Aadjusted Analysis by Age, Sex, PSI, and Duration of Mechanical Ventilation;

Suppl. Table 3. The distribution of genotypes among NP patients with sepsis and MOF and in at-risk controls

Genes and genotypes / NP patients without sepsis / Sepsis / P-valuea,b (genetic model)c, OR,
95% CI / NP patients without MOF / MOF / P-value (genetic model), OR,
95% CI
Number (%) / Number (%)
CYP1A1
rs2606345 / n=190 / n=76 / 0.71 (dom)
0.90
0.53-1.55 / n=162 / n=105 / 0.45 (dom)
0.82
0.50-1.36
T/T / 75 (39.5) / 32 (42.1) / 62 (38.3) / 45 (43.3)
T/G / 91 (47.9) / 38 (50.0) / 78 (48.1) / 51 (49.0)
G/G / 24 (12.6) / 6 (7.9) / 22 (13.6) / 9 (7.7)
CYP1A1
rs4646903 / n=187 / n=76 / 0.77 (dom)
0.90
0.47-1.76 / n=161 / n=103 / 0.30 (dom)
0.72
0.38-1.35
T/T / 147 (78.6) / 61 (80.3) / 124 (77.0) / 84 (82.3)
T/C / 40 (21.4) / 14 (18.4) / 37 (23.0) / 18 (17.6)
C/C / 0 (0.0) / 1 (1.3) / 0 (0.0) / 1 (1.0)
CYP1A1
rs1048943 Ile462Val / n=189 / n=76 / 0.54 (dom)
1.36
0.52-3.56 / n=162 / n=103 / 0.60 (dom)
1.28
0.51-3.25
A/A / 176 (93.1) / 69 (90.8) / 151 (93.2) / 94 (91.3)
A/G / 13 (6.9) / 7 (9.2) / 11 (6.8) / 9 (8.7)
G/G / 0 (0.0) / 0 (0.0) / 0 (0.0) / 0 (0.0)
AhR
rs2066853
Arg554Lys / n=186 / n=75 / 0.99 (dom)
1.00
0.51-1.95 / n=160 / n=101 / 0.74 (dom)
1.11
0.60-2.08
G/G / 148 (79.6) / 60 (80.0) / 128 (80.0) / 80 (79.2)
G/A / 37 (19.9) / 14 (18.7) / 31 (19.4) / 20 (19.8)
A/A / 1 (0.5) / 1 (1.3) / 1 (0.6) / 1 (1.0)
ABCB1
rs1045642 Ile1145 = / n=188 / n=76 / 0.14 (rec)
0.56
0.24-1.27 / n=161 / n=103 / 0.17 (rec)
0.60
0.29-1.25
T/T / 65 (34.6) / 25 (32.9) / 53 (32.9) / 37 (35.9)
T/C / 90 (47.9) / 43 (56.6) / 79 (49.1) / 54 (52.4)
C/C / 33 (17.6) / 8 (10.5) / 29 (18.0) / 12 (11.7)
SOD2
rs4880
Ala16Val / n=191 / n=77 / 0.14 (dom)
1.62
0.85-3.11 / n=163 / n=105 / 0.13 (dom)
1.57
0.87-2.83
C/C / 53 (27.8) / 15 (19.5) / 46 (28.2) / 22 (20.9)
T/C / 91 (47.6) / 41 (53.2) / 75 (46.0) / 57 (54.3)
T/T / 47 (24.6) / 21 (27.3) / 42 (25.8) / 26 (25.8)
CAT
rs17880664 / n=185 / n=75 / 0.15 (dom)
1.51
0.86-2.66 / n=159 / n=101 / 0.19 (dom)
1.41
0.84-2.38
T/T / 79 (42.7) / 25 (33.3) / 68 (42.8) / 36 (35.6)
T/A / 82 (44.3) / 42 (56.0) / 71 (44.6) / 53 (52.5)
A/A / 24 (13.0) / 8 (10.7) / 20 (12.6) / 12 (11.9)
GCLC
rs17883901 / n=186 / n=76 / 0.29 (dom)
0.68
0.33-1.42 / n=159 / n=103 / 0.10 (dom)
0.57
0.29-1.13
C/C / 149 (80.1) / 65 (85.5) / 125 (78.6) / 89 (86.4)
C/T / 35 (18.8) / 10 (13.2) / 32 (20.1) / 13 (12.6)
T/T / 2 (1.1) / 1 (1.3) / 2 (1.3) / 1 (1.0)
ACE
rs4340
Alu-287 bp / n=190 / n=76 / 0.39 (rec)
1.31
0.71-2.45 / n=162 / n=104 / 0.33 (dom)
0.76
0.43-1.33
D/D / 50 (26.3) / 20 (26.3) / 39 (24.1) / 31 (29.8)
I/D / 100 (52.6) / 36 (47.4) / 87 (53.7) / 49 (47.1)
I/I / 40 (21.1) / 20 (26.3) / 36 (22.2) / 24 (23.1)
AGT
rs699
Met235Thr / n=188 / n=76 / 0.79 (dom)
0.92
0.51-1.68 / n=161 / n=103 / 0.48 (rec)
0.80
0.44-1.48
T/T / 49 (26.1) / 21 (27.6) / 41 (25.5) / 29 (28.2)
T/C / 97 (51.6) / 38 (50.0) / 82 (50.9) / 53 (51.5)
C/C / 42 (22.3) / 17 (22.4) / 38 (23.6) / 21 (20.4)
AGTR1
rs5186 / n=188 / n=76 / 0.43 (dom)
1.24
0.72-2.13 / n=161 / n=103 / 0.86 (dom)
0.95
0.58-1.58
A/A / 105 (55.9) / 39 (51.3) / 86 (53.4) / 58 (56.3)
A/C / 65 (34.6) / 30 (39.5) / 59 (36.6) / 36 (35.0)
C/C / 18 (9.6) / 7 (9.2) / 16 (9.9) / 9 (8.7)
MTHFR
rs1801133 Ala222Val / n=186 / n=75 / 0.25 (dom)
0.73
0.43-1.25 / n=159 / n=102 / 0.44 (dom)
0.82
0.49-1.36
C/C / 84 (45.2) / 40 (53.3) / 72 (45.3) / 52 (51.0)
C/T / 82 (44.1) / 28 (37.3) / 69 (43.4) / 41 (40.2)
T/T / 20 (10.8) / 7 (9.3) / 18 (11.3) / 9 (8.8)
NOS3
rs1799983 Glu298Asp / n=188 / n=76 / 0.86 (dom)
1.05
0.61-1.79 / n=161 / n=103 / 0.60 (dom)
1.15
0.69-1.89
G/G / 97 (51.6) / 38 (50.0) / 85 (52.8) / 50 (48.5)
G/T / 75 (39.9) / 34 (44.7) / 61 (37.9) / 48 (46.6)
T/T / 16 (8.5) / 4 (5.3) / 15 (9.3) / 5 (4.8)
VEGF-α
rs833061 / n=188 / n=76 / 0.55 (rec)
1.21
0.65-2.23 / n=161 / n=103 / 0.54 (dom)
0.84
0.48-1.47
T/T / 49 (26.1) / 20 (26.3) / 40 (24.8) / 29 (28.2)
C/T / 96 (51.1) / 36 (47.4) / 83 (51.5) / 49 (47.6)
C/C / 43 (22.9) / 20 (26.3) / 38 (23.6) / 25 (24.3)

aAdjusted analysis by age, sex, PSI, and duration of mechanical ventilation;

bGenotypes associated with response in the accordance with OR (protective, if OR<1, susceptible, if OR>1) are highlighted in grey; significant P-values are in bold;

cThe genetic model: rec - recessive, dom - dominant.