Canterbury DHB (Blood, Cancer and Palliative Care Service)
Page 1 of 3
AML 17 - APL treatment
Induction (continued)
ATRA with Arsenic Trioxide / Height / cm
Weight / kg
BSA / m2

Patient trial number:

Destination / BMTUHDWONC OPWD 27 / Limits / Hypersensitivities/Allergies
PRN antiemetics
± domperidone20mg PO QID / Agent
ATRA
Arsenic Trioxide
DOSE MODIFIED:No YesNoYes / Round
10mg
1mg
Date
Neuts
Plats
Reference: AML 17 trial protocol
WEEK / Date / Time / Agent / Dose / Route / Instructions / Doctor / Nurse / Check / Start / Stop
Tretinoin (ATRA) 45mg/m2(continued) / mg / PO / Administered daily in 2 equally divided doses, from day 1 until Haematological CR or for a maximum of 60 days. Chart on QMR4 or outpatient script.
2 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
2 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
3 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
  • You must read the protocol before prescribing this chemotherapy.
  • Continue tretinoin 45mg/m2/day in 2 equally divided doses until Haematological complete remission or for a maximum of 60 days
  • Baseline ECG + weekly. Ensure Mg > 0.6 and K+ > 40 prior to each dose of arsenic trioxide
  • Monitor closely for signs of differentiation (ATRA) syndrome and tumourlysis syndrome. See Red book for details.

Patient Category:
Y J A P O 1 3 Z / OSP Group:
1 2 3 4 5 6 7 / Consultant:
NZMC Reg. No: / Special Authority
AML 17 - APL treatment
Induction (continued)
ATRA with Arsenic Trioxide / Height / cm
Weight / kg
BSA / m2
WEEK / Date / Time / Agent / Dose / Route / Instructions / Doctor / Nurse / Check / Start / Stop
3 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
4 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
4 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
5 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
5 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
6 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
6 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
AML 17 - APL treatment
Induction (continued)
ATRA with Arsenic Trioxide / Height / cm
Weight / kg
BSA / m2
WEEK / Date / Time / Agent / Dose / Route / Instructions / Doctor / Nurse / Check / Start / Stop
7 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
7 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
8 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
8 / 0.9% saline / 100 / ml / IV / for flushing
Arsenic trioxide 0.25mg/kg / mg / IV / In 250ml 0.9% saline over 2 hours.
Authorised by PI RL SpearingPharmacist: B Harden / February 2011
\\cdhb.local\dfsgeneral\CHC13HomeLink\JennyR1\Jen\Chemo charts\Trial\AML17\APL\AML17 trial APL induction ATRA with Arsenic Trioxide.doc / Review 2012
CHEMOTHERAPY
MEDICATION
CHART
C260070