B1 You and Your Genes
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Target grade:-
CAG:-
Question overview
Question / Topic / Mark / % / Grade / DateB1a (i) / What are genes / /1
B1b (i) / Chromosomes, genes, alleles / /3
B1c(i) / Recessive disorders / /1
B1hsw (i) / How science works / /2
B1maths (i) / Calculations/Mathematics / /6
B1d (i) / Dominant disorders / /1
B1maths (ii) / Calculations/Mathematics / /2
B1e (i) / Clones / /4
B1f (i) / Stem Cells / /6
B1c (ii) / Recessive disorders / /7
B1 maths (iii) / Calculations/Mathematics / /4
B1e (ii) / Clones / /6
Colour code each subtopic using pencils, on target = orange, above = green, below = red.
B1a i 12Jan1a
Hugh has a DNA test.
This tests for genes that may increase his risk of developing certain diseases.
(a) Complete the sentence to describe a gene.
Put a tick (✓)next to the correct answer.
A gene is …
… a pair of chromosomes.
… a code for making DNA.
… a short section of protein.
… an instruction for making a protein.[1]
B1b i.12Jan2
Adam is similar to his parents in some ways but identical to neither.
Explain why Adam is similar to his parents but not identical to either of them.
Your answer should refer to
• chromosomes
• sex cells
• alleles.
......
...... [3]
B1 ci.13Jan2
Ali and Mary do not have cystic fibrosis, but their baby does.
(a) What does this tell us about Ali and Mary’s genes for this disorder?
......
...... [1]
B1 hsw i.13Jan2
Ali and Mary consider whether or not to have another child.
These are some of the questions that they could consider before making their decision.
A How much will it cost to have another child with cystic fibrosis?
B What is the chance of another child of ours having cystic fibrosis?
C If we find that the foetus has cystic fibrosis should we have a termination?
D Do we want to have a boy or a girl?
E What will other people think?
F Should we discuss this with the grandparents?
(i) Which question, A, B, C, D, E or F, is an ethical issue?
question = ...... [1]
(ii) Which question, A, B, C, D, E or F, can be answered by science?
question = ...... [1]
B1 Maths i13Jan2
Another couple, Rajesh and Sangeeta, are thinking of having a baby.
They talk to a genetic counsellor.
They are told that because of Sangeeta’s age they have a 1% chance of having a child with
Down’s syndrome.
This would mean that the child could have some physical and mental issues.
Look at the graph.
(i) Describe the trend shown by the graph.
...... [2]
(ii) It is possible to increase confidence in the trend shown by the graph.
Put ticks (✓)next to the two best methods.
- ask patients how they feel
- use a larger sample size
- collect data for other genetic conditions
- collect data for other ages
- use smaller graph paper
- collect data from just one hospital[2]
(iii) Explain how the information supplied by the graph and the genetic counsellor could affect any decision taken by Rajesh and Sangeeta about whether or not to have a baby.
...... [2]
B1d i.12Jan1ci
Complete the genetic diagram to explain the probability of a child inheriting Huntington’sdisorder if one parent has one copy of the allele for Huntington’s disorder and the otherparent has no copies of this allele.
Use
• H to represent the allele that causes Huntington’s disorder.
• hto represent the normal allele.
B1 Maths ii12Jan1cii
Write down the probability of a single child inheriting Huntington’s disorder.
...... [1]
It is estimated that there are 12.4 cases of Huntington’s disorder per 100 000 people. If the population of the UK is 60 000 000, how many cases of Huntington’s disorder does this estimate suggest?
Put a ring around the correct answer.
12.4,49.6,7 440,4838000, 1240000 [1]
B1e i.13Jan1ab
This question is about reproduction.
(a) Bacteria, plants and some animals can reproduce asexually.
Which of the statements about asexual reproduction are true?
Put ticks (✓)next to the correct statements.
- Only female individuals are produced.
- The individuals produced are clones.
- Mutation is always involved.
- The individuals are produced from a sperm and an egg.
- The majority of individuals produced are infertile.
- The individuals produced have identical genes.
- Two parents are always involved.[2]
(b) It is possible to produce clones of animals.
Explain how this can occur both naturally and artificially.
...... [2]
B1f i.13Jan1
Stem cells are found in the human body. Describe the different types of stem cells and explain how they might be used to treat some diseases.
The quality of written communication will be assessed in your answer.
...... [6]
B1c ii.12Jun1a
This question is about cystic fibrosis.
(a)Look at the family tree of Mary and Dave.
(i) Which two members of the family are definitely homozygous for the allele that causescystic fibrosis?
Write down their names.
name 1 ......
name 2 ...... [1]
(ii) Bill finds out that he is homozygous for the gene that determines whether an individualhas cystic fibrosis or not.
Which members of the family are definitely heterozygous for the gene that causes cysticfibrosis?
Write down their names.
...... [3]
(iii) Which of these statements about cystic fibrosis are true?
Put a tick (✓)next to each correct statement.
(b)Cystic fibrosis is caused by a recessive allele.
(c)The symptoms of cystic fibrosis appear at about the age of forty.
(d)Cystic fibrosis is caused by environmental factors.
(e)The symptoms include breathing difficulties because of thick mucus.
(f)If a person with cystic fibrosis has a non-carrier partner, there is a 50:50 chance of having children with cystic fibrosis.
(g)The genotype of a cystic fibrosis carrier is heterozygous.
(h)The alleles for cystic fibrosis occur in two different places on the same chromosome.
(i)Cystic fibrosis can be transmitted by coughs and sneezes.[3]
B1 Maths iii12Jun1b
The graph shows the average length of life for people with an inherited disorder.
(i) Compare the patterns shown by the lines for females and males on the graph.
...... [2]
(ii) Predict what the graph will show for 2015. Explain your answer.
...... [2]
B1e ii.13Jun2
Clones exist in nature and can be created by scientists.
What are clones? Explain how they are created in both plants and animals.
The quality of written communication will be assessed in your answer.
...... [6]