Table S2
The reversion of 7-CTKA treatment to miRNAs expression changes induced by chronic unpredictable mild stress.(Data are expressed as normalized median. Group 2, vehicle-vehicle-CUMS; Group 3, vehicle-7-CTKA-CUMS. #P < 0.05 vs. Group 2, and fold change > = 1.3)
No. / Name / Group 2 / Group 3 / Ratio of Group 3 to 2 / Regulation#1 / mmu-miR-711 / 0.721581549 / 0.262015504 / 0.363112810 / Down
2 / mmu-miR-34c-3p / 0.449752883 / 0.190697674 / 0.424005452 / Down
3 / (mmu-miR-1954)a / 0.337726524 / 0.201550388 / 0.596785782 / Down
4 / mmu-miR-137-5p / 3.917627677 / 2.418604651 / 0.617364602 / Down
5 / (mmu-miR-450a-1-3p)a / 0.499176277 / 0.229457364 / 0.459672014 / Down
6 / (mghv-miR-M1-2-5p)a / 0.084019769 / 0.044961240 / 0.535126919 / Down
7 / mmu-miR-495-5p / 0.443163097 / 0.133333333 / 0.300867410 / Down
8 / (mmu-miR-96-3p)a / 0.115321252 / 0.054263566 / 0.470542636 / Down
9 / mmu-miR-290a-3p / 0.360790774 / 0.049612403 / 0.137510177 / Down
10 / (mmu-miR-299a-5p)a / 0.749588138 / 0.537984496 / 0.717706789 / Down
11 / mmu-miR-466f-5p / 0.107084020 / 0.049612403 / 0.463303518 / Down
12 / (mmu-miR-669o-5p)a / 0.415156507 / 0.314728682 / 0.758096469 / Down
13 / (mmu-miR-669n)a / 0.807248764 / 0.452713178 / 0.560809998 / Down
14 / mmu-miR-668-3p / 1.640856672 / 0.347286822 / 0.211649700 / Down
15 / (mmu-miR-3082-5p)a / 0.504118616 / 0.286821705 / 0.568956782 / Down
16 / mmu-miR-3084-3p / 6.881383855 / 4.629457364 / 0.672750927 / Down
17 / (mmu-miR-574-5p)a / 0.329489292 / 0.217054264 / 0.658759690 / Down
18 / (mmu-miR-21a-3p)a / 0.255354201 / 0.117829457 / 0.461435359 / Down
19 / mmu-miR-1298-5p / 1.036243822 / 0.483720930 / 0.466802233 / Down
20 / (mmu-miR-673-3p)a / 0.087314662 / 0.066666667 / 0.763522013 / Down
21 / mmu-miR-669m-3p / 0.449752883 / 0.153488372 / 0.341272681 / Down
22 / mmu-miR-216a-3p / 0.077429984 / 0.029457364 / 0.380438727 / Down
23 / mmu-miR-3099-5p / 0.349258649 / 0.116279070 / 0.332931110 / Down
24 / mmu-miR-679-5p / 0.123558484 / 0.032558140 / 0.263503876 / Down
25 / (mmu-miR-323-5p)a / 0.095551895 / 0.072868217 / 0.762603582 / Down
26 / mmu-miR-758-3p / 0.098846787 / 0.031007752 / 0.313695090 / Down
27 / mmu-miR-1894-5p / 0.029654036 / 0.013953488 / 0.470542636 / Down
28 / mmu-miR-1936 / 0.133443163 / 0.089922481 / 0.673863528 / Down
29 / (mmu-miR-3474)a / 0.474464580 / 0.083720930 / 0.176453488 / Down
30 / mmu-miR-3103-5p / 0.629324547 / 0.213953488 / 0.339973213 / Down
No. / Name / Group 2 / Group 3 / Ratio of Group 3 to 2 / Regulation#
31 / (mmu-miR-219b-5p)a / 0.192751236 / 0.116279070 / 0.603259789 / Down
32 / mmu-miR-714 / 0.103789127 / 0.026356589 / 0.253943645 / Down
33 / (mmu-miR-204-3p)a / 0.629324547 / 0.347286822 / 0.551840578 / Down
34 / (mmu-miR-34c-5p)a / 6.408566722 / 4.674418605 / 0.729401566 / Down
35 / (mghv-miR-M1-6-3p)a / 0.062602965 / 0.032558140 / 0.520073439 / Down
36 / (mmu-miR-883b-5p)a / 1.451400329 / 0.296124031 / 0.204026432 / Down
37 / mmu-miR-1958 / 0.245469522 / 0.106976744 / 0.435804589 / Down
38 / (mmu-miR-466b-5p)a / 0.138385502 / 0.074418605 / 0.537763012 / Down
39 / mmu-miR-3076-3p / 0.130148270 / 0.052713178 / 0.405024041 / Down
40 / mmu-miR-1298-3p / 0.342668863 / 0.128682171 / 0.375529219 / Down
41 / (mmu-miR-3100-3p)a / 0.194398682 / 0.120930233 / 0.622073315 / Down
42 / mmu-miR-678 / 0.280065898 / 0.031007752 / 0.110715914 / Down
43 / (mmu-miR-700-3p)a / 0.082372323 / 0.048062016 / 0.583472868 / Down
44 / mmu-miR-653-3p / 0.036243822 / 0.015503876 / 0.427766032 / Down
45 / (mmu-miR-340-3p)a / 0.754530478 / 0.446511628 / 0.591774144 / Down
46 / mmu-miR-193b-5p / 0.070840198 / 0.024806202 / 0.350171264 / Down
47 / (mmu-miR-342-5p)a / 0.220757825 / 0.091472868 / 0.414358440 / Down
48 / (mmu-miR-467e-5p)a / 0.153212521 / 0.113178295 / 0.738701342 / Down
49 / (mmu-miR-698-3p)a / 0.024711697 / 0.013953488 / 0.564651163 / Down
50 / (mmu-miR-31-3p)a / 0.141680395 / 0.071317829 / 0.503371192 / Down
51 / mmu-miR-130b-3p / 0.148270181 / 0.082170543 / 0.554194660 / Down
52 / (mmu-miR-423-3p)a / 0.400329489 / 0.234108527 / 0.584789613 / Down
53 / mmu-miR-135a-5p / 11.454695222 / 7.618604651 / 0.665107583 / Down
54 / (mmu-miR-466d-5p)a / 0.164744646 / 0.111627907 / 0.677581395 / Down
55 / (mmu-miR-297a-5p)a / 0.075782537 / 0.038759690 / 0.511459387 / Down
56 / mmu-miR-92a-2-5p / 0.179571664 / 0.111627907 / 0.621634308 / Down
57 / mmu-miR-122-3p / 0.759472817 / 0.494573643 / 0.651206511 / Down
58 / (mmu-miR-377-5p)a / 0.263591433 / 0.186046512 / 0.705813953 / Down
59 / (mmu-miR-1193-3p)a / 0.622734761 / 0.373643411 / 0.600004102 / Down
60 / (mmu-miR-1892)a / 0.342668863 / 0.147286822 / 0.429822600 / Down
No. / Name / Group 2 / Group 3 / Ratio of Group 3 to 2 / Regulation#
61 / (mmu-miR-2139)a / 0.186161450 / 0.065116279 / 0.349783906 / Down
62 / (mmu-miR-1941-3p)a / 0.227347611 / 0.103875969 / 0.456903719 / Down
63 / mmu-miR-1904 / 0.054365733 / 0.015503876 / 0.285177355 / Down
64 / mmu-miR-1948-5p / 0.062602965 / 0.015503876 / 0.247654019 / Down
65 / mghv-miR-M1-10-3p / 0.626029654 / 0.368992248 / 0.589416565 / Down
66 / mmu-miR-467c-3p / 0.138385502 / 0.091472868 / 0.661000369 / Down
67 / (mmu-miR-669k-5p)a / 0.344316310 / 0.147286822 / 0.427766032 / Down
68 / (mmu-miR-5622-5p)a / 0.431630972 / 0.254263566 / 0.589076277 / Down
69 / mmu-miR-342-3p / 2.054365733 / 0.613953488 / 0.298853061 / Down
70 / (mmu-miR-470-5p)a / 0.654036244 / 0.251162791 / 0.384019683 / Down
71 / mmu-miR-25-5p / 0.528830313 / 0.255813953 / 0.483735420 / Down
72 / (mmu-miR-155-3p)a / 0.154859967 / 0.102325581 / 0.660761999 / Down
73 / mmu-miR-5114 / 0.209225700 / 0.100775194 / 0.481657816 / Down
74 / mmu-miR-183-3p / 0.754530478 / 0.182945736 / 0.242463018 / Down
75 / (mmu-miR-196a-2-3p)a / 0.087314662 / 0.035658915 / 0.408395495 / Down
76 / mmu-miR-1894-3p / 0.120263591 / 0.086821705 / 0.721928427 / Down
77 / (mmu-miR-2183)a / 0.650741351 / 0.474418605 / 0.729043273 / Down
78 / (mmu-miR-3060-3p)a / 0.077429984 / 0.051162791 / 0.660761999 / Down
79 / (mmu-miR-503-5p)a / 0.509060956 / 0.193798450 / 0.380697925 / Down
80 / (mmu-miR-27b-5p)a / 0.186161450 / 0.077519380 / 0.416409412 / Down
81 / (mmu-miR-3080-5p)a / 0.321252059 / 0.165891473 / 0.516390380 / Down
82 / (mmu-miR-374c-3p)a / 0.433278418 / 0.296124031 / 0.683449760 / Down
83 / mmu-miR-1964-5p / 0.250411862 / 0.134883721 / 0.538647491 / Down
84 / mmu-miR-3081-5p / 0.337726524 / 0.094573643 / 0.280030251 / Down
85 / mmu-miR-3473a / 0.747940692 / 0.150387597 / 0.201068880 / Down
86 / (mmu-miR-592-3p)a / 0.112026359 / 0.043410853 / 0.387505700 / Down
87 / (mmu-miR-5621-3p)a / 0.156507414 / 0.106976744 / 0.683525092 / Down
88 / mmu-miR-5616-3p / 0.350906096 / 0.153488372 / 0.437405830 / Down
89 / mmu-miR-675-3p / 0.151565074 / 0.068217054 / 0.450084260 / Down
90 / mmu-miR-466a-5p / 0.191103789 / 0.077519380 / 0.405640203 / Down
No. / Name / Group 2 / Group 3 / Ratio of Group 3 to 2 / Regulation#
91 / mmu-miR-297c-5p / 0.059308072 / 0.043410853 / 0.731955211 / Down
92 / (mmu-miR-297a-3p)a / 0.268533773 / 0.139534884 / 0.519617634 / Down
93 / (mmu-miR-505-5p)a / 0.785831960 / 0.251162791 / 0.319613866 / Down
94 / mmu-miR-465c-5p / 0.640856672 / 0.094573643 / 0.147573783 / Down
95 / mmu-miR-466i-3p / 0.281713344 / 0.128682171 / 0.456784079 / Down
96 / mmu-miR-206-3p / 0.472817133 / 0.041860465 / 0.088534154 / Down
97 / mmu-miR-1903 / 0.423393740 / 0.173643411 / 0.410122764 / Down
98 / mmu-miR-1899 / 1.192751236 / 0.815503876 / 0.683716647 / Down
99 / mmu-miR-3095-3p / 0.121911038 / 0.049612403 / 0.406955793 / Down
100 / mmu-miR-3064-5p / 0.034596376 / 0.012403101 / 0.358508675 / Down
101 / (mmu-miR-201-5p)a / 0.128500824 / 0.040310078 / 0.313695090 / Down
102 / mmu-miR-3087-3p / 0.200988468 / 0.088372093 / 0.439687381 / Down
103 / (mmu-miR-5107-5p)a / 0.563426689 / 0.189147287 / 0.335708781 / Down
104 / mmu-miR-693-5p / 0.257001647 / 0.195348837 / 0.760107335 / Down
105 / mmu-miR-375-3p / 2.703459638 / 0.638759690 / 0.236274913 / Down
106 / mmu-miR-1187 / 0.204283361 / 0.041860465 / 0.204913728 / Down
107 / mmu-miR-466a-3p / 0.225700165 / 0.114728682 / 0.508323431 / Down
108 / (mmu-miR-468-3p)a / 0.120263591 / 0.051162791 / 0.425422109 / Down
109 / (mmu-miR-487b-5p)a / 0.187808896 / 0.088372093 / 0.470542636 / Down
110 / mmu-miR-1981-3p / 0.489291598 / 0.148837209 / 0.304189179 / Down
111 / mmu-miR-3109-5p / 0.477759473 / 0.114728682 / 0.240139000 / Down
112 / mmu-miR-3544-3p / 0.097199341 / 0.027906977 / 0.287110761 / Down
113 / mmu-miR-130b-5p / 0.184514003 / 0.100775194 / 0.546165559 / Down
114 / mmu-miR-5121 / 0.182866557 / 0.049612403 / 0.271303862 / Down
115 / mmu-miR-378b / 1.377265239 / 0.872868217 / 0.633769148 / Down
116 / (mmu-miR-141-3p)a / 0.120263591 / 0.089922481 / 0.747711585 / Down
117 / mmu-miR-877-5p / 0.902800659 / 0.184496124 / 0.204359758 / Down
118 / mmu-miR-22-5p / 1.677100494 / 0.838759690 / 0.500124884 / Down
119 / mmu-miR-1946b / 0.075782537 / 0.023255814 / 0.306875632 / Down
120 / mmu-miR-669d-3p / 0.365733114 / 0.127131783 / 0.347608073 / Down
No. / Name / Group 2 / Group 3 / Ratio of Group 3 to 2 / Regulation#
121 / (mmu-miR-34a-5p)a / 5.561779242 / 3.607751938 / 0.648668669 / Down
122 / mmu-miR-5128 / 0.074135091 / 0.048062016 / 0.648303187 / Down
123 / mmu-miR-488-5p / 0.088962109 / 0.035658915 / 0.400832616 / Down
124 / (mmu-miR-697)a / 0.390444811 / 0.153488372 / 0.393111569 / Down
125 / mmu-miR-879-5p / 0.153212521 / 0.044961240 / 0.293456698 / Down
126 / (mmu-miR-7b-3p)a / 0.429983526 / 0.079069767 / 0.183890225 / Down
127 / mmu-miR-1943-3p / 0.477759473 / 0.184496124 / 0.386169473 / Down
128 / mmu-miR-544-5p / 1.960461285 / 0.686821705 / 0.350336786 / Down
129 / (mmu-miR-3090-5p)a / 0.113673806 / 0.071317829 / 0.627390181 / Down
130 / mmu-miR-3085-5p / 0.013179572 / 0.001550388 / 0.117635659 / Down
131 / (mmu-miR-323-3p)a / 0.451400329 / 0.217054264 / 0.480846489 / Down
132 / (mmu-miR-221-5p)a / 0.255354201 / 0.100775194 / 0.394648662 / Down
133 / mmu-miR-652-3p / 2.897858320 / 1.837209302 / 0.633988656 / Down
134 / (mmu-miR-325-5p)a / 0.401976936 / 0.089922481 / 0.223700597 / Down
135 / mmu-miR-691 / 10.818780890 / 1.596899225 / 0.147604360 / Down
136 / (mmu-miR-378a-3p)a / 2.446457990 / 0.927131783 / 0.378969018 / Down
137 / (mmu-miR-3068-3p)a / 3.321252059 / 2.469767442 / 0.743625415 / Down
138 / (mmu-miR-669f-5p)a / 0.565074135 / 0.200000000 / 0.353935860 / Down
139 / mmu-miR-194-2-3p / 0.052718287 / 0.029457364 / 0.558769380 / Down
140 / (mmu-miR-200a-3p)a / 0.247116969 / 0.150387597 / 0.608568475 / Down
141 / (mmu-miR-346-5p)a / 0.459637562 / 0.204651163 / 0.445244644 / Down
142 / (mmu-miR-490-5p)a / 0.314662273 / 0.145736434 / 0.463151914 / Down
143 / mmu-miR-881-3p / 0.097199341 / 0.031007752 / 0.319011956 / Down
144 / mghv-miR-M1-5-5p / 0.627677100 / 0.141860465 / 0.226008668 / Down
145 / mmu-miR-30b-3p / 0.858319605 / 0.170542636 / 0.198693627 / Down
146 / mmu-miR-574-3p / 0.327841845 / 0.094573643 / 0.288473375 / Down
147 / mmu-miR-135a-2-3p / 0.143327842 / 0.048062016 / 0.335329235 / Down
148 / (mmu-miR-103-1-5p)a / 0.065897858 / 0.032558140 / 0.494069767 / Down
149 / (mmu-miR-669e-3p)a / 0.327841845 / 0.114728682 / 0.349951307 / Down
150 / mmu-miR-1224-3p / 0.423393740 / 0.182945736 / 0.432093627 / Down
No. / Name / Group 2 / Group 3 / Ratio of Group 3to 2 / Regulation#
151 / mmu-miR-363-5p / 0.306425041 / 0.193798450 / 0.632449779 / Down
152 / mmu-miR-301b-5p / 0.121911038 / 0.069767442 / 0.572281584 / Down
153 / mghv-miR-M1-8-3p / 0.329489292 / 0.229457364 / 0.696403101 / Down
154 / mmu-miR-758-5p / 0.250411862 / 0.077519380 / 0.309567523 / Down
1 / (mmu-miR-181a-2-3p)b / 0.019769357 / 0.032713178 / 1.654741602 / Up
2 / mmu-miR-210-5p / 0.092257002 / 0.213953488 / 2.319102990 / Up
3 / mmu-miR-1843b-3p / 10.741350906 / 28.463565891 / 2.649905598 / Up
4 / (mmu-miR-151-3p)b / 0.747940692 / 1.100775194 / 1.471741283 / Up
5 / mmu-miR-191-3p / 0.041186161 / 0.077519380 / 1.882170543 / Up
6 / (mmu-miR-101a-3p)b / 39.080724876 / 62.899224806 / 1.609469246 / Up
7 / mmu-miR-767 / 7.871499176 / 34.314728682 / 4.359363815 / Up
8 / (mmu-miR-128-3p)b / 31.563426689 / 43.396899225 / 1.374910895 / Up
9 / (mmu-miR-132-5p)b / 2.813838550 / 3.697674419 / 1.314103262 / Up
10 / (mmu-miR-201-3p)b / 0.667215815 / 1.412403101 / 2.116860944 / Up
11 / (mmu-miR-144-3p)b / 9.237232290 / 12.824806202 / 1.388381909 / Up
12 / mmu-miR-872-3p / 3.202635914 / 8.528682171 / 2.663019587 / Up
13 / (mmu-miR-142-3p)b / 6.230642504 / 8.285271318 / 1.329761949 / Up
14 / (mmu-miR-125a-3p)b / 0.255354201 / 0.372093023 / 1.457164291 / Up
15 / (mmu-miR-99a-5p)b / 8.896210873 / 14.272868217 / 1.604376113 / Up
16 / mmu-miR-29c-3p / 21.036243822 / 36.964341085 / 1.757174018 / Up
17 / (mmu-miR-22-3p)b / 23.140032949 / 32.010852713 / 1.383353809 / Up
anormalizations of 7-CTKA to CUMS-upregulated miRNAs expressions
b a normalization of 7-CTKA to CUMS-downregulated miRNAs expressions