CURRICULUM VITAE

Andrew C. Harris, Ph.D.


Department of Medicine
Minneapolis Medical Research Foundation

701 Park Avenue

Minneapolis, MN 55415


Department of Medicine
University of Minnesota Medical School

Minneapolis, MN 55455

Department of Psychology
University of Minnesota

Minneapolis, MN 55455

PERSONAL

Telephone: 612-250-0863

Fax: 612-873-6644

E-mail: harr0547@ umn.edu

EDUCATION

1996-2000 University of Wisconsin-Eau Claire B.S. Psychology (Summa Cum Laude)

Eau Claire, WI

2000-2005 University of Minnesota Ph.D. Psychology

Minneapolis, MN

2005-2008 Minneapolis Medical Research Foundation Postdoctoral Fellow

Minneapolis, MN

POSITIONS HELD
2008-2010 Associate Investigator
Department of Medicine, Minneapolis Medical Research Foundation

2010-present Investigator
Department of Medicine, Minneapolis Medical Research Foundation

2008-present Assistant Professor
Department of Medicine, University of Minnesota Medical School
2011-present Adjunct Assistant Professor
Department of Psychology, University of Minnesota


MEMBERSHIPS IN PROFESSIONAL ORGANIZATIONS

American Psychological Association Division 28: Psychopharmacology and Substance Abuse

College on Problems of Drug Dependence

Society for Neuroscience

Society for Research on Nicotine and Tobacco

University of Minnesota Tobacco Use Research Center
University of Minnesota Masonic Cancer Center


AWARDS

1996 Academic Achievement Scholarship
Scholarships, Incorporated

2000 Outstanding Student Paper Award Experimental Analysis of Behavior-Special Interest Group

2002 Center for Cognitive Sciences Travel Grant University of Minnesota
2002 David Campbell Graduate Research Fellowship for International Travel University of Minnesota

2003,04 Harrison Gough Research Support Fund

University of Minnesota

2006 Best Dissertation Award Nominee
University of Minnesota

2007 Early Career Investigator Travel Award College on Problems of Drug Dependence

AD HOC REFEREE

Neuropharmacology

Psychopharmacology

Pharmacology, Biochemistry, and Behavior

Nicotine and Tobacco Research

Drug and Alcohol Dependence

PUBLICATIONS
1. Harris, A.C., & Madden, G.J. (2002) Delay discounting and performance on the
Prisoner’s Dilemma game. The Psychological Record, 52, 429-440.

2. Harris, A.C., & Gewirtz, J.C. (2004) Elevated startle during withdrawal from acute
morphine: A model of opiate withdrawal and anxiety. Psychopharmacology, 171,
140-147.

3. Harris, A.C., Hanes, S.L., & Gewirtz, J.C. (2004) Potentiated startle and hyperalgesia

during withdrawal from acute morphine: Effects of multiple opiate exposures.
Psychopharmacology, 176, 266-273.

4. Hamilton, K.L., Harris, A.C., Sparber, S.B., Gewirtz, J.C., & Schrott, L.M. (2005)
HPA axis dysregulation following prenatal opiate exposure and postnatal
withdrawal. Neurotoxicology and Teratology, 27, 95-103.

5. Harris, A.C., & Gewirtz, J.C. (2005) Acute opioid dependence: Characterizing the early
adaptations underlying drug withdrawal. Psychopharmacology, 178, 353-366.

6. Harris, A.C., Atkinson, D.M., Aase, D.M., & Gewirtz, J.C. (2006) Double dissociation
in the neural substrates of acute opiate dependence as measured by withdrawal-
potentiated startle. Neuroscience, 139, 1201-1210.

7. Harris, A.C., Pentel, P.R., & LeSage, M.G. (2007) Prevalence, magnitude, and
correlates of an extinction burst in drug-seeking behavior in rats trained to self-
administer nicotine during unlimited access (23 hr/day) sessions.
Psychopharmacology, 194, 395-402.

8. Harris, A.C., Burroughs, D., Pentel, P.R., & LeSage, M.G. (2008) Compensatory
nicotine self-administration in rats during reduced access to nicotine: An animal
model of smoking reduction. Experimental and Clinical Psychopharmacology, 16,
86-97.

9. Harris, A.C., Rothwell, P.E., & Gewirtz, J.C. (2008) Effects of the NMDA receptor

antagonist memantine on the expression and development of acute opiate dependence as assessed by withdrawal-potentiated startle and hyperalgesia.
Psychopharmacology, 196, 649-660.

10. Roiko, S.A., Harris, A.C., Keyler, D.E., LeSage, M.G., Zhang, Y., & Pentel, P.R. (2008) Combined active and passive immunization enhances the efficacy of

immunotherapy against nicotine in rats. Journal of Pharmacology and

Experimental Therapeutics, 325, 985-993.

11. Roiko, S.A., Harris, A.C., Keyler, D. E., LeSage, M.G., & Pentel, P.R. (2009)
Passive immunization with a nicotine-specific monoclonal antibody decreases
brain nicotine levels but does not precipitate withdrawal in nicotine-dependent

rats. Pharmacology, Biochemistry, and Behavior, 93, 105-111.

12. Harris, A.C., Pentel, P.R., & LeSage, M.G. (2009) Correlates of individual differences
in compensatory nicotine self-administration in rats following a decrease in
nicotine unit dose. Psychopharmacology, 205, 599-611.

13. Harris, A.C., Mattson, C., LeSage, M.G., Keyler, D.E., & Pentel, P.R. (2010)
Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats.
Pharmacology, Biochemistry, and Behavior, 96, 217-227.

14. Pravetoni, M., Keyler, D.E., Raleigh, M.D., Harris, A.C., LeSage, M.G., Mattson, C.K.,
Pettersson, S., Pentel, P.R. (2011). Vaccination against nicotine alters the
distribution of nicotine delivered via cigarette smoke inhalation to rats.
Biochemical Pharmacology, 81, 1164-1170.

15. Harris, A.C., Pentel, P.R., Burroughs, D., Staley, M.D., LeSage, M.G. (2011). A lack of
association between severity of nicotine withdrawal and individual differences in
compensatory nicotine self-administration in rats. Psychopharmacology, 217,
153-156.

16. Cornish, K.E., Harris, A.C., LeSage, M.G., Keyler, D.E., Burroughs, D., Earley, C.,
Pentel, P.R. (2011). Combined active and passive immunization against nicotine:
Minimizing monoclonal antibody requirements using a target antibody
concentration strategy. International Immunopharmacology, 11, 1809-1815.

17. Harris, A.C., Stepanov, I., Pentel, P.R., & LeSage, M.G. (2012). Delivery of nicotine in
an extract of a smokeless tobacco product reduces its reinforcement-attenuating
and discriminative stimulus effects in rats. Psychopharmacology, 220, 565-576.
18. Harris, A.C., Manbeck, K.E., Schmidt, C.E., and Shelley, D. (2013). Mecamylamine
elicits withdrawal-like signs in rats following a single dose of nicotine. Psychopharmacology, 225, 291-302.

19. Raleigh, M.D., Pravetoni, M., Harris, A.C., Birnbam, A.K., and Pentel, P.R. (2013).

Selective effects of a morphine conjugate vaccine on heroin and metabolite

distribution and heroin-induced behaviors in rats. Journal of Pharmacology and
Experimental Therapeutics, 344, 397-406.

20. Hamilton, K.L., Harris, A.C., & Gewirtz, J.C. (2013). Affective and neuroendocrine
effects of withdrawal from chronic, long-acting opiate administration. Brain
Research, 1538, 73-82.

21. Manbeck, K.E., Shelley, D., Schmidt, C.E., and Harris, A.C. (2014). Effects of
oxytocin on nicotine withdrawal in rats. Pharmacology, Biochemistry, and
Behavior, 116, 84-89.

22. Harris, A.C., Mattson, C., Shelley, D. and LeSage, M.G (2014). Restraint stress
attenuates nicotine’s locomotor stimulant but not discriminative stimulus effects
in rats. Pharmacology, Biochemistry, and Behavior, 124, 92-100.

23. Harris, A.C., Tally, L., Schmidt C.E., Muelken, P., Stepanov, I., Saha, S., Isaksson
Vogel, R., LeSage, MG. (2015). Animal models to assess the abuse liability of
tobacco products: Effects of smokeless tobacco extracts on intracranial self-
stimulation. Drug and Alcohol Dependence. 147, 60-67.

24. Holtz, N.A., Radke, A.K., Zlebnik, N.E., Harris, A.C., Carroll, M.E. (2015). Intracranial
self-stimulation reward thresholds during morphine withdrawal in rats bred for
High (HiS) and low (LoS) saccharin intake. Brain Research. In press.

25. Harris, A.C., LeSage, M.G., Shelley, D., Perry, J.L., Pentel, P.R., Owens, S.M,. (2015).
The anti-(+)- methamphetamine monoclonal antibody mAb7F9 attenuates acute
(+)- methamphetamine effects on intracranial self-stimulation in rats. PLOS One.

10(3): e0118787. doi:10.1371/journal.pone.0118787

GRANT SUPPORT - CURRENT

NIDA R21 DA037728 . Co - Principal Investigator. A novel approach for identifying addiction vulnerability in animals. 2015-2017.

NCI U19 CA157345. Co-Investigator. Models for tobacco product evaluation (PIs D. Hatsukami, P. Shields). Subproject: Animal models for assessing the relative abuse liability of tobacco products (Project Leader M. Le Sage). 2012-2017.

NIDA R01 DA030715. Collaborator. Preclinical studies of a heroin/morphine vaccine for opiate addiction (PI P. Pentel). 2010 – 2015.

Minneapolis Medical Research Foundation. Core Faculty. Translational Addiction Research Program. 2008-2015.

NIDA #T32-DA07097. Core Faculty. Training in Neurobehavior/Neuroimmune Addiction Research (PIs S. Roy, T. Molitor). 2009-017.

GRANT SUPPORT - PREVIOUS

NIDA #1 F32 DA021935-01A1. Principal Investigator. NRSA Postdoctoral Fellowship training

award. Compensation of nicotine self-administration. 2007-08.

University of Minnesota Transdisciplinary Tobacco Use Research Center Pilot Grant. Co-Principal Investigator. An animal model of tobacco withdrawal using a cigarette smoke exposure system. 2007-08.

NIDA #T32-DA07097. Pre- and Post-doctoral Trainee. Training in Neurobehavior / Neuroimmune Addiction Research (PIs T. Molitor, S. Roy, S. Sparber). 2001-07.

University of Wisconsin-Eau Claire Faculty Student Collaborative Grant. Co-Principal Investigator. Delay discounting and choice. 2000.

INVITED LECTURES

Electronic Cigarettes and the Public Health: A Public Workshop (Food and Drug Administration (FDA) Center for Tobacco Products). Hyattsville, MD. “Animal models for assessing the relative abuse liability of electronic cigarettes”. 3/15.

19th Annual Duke Nicotine Research Conference (Duke University). Durham, NC. “Development of animal models of tobacco dependence using tobacco products”. 10/13.

Tobacco Research Studies Group (University of Minnesota). Minneapolis, MN. “Animal models of tobacco dependence using smokeless tobacco extracts”. 9/12.


Graduate Program in Neuroscience Colloquium (University of Minnesota). Minneapolis, MN. “Toward the development of animal models of tobacco dependence.” 12/10.

PharmacoNeuroImmunology Training Program Seminar Series (University of Minnesota). Minneapolis, MN. “Toward the development of novel animal models of tobacco dependence.” 09/10.

Transdisciplinary Tobacco Use Research Center Partners Meeting. Washington, DC. “Evaluating the use of reduced nicotine tobacco products using animal models.” 10/08.

PharmacoNeuroImmunology Training Program Retreat (University of Minnesota). Minneapolis, MN. “Examining determinants and consequences of compensatory smokingusing animal models.” 10/08.

Transdisciplinary Tobacco Use Research Center Seminar (University of Minnesota). Minneapolis, MN. “Examining determinants and consequences of smoking reduction using animal models.” 11/07.

Graduate Program in Neuroscience Colloquium (University of Minnesota). Minneapolis, MN. “Acoustic startle as an affective measure of acute opioid dependence in rats.” 10/05.

Center for Cognitive Sciences Colloquium (University of Minnesota). Minneapolis, MN. “Acoustic startle as a tool for characterizing the neural substrates of fear and anxiety.” 11/03.

TRAINEES

Molly Uvaas, B.S., 2010.

Katherine Manbeck, B.S., 2011-2012. Received an Undergraduate Research Opportunity
Program (UROP) award for her work in the lab in 2012.

Clare Schmidt, B.S., 2011-2014. Received UROP awards in 2012 and 2013.

Peter Muelken, B.S., 2012-2014. Received a UROP award in 2013.

Andrew Banal. 2014- Present.

Jack Smethells, PhD., 2014-Present.

Joseph, Tombers, 2015 – Present.

TEACHING EXPERIENCE

Course coordinator / Instructor. Neuropsychopharmacology (University of Minnesota; PHCL 8208 / PSY 8061). 2008, 2010, 2012, 2014

Guest lecturer. Introduction to Biological Psychology (University of Minnesota; PSY 3061). Minneapolis, MN. 2002, 2010, 2011.

Guest lecturer. Substance Abuse at the Bedside (University of Minnesota; PHCL 8209). Minneapolis, MN. 2010, 2011, 2012, 2014.

Instructor. Introduction to Cognitive Psychology (University of Minnesota; PSY 3015). 2001.

Teaching assistant. Introduction to Biological Psychology (University of Minnesota; PSY 3061). 2000, 2001.

Teaching assistant. Abnormal Psychology (University of Wisconsin-Eau Claire; PSY 3050). 1999.