Appendix 1. Lists the individual data of the 201 patients

Baseline / Longitudinal / Responses
Day 1 / Day 7 / Day 14 / Day 21
No. / Patients / Basal Opioid / API / DD / API / DD / API / DD / API / DD / R/NR / OEI% / SWITCH
1 / M(82); Colorectal; mts+; KI≥50; NP-; BTP- / Morphine / 7 / 20 / 0 / 20 / 3 / 30 / 3 / 30 / R / <5%
2 / M(81); nsclc; mts-; KI≥50; NP-; BTP+ / Morphine / 5 / 20 / 5 / 60 / 6 / 120 / 5 / 90 / NR / >5%
3 / M(68); nsclc; mts+; KI≥50; NP+; BTP- / Morphine / 6 / 80 / 5 / 100 / 4 / 80 / 3 / 80 / R / 0%
4 / M(66); Colorectal; mts+; KI≥50; NP-;BTP- / Morphine / 5 / 20 / 5 / 20 / 4 / 20 / 5 / 20 / NR / 0%
5 / M(28); Others; mts+; KI≥50; NP+; BTP- / Morphine / 5 / 60 / 2 / 20 / 3 / 60 / 2 / 60 / R / 0%
6 / M(60); nsclc; mts+; KI≥50; NP-; BTP+ / Morphine / 5 / 80 / 3 / 60 / 1 / 40 / 1 / 40 / R / <0%
7 / F(67); Breast; mts+; KI≥50; NP-; BTP+ / Morphine / 4 / 20 / 1 / 20 / 3 / 20 / 1 / 20 / R / 0%
8 / M(61); nsclc; mts+; KI≥50; NP-; BTP- / Morphine / 8 / 20 / 2 / 20 / 2 / 20 / 3 / 20 / R / 0%
9 / M(67); Pancreas; mts+; KI≥50; NP-; BTP+ / Morphine / 5 / 40 / 1 / 40 / 2 / 40 / 0 / 40 / R / 0%
10 / M(61); Others; mts+; KI≥50; NP+; BTP+ / Morphine / 8 / 60 / 3 / 60 / 3 / 60 / 3 / 60 / R / 0%
11 / F(65); Breast; mts+; KI≥50; NP-; BTP+ / Morphine / 6 / 15 / 2 / 40 / 3 / 40 / 2 / 60 / R / >5%
12 / F(44); Others; mts+; KI≥50; NP+; BTP+ / Morphine / 8 / 60 / 5 / 90 / 4 / 120 / 2 / 120 / R / 5%
13 / M(64); Genit.nary; mts+; KI≥50; NP-; BTP+ / Morphine / 10 / 60 / 0 / 60 / 0 / 60 / 2 / 60 / R / 0%
14 / F(58); Colorectal; mts+; KI≥50; NP-; BTP- / Morphine / 10 / 60 / 3 / 40 / 0 / 20 / 0 / 20 / R / <0%
15 / F(68); Breast; mts+; KI≥50; NP-; BTP- / Morphine / 5 / 30 / 4 / 30 / 2 / 30 / 2 / 20 / R / <0%
16 / F(34); Breast; mts+;KI<50; NP-; BTP+ / Morphine / 5 / 20 / 0 / 20 / 5* / 70 / 4 / 140 / NR / >5% / Yes
17 / M(61); Pancreas; mts+; KI≥50; NP+; BTP- / Morphine / 4 / 40 / 0 / 40 / 0 / 40 / 0 / 30 / R / <0%
18 / F(51); Breast; mts+; KI≥50; NP-; BTP+ / Morphine / 7 / 20 / 2 / 40 / 2 / 60 / 3 / 60 / R / >5%
19 / M(53); nsclc; mts+; KI<50; NP-; BTP+ / Morphine / 7 / 20 / 7 / 60 / 6 / 150 / 7 / 150 / NR / >5%
20 / M(62); Stomach; mts+; KI≥50; NP-; BTP- / Morphine / 6 / 20 / 0 / 30 / 7 / 40 / 5 / 60 / NR / >5%
21 / M(69); nsclc; mts+; KI<50; NP-; BTP+ / Morphine / 6 / 20 / 5 / 40 / 5 / 70 / 4 / 50 / R / >5%
22 / M(53); H&N; mts+; KI≥50; NP-; BTP+ / Morphine / 4 / 20 / 0 / 20 / 2 / 20 / 4 / 60 / NR / >5%
23 / M(74); Hepat.ca; mts+; KI<50; NP+; BTP+ / Morphine / 8 / 20 / 6 / 20 / 4 / 10 / 4 / 10 / R / <0%
24 / M(61); Prostate; mts+; KI≥50; NP-; BTP+ / Morphine / 7 / 30 / 5 / 20 / 6* / 210 / 6 / 125 / NR / >5% / Yes
25 / M(74); Others; mts+; KI≥50; NP-; BTP+ / Morphine / 5 / 30 / 3 / 70 / 3 / 70 / 7* / 120 / NR / >5% / Yes
26 / F(66); Gynec; mts+; KI≥50; NP+; BTP- / Morphine / 5 / 60 / 4 / 20 / 5 / 40 / 4 / 60 / NR / 0%
27 / M(71); H&N; mts-; KI≥50; NP-; BTP- / Morphine / 4 / 30 / 4 / 30 / 4 / 60 / 5* / 60 / NR / 5% / Yes
28 / M(61); H&N; mts+; KI≥50; NP-; BTP- / Morphine / 5 / 30 / 3 / 40 / 2 / 20 / 3* / 60 / R / 5% / Yes
29 / M(71); Pancreas; mts+; KI≥50; NP+; BTP- / Morphine / 6 / 30 / 4 / 30 / 2 / 60 / 7* / 300 / NR / >5% / Yes
30 / F(94); Colorectal; mts-; KI≥50; NP-; BTP+ / Morphine / 4 / 40 / 2 / 60 / 3 / 60 / 2 / 80 / R / 5%
31 / F(77); Breast; mts+; KI≥50; NP-; BTP+ / Morphine / 4 / 20 / 3 / 30 / 2 / 30 / 2 / 30 / R / >5%
32 / F(41); Mesoth; mts+; KI≥50; NP-; BTP+ / Morphine / 5 / 60 / 8 / 210 / 6 / 300 / 4 / 120 / NR / 5%
33 / F(56); Bil.tract; mts+; KI≥50; NP-; BTP- / Oxycodone / 5 / 30 / 3 / 30 / 4 / 10 / 3 / 10 / R / <0%
34 / F(56); Breast; mts+; KI≥50; NP+; BTP+ / Oxycodone / 5 / 40 / 4 / 180 / 4* / 120 / 3 / 180 / R / >5% / Yes
35 / M(71); nsclc; mts+; KI≥50; NP-; BTP+ / Oxycodone / 4 / 30 / 2 / 45 / 2 / 30 / 6 / 30 / NR / 0%
36 / F(49); Breast; mts+; KI<50; NP-; BTP- / Oxycodone / 4 / 30 / 2 / 40 / 1 / 40 / 1 / 40 / R / <5%
37 / M(63); Colorectal; mts+; KI<50; NP-; BTP+ / Oxycodone / 4 / 60 / 2 / 150 / 0 / 180 / 1 / 180 / R / >5%
38 / M(67); nsclc; mts+; KI≥50; NP-; BTP- / Oxycodone / 5 / 40 / 0 / 40 / 0 / 40 / 2 / 40 / R / 0%
39 / M(71); nsclc; mts+; KI≥50; NP-; BTP+ / Oxycodone / 5 / 40 / 3 / 90 / 3 / 180 / 5 / 150 / NR / >5%
40 / F(58); Breast; mts+; KI≥50; NP+; BTP- / Oxycodone / 8 / 60 / 3 / 60 / 3 / 60 / 3 / 30 / R / <0%
41 / F(79); Breast; mts+; KI≥50; NP+; BTP- / Oxycodone / 8 / 60 / 7 / 120 / 6 / 120 / 4 / 120 / R / 5%
42 / M(59); Others; mts+; KI≥50; NP+; BTP+ / Oxycodone / 5 / 40 / 3 / 60 / 3 / 60 / 3 / 60 / R / <5%
43 / M(77); nsclc; mts+; KI≥50; NP+; BTP- / Oxycodone / 6 / 30 / 4 / 30 / 3 / 30 / 2 / 60 / R / 5%
44 / F(46); nsclc; mts+; KI≥50; NP+; BTP+ / Oxycodone / 6 / 30 / 6 / 30 / 5 / 60 / 5 / 60 / NR / 5%
45 / F(59); Breast; mts+; KI≥50; NP+; BTP- / Oxycodone / 7 / 15 / 5 / 15 / 5 / 15 / 3 / 30 / R / 5%
46 / F(53); Others; mts+; KI≥50; NP+; BTP+ / Oxycodone / 6 / 30 / 4 / 30 / 5 / 15 / 3 / 15 / R / <0%
47 / M(57); Genit.nary; mts+; KI≥50; NP-; BTP- / Oxycodone / 4 / 40 / 2 / 40 / 2 / 40 / 4 / 40 / NR / 0%
48 / F(42); H&N; mts+; KI≥50; NP+; BTP+ / Oxycodone / 4 / 30 / 2 / 30 / 4 / 30 / 3 / 60 / NR / 5%
49 / F(37); Pancreas; mts+; KI≥50; NP+; BTP+ / Oxycodone / 7 / 30 / 2 / 30 / 3* / 60 / 3 / 120 / R / >5% / Yes
50 / F(59);nsclc; mts+; KI≥50; NP-; BTP+ / Oxycodone / 4 / 60 / 3 / 30 / 4 / 60 / 4 / 60 / NR / 0%
51 / M(45); Kidney; mts+; KI≥50; NP-; BTP- / Oxycodone / 5 / 40 / 2 / 60 / 3 / 60 / 3 / 60 / R / <5%
52 / F(60); Breast; mts+; KI≥50; NP+; BTP+ / Oxycodone / 8 / 40 / 7 / 80 / 6 / 80 / 8* / 60 / NR / <5% / Yes
53 / M(73); H&N; mts+; KI≥50; NP-; BTP+ / Oxycodone / 8 / 40 / 3 / 40 / 1 / 40 / 1 / 30 / R / <0%
54 / M(79); Genit.nary; mts+; KI≥50; NP-; BTP+ / Oxycodone / 7 / 40 / 6* / 60 / 4 / 120 / 3 / 120 / R / >5% / Yes
55 / F(65); Breast; mts+; KI≥50; NP+; BTP+ / Oxycodone / 5 / 40 / 2 / 60 / 1 / 40 / 2 / 40 / R / 0%
56 / F(65); Mesoth; mts+; KI≥50; NP-; BTP+ / Oxycodone / 6 / 80 / 5 / 80 / 5 / 80 / 5* / 60 / NR / <0% / Yes
57 / M(54); Others; mts-; KI≥50; NP-; BTP+ / Oxycodone / 5 / 20 / 4 / 40 / 0 / 60 / 5 / 80 / NR / >5%
58 / M(66); Prostate; mts+; KI≥50; NP+; BTP+ / Oxycodone / 5 / 20 / 4 / 60 / 3 / 80 / 3 / 80 / R / >5%
59 / M(73); nsclc; mts+; KI≥50; NP-; BTP+ / Oxycodone / 5 / 60 / 3 / 60 / 3 / 60 / 3 / 60 / R / 0%
60 / F(92); H&N; mts-; KI≥50; NP-; BTP+ / Oxycodone / 5 / 40 / 3 / 40 / 4 / 40 / 3 / 20 / R / <0%
61 / F(80); unknow; mts+; KI≥50; NP-; BTP- / Oxycodone / 8 / 30 / 2 / 30 / 3 / 30 / 4 / 40 / R / <5%
62 / F(74); Breast; mts+; KI≥50; NP-; BTP- / Oxycodone / 6 / 30 / 6 / 30 / 6 / 30 / 5 / 30 / NR / 0%
63 / F(64); unknow; mts+; KI≥50; NP-; BTP- / Oxycodone / 8 / 40 / 7 / 60 / 7 / 80 / 8 / 80 / NR / 5%
64 / M(59); Mesoth; mts+; KI≥50; NP-; BTP- / Oxycodone / 5 / 80 / 3 / 100 / 3 / 100 / 2 / 100 / R / <5%
65 / F(54); Colorectal; mts+; KI≥50; NP-; BTP+ / Oxycodone / 5 / 20 / 3 / 30 / 4 / 60 / 3 / 60 / R / >5%
66 / M(67); H&N; mts+; KI≥50; NP+; BTP+ / Oxycodone / 6 / 40 / 5 / 60 / 5 / 90 / 5 / 120 / NR / >5%
67 / M(54); nsclc; mts+; KI≥50; NP-; BTP+ / Oxycodone / 7 / 30 / 5 / 30 / 6 / 30 / 4 / 30 / R / 0%
68 / F(53); Gynec; mts+; KI≥50; NP-; BTP- / Oxycodone / 4 / 40 / 3 / 30 / 2 / 60 / 2 / 90 / R / >5%
69 / M(82); H&N; mts+; KI≥50; NP+; BTP+ / Oxycodone / 4 / 30 / 4 / 30 / 4 / 40 / 2 / 40 / R / <5%
70 / F(72); Others; mts+; KI≥50; NP-; BTP- / Oxycodone / 4 / 30 / 1 / 15 / 1 / 15 / 1 / 15 / R / <0%
71 / M(69); nsclc; mts+; KI≥50; NP-; BTP+ / Oxycodone / 7 / 20 / 7 / 20 / 4 / 10 / 4 / 10 / R / <0%
72 / M(71); nsclc; mts+; KI≥50; NP-; BTP+ / Oxycodone / 4 / 40 / 4 / 40 / 3 / 60 / 2 / 60 / R / <5%
73 / M(87); nsclc; mts+; KI≥50; NP-; BTP- / Oxycodone / 4 / 40 / 1 / 40 / 2 / 90 / 3 / 90 / NR / 5%
74 / F(58); Pancreas; mts+; KI≥50; NP-; BTP- / Oxycodone / 8 / 60 / 4 / 60 / 4 / 90 / 2 / 90 / R / <5%
75 / M(75); Genit.nary; mts+; KI≥50; NP-; BTP+ / Oxycodone / 7 / 30 / 5 / 30 / 4 / 90 / 5 / 120 / NR / >5%
76 / M(76); Others; mts+; KI≥50; NP-; BTP+ / Oxycodone / 4 / 60 / 2 / 240 / 4 / 240 / 3 / 240 / NR / >5%
77 / M(57); Kidney; mts+; KI≥50; NP+; BTP+ / Oxycodone / 5 / 120 / 4 / 90 / 3 / 90 / 3 / 90 / R / <0%
78 / F(73); Others; mts-; KI≥50; NP-; BTP+ / Fentanyl / 6 / 60 / 6 / 60 / 3 / 120 / 6 / 120 / NR / 5%
79 / M(66); Pancreas; mts-; KI≥50; NP-; BTP+ / Fentanyl / 4 / 60 / 8 / 60 / 5 / 60 / 3 / 60 / NR / 0%
80 / M(65); nsclc; mts+; KI≥50; NP-; BTP- / Fentanyl / 6 / 60 / 6 / 60 / 6 / 60 / 4 / 180 / R / >5%
81 / F(43); Colorectal; mts+; KI≥50; NP-; BTP+ / Fentanyl / 6 / 120 / 6 / 120 / 6 / 120 / 3 / 120 / R / 0%
82 / M(52); nsclc; mts+; KI≥50; NP-; BTP- / Fentanyl / 4 / 120 / 4 / 120 / 1 / 120 / 1 / 120 / R / 0%
83 / F(85); Others; mts-; KI≥50; NP-; BTP- / Fentanyl / 6 / 60 / 0 / 60 / 0 / 60 / 0 / 60 / R / 0%
84 / F(80); nsclc; mts+; KI≥50; NP-; BTP+ / Fentanyl / 7 / 60 / 6 / 60 / 4* / 90 / 4 / 90 / R / <5% / Yes
85 / M(41); nsclc; mts+; KI≥50; NP-; BTP- / Fentanyl / 5 / 60 / 5 / 120 / 5* / 40 / 1 / 40 / R / <0% / Yes
86 / F(62); Breast; mts+; KI≥50; NP+; BTP+ / Fentanyl / 7 / 30 / 5 / 60 / 4 / 60 / 4 / 60 / R / 5%
87 / M(76); sclc; mts+; KI≥50; NP-; BTP+ / Fentanyl / 4 / 60 / 3 / 60 / 5 / 120 / 3 / 120 / NR / 5%
88 / M(51); Others; mts-; KI≥50; NP-; BTP+ / Fentanyl / 5 / 45 / 5 / 120 / 5 / 120 / 6 / 120 / NR / >5%
89 / M(62); Prostate; mts+; KI≥50; NP-; BTP- / Fentanyl / 7 / 60 / 2 / 60 / 1 / 60 / 1 / 60 / R / 0%
90 / F(59); Pancreas; mts+; KI≥50; NP-; BTP- / Fentanyl / 6 / 60 / 3 / 60 / 6 / 120 / 2 / 120 / R / 5%
91 / M(57); nsclc; mts+; KI≥50; NP-; BTP+ / Fentanyl / 5 / 60 / 3 / 60 / 2 / 120 / 3 / 120 / R / 5%
92 / M(68); Colorectal; mts+; KI≥50; NP-; BTP- / Fentanyl / 8 / 60 / 2 / 60 / 3 / 60 / 4 / 60 / R / 0%
93 / F(88); Gynec; mts+; KI≥50; NP-; BTP- / Fentanyl / 5 / 60 / 3 / 120 / 2 / 120 / 2 / 120 / R / 5%
94 / F(77); Pancreas; mts+; KI≥50; NP-; BTP+ / Fentanyl / 5 / 60 / 6 / 120 / 4 / 120 / 4 / 180 / NR / >5%
95 / F(45); Others; mts+; KI≥50; NP-; BTP- / Fentanyl / 5 / 60 / 2 / 60 / 2 / 60 / 2 / 120 / R / 5%
96 / F(56); Others; mts+; KI≥50; NP-; BTP+ / Fentanyl / 6 / 60 / 5 / 60 / 3 / 120 / 4 / 120 / R / 5%
97 / M(71); nsclc; mts+; KI≥50; NP+; BTP+ / Fentanyl / 5 / 120 / 3 / 120 / 4 / 120 / 3 / 240 / R / 5%
98 / M(70); Mesoth; mts+; KI≥50; NP-; BTP+ / Fentanyl / 5 / 60 / 3 / 30 / 5 / 45 / 4 / 120 / NR / 5%
99 / M(71); Pancreas; mts+; KI≥50; NP-; BTP+ / Fentanyl / 5 / 60 / 3 / 120 / 3 / 120 / 2 / 180 / R / >5%
100 / F(56); Colorectal; mts+; KI≥50; NP-; BTP- / Fentanyl / 6 / 60 / 6 / 120 / 7 / 120 / 6 / 180 / NR / >5%
101 / M(74); nsclc; mts+; KI≥50; NP-; BTP- / Fentanyl / 5 / 120 / 4 / 240 / 5 / 240 / 6* / 80 / NR / <0% / Yes
102 / M(72); Others; mts+; KI≥50; NP-; BTP- / Fentanyl / 4 / 60 / 1 / 60 / 1 / 60 / 2 / 120 / R / 5%
103 / F(71); H&N; mts+; KI≥50; NP+; BTP- / Fentanyl / 7 / 60 / 6 / 120 / 5 / 120 / 6 / 180 / NR / >5%
104 / F(82); others; mts+; KI≥50; NP+; BTP+ / Fentanyl / 5 / 120 / 6 / 120 / 6 / 120 / 5 / 180 / NR / <5%
105 / F(52); Colorectal; mts+; KI≥50; NP+; BTP+ / Fentanyl / 6 / 120 / 7 / 120 / 7 / 180 / 7 / 180 / NR / <5%
106 / M(70); Bil.tract; mts+; KI≥50; NP-; BTP+ / Fentanyl / 6 / 120 / 4 / 120 / 3 / 120 / 3 / 120 / R / 0%
107 / M(72); nsclc; mts+; KI<50; NP+; BTP+ / Fentanyl / 6 / 120 / 2 / 120 / 2 / 180 / 1 / 180 / R / <5%
108 / F(44); Gynec; mts+; KI<50; NP-; BTP- / Fentanyl / 4 / 120 / 4 / 180 / 4 / 240 / 1 / 180 / R / <5%
109 / M(70); Others; mts+; KI≥50; NP-; BTP+ / Fentanyl / 5 / 60 / 4 / 120 / 2 / 120 / 1 / 120 / R / 5%
110 / F(66); Colorectal; mts+; KI<50; NP-; BTP- / Fentanyl / 4 / 60 / 2 / 120 / 1 / 120 / 1 / 120 / R / 5%
111 / M(86); H&N; mts-; KI≥50; NP+; BTP+ / Fentanyl / 5 / 120 / 3 / 120 / 3 / 180 / 3 / 240 / R / 5%
112 / M(68); nsclc; mts+; KI≥50; NPne; BTP- / Buprenorphine / 4 / 30 / 2 / 30 / 2 / 30 / 4 / 30 / NR / 0%
113 / F(69); Pancreas; mts+; KI≥50; NP-; BTP- / Buprenorphine / 6 / 90 / 4 / 90 / 2 / 90 / 1 / 90 / R / 0%
114 / F(54); nsclc; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 4 / 60 / 1 / 60 / 0 / 60 / 2 / 60 / R / 0%
115 / F(66); Colorectal; mts+; KI≥50; NP-; BTP- / Buprenorphine / 5 / 60 / 0 / 60 / 0 / 60 / 0 / 60 / R / 0%
116 / M(75); Stomach; mts+; KI≥50; NP-; BTP- / Buprenorphine / 6 / 60 / 5 / 90 / 5 / 90 / 4 / 90 / R / <5%
117 / F(55); Colorectal; mts+; KI≥50; NP-; BTP- / Buprenorphine / 6 / 60 / 1 / 60 / 1 / 60 / 1 / 60 / R / 0%
118 / M(52); HCC; mts-; KI≥50; NP-; BTP- / Buprenorphine / 4 / 60 / 2 / 60 / 2 / 60 / 6 / 60 / NR / 0%
119 / F(57); nsclc; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 4 / 60 / 6 / 60 / 6 / 60 / 8 / 90 / NR / 0%
120 / M(51); Colorectal; mts+; KI≥50; NP-; BTP- / Buprenorphine / 9 / 90 / 6 / 120 / 6 / 150 / 7 / 150 / NR / >5%
121 / F(64); Lung; mts+; KI≥50; NP-; BTP- / Buprenorphine / 4 / 60 / 3 / 60 / 3 / 60 / 2 / 40 / R / <0%
122 / M(80); Prostate; mts+; KI≥50; NP+; BTP- / Buprenorphine / 9 / 70 / 8 / 90 / 8 / 90 / 7 / 120 / NR / <5%
123 / M(79); H&N; mts+; KI≥50; NP+; BTP- / Buprenorphine / 5 / 60 / 5 / 60 / 3 / 120 / 3 / 120 / R / 5%
124 / F(55); Bil. tract; mts-; KI≥50; NP-; BTP- / Buprenorphine / 6 / 90 / 6 / 90 / 5 / 120 / 4 / 120 / R / <5%
125 / F(64); Pancreas; mts-; KI≥50; NP-; BTP- / Buprenorphine / 7 / 90 / 6 / 90 / 4 / 20 / 2* / 60 / NR / <0% / Yes
126 / M(55); Colorectal; mts+; KI≥50; NP+; BTP- / Buprenorphine / 7 / 60 / 7 / 90 / 5 / 90 / 5 / 180 / NR / >5%
127 / F(80); nsclc; mts+; KI≥50; NP-; BTP- / Buprenorphine / 6 / 60 / 3 / 60 / 6 / 120 / 6 / 120 / NR / 5%
128 / M(68); Mesoth; mts-; KI≥50; NPne; BTP- / Buprenorphine / 7 / 60 / 5 / 60 / 5 / 60 / 6 / 60 / NR / 0%
129 / F(56); Others; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 5 / 30 / 6 / 30 / 7 / 60 / 4 / 90 / NR / >5%
130 / F(67); Gynec; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 7 / 60 / 2 / 60 / 2 / 60 / 2 / 60 / R / 0%
131 / F(68); Pancreas; mts+; KI≥50; NP+; BTP- / Buprenorphine / 6 / 60 / 5 / 90 / 4 / 90 / 2 / 90 / R / <5%
132 / M(67); Prostate; mts+; KI≥50; NP+; BTP+ / Buprenorphine / 7 / 60 / 4 / 60 / 4 / 60 / 4 / 60 / R / 0%
133 / M(79); Prostate; mts+; KI≥50; NP-; BTP- / Buprenorphine / 7 / 60 / 5 / 60 / 4 / 60 / 4 / 60 / R / 0%
134 / M(68); Lung; mts+; KI≥50; NP-; BTP- / Buprenorphine / 8 / 90 / 7 / 90 / 6 / 90 / 4 / 90 / R / 0%
135 / M(42); Stomach; mts+; KI≥50; NP-; BTP- / Buprenorphine / 8 / 60 / 3 / 60 / 0 / 60 / 0 / 90 / R / <5%
136 / M(78); Prostate; mts+; KI≥50; NPne; BTP- / Buprenorphine / 6 / 60 / 6 / 60 / 6 / 120 / 6 / 120 / NR / 5%
137 / M(73); Prostate; mts+; KI≥50; NP+; BTP+ / Buprenorphine / 6 / 60 / 8 / 60 / 7 / 60 / 5 / 90 / NR / <5%
138 / M(69); nsclc; mts+; KI≥50; NPne; BTP- / Buprenorphine / 5 / 60 / 5 / 60 / 4 / 60 / 4 / 60 / NR / 0%
139 / F(68); Stomach; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 7 / 90 / 4* / 60 / 2 / 60 / 3 / 60 / NR / <0% / Yes
140 / M(37); Colorectal; mts+; KI≥50; NP+; BTP+ / Buprenorphine / 5 / 90 / 5 / 120 / 5* / 90 / 2 / 120 / NR / <5% / Yes
141 / M(75); Colorectal; mts-; KI≥50; NP+; BTP+ / Buprenorphine / 7 / 30 / 0 / 20 / 8 / 60 / 6 / 60 / NR / 5%
142 / M(60); H&N; mts+; KI≥50; NP+; BTP+ / Buprenorphine / 7 / 30 / 6 / 60 / 2 / 60 / 5 / 30 / NR / 0%
143 / M(64); H&N; mts-; KI≥50; NP-; BTP- / Buprenorphine / 7 / 60 / 3 / 90 / 2 / 120 / 2 / 120 / R / 5%
144 / M(74); Colorectal; mts+; KI≥50; NP-; BTP- / Buprenorphine / 6 / 60 / 3 / 60 / 2 / 60 / 3 / 90 / R / <5%
145 / F(59); Breast; mts+; KI≥50; NP+; BTP+ / Buprenorphine / 9 / 60 / 0 / 60 / 1 / 60 / 0 / 60 / R / 0%
146 / F(80); Pancreas; mts+; KI≥50; NP-; BTP- / Buprenorphine / 7 / 90 / 1 / 90 / 1 / 90 / 2 / 90 / R / 0%
147 / M(63); Others; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 5 / 60 / 6 / 60 / 5 / 90 / 6 / 90 / NR / <5%
148 / M(73); Others; mts+; KI≥50; NP+; BTP- / Buprenorphine / 6 / 60 / 3 / 60 / 4 / 60 / 6 / 90 / NR / <5%
149 / F(78); Breast; mts+; KI≥50; NP-; BTP- / Buprenorphine / 8 / 60 / 8 / 60 / 8 / 90 / 3 / 90 / R / <5%
150 / F(61); Colorectal; mts+; KI≥50; NP-; BTP- / Buprenorphine / 5 / 60 / 0 / 60 / 0 / 60 / 0 / 60 / R / 0%
151 / F(50); Breast; mts+; KI≥50; NP-; BTP- / Buprenorphine / 9 / 60 / 2 / 60 / 3 / 60 / 2 / 60 / R / 0%
152 / M(59); Bil. tract; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 6 / 60 / 4 / 60 / 2 / 60 / 6 / 60 / NR / 0%
153 / M(72); nsclc; mts+; KI<50; NP+; BTP+ / Buprenorphine / 4 / 60 / 4 / 60 / 2 / 60 / 2 / 60 / R / 0%
154 / F(65); Gynec; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 5 / 60 / 3 / 60 / 1 / 60 / 1 / 60 / R / 0%
155 / F(79); Breast; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 7 / 60 / 6 / 60 / 6 / 90 / 4 / 90 / R / <5%
156 / M(55); nsclc; mts+; KI≥50; NP-; BTP- / Buprenorphine / 4 / 60 / 2 / 60 / 2 / 60 / 2 / 60 / R / 0%
157 / M(70); nsclc; mts-; KI≥50; NP-; BTP- / Buprenorphine / 5 / 60 / 2 / 60 / 2 / 60 / 2 / 60 / R / 0%
158 / M(59); Colorectal; mts+; KI≥50; NP-; BTP- / Buprenorphine / 7 / 60 / 1 / 60 / 0 / 60 / 0 / 60 / R / 0%
159 / F(65); Breast; mts+; KI≥50; NP-; BTP- / Buprenorphine / 6 / 60 / 3 / 60 / 5 / 60 / 3 / 60 / R / 0%
160 / F(69); Breast; mts+; KI≥50; NP-; BTP- / Buprenorphine / 5 / 60 / 2 / 60 / 1 / 60 / 1 / 60 / R / 0%
161 / F(42); Others; mts+; KI≥50; NP-; BTP- / Buprenorphine / 7 / 60 / 1 / 60 / 4 / 90 / 1 / 90 / R / <5%
162 / F(81); Kidney; mts+; KI≥50; NP+; BTP+ / Buprenorphine / 7 / 60 / 8 / 90 / 5 / 90 / 7 / 90 / NR / <5%
163 / F(67); Breast; mts+; KI≥50; NP-; BTP- / Buprenorphine / 7 / 15 / 1 / 60 / 1 / 60 / 0 / 60 / R / >5%
164 / F(73); Gynec; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 4 / 60 / 4 / 60 / 1 / 90 / 1 / 90 / R / <5%
165 / M(71); nsclc; mts+; KI≥50; NP+; BTP- / Buprenorphine / 8 / 15 / 8 / 60 / 7 / 75 / 4 / 75 / R / >5%
166 / M(48); Colorectal; mts+; KI≥50; NP+; BTP- / Buprenorphine / 4 / 60 / 3 / 60 / 3 / 90 / 2 / 90 / R / <5%
167 / M(81); nsclc; mts+; KI≥50; NP+; BTP- / Buprenorphine / 4 / 60 / 4 / 90 / 3 / 90 / 3 / 90 / NR / <5%
168 / F(56); Lung; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 4 / 60 / 2 / 60 / 2 / 90 / 2 / 90 / R / <5%
169 / M(56); nsclc; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 5 / 60 / 2 / 60 / 2 / 60 / 4 / 90 / NR / <5%
170 / M(66); Prostate; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 5 / 60 / 2 / 90 / 2 / 90 / 2 / 90 / R / <5%
171 / M(79); Prostate; mts+; KI≥50; NP-; BTP- / Buprenorphine / 5 / 30 / 3 / 60 / 2 / 60 / 2 / 60 / R / 5%
172 / M(64); Bladderc; mts+; KI≥50; NP-; BTP- / Buprenorphine / 4 / 30 / 3 / 60 / 2 / 60 / 1 / 60 / R / 5%
173 / F(43); Breast; mts+; KI≥50; NP+; BTP+ / Buprenorphine / 7 / 30 / 6 / 60 / 5 / 90 / 6 / 90 / NR / >5%
174 / F(79); Colorectal; mts+; KI≥50; NP-; BTP- / Buprenorphine / 7 / 30 / 6 / 60 / 6 / 60 / 6 / 90 / NR / >5%
175 / F(72); Bil. tract; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 5 / 60 / 4 / 60 / 1 / 60 / 1 / 60 / R / 0%
176 / M(58); Kidney; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 6 / 60 / 5* / 45 / 2 / 45 / 3 / 45 / NR / <0% / Yes
177 / M(41); H&N; mts+; KI≥50; NP-; BTP- / Buprenorphine / 5 / 60 / 4 / 90 / 3 / 90 / 2 / 90 / R / <5%
178 / M(60); Prostate; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 4 / 60 / 3 / 60 / 2 / 60 / 1 / 60 / R / 0%
179 / M(73); Lung; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 6 / 90 / 2 / 90 / 2 / 90 / 1 / 90 / R / 0%
180 / M(68); Pancreas; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 4 / 60 / 4 / 60 / 6 / 60 / 6 / 60 / NR / 0%
181 / M(65); nsclc; mts+; KI≥50; NP-; BTP- / Buprenorphine / 4 / 20 / 2 / 20 / 2 / 20 / 1 / 20 / R / 0%
182 / M(60); Lung; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 6 / 30 / 5 / 30 / 5 / 60 / 7 / 90 / NR / >5%
183 / M(66); nsclc; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 6 / 30 / 6 / 30 / 3 / 30 / 3 / 30 / R / 0%
184 / M(71); nsclc; mts+; KI≥50; NP-; BTP- / Buprenorphine / 5 / 60 / 5 / 60 / 5 / 60 / 4 / 60 / NR / 0%
185 / M(50); nsclc; mts+; KI≥50; NP-; BTP- / Buprenorphine / 8 / 60 / 4 / 60 / 6 / 60 / 2 / 60 / R / 0%
186 / M(74); Prostate; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 7 / 60 / 5 / 60 / 4 / 90 / 3 / 90 / R / <5%
187 / F(78); Breast; mts+; KI≥50; NP-; BTP- / Buprenorphine / 8 / 60 / 7 / 60 / 10 / 120 / 5 / 120 / NR / 5%
188 / F(76); nsclc; mts+; KI≥50; NP-; BTP- / Buprenorphine / 7 / 60 / 6 / 90 / 6 / 90 / 0 / 80 / R / <5%
189 / M(76); Other; mts+; KI≥50; NP-; BTP- / Buprenorphine / 4 / 30 / 5 / 60 / 8 / 30 / 5 / 60 / NR / 5%
190 / M(64); nsclc; mts+; KI≥50; NP-; BTP- / Buprenorphine / 6 / 60 / 4 / 60 / 7* / 120 / 5 / 50 / NR / <5% / Yes
191 / F(59); Colorectal; mts+; KI≥50; NP+; BTP+ / Buprenorphine / 8 / 60 / 5 / 90 / 5 / 90 / 4 / 120 / R / 5%
192 / F(80); Colorectal; mts+; KI<50; NP-; BTP+ / Buprenorphine / 7 / 30 / 6 / 60 / 4 / 60 / 6 / 60 / NR / 5%
193 / M(74); Kidney; mts+; KI≥50; NP+; BTP- / Buprenorphine / 5 / 45 / 3 / 45 / 3 / 60 / 3 / 60 / R / <5%
194 / M(77); nsclc; mts+; KI≥50; NP+; BTP- / Buprenorphine / 4 / 35 / 2 / 35 / 2 / 35 / 2 / 35 / R / 0%
195 / M(54); nsclc; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 5 / 90 / 3 / 90 / 3 / 90 / 5 / 120 / NR / <5%
196 / M(68); Colorectal; mts+; KI≥50; NP-; BTP- / Buprenorphine / 5 / 120 / 5* / 240 / 3* / 160 / 2 / 160 / NR / <5% / Yes
197 / F(83); Stomach; mts+; KI<50; NP-; BTP+ / Buprenorphine / 5 / 60 / 4 / 120 / 3 / 250 / 3 / 360 / R / >5%
198 / M(83); Prostate; mts+; KI≥50; NP-; BTP+ / Buprenorphine / 5 / 90 / 3 / 120 / 3 / 120 / 3 / 120 / R / <5%
199 / F(67); Breast; mts+; KI<50; NP+; BTP+ / Buprenorphine / 4 / 90 / 3 / 120 / 2 / 160 / 1 / 160 / R / <5%
200 / F(72); Breast; mts+; KI≥50; NP+; BTP- / Buprenorphine / 9 / 60 / 0 / 90 / 3 / 90 / 2 / 90 / R / <5%
201 / M(50); Other; mts+; KI≥50; NP-; BTP- / Buprenorphine / 5 / 60 / 2 / 60 / 5 / 60 / 5 / 60 / NR / 0%

Legends: The ‘Patients’ column gives: 1. sex; 2. age; 3. primary tumor site; 4. presence/lack of metastases (mts+ or mts-); 5. Karnofsky performance status (KI≥ 50 or < 50); 6. neuropathic pain (NP+ or NP-); 7. breakthrough pain (BTP+ or BTP-). The columns show the API and the OMEDD on days 1, 7, 14 and 21. The third-to-last column specifies the R or NR status for analgesic response. The second-to-last column reports the OEI% (< 0% or 0%, < 5%, 5% or > 5%). The last column indicates whether the patients switched to another opioid.