Anti-CXCR4 / EI
6h / 12h / 24h / 45min / 3h / 6h / 12h
Myeloid granules proteins
Down-regulated
MPO / 203948_s_at / Myeloperoxidase / 776 / 1783 / 294 / 239 / 1552 / 1782 / 831
DEFB1 / 210397_at / Defensin beta 1 / 119 / 1663 / 137 / 181 / 147 / 157 / 2048
DEFA4 / 207269_at / Defensin alpha 4 / 90 / 52 / 181 / 52 / 60 / 208 / 56
CTSL / 202087_s_at / Cathepsin L / 3 / 4 / 13 / 3 / 6 / 24 / 8
ELA2 / 206871_at / Elastase / 9 / 7 / 7 / 7 / 6 / 6 / 5
PRTN3 / 207341_at / Proteinase 3 / 7 / 6 / 4 / 5 / 5 / 5 / 4
CTSG / 205653_at / Cathepsin G / 4 / 4 / 3 / 4 / 4 / 4 / 3
Receptor and receptor ligands
Down-regulated
TNFSF7 / 206508_at / Tumor necrosis factor (ligand) 7 / 45 / 34 / 23 / 14 / 10 / 52 / 64
TLR2 / 204924_at / Toll-like receptor 2 / 32 / 32 / 9 / 34 / 6 / 20 / 16
CCL2 / 216598_s_at / Chemokine (C-C motif) ligand 2 / 26 / 30 / 30 / 34 / 37 / 28 / 37
Flt3 / 206674_at / Fms-related tyrosine kinase 3 / 4 / 5 / 5 / 4 / 6 / 13 / 6
CCR2 / 206978_at / Chemokine (C-C motif) receptor 2 / 3 / 6 / 5 / 6 / 5 / 6 / 3
P2RY2 / 206277_at / Purinergic receptor P2Y / 4 / 4 / 4 / 2 / 3 / 3 / 3
NR3C1 / 216321_s_at / Nuclear receptor subfamily 3, group C, member 1 / 4 / 4 / 3 / 4 / 3 / 3 / 2
GIT2 / 204892_at / G protein-coupled receptor kinase interactor 2 / 4 / 3 / 6 / 3 / 3 / 2 / 5
THBD / 203887_s_at / Thrombomodulin / 3 / 4 / 2 / 4 / 5 / 5 / 5
CD38 / 205692_s_at / CD38 antigen / 3 / 9 / 4 / 3 / 3 / 3 / 2
Up-regulated
C1QR1 / 202878-s-at / Complement component 1, q subcomponent, receptor 1 / 48 / 56 / 64 / 45 / 60 / 60 / 69
CLEC5A / 219890_at / C-type lectin domain family 5, member A / 24 / 24 / 12 / 21 / 32 / 27 / 26
IL27RA / 222062_at / Interleukin 27 receptor, alpha / 23 / 20 / 13 / 11 / 11 / 23 / 26
IL2RG / 204116_at / Interleukin 2 receptor gamma / 12 / 14 / 23 / 13 / 16 / 15 / 20
CX3CR1 / 205898_at / Chemokine (C-X3-C motif) receptor 1 / 18 / 14 / 17 / 17 / 13 / 20 / 18
TBXA2R / 207555_s_at / Thromboxane A2 receptor / 5 / 7 / 7 / 5 / 7 / 9 / 7
PTPRC / 212588_at / Protein tyrosine phosphatase, receptor type, C (CD45) / 3 / 4 / 5 / 4 / 4 / 4 / 6
PROCR / 203650_at / Protein C receptor, endothelial / 5 / 4 / 4 / 4 / 5 / 4 / 5
FCGR1A / 216950_s_at / Fc fragment of IgG, high affinity Ia, receptor for (CD64) / 3 / 3 / 2 / 2 / 4 / 4 / 4
MYBL2 / 201710_at / v-myb myeloblastosis viral oncogene homolog / 3 / 3 / 2 / 3 / 3 / 3 / 2
IL10RA / 204912_at / Interleukin 10 receptor alpha / 2 / 2 / 3 / 2 / 2 / 2 / 2
IGF2R / 201393_s_at / Insulin-like growth factor 2 receptor / 2 / 2 / 4 / 3 / 3 / 3 / 4
G-CSFR / 203591_s_at / Colony stimulating factor 3 receptor (granulocyte) / 2 / 2 / 3 / 3 / 3 / 3 / 3
GM-CSFR / 205159_at / Colony stimulating factor 2 receptor, beta (granulocyte-macrophage) / 2 / 3 / 3 / 2 / 3 / 3 / 3
IL13RA1 / 201887_at / Interleukin 13 receptor alpha 1 / 2 / 2 / 2 / 2 / 2 / 2 / 2
Cell cycle regulated genes
/ / / / / /Down-regulated
TP53 / 201746_at / Tumor protein 53 / 28 / 39 / 23 / 26 / 23 / 24 / 16
G0S2 / 213524_s_at / G0/G1switch 2 / 11 / 74 / 21 / 12 / 42 / 60 / 32
GADD45A / 203725_at / Growth arrest and DNA damage inducible, alpha / 16 / 6 / 17 / 20 / 39 / 6 / 3
BCCIP / 218264_at / BRCA2 and CDKN1A interacting protein / 6 / 32 / 11 / 28 / 18 / 6 / 11
CDKN2D / 210240_s_at / Cyclin-dependent kinase inhibitor 2D (p19) / 20 / 5 / 5 / 4 / 4 / 6 / 3
BIRC5 / 02095_s_at / Survivin / 4 / 4 / 3 / 5 / 3 / 3 / 2
CCNB1IP1 / 217988_at / cyclin B1 interacting protein 1 / 4 / 5 / 3 / 3 / 3 / 3 / 3
GADD45B / 207574_s_at / Growth arrest and DNA-damage-inducible, beta / 3 / 4 / 3 / 3 / 3 / 3 / 3
CKS1B / 201897_s_at / CDC28 protein kinase regulatory subunit 1B / 3 / 3 / 2 / 3 / 3 / 3 / 2
Up-regulated
CCND2 / 200953_s_at / Cyclin D2 / 42 / 48 / 56 / 45 / 50 / 56 / 73
Apoptosis related genes
Down-regulated
BIK / 205780_at / Bcl2-interacting killer / 48 / 37 / 64 / 111 / 60 / 91 / 52
BIRC5 / 202095_s_at / Survivin / 4 / 4 / 3 / 5 / 3 / 3 / 2
DAPK1 / 203139_at / Death-associated protein kinase 1 / 5 / 4 / 3 / 4 / 3 / 6 / 3
Up-regulated
BCL2A1 / 205681_at / BCL2-related protein A1 / 16 / 16 / 20 / 7 / 28 / 30 / 32
BIRCF / 220451 / Livin / 13 / 16 / 14 / 7 / 13 / 15 / 18
CIDEB / 221188_s_at / Cell death-inducing DFFA-like effector b / 3 / 3 / 5 / 3 / 4 / 4 / 5
CLU / 208792_s_at / Clusterin / 2 / 2 / 3 / 3 / 3 / 2 / 3
BCL2L1 / 212312_at / BCL2-like 1 / 4 / 4 / 3 / 2 / 3 / 4 / 4
Transcription factors and regulators
Down-regulated
CSDA / 201160_s_at / Cold shock domain protein A / 119 / 891 / 84 / 724 / 776 / 55 / 337
HOXA9 / 214651_s_at / Homeo box A9 / 28 / 48 / 52 / 256 / 256 / 64 / 56
WT1 / 206067_s_at / Wilms tumor 1 / 90 / 56 / 32 / 79 / 21 / 52 / 85
CEBPD / 203973_s_at / CCAAT/enhancer binding protein (C/EBP), delta / 17 / 64 / 39 / 39 / 39 / 147 / 26
TP53 / 201746_at / Tumor protein p53 / 28 / 39 / 23 / 26 / 23 / 24 / 16
ATF5 / 204998_s_at / Activating transcription factor 5 / 21 / 21 / 15 / 16 / 12 / 15 / 20
TCF4 / 203753_at / Transcription factor 4 / 9 / 11 / 5 / 9 / 6 / 7 / 6
CTBP2 / 210835_s_at / C-terminal binding protein 2 / 8 / 9 / 7 / 13 / 13 / 18 / 8
HOXA10 / 213150_at / Homeo box A10 / 6 / 9 / 5 / 6 / 7 / 6 / 4
NRIP1 / 202600_s_at / Nuclear receptor interacting protein 1 / 6 / 39 / 7 / 5 / 48 / 6 / 9
ETS2 / 201329_s_at / V-ets erythroblastosis virus E26 oncogene homolog 2 / 6 / 5 / 3 / 2 / 3 / 3 / 3
TCEAL1 / 204045_at / Transcription elongation factor A (SII)-like 1 / 5 / 6 / 3 / 4 / 4 / 9 / 5
IRF1 / 202531_at / Interferon regulatory factor 1 / 4 / 4 / 3 / 5 / 3 / 3 / 3
MLLT10 / 205408_at / Mixed-lineage leukemia translocated to, 10 / 3 / 6 / 2 / 3 / 2 / 2 / 2
ETV6 / 205585_at / Ets variant gene 6 / 3 / 4 / 15 / 5 / 23 / 5 / 6
GTF3A / 215091_s_at / General transcription factor IIIA / 3 / 3 / 2 / 3 / 3 / 2 / 2
Up-regulated
C/EBPe / 214523_at / CCAAT/enhancer binding protein, epsilon / 11 / 15 / 14 / 13 / 15 / 10 / 11
HOXC10 / 218959_at / Homeo box C10 / 6 / 6 / 10 / 6 / 10 / 5 / 12
KLF4 / 221841_s_at / Kruppel-like factor 4 / 6 / 4 / 7 / 11 / 6 / 6 / 10
TFEC / 206715_at / Transcription factor EC / 5 / 5 / 6 / 5 / 7 / 5 / 6
ZNF593 / 204175_at / Zinc finger protein 593 / 5 / 5 / 4 / 3 / 4 / 6 / 6
ID1 / 208937_s_at / Inhibitor of DNA binding 1, / 2 / 4 / 4 / 3 / 4 / 3 / 5
RUNX3 / 204197_s_at / Runt-related transcription factor 3 / 3 / 3 / 3 / 2 / 3 / 3 / 3
HHEX / 204689_at / Hematopoietically expressed homeobox / 2 / 2 / 3 / 3 / 3 / 3 / 3
Supplementary Table 1: Genes with 2-fold or greater expression in U937 cells cultured in
the presence of anti CXCR4 Abs or EI compared to untreated cells.