ANTIMICROBIAL AND ANTIHYPERLIPIDEMIC ACTIVITIES OF ISOLATED QUERCETIN FROM ANABAENA AEQUALIS†

  1. Neveen Abdel-Raouf1,
  2. Ibraheem B. M. Ibraheem2,‡,
  3. Sanaa Abdel-Tawab3,
  4. Yamna A. G. Naser4

Article first published online: 7 JUL 2011

DOI:10.1111/j.1529-8817.2011.01020.x

© 2011 Phycological Society of America

Issue

Journal of Phycology

Volume 47, Issue 4, pages 955–962, August 2011

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How to Cite

Abdel-Raouf, N., Ibraheem, I. B. M., Abdel-Tawab, S. and Naser, Y. A. G. (2011), ANTIMICROBIAL AND ANTIHYPERLIPIDEMIC ACTIVITIES OF ISOLATED QUERCETIN FROM ANABAENA AEQUALIS. Journal of Phycology, 47:955–962. doi:10.1111/j.1529-8817.2011.01020.x

Author Information

  1. 1

Botany and Microbiology Department, Faculty of Science and Medical Studies, Women Students Medical Studies and Sciences Sections, King Saud University for Girls, Riyadh, Saudi Arabia

  1. 2

Botany and Microbiology Department, Faculty of Science, King Saud University, Riyadh, Saudi Arabia

  1. 3

Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt

  1. 4

Botany Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt

Publication History

  1. Issue published online: 25 JUL 2011
  2. Article first published online: 7 JUL 2011

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Keywords:

Anabaena aequalis; antihyperlipidemic agent; antimicrobial activity; cyanobacteria; quercetin

This study aimed to isolate quercetin (for the first time) from Anabaena aequalis Borge, which inhabits soil surface of Wadi El-Alaqui Protectorate located in Aswan city, Egypt. The isolated compound showed significant antibacterial activity against the gram-positive bacteria Sarcina maxima and Micrococcus kristinae, the gram-negative bacterium Klebsiella pneumoniae, as well as against the filamentous fungus Aspergillus flavus. The isolated compound was identified as quercetin using the structure elucidation based on UV, electrospray ionization mass spectrometry (ESIMS), 1H and 13C NMR, proton–proton correlation spectroscopy (1H-1H COSY), distortionless enhancement by polarization transfer (DEPT), heteronuclear single quantum coherence (HSQC), and heteronuclear multiple bond correlations spectrum (HMBC). Medium lethal dose (LD50) of the isolated compound and its side effects against hyperlipidemia induced by ethanol intake in albino rats were carried out. No deaths were reported in rats within 72h, which suggests that the isolated compound plays a beneficial role as an antihyperlipidemic agent in the treatment of alcohol-induced hepatic tissue damage, which can be described as one of the therapeutic values.

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