Binding of anti-Trypanosoma natural products from African flora against selected drug targets: a docking study.
Akachukwu Ibezim1 · Biplab Debnath2· Fidele Ntie-Kang3,4* (✉) · Chika John Mbah1· Ngozi Justina Nwodo (✉)1*
*Corresponding authors
✉ Fidele Ntie-Kang
✉Ngozi Justina Nwodo
1Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka, Nigeria
2Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi-835215, India
3Department of Pharmaceutical Chemistry, Martin-Luther University Halle-Wittenberg, Wolfgang Langenbeck-Str. 4, 06120 Halle, Germany
4Department of Chemistry, University of Buea, Buea, Cameroon
SUPPLEMENTARY DATA
Compound code / Compound name / Species name / plant family / plant part / country / cpd class / Reference / PublisherBEN-001 / Boldine / Cassytha filiformis / Lauraceae / leaves / Benin / alkaloids / Quetin-Leclercq et al, 2004.
BEN-002 / Actinodaphnine / Cassytha filiformis / Lauraceae / leaves / Benin / alkaloids / Quetin-Leclercq et al, 2004.
BEN-003 / Cassythine / Cassytha filiformis / Lauraceae / leaves / Benin / alkaloids / Quetin-Leclercq et al, 2004.
BEN-004 / Dicentrine / Cassytha filiformis / Lauraceae / leaves / Benin / alkaloids / Quetin-Leclercq et al, 2004.
BEN-005 / Norneolitsine / Cassytha filiformis / Lauraceae / leaves / Benin / alkaloids / Quetin-Leclercq et al, 2004.
BEN-006 / Neolitsine / Cassytha filiformis / Lauraceae / leaves / Benin / alkaloids / Quetin-Leclercq et al, 2004.
BEN-007 / Cassythidine / Cassytha filiformis / Lauraceae / leaves / Benin / alkaloids / Quetin-Leclercq et al, 2004.
BEN-008 / alpha-amyrin / Strychnos spinosa / Loganiaceae / Leaves / benin / triterpenes / Hoet et al, 2007
BEN-009 / stigmastanol / Strychnos spinosa / Loganiaceae / Leaves / benin / tripene / Hoet et al, 2016
BEN-010 / beta-sitosterol / Strychnos spinosa / Loganiaceae / Leaves / benin / steroids / Hoet et al, 2017
BEN-011 / stigmasterol / Strychnos spinosa / Loganiaceae / Leaves / benin / steroids / Hoet et al, 2018
BEN-012 / clerosterol / Strychnos spinosa / Loganiaceae / Leaves / benin / steroids / Hoet et al, 2019
BEN-013 / saringosterol / Strychnos spinosa / Loganiaceae / Leaves / benin / steroids / Hoet et al, 2020
BEN-014 / 24-hydroperoxy-24-
vinylcholesterol / Strychnos spinosa / Loganiaceae / Leaves / benin / steroids / Hoet et al, 2021
BEN-015 / beta-amyrin / Strychnos spinosa / Loganiaceae / Leaves / benin / triterpenes / Hoet et al, 2008
BEN-016 / lupeol / Strychnos spinosa / Loganiaceae / Leaves / benin / triterpenoid / Hoet et al, 2009
BEN-017 / uvaol / Strychnos spinosa / Loganiaceae / Leaves / benin / triterpenes / Hoet et al, 2010
BEN-018 / erythrodiol / Strychnos spinosa / Loganiaceae / Leaves / benin / triterpenes / Hoet et al, 2011
BEN-019 / betulin / Strychnos spinosa / Loganiaceae / Leaves / benin / triterpenoid / Hoet et al, 2012
BEN-020 / ursolic acid / Strychnos spinosa / Loganiaceae / Leaves / benin / triterpenoid / Hoet et al, 2013
BEN-021 / oleanolic acid / Strychnos spinosa / Loganiaceae / Leaves / benin / triterpenoid / Hoet et al, 2014
BEN-022 / betulinic acid / Strychnos spinosa / Loganiaceae / Leaves / benin / triterpenoid / Hoet et al, 2015
BEN-023 / 15-acetoxy-8beta -[(2-methylbutyryloxy)]-
14-oxo-4,5-cis-acanthospermolide / Acanthospermum
hispidum / Asteraceae / aerial / Benin / sesquiterpenic lactones / Ganfon et al, 2012
BEN-024 / 9alpha-acetoxy-15-hydroxy-8beta-(2-methylbutyryloxy)-14-oxo-
4,5-trans-acanthospermolide / Acanthospermum
hispidum / Asteraceae / aerial / Benin / sesquiterpenic lactones / Ganfon et al, 2013
CIV-025 / 15E-methoxy-labdan-8(17),11(E),13(14)-trien-15,16-olide / Aframomum sceptrum / Zingiberaceae / rhizomes / Ivory
Coast / Labdane diterpenoids / Cheikh-Ali et al, 2011
CIV-026 / 12(S)-hydroxy-15j-methoxy-labdan-8(17),13(14)-dien-
15,16-olide (2) / Aframomum sceptrum / Zingiberaceae / rhizomes / Ivory
Coast / Labdane diterpenoids / Cheikh-Ali et al, 2012
CIV-027 / hosloppin / Hoslundia opposita / Lamiaceae / Leaves / Ivory
Coast / Flavones / Salame et al, 2012
CIV-028 / hoslundin / Hoslundia opposita / Lamiaceae / Leaves / Ivory
Coast / Flavones / Salame et al, 2013
CIV-029 / [4], 5-O-methylhoslundin / Hoslundia opposita / Lamiaceae / Leaves / Ivory
Coast / Flavones / Salame et al, 2014
CIV-030 / oppositin / Hoslundia opposita / Lamiaceae / Leaves / Ivory
Coast / Flavones / Salame et al, 2015
CIV-031 / (E)-6-(5-
ethylidene-4-oxo-4,5-dihydrofuran-3-yl)-5-hydroxy-7-methoxy-
2-phenyl-4H-chromen-4-one. / Hoslundia opposita / Lamiaceae / Leaves / Ivory
Coast / Flavones / Salame et al, 2016
CIV-032 / 5-O-methyl-hoslunfuranine. / Hoslundia opposita / Lamiaceae / Leaves / Ivory
Coast / Flavones / Salame et al, 2017
CMR-33 / ester-15-kolavic
acid / Entada abyssinica / stem bark / Cameroon / triterpenoid / Nyasse et al / Pharmazie 59 (2004) 11
CMR-34 / 14-O-Methyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-35 / 14-O-Benzyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-36 / 13,14-Bis-O-benzyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-37 / 14-O-2-Methoxy-5-nitrobenzyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-38 / 13,14-Bis-O-2-methoxy-5-nitrobenzyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-39 / 14-O-2-Ethyl-1,3-dioxolane-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-40 / 13,14-Bis-O-2-Ethyl-1,3-dioxolane-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-41 / 13-O-Acetyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-42 / 13,14-Bis-O-acetyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-43 / 13,14-Bis-O-butyrate-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-44 / 13,14-Bis-O-pivaloate-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-45 / 13,14-Bis-O-methyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-46 / 13,14-Bis-O-3,3-dimethylacryloylate-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-47 / 14-O-Methoxymethyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-48 / 13,14-Bis-O-methoxymethyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-49 / lapachol / Markhamia tomentosa / Bignoniaceae / stem bark / Cameroon / alkaloid quinone / TANTANGMO et al / Annals of Tropical Medicine & Parasitology, Vol. 104, No. 5, 391–398 (2010)
CMR-50 / sterokunthal A. / Markhamia tomentosa / Bignoniaceae / stem bark / Cameroon / alkaloid quinone / TANTANGMO et al / Annals of Tropical Medicine & Parasitology, Vol. 104, No. 5, 391–398 (2010)
CMR-51 / 14-O-Ethyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-52 / 14-O-Propyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-53 / 14-O-Allyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-54 / 14-O-Propargyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-55 / 14-O-Isopropyl-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-56 / guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / flavonoid / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-57 / Palmatine / Enantia chlorantha / Annonaceae / stem bark / Cameroon / alkaloid / Nkwengoua et al / Natural Product Research
Vol. 23, No. 12, 15 August 2009, 1144–1150.
CMR-58 / 8-Hydroxypalmatine / Enantia chlorantha / Annonaceae / stem bark / Cameroon / alkaloid / Nkwengoua et al / Natural Product Research
Vol. 23, No. 12, 15 August 2009, 1144–1150.
CMR-59 / 8-Cyanopalmatine / Enantia chlorantha / Annonaceae / stem bark / Cameroon / alkaloid / Nkwengoua et al / Natural Product Research
Vol. 23, No. 12, 15 August 2009, 1144–1150.
CMR-60 / benzoic acid / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / carboxylic / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-61 / caffeic acid / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / phenolic / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-62 / nonacosanoic acid, 2-(4-hydroxyphenyl)ethyl ester / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / ester / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-63 / beta-sitosterol / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / steroids / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-64 / kigelinol / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / naphthoquinone / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-65 / oleanolic acid / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-66 / beta-friedelinol / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-67 / pomolic acid / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-68 / kojic acid / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-69 / 1-naphthaleneacetic acid, 5-carboxy-
1,2,3,4,4a,7,8,8a-octahydro-1,2,4a-trimethyl-[1S-(1alpha ,2beta ,4abeta,8aalpha )] / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-70 / betulinic acid / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-71 / lupeol / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-72 / ursolic acid / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-73 / lapachol / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-74 / dehydro-alpha-apachone / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-75 / 2- acetylfuro-1, 4-naphthoquinone / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-76 / p-coumaric acid / Jacaranda mimosifolia / Bignoniaceae / stem barks / Cameroon / Sidjui et al / Rec. Nat. Prod. 8:3 (2014) 307-311.
CMR-77 / ent-kaur-16-en-19-oic acid / Xylopia
aethiopica / Annonaceae / Fruits / Cameroon / SOH et al / Journal of Applied Pharmaceutical Science Vol. 3 (12), pp. 013-019, December, 2013.
CMR-78 / 15-oxo-ent-kaur-16-
en-19-oic acid / Xylopia
aethiopica / Annonaceae / Fruits / Cameroon / SOH et al / Journal of Applied Pharmaceutical Science Vol. 3 (12), pp. 013-019, December, 2013.
CMR-79 / 15α-acetoxy-ent-kaur-16-en-19-oic acid / Xylopia
aethiopica / Annonaceae / Fruits / Cameroon / SOH et al / Journal of Applied Pharmaceutical Science Vol. 3 (12), pp. 013-019, December, 2013.
CMR-80 / xylopioxyde or 16,17β-epoxy-
15-oxo-ent-kauran-19-oic acid / Xylopia
aethiopica / Annonaceae / Fruits / Cameroon / SOH et al / Journal of Applied Pharmaceutical Science Vol. 3 (12), pp. 013-019, December, 2013.
CMR-81 / 15α-Hydroxy-ent-kaur-16-en-19-oic acid / Xylopia
aethiopica / Annonaceae / Fruits / Cameroon / SOH et al / Journal of Applied Pharmaceutical Science Vol. 3 (12), pp. 013-019, December, 2013.
CMR-82 / 15α-acetoxy-16,17β-epoxy-entkauran-
19-oic acid / Xylopia
aethiopica / Annonaceae / Fruits / Cameroon / SOH et al / Journal of Applied Pharmaceutical Science Vol. 3 (12), pp. 013-019, December, 2013.
CMR-83 / 15α-acetoxy-16,17α-
epoxy-ent-kauran-19-oic acid. / Xylopia
aethiopica / Annonaceae / Fruits / Cameroon / SOH et al / Journal of Applied Pharmaceutical Science Vol. 3 (12), pp. 013-019, December, 2013.
CMR-84 / 3,16-oxy-guttiferone A / Symphonia
globulifera / Clusiaceae / root / Cameroon / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-85 / 2-acetylnaphtho[2,3-b]
furan-4,9-dione / Markhamia tomentosa / Bignoniaceae / stem bark / Cameroon / TANTANGMO et al / Annals of Tropical Medicine & Parasitology, Vol. 104, No. 5, 391–398 (2010)
CMR-86 / 2-acetyl-6-methoxynaphtho[
2,3-b]furan-4,9-dione / Markhamia tomentosa / Bignoniaceae / stem bark / Cameroon / TANTANGMO et al / Annals of Tropical Medicine & Parasitology, Vol. 104, No. 5, 391–398 (2010)
CMR-87 / oleanolic
acid / Markhamia tomentosa / Bignoniaceae / stem bark / Cameroon / TANTANGMO et al / Annals of Tropical Medicine & Parasitology, Vol. 104, No. 5, 391–398 (2010)
CMR-88 / pomolic acid / Markhamia tomentosa / Bignoniaceae / stem bark / Cameroon / TANTANGMO et al / Annals of Tropical Medicine & Parasitology, Vol. 104, No. 5, 391–398 (2010)
CMR-89 / 3-acetylpomolic
acid / Markhamia tomentosa / Bignoniaceae / stem bark / Cameroon / TANTANGMO et al / Annals of Tropical Medicine & Parasitology, Vol. 104, No. 5, 391–398 (2010)
CMR-90 / tormentic acid / Markhamia tomentosa / Bignoniaceae / stem bark / Cameroon / TANTANGMO et al / Annals of Tropical Medicine & Parasitology, Vol. 104, No. 5, 391–398 (2010)
CMR-91 / vernoguinosterol / Vernonia guineensis / Asteraceae / stem bark / Cameroon / Tchinda et al / Phytochemistry 59 (2002) 371–374.
CMR-92 / Diacetylvernoguinosterol / Vernonia guineensis / Asteraceae / stem bark / Cameroon / Tchinda et al / Phytochemistry 59 (2002) 371–374.
CMR-93 / vernoguinoside / Vernonia guineensis / Asteraceae / stem bark / Cameroon / Tchinda et al / Phytochemistry 59 (2002) 371–374.
CMR-94 / letestuianin A / Aframomum letestuianum / Zingiberaceae / seed / Cameroon / Kamnaing et al / J. Nat. Prod. 2003, 66, 364-367.
CMR-95 / letestuianin B / Aframomum letestuianum / Zingiberaceae / seed / Cameroon / Kamnaing et al / J. Nat. Prod. 2003, 66, 364-367.
CMR-96 / etestuianin C / Aframomum letestuianum / Zingiberaceae / seed / Cameroon / Kamnaing et al / J. Nat. Prod. 2003, 66, 364-367.
CMR-97 / 5-acetoxy-
1,7-bis(4-acetoxyphenyl)hepta-4-en-3-one / Aframomum letestuianum / Zingiberaceae / seed / Cameroon / Kamnaing et al / J. Nat. Prod. 2003, 66, 364-367.
CMR-98 / (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one / Aframomum letestuianum / Zingiberaceae / seed / Cameroon / Kamnaing et al / J. Nat. Prod. 2003, 66, 364-371
CMR-99 / sitosterol / Piptostigma preussi / Annonaceae / stem bark / Cameroon / Ngantchou et al / Fitoterapia 80 (2009) 188–191.
CMR-100 / lanosta-
7,9(11),24-trien-3β,15α-diol (polycarpol) / Piptostigma preussi / Annonaceae / stem bark / Cameroon / Ngantchou et al / Fitoterapia 80 (2009) 188–191.
CMR-101 / Aulacocarpin C / Aframomum aulacocarpos / Zingiberaceae / seed / Cameroon / S. V. T. Sob et al. / Tetrahedron 63 (2007) 8993–8998.
CMR-102 / 8b(17)-epoxy-14,15,16-triacetoxylabd-
12(E)-ene / Aframomum aulacocarpos / Zingiberaceae / seed / Cameroon / S. V. T. Sob et al. / Tetrahedron 63 (2007) 8993–8998.
CMR-103 / Aulacocarpin D / Aframomum aulacocarpos / Zingiberaceae / seed / Cameroon / S. V. T. Sob et al. / Tetrahedron 63 (2007) 8993–8998.
CMR-104 / 17-hydroxy-14,15,16-triacetoxylabda-
8(E),12(Z)-diene. / Aframomum aulacocarpos / Zingiberaceae / seed / Cameroon / S. V. T. Sob et al. / Tetrahedron 63 (2007) 8993–8998.
CMR-105 / 17-hydroxy-14,15,16-triacetoxylabda-
7(E),12(Z)-diene / Aframomum aulacocarpos / Zingiberaceae / seed / Cameroon / S. V. T. Sob et al. / Tetrahedron 63 (2007) 8993–8998.
CMR-106 / 15,16-epoxy-12b-methoxylabda-
8(17)-13(16),14-triene / Aframomum aulacocarpos / Zingiberaceae / seed / Cameroon / S. V. T. Sob et al. / Tetrahedron 63 (2007) 8993–8998.
CMR-107 / 15,16-epoxy-12a-hydroxylabda-
8(17)-13(16),14-triene / Aframomum aulacocarpos / Zingiberaceae / seed / Cameroon / S. V. T. Sob et al. / Tetrahedron 63 (2007) 8993–8998.
CMR-108 / 15,16-epoxy-12b-hydroxylabda-8(17)-13(16),14-triene / Aframomum aulacocarpos / Zingiberaceae / seed / Cameroon / S. V. T. Sob et al. / Tetrahedron 63 (2007) 8993–8998.
CMR-109 / catechol / Symphonia
globulifera / Clusiaceae / root / Cameroon / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-110 / guttiferone E / Symphonia
globulifera / Clusiaceae / root / Cameroon / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
CMR-111 / xanthochymol / Symphonia
globulifera / Clusiaceae / root / Cameroon / Fromentin et al / European Journal of Medicinal Chemistry 65 (2013) 284-294.
DRC-112 / ancistrolikokines A / Ancistrocladus likoko / Ancistrocladaceae / root / Congo / Bringmann et al / Phytochemistry 62 (2003) 631–636.
DRC-113 / ancistrolikokines B / Ancistrocladus likoko / Ancistrocladaceae / root / Congo / Bringmann et al / Phytochemistry 62 (2003) 631–636.
DRC-114 / ancistrolikokines C / Ancistrocladus likoko / Ancistrocladaceae / root / Congo / Bringmann et al / Phytochemistry 62 (2003) 631–636.
DRC-115 / korupensamine A / Ancistrocladus likoko / Ancistrocladaceae / root / Congo / Bringmann et al / Phytochemistry 62 (2003) 631–636.
DRC-116 / ancistrolikokine D / Ancistrocladus likoko / Ancistrocladaceae / root / Congo / Bringmann et al / Phytochemistry 62 (2003) 631–636.
DRC-117 / ancistroealaine A / Ancistrocladus likoko / Ancistrocladaceae / root / Congo / Bringmann et al / Phytochemistry 62 (2003) 631–636.
DRC-118 / ancistronaphthoic
acid B / Ancistrocladus likoko / Ancistrocladaceae / root / Congo / Bringmann et al / Phytochemistry 62 (2003) 631–636.
DRC-119 / cis-isoshinanolone / Ancistrocladus likoko / Ancistrocladaceae / root / Congo / Bringmann et al / Phytochemistry 62 (2003) 631–636.
ETH-120 / 4(13),7-coloratadiene-12,11-olide / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-121 / 7α-hydroxy-8-
drimen-11,12-olide / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-122 / 7β-hydroxy-4(13),7-coloratadiene-
11,12-olide / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-123 / ugandensolide / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-124 / muzigadiolide / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-125 / 11α-hydroxymuzigadiolide / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-126 / muzigadial / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-127 / 6α,9α-dihydroxy-4(13),7-coloratadiene-
11,12-dial / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-128 / cinnamolide / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-129 / cinnamolide-3β-acetate / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-130 / mukaadial / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-131 / ugandensidial / Warburgia ugandensis / Canellaceae / stem bark / Ethiopia / A. A. WUBE ET AL. / Phytother. Res. 24: 1468–1472 (2010)
ETH-132 / arjunglucoside / Combretum molle / Combretaceae / Stem Bark / Ethiopia / Saponin / Asres et al / Phytother. Res. 15, 613–617 (2001)
ETH-133 / Punicalagin / Combretum molle / Combretaceae / Stem Bark / Ethiopia / Tannins / Asres et al / Phytother. Res. 15, 613–617 (2001)
ETH-134 / sericoside / Combretum molle / Combretaceae / Stem Bark / Ethiopia / Saponin / Asres et al / Phytother. Res. 15, 613–617 (2001)
GAB-135 / benzyl benzoate / Uvaria klaineana / Annonaceae / stem / Gabon / Akendengue et al / Phytochemistry 59 (2002) 885–888
GAB-136 / Klaivanolide / Uvaria klaineana / Annonaceae / stem / Gabon / Akendengue et al / Phytochemistry 59 (2002) 885–888
GAB-137 / dioncophyllines A / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GAB-138 / dioncophyllines B / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GAB-139 / dioncophyllines C / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GAB-140 / 5'-O-demethyldioncophylline A / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GAB-141 / ancistrocladidine / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GAB-142 / ancistrotectorine / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GAB-143 / N-methyldioncophylline
A and its 7-epimer [(P)-5 and (M)-5] / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GAB-144 / (M)-dioncophylline E / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GAB-145 / N-methyldioncophylline
A and its 7-epimer [(P)-5 and (M)-5] / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GAB-146 / (P)-dioncophylline E / Dioncophyllum thollonii / Dioncophyllaceae / root / Gabon / Bringmann et al / Phytochemistry 60 (2002) 389–397.
GHA-147 / ancistrocladine / Ancistrocladus heyneanus / Ancistrocladaceae / leaves / Ghana / alkaloid / Bringmann et al / Phytochemistry 65 (2004) 2903–2907.
GHA-148 / ancistrocladisine / Ancistrocladus heyneanus / Ancistrocladaceae / leaves / Ghana / alkaloid / Bringmann et al / Phytochemistry 65 (2004) 2903–2907.
GHA-149 / ancistrocladidine / Ancistrocladus heyneanus / Ancistrocladaceae / leaves / Ghana / alkaloid / Bringmann et al / Phytochemistry 65 (2004) 2903–2907.
GHA-150 / ancistroheynine
A / Ancistrocladus heyneanus / Ancistrocladaceae / leaves / Ghana / alkaloid / Bringmann et al / Phytochemistry 65 (2004) 2903–2907.
GHA-151 / ancisheynine / Ancistrocladus heyneanus / Ancistrocladaceae / leaves / Ghana / alkaloid / Bringmann et al / Phytochemistry 65 (2004) 2903–2907.
GHA-152 / ancistrotanzanine C / Ancistrocladus heyneanus / Ancistrocladaceae / leaves / Ghana / alkaloid / Bringmann et al / Phytochemistry 65 (2004) 2903–2907.
GHA-153 / ancistroheynine B / Ancistrocladus heyneanus / Ancistrocladaceae / leaves / Ghana / alkaloid / Bringmann et al / Phytochemistry 65 (2004) 2903–2907.
NIG-154 / 3-hydroxyflavone / Tridax procumbens / Asteraceae / whole plant / Nigeria / Flavonoid / Abubakar et al / Int. J. Med. Arom. Plants. 2012, 2(1), 185-194.
NIG-155 / quercetin / Tridax procumbens / Asteraceae / whole plant / Nigeria / Flavonoid / Abubakar et al / Int. J. Med. Arom. Plants. 2012, 2(1), 185-194.
NIG-156 / 7,8-dihydroxyflavone / Tridax procumbens / Asteraceae / whole plant / Nigeria / Flavonoid / Abubakar et al / Int. J. Med. Arom. Plants. 2012, 2(1), 185-194.
NIG-157 / catechin / Tridax procumbens / Asteraceae / whole plant / Nigeria / Flavonoid / Abubakar et al / Int. J. Med. Arom. Plants. 2012, 2(1), 185-194.
NIG-158 / 3,4-dihydro-2-(3,4-dihydroxyphenyl)-
2H-chromene-3,5,7-triol / Spondias mombim / Anacardiaceae / root / Nigeria / Igoli et al / John O. Igoli, Alexander I. Gray, Carol J. Clements and Hazar A. Mouad (2011). Anti-Trypanosomal Activity
and Cytotoxicity of Some Compounds and Extracts from Nigerian Medicinal Plants, Phytochemicals -
Bioactivities and Impact on Health, Prof. Iraj Rasooli (Ed.), ISBN: 978-953-307-424-5, InTech, Available from:
and-cytotoxicity-of-some-compounds-and-extracts-from-nigerian-medicinal-p
NIG-159 / 7α-
acetyl-15β-methoxy-29 methylene 7,15-deoxo nimbolide / Azadirachta indica / Meliaceae / leaves / Nigeria / terpenoids / Githua et al / Afr. J. Trad. CAM (2010) 7 (3): 207 - 213.
NIG-160 / 2-oxo-3-deacetyl salannin / Azadirachta indica / Meliaceae / leaves / Nigeria / terpenoids / Githua et al / Afr. J. Trad. CAM (2010) 7 (3): 207 - 213.
NIG-161 / 7α-hydroxy-15β-hydroxy-7,15-deoxo nimbin / Azadirachta indica / Meliaceae / leaves / Nigeria / terpenoids / Githua et al / Afr. J. Trad. CAM (2010) 7 (3): 207 - 213.
NIG-162 / nimbolide / Azadirachta indica / Meliaceae / leaves / Nigeria / terpenoids / Githua et al / Afr. J. Trad. CAM (2010) 7 (3): 207 - 213.
NIG-163 / 4-epi-hederagenin / Crateva adansonii / Capparaceae / leaves / Nigeria / Igoli et al / Indo Global Journal of Pharmaceutical Sciences, 2012; 2(3): 226-229
NIG-164 / Methyl 1,2,3,4,4a,5,11,12b,13,14,14a,14b-dodecahydro-3,10-dihydroxy-
2,4a,6,12b,14a-pentamethyl-11-oxopicene-2-carboxylate / Maytenus laevis / Celastraceae / root / Nigeria / Igoli et al / John O. Igoli, Alexander I. Gray, Carol J. Clements and Hazar A. Mouad (2011). Anti-Trypanosomal Activity
and Cytotoxicity of Some Compounds and Extracts from Nigerian Medicinal Plants, Phytochemicals -
Bioactivities and Impact on Health, Prof. Iraj Rasooli (Ed.), ISBN: 978-953-307-424-5, InTech, Available from:
and-cytotoxicity-of-some-compounds-and-extracts-from-nigerian-medicinal-p
NIG-165 / Methyl 1,2,3,4,4a,5,11,12b,13,14,14a,14b-dodecahydro-3,10-dihydroxy-
2,4a,6,12b,14a-pentamethyl-4,11-dioxopicene-2-carboxylate / Maytenus laevis / Celastraceae / root / Nigeria / Igoli et al / John O. Igoli, Alexander I. Gray, Carol J. Clements and Hazar A. Mouad (2011). Anti-Trypanosomal Activity
and Cytotoxicity of Some Compounds and Extracts from Nigerian Medicinal Plants, Phytochemicals -
Bioactivities and Impact on Health, Prof. Iraj Rasooli (Ed.), ISBN: 978-953-307-424-5, InTech, Available from:
and-cytotoxicity-of-some-compounds-and-extracts-from-nigerian-medicinal-p
NIG-166 / compound13 / Terminalia avicennioides / Combretaceae / Nigeria / Atawodi et al / African Journal of Biotechnology Vol. 4 (2), pp. 177-182, February 2005.
NIG-167 / 2,3,4,4a,5,6,6a,7,7a,8,9,10,10a,11,11a,12,13,13aoctadecahydro-