Appendix 1: List of MeSH and search terms

Medline:

1opioids.mp. or exp Analgesics, Opioid/

2analgesics, opioid.rn.

3alfentanil.mp.

4buprenorphine.mp.

5codeine*.mp.

6ethylmorphine?.mp.

7fentanyl*.mp.

8hydrocodone?.mp.

9hydromorphone?.mp.

10meperidine?.mp.

11morphine*.mp.

12opioid?.mp.

13opium?.mp.

14oxycodone?.mp.

15oxymorphone?.mp.

16remifentanil?.mp.

17sufentanil?.mp.

18methadone*.mp.

19tramadol?.mp.

20duramor*.mp.

21or/1-20

22injections,epidural/

23exp analgesia, epidural/

24exp anesthesia, epidural/

25neuraxial*2.mp.

26epidural*2.mp.

27extradural*2.mp.

28extra-dural*.mp.

29extra-dural*2.mp.

30peridural*2.mp.

31(lumbar adj2 an?esth*).mp.

32(lumbar adj2 inject*).mp.

33(lumbar adj2 analges*).mp.

34(lumbar adj2 block*3).mp.

35(lumbar adj2 infus*).mp.

36(thoracic adj2 an?esth*).mp.

37(thoracic adj2 inject*).mp.

38(thoracic adj2 analges*).mp.

39(thoracic adj2 block*3).mp.

40(thoracic adj2 infus*).mp.

41central block*3.mp.

42or/22-41

4321 and 42

44limit 43 to (english language and humans and (clinical trial, all or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or clinical trial or comparative study or controlled clinical trial or evaluation studies or meta analysis or multicenter study or randomized controlled trial or "review"))

EMBASE:

45epidural drug administration/

46exp epidural anesthesia/

47continuous epidural anesthesia/

48thorax epidural anesthesia/

49neuraxial*2.mp.

50epidural*2.mp.

51extra-dural*2.mp.

52extradural*2.mp.

53peridural*2.mp.

54(lumbar adj2 an?esth*).mp.

55(lumbar adj2 inject*).mp.

56(lumbar adj2 analges*).mp.

57(lumbar adj2 block*3).mp.

58(lumbar adj2 infus*).mp.

59ei.fs. [epidural drug administration subheading]

60(thoracic adj2 an?esth*).mp.

61(thoracic adj2 inject*).mp.

62(thoracic adj2 analges*).mp.

63(thoracic adj2 block*3).mp.

64(thoracic adj2 infus*).mp.

65central block*3.mp.

66or/1-21

67exp Opiate/

68Alfentanil.mp.

69buprenorphine.mp.

70codeine*.mp.

71ethylmorphine?.mp.

72fentanyl*.mp.

73hydrocodone?.mp.

74hydromorphone?.mp.

75meperidine?.mp.

76morphine*.mp.

77opiate?.mp.

78opioid?.mp.

79opium?.mp.

80oxycodone?.mp.

81oxymorphone?.mp.

82remifentanil?.mp.

83sufentanil?.mp.

84methadone*.mp.

85tramadol?.mp.

86duramor*.mp.

87or/23-42

8822 and 43

89limit 44 to english language

90limit 45 to humans

limit 46 to (clinical trial or randomized controlled trial or controlled clinical trial or multicenter study or phase 1 clinical trial or phase 2 clinical trial or phase 3 clinical trial or phase 4 clinical trial)

Cochrane:

91injections,epidural/

92exp analgesia, epidural/

93exp anesthesia, epidural/

94neuraxial*2.mp.

95epidural*2.mp.

96extradural*2.mp.

97extra-dural*2.mp.

98peridural*2.mp.

99(lumbar adj2 an?esth*).mp.

100(lumbar adj2 inject*).mp.

101(lumbar adj2 analges*).mp.

102(lumbar adj2 block*3).mp.

103(lumbar adj2 infus*).mp.

104(thoracic adj2 an?esth*).mp.

105(thoracic adj2 inject*).mp.

106(thoracic adj2 analges*).mp.

107(thoracic adj2 block*3).mp.

108(thoracic adj2 infus*).mp.

109central block*3.mp.

110or/1-19

111Alfentanil.mp.

112Buprenorphine.mp.

113Codeine*.mp.

114ethylmorphine?.mp.

115fentanyl*.mp.

116hydrocodone?.mp.

117hydromorphone?.mp.

118meperidine?.mp.

119methadone*.mp.

120morphine*.mp.

121opiate?.mp.

122opioid?.mp.

123opium?.mp.

124oxycodone?.mp.

125oxymorphone?.mp.

126remifentanil?.mp.

127sufentanil?.mp.

128tramadol?.mp.

129or/21-38

13020 and 39

limit 40 to (clinical trial or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or comparative study or controlled clinical trial or meta analysis or multicenter study or randomized controlled trial)