Supplemental Table 1: Smoking history among controls and lung cancer cases by lung cancer histology, Bay Area Lung Cancer Study 1998-2003 and Northern California Lung Study 2005-2008
Histology / All / Ever Smoker / Never Smokera / Unk/MissingN (%b) / n / % / n / % / n / %
Adenocarcinoma / 2146 (35.6) / 1631 / 76.0 / 411 / 19.2 / 104 / 4.8
Adenocarcinoma in situ (formerly BAC) / 338 (5.6) / 225 / 66.6 / 95 / 28.1 / 18 / 5.3
Carcinoma, NOS / 492 (8.2) / 405 / 82.3 / 51 / 10.4 / 36 / 7.3
Carcinoid Tumor / 16 (0.3) / 9 / 56.3 / 6 / 37.5 / 1 / 6.3
Large Cell Carcinoma / 214 (3.5) / 187 / 87.4 / 16 / 7.5 / 11 / 5.1
Mixed Carcinoma / 123 (2.0) / 98 / 79.7 / 18 / 14.6 / 7 / 5.7
Non-small Cell Carcinoma / 818 (13.6) / 682 / 83.4 / 114 / 13.9 / 22 / 2.7
Small Cell Carcinoma / 675 (11.2) / 622 / 92.1 / 22 / 3.3 / 31 / 4.6
Squamous Carcinoma / 1121 (18.6) / 1013 / 90.4 / 55 / 4.9 / 53 / 4.7
Other Carcinoma / 89 (1.5) / 58 / 65.2 / 26 / 29.2 / 5 / 5.6
Controls (n=2073) / --- / 983 / 47.4 / 1071 / 51.7 / 19 / 0.9
TOTAL / 5913 / 1885 / 307
Among Ever Smokers (N=5913)
Current Smoker / Former Smoker
n / % / n / %
Adenocarcinoma / 637 / 29.7 / 994 / 46.3
Adenocarcinoma in situ (formerly BAC) / 50 / 14.8 / 175 / 51.8
Carcinoma, NOS / 155 / 31.5 / 250 / 50.8
Carcinoid Tumor / 2 / 12.5 / 7 / 43.8
Large Cell Carcinoma / 86 / 40.2 / 101 / 47.2
Mixed Carcinoma / 36 / 29.3 / 62 / 50.4
Non-small Cell Carcinoma / 280 / 34.2 / 402 / 49.1
Small Cell Carcinoma / 329 / 48.7 / 293 / 43.4
Squamous Carcinoma / 441 / 39.3 / 572 / 51.0
Other Carcinoma / 14 / 15.7 / 44 / 49.4
Controls (n=983) / 178 / 8.6 / 805 / 38.8
TOTAL / 2208 / 3705
Abbreviations: BAC, bronchioloalveolar carcinoma
a includes 'never smoked', smoked, but not cigarettes, smoked but didn’t smoke 20+ cigarettes in lifetime
b percent of total cases
Supplemental Table 2: Years and pack-years of smoking among all cases and controls and those who were ever smokers; Bay Area Lung Cancer Study 1998-2003 and Northern California Lung Study 2005-2008
Group / Histology / Years Smoked / Pack-yearsN / Mean / Std err / Median / N / Mean / Std err / Median
All participants / Adenocarcinoma / 2001 / 28.92 / 0.43 / 32.00 / 1952 / 33.58 / 0.73 / 30.00
Adenocarcinoma in situ (formerly BAC) / 319 / 21.77 / 1.05 / 22.00 / 312 / 22.65 / 1.50 / 14.00
Carcinoma, NOS / 440 / 35.62 / 0.92 / 40.00 / 426 / 45.33 / 1.90 / 40.00
Carcinoid Tumor / 15 / 15.07 / 4.29 / 10.00 / 14 / 19.25 / 7.80 / 1.98
Large Cell Carcinoma / 198 / 37.77 / 1.22 / 39.00 / 193 / 51.88 / 2.61 / 48.75
Mixed Carcinoma / 113 / 31.66 / 1.77 / 38.00 / 110 / 41.45 / 3.32 / 40.00
Non-small Cell Carcinoma / 775 / 33.85 / 0.68 / 38.00 / 751 / 40.32 / 1.26 / 35.00
Small Cell Carcinoma / 630 / 40.31 / 0.59 / 40.00 / 615 / 51.21 / 1.35 / 45.00
Squamous Carcinoma / 1048 / 40.17 / 0.48 / 42.00 / 1025 / 51.14 / 1.08 / 46.50
Other CA / 80 / 23.11 / 2.31 / 24.00 / 77 / 26.05 / 3.54 / 15.00
All Cases / 5619 / 33.34 / 0.25 / 37.00 / 5475 / 40.72 / 0.47 / 37.50
Controls (n=2073) / 2046 / 11.95 / 0.36 / 0.00 / 1999 / 10.57 / 0.43 / 0.00
Ever Smokers Only / Adenocarcinoma / 1590 / 36.40 / 0.36 / 38.00 / 1541 / 42.53 / 0.78 / 39.00
Adenocarcinoma in situ (formerly BAC) / 224 / 31.01 / 0.97 / 33.00 / 217 / 32.56 / 1.78 / 30.00
Carcinoma, NOS / 389 / 40.28 / 0.77 / 40.00 / 375 / 51.50 / 1.96 / 46.00
Carcinoid Tumor / 9 / 25.11 / 4.69 / 21.00 / 8 / 33.68 / 11.33 / 34.75
Large Cell Carcinoma / 182 / 41.09 / 1.01 / 41.50 / 177 / 56.57 / 2.57 / 51.00
Mixed Carcinoma / 95 / 37.66 / 1.43 / 40.00 / 92 / 49.56 / 3.35 / 44.00
Non-small Cell Carcinoma / 661 / 39.68 / 0.53 / 40.00 / 637 / 47.54 / 1.29 / 41.00
Small Cell Carcinoma / 608 / 41.77 / 0.53 / 41.00 / 593 / 53.11 / 1.34 / 48.00
Squamous Carcinoma / 993 / 42.40 / 0.40 / 43.00 / 970 / 54.04 / 1.07 / 49.00
Other CA / 54 / 34.23 / 2.14 / 37.00 / 51 / 39.32 / 4.29 / 35.00
All Cases / 4805 / 38.99 / 0.20 / 40.00 / 4661 / 47.84 / 0.48 / 42.00
Controls (n=2073) / 975 / 25.08 / 0.47 / 24.00 / 928 / 22.78 / 0.75 / 16.10
BAC, bronchioloalveolar carcinoma
Supplemental Table 3. Second-handtobacco smoke (SHS) exposure among case and controlparticipants; Bay Area Lung Cancer Study 1998-2003 and Northern California Lung Study 2005-2008
Histology / All / No ETS exposure / Workplace only / Household only / Work and household / UnknownN / N-SHS unk / n / % / %-SHS unk / n / % / %-SHS unk / n / % / %-SHS unk / n / % / %-SHS unk / n / %
Adenocarcinoma / 2146 / 1705 / 137 / 6.4 / 8.0 / 202 / 9.4 / 11.8 / 601 / 28.0 / 35.2 / 765 / 35.6 / 44.9 / 441 / 20.5
Adenocarcinoma in situ (formerly BAC) / 338 / 283 / 25 / 7.4 / 8.8 / 33 / 9.8 / 11.7 / 95 / 28.1 / 33.6 / 130 / 38.5 / 45.9 / 55 / 16.3
Carcinoma, NOS / 492 / 396 / 27 / 5.5 / 6.8 / 50 / 10.2 / 12.6 / 133 / 27.0 / 33.6 / 186 / 37.8 / 47.0 / 96 / 19.5
Carcinoid Tumor / 16 / 14 / 3 / 18.8 / 21.4 / 2 / 12.5 / 14.3 / 5 / 31.3 / 35.7 / 4 / 25.0 / 28.6 / 2 / 12.5
Large Cell Carcinoma / 214 / 180 / 13 / 6.1 / 7.2 / 15 / 7.0 / 8.3 / 66 / 30.8 / 36.7 / 86 / 40.2 / 47.8 / 34 / 15.9
Mixed Carcinoma / 123 / 91 / 3 / 2.4 / 3.3 / 14 / 11.4 / 15.4 / 28 / 22.8 / 30.8 / 46 / 37.4 / 50.5 / 32 / 26.0
Non-small Cell Carcinoma / 818 / 643 / 46 / 5.6 / 7.2 / 79 / 9.7 / 12.3 / 231 / 28.2 / 35.9 / 287 / 35.1 / 44.6 / 175 / 21.4
Small Cell Carcinoma / 675 / 539 / 17 / 2.5 / 3.2 / 56 / 8.3 / 10.4 / 190 / 28.1 / 35.3 / 276 / 40.9 / 51.2 / 136 / 20.1
Squamous Carcinoma / 1121 / 867 / 40 / 3.6 / 4.6 / 95 / 8.5 / 11.0 / 283 / 25.2 / 32.6 / 449 / 40.1 / 51.8 / 254 / 22.7
Other CA / 89 / 65 / 5 / 5.6 / 7.7 / 5 / 5.6 / 7.7 / 29 / 32.6 / 44.6 / 26 / 29.2 / 40.0 / 24 / 27.0
All Cases / 6032 / 4783 / 316 / 5.2 / 6.6 / 551 / 9.1 / 11.5 / 1661 / 27.5 / 34.7 / 2255 / 37.4 / 47.1 / 1249 / 20.7
Controls / 2073 / 1538 / 182 / 8.8 / 11.8 / 173 / 8.3 / 11.2 / 556 / 26.8 / 36.2 / 627 / 30.2 / 40.8 / 535 / 25.8
BAC, bronchioloalveolar carcinoma; SHS, second-hand tobacco smoke; unk, unknown
Supplemental Table 4. Odds ratios and 95% confidence intervals for pack-years smoking among AIS (formerly BAC) and non-AISlung cancer cases by race, Bay Area Lung Cancer Study 1998-2003 and Northern California Lung Study 2005-2008
Whites / Non-WhitesModel / AIS / Non-AIS / OR / 95% CI / P-value / AIS / Non-AIS / OR / 95% CI / P-value
214 / 3555 / 66 / 979
Age / 1.01 / 1.00 / 1.02 / 0.1328 / 1.00 / 0.98 / 1.02 / 0.7043
Sex / 0.68 / 0.51 / 0.92 / 0.0117 / 0.92 / 0.51 / 1.66 / 0.7871
Any SHS / 1.08 / 0.66 / 1.78 / 0.7490 / 1.42 / 0.76 / 2.65 / 0.2711
Never smokers / Referent / Referent
Packyear QRT1 / 0.94 / 0.52 / 1.68 / 0.8326 / 0.65 / 0.24 / 1.78 / 0.4034
Packyear QRT2 / 0.76 / 0.47 / 1.23 / 0.2662 / 0.17 / 0.04 / 0.74 / 0.0183
Packyear QRT3 / 0.36 / 0.22 / 0.57 / <0.0001 / 0.567 / 0.25 / 1.28 / 0.1719
Packyear QRT4 / 0.23 / 0.16 / 0.34 / <0.0001 / 0.29 / 0.14 / 0.60 / 0.0008
P for trend / <0.0001 / 0.0008
AIS, Adeocarcinoma in situ; BAC, bronchioloalveolar carcinoma; OR, odds ratio; CI, confidence interval; SHS, second-hand tobacco smoke; QRT, quartile
Supplemental Table 5. Adjusted additive odds ratios and 95% confidence intervals for Adenocarcinoma in situ (formerly BAC) associated with polymorphisms in known lung cancer risk SNPs, Bay Area Lung Cancer Study 1998-2003 and Northern California Lung Study 2005-2008
SNP / All lung cancer / AIS / Adenorsnumber / CHR# / Genotype / ALL cases / AIS / Adeno / Controls / OR / 95% CI / OR / 95% CI / OR / 95% CI
rs2736100 / Chr5p15 / CC / 482 / 42 / 196 / 153
AC / 808 / 81 / 288 / 270
AA / 367 / 21 / 130 / 109 / 1.03 / 0.90, 1.2 / 0.88 / 0.67, 1.1 / 0.95 / 0.81, 1.1
P-value / 0.71 / 0.33 / 0.56
rs402710 / Chr5p15 / GG / 847 / 71 / 319 / 281
AG / 719 / 58 / 259 / 228
AA / 148 / 17 / 58 / 58 / 0.97 / 0.84, 1.1 / 1.05 / 0.80, 1.4 / 0.96 / 0.81, 1.1
P-value / 0.64 / 0.71 / 0.65
rs2256543 / Chr6p / GG / 529 / 51 / 203 / 174
AG / 831 / 71 / 299 / 287
AA / 339 / 21 / 127 / 97 / 1.1 / 0.92, 1.2 / 0.86 / 0.65, 1.1 / 1.0 / 0.88, 1.2
P-value / 0.44 / 0.26 / 0.67
rs4324798 / Chr6p / GG / 1435 / 127 / 543 / 483
AG / 263 / 18 / 91 / 81
AA / 14 / 1 / 1 / 1 / 1.2 / 0.91, 1.5 / 0.92 / 0.55, 1.5 / 1.0 / 0.73, 1.4
P-value / 0.22 / 0.77 / 0.98
rs8034191 / Chr15q25 / GG / 252 / 21 / 96 / 66
AG / 796 / 64 / 291 / 241
AA / 667 / 61 / 247 / 259 / 1.2 / 1.1, 1.4 / 1.2 / 0.89, 1.5 / 1.2 / 1.05, 1.5
P-value / 0.003 / 0.29 / 0.01
rs16969968 / Chr15q25 / GG / 670 / 61 / 250 / 252
AG / 794 / 63 / 291 / 243
AA / 257 / 22 / 95 / 72 / 1.2 / 1.02, 1.4 / 1.1 / 0.86, 1.4 / 1.2 / 0.99, 1.4
P-value / 0.02 / 0.43 / 0.07
AIS, adenocarcinoma in situ, Adeno, adenocarcinoma; BAC, bronchioloalveolar carcinoma; OR, odds ratio; CI, confidence interval; CHR, chromosome; SNP, single nucleotide polymorphism