Bradley Postle, PhD
Bradley Postle, PhD, a graduate of MIT, is a post-doctoral fellow in the department of Neurology at the University of Pennsylvania School of Medicine. Dr Postle is examining the way in which memory for recent events is organized in the healthy human brain and how memory is impaired in patients with Alzheimer's disease, Parkinson's disease, and related disorders. Dr Postle has given an acclaimed series of lectures on memory at the university and is well known for his clarity of presentation, enthusiasm and warm sense of humor.
Bradley R. Postle, Ph.D.
Dept. of Psychology, room 515
Univ. of Wisconsin
1202 West Johnson St.
Madison, WI 53706-1696 USA
Phone: 608-236-4330
Fax. 608-262-4029
Email :
Research Interests: fMRI, experimental psychology, neuropsychology, and rTMS of working memory and nondeclarative memory
______
Cognitive Neuroscience Society Meeting, 2000
April 9-11, 2000
Nob Hill Masonic Center, San Francisco, CA
EVALUATING MODELS OF THE FUNCTIONAL ORGANIZATION OF WORKING MEMORY IN FRONTAL CORTEX WITH EVENT-RELATED FMRI
Bradley R. Postle and Mark D'Esposito
Department of Neurology, University of Pennsylvania Medical Center
Many influential claims about the organization of working memory function in prefrontal cortex have been developed and/or tested with functional neuroimaging methods featuring the blocking of behavioral trials and the averaging across blocks of neuroimaging signal. Interpretation of the results of these first generation neuroimaging studies is subject to several inferential constraints, which thereby weaken the models derived from them. We reassessed several models of the functional organization of working memory in prefrontal cortex by examining or reanalyzing data from three event-related fMRI studies of working memory function performed in our laboratory , data that were not subject to the same inferential constraints. This process permitted us to reject some of the models derived from first generation neuroimaging data, to refine others, and to synthesize our results into a revised hybrid model of the working memory functions of prefrontal cortex.
______
#1Functional NeuroAnatomical Double Dissociation Of Mnemonic And Executive Control Processes Contributing To Working Memory Performance
Bradley R. Postle*, Jeffrey S. Berger, and Mark D'Esposito
Vol. 96, Issue 22, 12959-12964, October 26, 1999
University of Pennsylvania Medical Center,
Department of Neurology,
3 West Gates, 3400 Spruce Street,
Philadelphia, PA 19104-4283
Abstract
We used event-related Functional MRI to investigate the Neural bases of two categories of mental processes believed to contribute to performance of an alphabetization Working Memory task: Memory Storage and Memory Manipulation.
Our Delayed-Response Tasks required Memory for the identity and position-in-the-display of items in two- or five-letter Memory sets (to identify load-sensitive regions) or Memory for the identity and relative position-in-the-alphabet of items in five-letter Memory sets (to identify manipulation-sensitive regions).
Results revealed voxels in the Left PeriSylvian Cortex of five of five subjects showing load sensitivity (as contrasted with alphabetization-sensitive voxels in this region in only one subject) and voxels of DorsoLateral PreFrontal Cortex in all subjects showing alphabetization sensitivity (as contrasted with load-sensitive voxels in this region in two subjects).
This double dissociation was reliable at the group level. These data are consistent with the hypothesis that the NonMnemonic Executive Control processes that can contribute to Working Memory function are primarily PreFrontal Cortex-mediated, whereas Mnemonic processes necessary for Working Memory storage are primarily Posteriorly mediated.
More broadly, they support the view that Working Memory is a faculty that arises from the coordinated interaction of computationally and NeuroAnatomically dissociable processes.
______
Intact Implicit Memory for Novel Patterns in Alzheimer's Disease
Bradley R. Postle,1,3 Suzanne Corkin,1 and John H. Growdon1,2
1Department of Brain and Cognitive Sciences and the Clinical Research Center
Massachusetts Institute of Technology
Cambridge, Massachusetts 02139
2Department of Neurology
Massachusetts General Hospital
Boston, Massachusetts 02114
Repetition priming is a kind of implicit memory (learning without awareness) that does not depend on the medial temporal-lobe system. For example, the amnesic patient H.M., who underwent bilateral medial temporal-lobe resection, shows intact priming with novel patterns, suggesting that perceptual priming with nonverbal material does not depend on areas critical for explicit memory. A logical candidate for the neural substrate that supports this kind of priming is the peristriate cortex, an area that is relatively spared in Alzheimer's disease (AD). We therefore predicted that AD subjects would be unimpaired on pattern priming. Subjects copied each of six target figures onto dot patterns. After performing a 3-min distractor task, they were given the same dot patterns (without lines) and asked to draw the first figure that came to mind by connecting the dots with straight lines. Subsequently, in a test of recognition (explicit) memory, subjects viewed each of the six patterns of dots that they had copied previously and were asked to indicate which of four possible completions corresponded to the figure that they had copied 3 min earlier. The AD and control groups achieved comparable priming scores, but AD subjects were significantly impaired in recognizing the patterns explicitly. Our finding of intact pattern priming in AD provides, for the first time, evidence that pattern priming depends on the peristriate cortex.
Received April 12, 1996; accepted in revised form August 23, 1996.
3Corresponding author.
3:305-312 © 1996 by Cold Spring Harbor Laboratory Press ISSN1072-0502/96
______
WORKS IN PROGRESS
PROSPECTIVE MOTOR CODING IN SPATIAL WORKING MEMORY
Bradley R. Postle, Dept. of Neurology, U. of Penn. Med. Cntr., Philadelphia, PA
Patients with early stages of Parkinson’s disease demonstrate selective impairment of spatial working memory (Postle et al., 1997-a, -b; Owen et al., 1997), implicating a differential contribution of frontostriatal systems to spatial working memory. Recent fMRI studies of healthy adults have extended these findings, indicating that spatial delay-period activity in the caudate nucleus is greater when it precedes a motor response than when no overt response follows the delay period, a contingent relationship not observed with nonspatial memoranda (Postle & D'Esposito, 1999-a, -b), and that caudate nucleus activity is reliably greater for ego- than allocentric spatial delayed response (Postle & D'Esposito, 1999-c). These data have prompted the hypothesis that one way that the nervous system stores spatial information for short periods of time is to calculate the motor response that would be required to acquire the target stimulus (e.g., with a reach or with an eye movement), and to maintain this prospective motor code during the delay period of the task. My talk will present preliminary null results and data from a to-be-conducted follow-up experiment that represent attempts to marshal evidence consistent with the prospective motor coding model.
There are 400 web sites for Mark D’Esposito. Some of these may be of interest to you. I am not putting 400 here – Rita
Click on the websites that reference fMRI.Some of them have interesting images.
Mark D’Esposito
- UC Berkeley Psychology Department: MarkD'Esposito, Research ...
...MarkD'Esposito, Professor MD, State University of New York, Syracuse College
of Medicine 3309 Tolman, 510-643-3340 D'Esposito Lab. ...
[More results from psychology.berkeley.edu] - IRCS Colloquium Series - MarkD'Esposito, University of ...
...MarkD'Esposito, University of Pennsylvania Dissecting working memory using event-related
functional MRI Friday, January 29, 1999, 12-2 pm. ...
[More results from - Helen Wills Neuroscience Institute
...D’Esposito M., Zarahn E., Aguirre G. (1999). Event-related fMRI: implications
for cognitive psychology, Psychological Bulletin, 125:155-64. ...
[More results from neuroscience.berkeley.edu]
... TASK. Eric H. Schumacher and MarkDEsposito. Department
of Neurology, University of Pennsylvania. ...
[More results from socrates.berkeley.edu]- Member Information
MarkD'Esposito, MD Neuroscience Institute and Department of Psychology Director,
Brain Imaging Center 3210 Tolman Hall University of California, Berkeley ...
[More results from nba19.med.uth.tmc.edu] - Health Sciences Initiative
... Neuroscience Institute s Brain Imaging Center, is under the direction of neurologist
MarkDEsposito, the first of six full-time faculty members to be hired at ... - 11.20.00 - Nation's most powerful brain scanner devoted ...
... Mental events last only a few milliseconds," said MarkD'Esposito, MD, UC Berkeley
professor of neuroscience and psychology and director of the new Brain ...
[More results from - Executive Control and Frontal Lobe, Delmenhorst
... Germany. Jon Cohen, Betsy Murray, Jim Haxby, Earl Miller,
MarkD'Esposito. Jim Haxby and MarkD'Esposito. ...
[More results from - Healthy News - HealthWorld Online
... three times more powerful than other MRIs used for clinical purposes, said Mark
D'Esposito, director of the new center and a professor of neuroscience and ... - VC2000 Virtual Lecture Guest Site - University of ...
... 1666. Neurology: Frontal Lobe Syndromes, MarkD'Esposito, MD, 3/30/2000.
1665. Psychiatry: Dementias/Delirium, Joel E. Streim, MD, 3/30/2000. ... - UC Berkeley Psychology Department: Fall 2000 Class ...
... PSYCHOLOGY 290B:4 Biological Seminar: Clinical Neuroscience
Professors Robert Knight, MarkD'Esposito. ...
[More results from - Summer Institute in Cognitive Neuroscience
... Institute Directors: MarkD’Esposito — Michael
S. Gazzaniga — Scott Grafton. Faculty include: ... - Neural Bases of Semantic Memory
... Sharon L Thompson-Schill, MarkD'Esposito, & Irene P. Kan. Neuroimaging studies
have revealed an association between word generation and activity in the left ...
[More results from
... Joseph Maldjian, MD; David Alsop, Ph.D.; John A. Detre, MD; John Listerud, MD, Ph.D.;
MarkD'Esposito, MD; Kevin D. Judy, MD; Eric Zager, MD; Mark Stecker, MD, ...- Scientific American: Article: Trends in Neuroscience: 8/97
... prefrontal cortex are key for self-monitoring. In an experiment by MarkD'Esposito
and his associates at the University of Pennsylvania, volunteers performed ... - Nation's most powerful brain scanner devoted solely to ...
... Mental events last only a few milliseconds," said MarkD'Esposito, MD, UC Berkeley
professor of neuroscience and psychology and director of the new Brain ...
And more and more……..
UC Berkeley unveils powerful MRI
... With these images of the brain, we expect results in the course of
years rather than decades," center director MarkD'Esposito said. ...
[More results from
New MRI scans brain more accurately
... three times more powerful than other MRIs used for clinical purposes, said Mark
D'Esposito, director of the new center and a professor of neuroscience and ...
[More results from news.excite.ca]
Joint Seminars in Neuroscience 2000-2001
... Cortex in Cognition: Evidence from Functional MRI" MARKD'ESPOSITO, MD (Hosted by
Michael Fanselow) Professor of Neuroscience and Psychology; Director,Brain ...
[More results from
UCLA Neuroscience Lectures and Seminars Calendar
... Tuesday, November 28, 2000: MarkD'Esposito, MD, Department of Neurology,
Hospital of the University of Pennsylvania, Philadelphia. ...
[More results from
This Is Your Brain on VR
... bringing virtual reality to the imaging table with his graduate adviser, MarkD'Esposito,
who immediately saw the potential. "My initial response was that it ...
[More results from
Media Review
... Assistant professor of neurology MarkD'Esposito, MD, and his colleagues are searching
for the brain's center of navigation. Brain scans record the mental ...
[More results from health.upenn.edu]
UNIVERSITY OF PENNSYLVANIA
...MarkD'Esposito, MD, Assistant Professor of Neurology. Determining the neuroanatomical
and neurochemical bases of working memory and frontal lobe function in ...
[More results from
Satellite Symposium of the 1999 Cognitive Neuroscience Society ...
... Dissecting Working Memory Using Functional MRI" MarkD'Esposito,
MD Department of Neurology University of Pennsylvania. ...
[More results from
Bromocriptine Therapy for Executive Dysfunction in Traumatic ...
... in Traumatic Brain Injury Patients Article by Sharon McDowell, John Whyte, and
MarkD'Esposito.* Brain 1998;121:1155-1164 See PubMed Citation See Other ...
[More results from
Working Memory
... executive role for the prefrontal cortex: switching attention between tasks. Mark
D'Esposito and his University of Pennsylvania Medical School colleagues used ...
[More results from
exn.ca Goes Full Frontal! March 21 - Day 2
... At the frontal lobe conference in Toronto today, MarkD'Esposito of the University
of California Berkeley presented results of experiments that illustrate how ...
[More results from exn.ca]
Transition Economies
... PSY 306 was taught by MarkD'Esposito last spring. He welcomed people of all majors
and psych experience, but you may want to check with Professor Treisman to ...
[More results from campuscgi.princeton.edu]
speakers
... Professor of , Dept of. Vollum Institute " Title TBA" Host: 22 MarkD'Esposito.
Professor of , Department of Psychology University of California Berkeley ...
[More results from medicine.ucsd.edu]
The Journal : Back Issues
... Agonist on Prefrontal Function in Traumatic Brain Injury Patients Article by Sharon
McDowell, John Whyte, and MarkD'Esposito.* Brain 1998; 121: 1155 1164. ...
[More results from
Contributors
... Judith Campisi, Ph.D University of California - Berkeley.
MarkD'Esposito, MD University of California-Berkeley. ...
[More results from
The Verdict, February 1998
... James F. Hahn, Jr., PE, (Remote Control), Manlius, New York. Damages:
MarkD'Esposito, MD (Cognitive Neurology), Philadelphia;. ...
[More results from
Marcia K. Johnson - home page
... collaboration with Dr. MarkD'Esposito (University of Pennsylvania), we are using
fMRI to investigate the neural basis of age-related changes in memory. We are ...
[More results from
THE JAMES S
... travel. Institute Directors: MarkDEsposito Michael
S. Gazzaniga Scott Grafton. Faculty include: ...
[More results from
KOGLIST: koglist: Fwd: SUMMER INSTITUTE IN COGNITIVE ...
... room, partial board, and limited support for travel. Institute Directors Mark
D'Esposito - Michael S. Gazzaniga - Scott Grafton Faculty Andrew Barto CR ...
[More results from
... faculty include: Steve Bird, Ty Cannon, Robin Clark, Kostas Daniilidis, MarkD'Esposito,
Martha Farah, Leif Finkel, Lila Gleitman, Aravind Joshi, David Knill ...
[More results from devpsy.lboro.ac.uk]