Olga Kotova

Address: Adelgatan 6, 22350 Lund, Sweden

Tel.: +46 -73-721 43 49 (mob)

E-mail:

CURRICULUM VITAE

Personal information:

Date of birth:July 3, 1970

Place of birth:Moscow, Russia

Citizenship:Russian

Education and experience in biology:

1987-1992Moscow State University, Biology Department, Moscow, Russia

Master of Science in Biology, Biochemistry

Diploma thesis “Investigation of the interaction of monoclonal anti-idiotypic antibodies to GMDP (N-acetylglucosaminyl-(β1-4)-N-acetylmuramoylalanyl-D-isoglutamine) with WEHI-3 cell line”

1992-1993Shemyakin Institute of Bioorganic Chemistry of RussianAcademy of Science, Immunochemistry Laboratory, Moscow, Russia

Research assistant

1998-1999Russian Institute of Scientific/Technical Information, Biology Section, Moscow, Russia

Translator of literature in Endocrinology field (English-Russian)

Jan, 2000-

Apr, 2002Karolinska Institute, Department of Molecular Medicine, Rolf Luft Center for Diabetes Research, Stockholm, Sweden

PhD Student

Project: “Mechanisms of development of diabetes mellitus in BB rat, the animal model of type 1 diabetes”.

Oct, 2002 – Nov, 2006

Karolinska Institute, Section of Integrative Physiology, Department of Medical Sciences and Surgery, Stockholm, Sweden

PhD Student

Project: “Signaling to and from the sodium pump: effects of insulin and cardiotonic steroids”.

Nov 10, 2006 – Doctorate thesis defence.

Summer 2003 – 2006

Working with summer students Viking Heter, Sara Talia, Catherine Hook,

Victoria Fröjd, Angelique Axen, Heidi Kuoppamaa

May 2005 Student practice (PRAO) with Shan Jolin

Jan 2007 – Post-doctorate fellow, LundUniversity, Molecular metabolism,

Dr. Hindrik Mulder’s group

Special interests: studying languages, music (especially classic, and I myself play violin), nature

Publications, abstracts, posters

  1. T.Yu. Mareeva, O.V. Kotova, E.A. Makarov, T.M. Andronova, V.A.Nesmeyanov. Preparation and characterization of monoclonal antibodies to N- acetylglucosaminyl- (β1-4)-N-acetylmuramyl-L-alanyl-D-isoglutamine. Russian Journal of Bioorganic Chemistry, vol.19, #5, May 1993, pp.291-296).
  2. T.Yu. Mareeva, O.V. Kotova, T.N. Golovina, V.A. Nesmeyanov. Production and characterization of monoclonal anti-idiotypic antibodies to muramylpeptide. FEBS Letters 356:13-16, 1994.
  3. Symposium: Structure and functions of regulatory polypeptides. Shemyakin Institute of Bioorganic Chemistry, Moscow, Russia, June, 1992. Abstract. Interaction of anti-idiotypic antibodies with muramyl peptide-binding sites. T. Yu. Mareeva, O. V. Kotova, I. S. Litvinov, V. A. Nesmeyanov.
  4. Novo Nordisk Foundation Consortium conference “Angiogenesis and Vascular Biology, Role in Diabetic Complications”, Helsinki, Finland, May, 2001. Poster: Changes in intracellular Ca 2+ concentration and insulin secretion in pancreatic islets of pre-diabetic BB rats. Olga Kotova et al.
  5. FASEB meeting, 2003. Poster: The effect of ouabain on glucose uptake and insulin-

dependent intracellular signaling in isolated rat soleus muscle. Chibalin A, Kotova O,

Galuska D, Holman GD* and Zierath JR.

  1. Lubna Al-Khalili*, Olga Kotova*, Hiroki Tsuchida, Ingrid Ehrén, Eric Féraille, Anna Krook, and Alexander V. Chibalin. ERK 1/2 mediates insulin stimulation of Na,K-ATPase by phosphorylation of the -subunit in human skeletal muscle cells. J. Biol. Chem. 279(24): 25211-25218, 2004. * These authors contributed equally to this study.

7.Zhihui Zhong, Olga Kotova, Alexandra Davidescu, Ingrid Ehrén, Karin Ekberg, John Wahren, and Alexander Chibalin. C-peptide stimulates Na+,K+-ATPase via activation of ERK1/2 MAP kinases in human renal tubular cells. Cell. and Mol. Life Sci. 61 (2004), 2782-2790.

  1. Bustamante M, Hasler U, Kotova O, Chibalin AV, Mordasini D, Rousselot M, Vandewalle A, Martin PY, Feraille E.Insulin potentiates AVP-induced AQP2 expression in cultured renal collecting duct principal cells.Am J Physiol Renal Physiol. 2005 Feb;288(2):F334-44.
  2. Kotova O, Al-Khalili L, Talia S, Hooke C, Fedorova OV, Bagrov AY, Chibalin AV. Cardiotonic steroids stimulate glycogen synthesis in human skeletal muscle cells via a Src- and ERK1/2-dependent mechanism.J Biol Chem. 281 (29): 20085-20094, July 21, 2006

10. Olga Kotova , Dana Galuska, Birgitta Essen-Gustavsson, and Alexander V. Chibalin.

Metabolic and signaling events mediated by cardiotonic steroid ouabain in rat

skeletal muscle. Cell. Mol. Biology. In press.

11.IXth international symposium on insulin receptors and insulin action. Nice, France, October 14-17, 2004.

Posters: 1) Cardiac glycoside ouabain stimulates glycogen synthesis in skeletal muscle additively to insulin. Kotova O, Talia S, Galuska D, and Chibalin AV.

2) Changes in expression and insulin-induced trafficking of Na+,K+-ATPase in rat skeletal muscle: effects of high-fat diet. Galuska D, Kotova O, Gospic K, Chibalina D, Krook A, and Chibalin AV.

12.An opening symposium for an international interest group on ”Potassium and the function of heart and skeletal muscle”. Sandbjerg Estate, Denmark, June 5 – 8, 2005. Poster: Ouabain stimulates glycogen synthesis in rat soleus muscle and human skeletal muscle cells via ERK 1/2 and c-Src-dependent mechanisms. Olga Kotova, Dana Galuska, Sara Talia, Catherine Hook, and Alexander V. Chibalin.