THE ROYAL AUSTRALIAN CHEMICAL INSTITUTE

RACI NSW Branch Organic One-Day Symposium 2014

VENUE:Research School of Chemistry,

The Australian National University

Lectures:Arthur Hambly Lecture Theatre T1 (Building 34);

Lunch and Refreshments: RSC Courtyard (Building 137).

DATE:Wednesday, 3rdDecember 2014

TIME: Registrationfrom 8.30am

Lectures begin 9.00 am and end at 5.30 pm.

Plenary Speakers:

  • ProfessorRegan Thomson (Northwestern University, USA)
  • ProfessorChris Vanderwal (University of California Irvine, USA)

Call for Papers and Posters

We call for abstracts for 20 minuteoral presentations (15 min lecture, 5 min questions) or poster presentations with the deadline for submissions Monday November 10th 2014.

Abstracts, using the template attached, should be sent by e-mail as an attached file to with the subject of the email ‘Organic One Day Symposium Abstract'.

Abstracts not received in the appropriate format may not be considered. Please also note your preference for an oral or poster presentation.

Students delivering an oral presentation will have their registration fee waived.

You will be notified by email of your acceptance for an oral presentation by Wednesday 12th November.

For enquiries regarding abstracts, please contactProfessor Mick Sherburn ()

Registration FormKeep for tax purposes

RACI New South Wales Branch ABN: 69 030 287 244 In Reg Number: A0040386

Title: ______Name:______

Name For Badge: ______

Organisation: ______

Mailing Address: ______

Phone: ______

Email: ______

Presentation Type: Poster Oral Presentation Participant

Registration Fee (Includes morning/afternoon teas, lunch, refreshments and abstract booklet)

Please check one box:

$60(RACI member) $90 (Non-member)

$40 (RACI student member) $60 (Student non-member)

Studentsdeliveringtalks will not be charged conference fees.

Prices shown are for registration up to Monday 17thNovember 2014. After this date,registration costs are $20 extra.

Payment Type: Visa MasterCard

Amount:$______

Card Number : ______ExpiryDate______

Name: ______Signature: ______

Cheque (send via post) Cheque payable to: RACI NSW (Organic Chemistry Group)

Staying overnight in Canberra?

YES! I would like to attend the conference dinner at a local restaurant.

(Leave box blank if not coming to dinner)

Return via fax (02 9385 6141), email () or post (RACI, New South Wales Branch, School of Chemistry, UNSW, SYDNEY, 2052)

ORALOn the Synthesis and Biosynthesis of Kingianin A

Samuel L. Drew*,Andrew L. Lawrence, and Michael S. Sherburn

Research School of Chemistry, Australian National University, ACT, Australia

*

Prof. Black first presented his now famous hypothesis for the biosynthesis of the endiandric acids some thirty years ago.[1] Central to this hypothesis was the formation of a bicyclo[4.2.0]octadiene core through a non-enzymatic 8π-6π electrocyclisation of either an E,Z,Z,E- or Z,Z,Z,Z-tetraene. Subsequent biomimetic syntheses of the endiandric acids by Nicoalou and co-workers found the E,Z,Z,E-tetraene to be a viable biosynthetic precursor.[2] However, the pathway via the Z,Z,Z,Z-tetraene remains unexplored, with all previous biomimetic syntheses of bicyclo[4.2.0]octadiene natural products being achieved through generation of E,Z,Z,E-tetraenes.[3] Evidently, synthetic chemists have been discouraged by the challenge of affording a Z,Z,Z,Z-tetraene in a stereoselective manner.[4]

The total synthesis of kingianins A and D from a Z,Z,Z,Z-tetraene will be presented. Access to this Z,Z,Z,Z-tetraene was achieved through the unprecedented four-fold cis-selective partial reduction of a tetrayne. The intriguing Diels-Alder dimerisation in the kingianin biosynthesis will also be discussed.

Please use this template/format as a guide for abstract submissions

[1]Bandaranayake, W. M.; Banfield, J. E.; Black, D. S. C. J. Chem. Soc., Chem. Commun. 1980, 902.

[2]Nicolaou, K. C.; Petasis, N. A.; Zipkin, R. E.; Uenishi, J. J. Am. Chem. Soc.1982, 104, 5555-5562.

[3]Beaudry, C. M.; Malerich, J. P.; Trauner, D. Chem. Rev. 2005, 105, 4757.

[4]Only three synthetic approaches to Z,Z,Z,Z-tetraenes have been reported in the literature.