DRUGNAME / DOSAGE AND
ROUTE / ACTION / INDICATION / ADVERSE EFFECTS / CONTRAINDICATION / NURSING
RESPONSIBILITY
Ibuprofen
  • Advil, Apo-Ibuprofen, Motrin, Excedrin IB, Genpril, Haltran, Ibu-tab, Medipren, Menadol, Midol IB, Motrin, Rufen, Trendar.
/ Rheumatoid arthritis, osteoarthritis, arthritis
  • Adult: 300 to 800 mg P.O. t.i.d. or q.i.d. Maximum daily dose is 3.2 g.
Mild to moderate pain, dysmenorrheal
  • Adult: 400 mg P.O. q 4 to 6 hours, p.r.n.
Fever
  • Adults: 200 to 400 mg. P.O. q 4 to 6 hours, for no longer than 3 days. Maximum daily dose is1.2 g.
  • Children ages 6 months to 12 years; If child’s temperature is below 102.5º F (39.2 ºC), give 5 mg/kg P.O. q 6 to 8 hours. Treat higher temperatures with 10mg/kg q to 6 hours. Maximum daily dose in 40mg/kg.
Juvenile arthritis
  • Children: 30 to 40 mg/kg daily P.O. in three or four divided doses. Maximum daily dose is 50 mg/kg.
/ Unknown. May inhibit prostaglandin synthesis, to produce anti-inflammatory, analgesic, and antipyretic effects. / Ibuprofen contains the active ingredient ibuprofen, which belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs).
It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause pain, swelling and inflammation. Ibuprofen is therefore used to relieve pain and inflammation.
All the medicines in this group (NSAIDs) reduce inflammation caused by the body's own immune system, and are effective pain killers. Ibuprofen can be used to relieve pain such as muscular aches and pains, period pains, headache, backache, rheumatic pain, dental pain and neuralgia. It can also reduce feverishness and the symptoms of colds and flu. / CNS
  • Headache, dizziness, nervousness, aseptic meningitis.
CV
  • Peripheral edema, fluid retention, edema.
EENT
  • Tinnitus
GI
  • Epigastric distress, nausea, occult blood loss, peptic ulceration, diarrhea, constipation, abdominal pain, bloating, GI fullness, dyspepsia, flatulence, heartburn, decreased appetite.
GU
  • Acute renal failure, azotemia, cystitis, hematuria.
HEMATOLOGIC
  • Plonged bleeding time, anemia, neutropenia, pancytopenia, thrombocytopenia, aplastic anemia, leucopenia, agranulocystocis.
METABOLIC
  • Hypoglycemia, hyperkalemia.
RESPIRATORY:
  • Bronchospasm
SKIN
  • Pruritus, rash, urticaria, stevens Johnson syndrome.
/
  • Contraindicated in patients hypersensitive to drug and in those with angioedema, syndrome of nasal polyps, or bronchospastic reaction to aspirin or other NSAIDs.
  • Contraindicated in pregnant women.
  • Use cautiously in patients with GI disorders, history of peptic ulcer disease, cardiac decompensation, hypertension, asthma, or intrinsic coagulation defects.
/
  • Tell patient to take with meals or milk to reduce adverse GI reactions.
  • Note: Drug is available at OTC. Instruct patient not to exceed 1.2 g daily, not to give to chidren younger than age 12, and not to take for extended periods ( longer than 3 days for fever or longer than 10 days for pain) without consulting presciber.
  • Tell patient that full therapeutic effect for arthritis may be delayed for 2 to 4 weeks. Although pain relief occurs at low dosage levels, inflammation doesn’t improve at dosages less than 400 mg q.i.d.
  • Teach patient to watch for and report to prescriber immediately signs and symptoms of GI bleeding, including blood in vomit, urine, or stool or coffee ground vomit, and black, tarry stool.
  • Warn patient to avoid hazardous activities that require mental alertness until effects on CNS are known.
  • Advise patient to wear sunscreen to avoid hypersensitivity to sunlight.

M /I