Alireza Nematollahi
3-1 Research Center of Natural Products Safety And Medicinal Plants
North Khorasan University of Medical Sciences
Bojnurd, North Khorasan, 9414975516
(0098) 584 - 2248003
Email:
Web Page:
POSITION
I am one of the members of the natural products and medicinal chemistry research team at the North Khorasan University of medical sciences.
Education
2010- 2011
Nottingham University – Malaysia Campus
Natural Products Research project
Link:
2003 – 2009
IAUPSTehran University of pharmaceutical science
Doctor of Pharmacy (Pharm.D)
Other Degrees
2008- 2010
Amirkabir University of Technology
Medical Information and Communications Technology (MSc)
2002 – 2006
Amirkabir University of Technology
Civil Engineering (BSc)
MAJOR AWARDS & RECOGNITIONS
* My dissertation was selected as the best thesis among the pharmaceutical branches at IAU in IRAN in 2009.
*Awarded the first prize in the 13th seminar of Iranian pharmaceutical students in Computational section (2007 Tabriz).
RESEARCH INTERESTS
“An ounce of prevention is better than a pound of cure” (old proverb)
We have four main research program areas in our group.
The first area of research is using the latest methods of organic synthesis combined with information gleaned from the methods of molecular modelling and docking simulation (both small molecule and protein modelling) to design and synthesize molecules that can be used to gain a better understanding of the function of specific molecular targets. Drug design is an exciting area of research in which the discipline of Medicinal Chemistry plays a central role. Intellectual challenges in drug design to develop superior drugs which provide new or more effective chemotherapy requires knowledge of organic chemistry, biochemistry, pharmacology and/or molecular biology. Our current research in rational drug design encompasses the design, synthesis and biological evaluation of novel next-generation types of phthalimides and their derivatives as potential anti-cancer and anti-convulsion agents. Experimental aspects of our projects include synthetic organic chemistry, enzyme inhibition, biological evaluation, structure-activity relationships (SARs), and molecular modeling studies (MD simulation and docking studies).
Future projects include:Design and synthesis of dual inhibitors of cyclooxygenases (COXs) and 5-lipoxygenase (5-LOX) with anti-inflammatory (AI) activity. Agents that act by two mechanisms of action have the potential to provide more efficacious anti-arthritic therapy. Novel 5-LOX pharmacophores that have the ability to act as competitive inhibitors of the 5-LOX isozyme, or extrude iron from the 5-LOX isozyme, are being investigated. (Isoindoles derivatives)
* The second one is on the total syntheses of novel natural products agents. We are currently focused on the syntheses of luteolin derivatives as anti-helicobacter and anti-inflammatory agents. Moreover our approach is based on structural modification of naturally occurring compounds. In this observe, the use of plants for the treatment and prevention of a wide variety of chronic diseases, including cancer, is a well known subject in traditional medicine practiced by many cultures around the world, and there is significant evidence to support the notion thatpolyphenolsmay be one of the main groups of naturally occurring molecules responsible for the therapeutic activity of these medicinal plants. Unlike clinical drugs, the mechanism of action of polyphenols involves the simultaneous interaction and modulation of multiple cellular mediators involved in the pathogenesis of the disease. We are particularly interested in three naturally occurring polyphenols: luteolin, curcumin and resveratrol. The research carried out in my group involves the chemical modification of these polyphenols to increase their potency, improve their bioavailability, and decrease the rate at which they are metabolized and eliminated from the body.
A third topic is to develop chemical strategies for the synthesis of novel alkaloids isolated from the Iranian medicinal plants. These molecules possess challenging structures and potent biological activity.
A fourth one is about the Iranian medicinal plants, including: 1.isolation, characterization, and structural elucidation of secondary metabolites from medicinal plants. 2.Evaluation of biological and pharmacological activity of fractions and isolated compounds 3.Chemical/biological standardization and quality assessment of herbal drugs and herb-based preparations. 4.Development of analytical techniques for herbal drug analysis (NMR, HPLC, GC-Mass).
Teaching Experience
University of PNU, College of Chemistry, Tutor , 2011- present (Medicinal Chemistry)
University of IAU, College of Pharmacy, Tutor, 2006-2008 (Medicinal Chemistry and Computer Sciences)
Private Institute Farhikhtegan, Tutor, 2003-2006, Chemistry
Professional Memberships
Member of the Medical Council, I.R.IRAN (M.C.NO:14781)
Member of the Iranian Pharmaceutical Association (Reg.NO:12082)
IPHSA ( Iranian Pharmaceutical Student Association )
Iranian Construction Engineers Organization (Membership code: 10-3-0-47679)
Amirkabir University Alumni (Membership code: 2400301)
International Conference
The 25th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology (MSPP) oral presentation
Books
1- Introduction of Advanced Chemistry (2nd Edition)
2- Applied NanoMedicine (In Press)
3- Steel Structures (1st Edition)
Publications
1-Alireza Nematollahi, Noushin Aminimoghadamfarouj, Christophe Wiart
Reviews On 1,4- naphthoquinones from Diospyros L., Journal of Asian Natural Products Research, In press, 2011.
2- Alireza Nematollahi, Noushin Aminimoghadamfarouj, Christophe Wiart, Tracy Bradshaw
In Vitro Cytotoxic Activity of Two Malaysia Rainforest Plants On Colon Carcinoma Cell-line, Asian Journal of Pharmaceutical and Health Sciences,In press, 2011.
3-Alireza Nematollahi, Noushin Aminimoghadamfarouj, Christophe Wiart
Anti-bacterial, Antioxidant activity and Phytochemical study of Diospyros wallichii — an Interesting Malaysia’s endemic species of Ebenaceae, International Journal of PharmTech Research,Vol.3, No.3, pp 1732-1736, 2011.
4- Alireza Nematollahi, Noushin Aminimoghadamfarouj, Christophe Wiart
Design and Modeling Studies on Liriodenine derivatives as novel topoisomerase II inhibitors, International Journal of ChemTech Research,Vol.3, No.3, pp 1622-1627, 2011.
5- Noushin Aminimoghadamfarouj, Alireza Nematollahi, Christophe Wiart
Annonaceae: Bio-resource For Tomorrow’s Drug Discovery, Journal of Asian Natural Products Research, Volume 13, Issue 5, 2011, Pages 465 - 476.
6- Noushin Aminimoghadamfarouj, Alireza Nematollahi, Christophe Wiart
Anti-bacterial, Antioxidant activity and Phytochemical study of Uvaria grandiflora : A rare species of Annonaceae, Journal of Pharmacy Research, (2011) 4( 4): 954-955.
7- Alireza Nematollahi ,Noushin Aminimoghadamfarouj, Mogana Rajagopal, Teng Jin Khoo, Christophe Wiart
The first antibacterial activity report of three selected Malaysian rainforest medicinal plants,GA 59th International Natural Products Conference, Turkey,2011.
8- Maryam Iman, Asghar Davood, Ali Reza Nematollahi, Ahmad Rerza Dehpoor, AbbasShafiee
Design and Synthesis of New 1,4-Dihydropyridines Containing 4(5)-chloro-5(4)-imidazolyl Substituent as a Novel Calcium Channel Blocker, Archives of Pharmacal Research, (March 2011 – In press)
9- Asghar Davood, Maryam Iman, Alireza Nematollahi and Abbas Shafiee
Docking and QSAR studies of new 1,4-dihydropyridines containing 4(5)-chloro-2-methyl-5(4)-imidazolyl substituent, Journal of medicinal chemistry research , (January 2011).
10- Alireza Nematollahi, Asghar Davood
Docking and QSAR studies of novel (E)-3-(4-methanesulfonylphenyl)-2-(aryl) acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases, International Journal of ChemTech Research,Vol.2, No.3, pp 1808-1815, 2010.
11-AsgharDavood, AlirezaNematollahi, MaryamImanand AbbasShafiee
Synthesis and docking studies of new 1,4-Dihydropyridines containing 4-(5)-Chloro-2-ethyl-5-(4)-imidazolyl substituent as novel calcium channel agonist , Archives of Pharmacal Research ,Vol 32, No4, 481-487, 2009.
12- AsgharDavood, AlirezaNematollahi, MaryamImanand AbbasShafiee
Computational studies of new 1, 4-Dihydropyridines containing 4-(5)-Chloro-2-ethyl5-(4)-imidazolyl substituent: QSAR and Docking, Journal of medicinal chemistry research, Volume 19, Number 1 , February 2010, pp. 58-70.
13- Asghar Davood, AlirezaNematollahi, Arash Nabbi
Design and modeling studies on isoindole derivatives as a novel non-classical Anti bacterial agents, The Internet Journal of Medical Informatics.2009 Volume 4 Number 2
14-Arash Nabbi , Alireza Nematollahi
A computational study to predict mechanism of putrescine 1, 4-dicinnamide from Pholiota spumosa and rational design of novel compounds as antiprostate cancer agents,Annals of Oncology 20 ,iii30–iii31,2009
15-Alireza Nematollahi , Arash Nabbi
Design of 1,4-dihydropyridine derivatives for overcoming ABC-mediated transporter multidrug resistance" European Journal of Cancer Supplements, Volume 7, Issue 3, Pages 15-16 ,2009
16- Sara Atayi, Asghar Davood, Alireza Nematollahi , Fatemeh Sarafzadeh Javadi
Docking and QSAR studies of novel (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases,14th seminar of Iranian pharmacy students,2009
17- Elaheh Saf Ara, Asghar Davood , Arezoo Ahmadi , Alireza Nematollahi
Computational studies of new 1,4-Dihydropyridines containing 4-(5)-Chloro-2-methyl5-(4)-imidazolyl substituent: QSAR and Docking, 14th seminar of Iranian pharmacy students,2009
18-Alireza Nematollahi , Asghar Davood
Synthesis and Docking studies of new 1,4 – dihydropyridines containing 4-(5-)chloro-2-methyl-5-(4)-imidazolyl substituent as novel calcium channel agonist, Iranian journal of pharmaceutical science,2008
19-Fatemeh Araghi, Nilofar Bozorgi, Alireza Nematollahi
The computational studies on the mechanism of isoindole derivatives as a novel anti bacterial agents,11th Iranian pharmaceutical sciences conference,2008
20- Shahin Khakpoor , Alireza Nematollahi
Design of 1,4-dihydropyridines for overcoming ABC-mediated transporter multidrug resistance(MDR),13th seminar of Iranian pharmacy students, 2007.