahane, A.; Sander, M. S.; Elston, R. C.; & Pepys, J. ( 1996 ). Delayed hypersensitivity skin tests and subsequent renal transplant outcome. Clinical and Experimental Allergy, 26, 104-107

13. Sotturai, V. S.; Stephens, A.; Champagne, Moradeshagi, P.; Frey, D. J.; Reisin, E. ( 1997 ).

Comparative results of early and delayed cannulation of arteriovenous graft in hemodialysis. Eur J Vasc Endovasc Surgery, 2, 139-141.

14. Meyers, M.O.; Frey, D.J.; Levine, E.A.; ( 1998 ). Pancreaticoduodenectomy For Melanoma Metastatic to the Duodenum: A Case Report and Review of the Literature. The American Surgeon 64, 1174- 1176

15. Catinis, G.E.; Frey, D.J.; Skinner, J.W.; Balart, L.A.; (1998) Hepatic Cystadenoma:

An Unusual Presentation. American Journal of Gastroenterology. May; 93 (5): 827-829.

16. Gulec S.,A., Mountcastle T.S., Frey D., Cundiff J.D., Mathews E., Anthony L., O’Leary J.P., Boudreaux J.P.: 2002) Cytoreductive surgery in patients with advanced-stage carcinoid tumors. The American Surgeon. August 2002; 68(8):667-71

17. Zhang, R.; Leslie, B.; Boudreaux, J. P.; Frey, D. J.; Reisin, E.; (2003) Hypertension after Kidney Transplantation: Impact. Pathogenesis and Therapy. The American Journal of the Medical Sciences. April; 325 (4):202-208.

18. Woltering EA, Lewis JM, Maxwell PJ 4th, Frey D. J, Wang YZ, Rothermel J, Anthony

CT, Balster DA, O’Leary JP, Harrison LH.; (2003) Development of a Novel In Vitro Human

Tissue Based Angiogenesis Assay to Evaluate the Effect of Antiangiogenic Drugs. Ann

Surg. June 2003; 237(6):790-800.

19. Kumar P, Chandrahasa U, Vitalpur G, Bhatnagar D, Boudreaux JP, Frey D J, Jerius J,

Arora B, Wiley K, O’Brien R, and Mercante D: Influence of Parity on Rejection and Graft Loss in Primary Renal Transplantation. Submitted to Transplantation Proceedings, 2003.

20. Anthony L, Boudreaux J P, Castaneda W, Daly I, Frey D J, Lopera J, Putty B, Ramcharan T, Woltering E; (2005) Surgical Treatment of Advanced-stage carcinoid Tumors – Lessons Learned. Annals of Surgery. June 2005; 241(6):

Publications—Non-refereed

1. Frey, D. J.; Sottiurai, V. S.; & Hollier, L. H. (1983). Dacron-reinforced bovine heterograft for hemodialysis: Long-term follow up of a new prosthesis. Trans American Society of Artificial Internal Organs, 19, 379.

2. Najarian, J. S.; Frey, D. J.; Matas, A. J.; So, S. K. S.; Cook, M.; Mauer, S. M.; Chavers, B. M.; Kashtan, C.; Gillingham, K. J.; & Nevins, T. E. (1991). Successful kidney transplantation in infants. Transplantation Proceedings 23, 1382-1383.

Publications-Non-refereed cont

3. Frey, D. J.; Gillingham, K. J.; & Najarian, J. S. (1991). ALG vs OKT3 following renal transplantation: A randomized prospective trial. Transplantation Proceedings. 23; 1048-1049.

4. Almond, P.S.; Troppmann, C.; Escobar, F. S.; & Frey, D. J. (1991). The economic impact of delayed graft function. Transplantation Proceedings, 23; 1304-1305.

5. McDonald, J.C.; Etheredge, E.E.; Frentz, G. D.; Frey, D. J.; Genre, C.F, Gonzalez, F.M.; Hayes, D.H.; Landreneau, M.D. (1991). Organ procurement and transplantation in Louisiana: An update after 16 years. LSU Medical Center, Shreveport. J La State Medical Society. September; 143(9): 29-31.

6. Prosad, M.; Kumar, P.: Rao, P.; Thompson, J.; Frey, D.; Webb, M.; Boudreaux, J.P.: Postitive B-cell crossmatch results and renal transplant outcome – Clinical Research, Dec. 1993; 41(4):795A.

7. Jacobbi, L. M.; McBride, V.; Etheredge, E.E.; McDonald J.C.; Feduska, N.; Frey D. J.; Boudreaux, J.P.; Van Meter, C.; Mc Millian, R.; Tesi, R.J. (1997). Cost associated with expanding donor criteria: A collaborative statewide prospective study. Louisiana Organ Procurement Agency, Metairie. Transplant Proceedings February-March; (1-2/01): 1550- 1556.

8. Boudreaux, J. P.; Frey, D. J.; Tesi, R. J., et al: Development of pancreatic transplantation in Louisiana: A multi-institutional program. Transplantation Proceedings. 1997 29;(1-2); 1550-56.

9. Vitalpur, G.; Dixit, S.;Boudreaux, J.; Frey, D. J.; Arora, B.;Wiley, K.;Mercante, D.; Kumar, P.; (2003) The influence of HL Alleles on Graft Loss and Rejection Episodes in Renal Transplantation: J of Allergy Clin Immunol, 111 (2).

10. Kumar P, Chandrahasa U Boudreaux P, Frey D, Mercante D: Renal Allograft Outcome in Multiparous Women. Accepted in Journal of Investigative Medicine.

Books and Book Chapters

Frey, D. J.; & Matas, A. J. ( 1990 ) Chapter on renal transplantation. Critical Care Clinics; 6,

899-910.

Frey, D. J.; & Fawzy, A. (1993). "Urinary System" in Physiologic Basis of Surgery,

O'Leary, J. P. (Ed.). New York: Williams & Wilkins.

Abstracts

1. Aviles, D.H.; Boudreaux, J. P.; Frey, D. J.; Irwin, K. C.; Vehaskari, V. M.; (1998). Blood pressure in pediatric kidney transplant recipients treated with tacrolimus. Southern Society for Pediatric Research, New Orleans

2. Kumar P, Frey D, Ahuja A, Shahane A, Sander M, and Elston R. The influence of donor-recipient race on cadaveric renal allograft survival. American Federation of Clinical Research, 39:874A, 1991.

3. Kumar P, Frey D, Ahuja A, Shahane A, Sander M, and Elston R. The influence of donor-recipient race on cadaveric renal allograft survival. Journal of Allergy and Clinical Immunology, 89:274, 1992.

4. Breeden L, Frey D, Kumar P, Pepys J, Thompson J, Welsh R, and Wiley K. Prolongation of delayed hypersentitivity skin test (DHST): Potential application for monitoring immunosuppressive therapy. American Federation of Clinical Research, 40:786A, 1992.

5. Breeden L, Frey D, Kumar P, Pepys J, Thompson J, Welsh R, and Wiley K. Prolongation of delayed hypersentitivity skin test (DHST): Potential application for monitoring immunosuppressive therapy. Journal of Allergy and Clinical Immunology, January 1993,

p. 214

6. Chadha S, Cai X, Rao P, Kumar P, Frey D, Boudreaux P, and Stewart D. The impact of CREG HLA matching on graft survival in primary cadaveric renal transplantation.

Journal of Investigative Medicine 45(1) 2A; 1997.

7. Kumar P, Chandrahasa U, Frey D, Bourdreaux P, Jerius J, Bhatnagar D, and Mercante D. The influence of Multiparity on Renal Allograft Outcome. Accepted for presentation at AFMR 2002.

8. Mabudian MI, Thomson JL, Sialkow J, Arora B, Urlej K, Frey D, Kumar P. Predictive Post Transplant and Diabetes. Supplement to Human Immunology, (Suppl 1) 65, 2004

9. Arora B, Boudreaux P, Daley I, Frey D, Kumar P, O’Brien, Thiagarajan R, Yao L. The impact of pre-transplant Flow Cytometry Crossmatches on renal allograft outcome: A Pilot Study. Presented at The American Society for Histocompatibility and Immunogenetics Annual Meeting; 2005.

Films

Cell Saver, (1983) Boudreaux, J. P.; & Frey, D. J. Teaching Film, LSU Dept of Surgery.

Management of Choledochal Cyst, (1987) Chappuis, C. W.; & Frey, D. J. Presented Fall

Meeting ACS.

Presentations

MALG vs OKT3 following renal transplantation - a randomized trial. XIII International

Congress, August 1990, Paris, France.

Ethics in Transplantation. Gulf States Nurse Attorney Association, November 1990.

Renal Transplantation in Infants.

New Orleans Surgical Society, January 1991.

Tulane University Surgical Grand Rounds ,1992

Family Practice Update - Transplantation, New Orleans, 1994, 1995, 1996

Transplantation. The Greater New Orleans Chapter of the American Association for Medical Transcription, November 1994.

Pancreas Transplantation in Louisiana. Louisiana Chapter of the American College of Surgeons,

January 1996.

Organ Donation - Coroner Association of Louisiana, 2000

Liver Transplantation in the Year 2000 - International Transplant Nurses Association,

March 2000

Surgical Treatment of Advanced Carcinoid Tumors- Carcinoid Update Conference- New Orleans, La May, 2004

Long Road to Successful Transplantation- Lafayette Parish Nurses Association-Sept 2006

Surgical Cure of Diabetes:An update on Pancreas Transplantation-Association of Surgical Technologists National Meeting, New Orleans, LA-May, 2007

Treatment of Chronic Allograft Nephropathy-University of Minnesota update on Immunosuppressive Therapy, Oct 2007

Considerations in Renal Living Donation-panel discussion University of Minnesota Update on Immunosuppressive Therapy Oct 2007

Renal Transplantation Update-Acadiana Continuing Education Program Oct,2008

Research

Pi ( ) and Alpha Gluthathione - s - Transferase (GST) as Indicators of Tubular Damage in

Renal Transplantation: Investigators: Rao, P.; Kumur, ; Boudreaux, J.P.; Frey, D. J.;

Etheridge, E.; & Bronsther, O.L.

The Evaluation of Story and Images in the Function of Transplanted Kidneys: Investigators:

Frey, D. J.; Gonzalez, N. K.

“A Randomized, Open- Label Preference Study of Gengraf™ Compared to Neoral® in

Stable Solid- Organs Transplant Subjects”: Investigators: Frey, D. J.; Butcher, B.T.

Pilot Trial to Determine the Feasibilty of a One Step Sentinel Lymph Node Biopsy Procedure Using Radiolabelled Methylene Blue (IND-70,627) Woltering, Frey, Chappuis, Harkrider-started Sept 2008

Grants

1. Enhancing Donor Registry Strategies to Increase Organ Donation: Investigators: Frey, D.J.; Robbins, M., NIH grant 5R18 AI133449-08 LOPA 9/93 – 9/03

2.  Enhancing Donor Registry to License Donation: Frey, D. J.; Ranum, K., NIH 5R18AI33449-08, $100.000 9/9/02 – 9/9/03

3. Isotechniska Grant – LSUHSC – Study of a Novel Immun Suppresant