SCIENTIFIC PROGRAM
Monday, October 15, 2012
13:00-18:30Registration
18:30-19:00Welcome Notes
19:00-20:00Keynote Lecture: Jonathan Weissman
A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
20:00-22:00Welcome Dinner
Tuesday, October 16, 2012
09:00-11:00Session 1: Translocation and Membrane Targeting
Chair: Peter Walter
09:00Robert Keenan
Tail-anchored Membrane Protein Biogenesis
09:25William Skach
Dynamic Regulation of ER Translocon Structure During Nascent Chain Translocation
09:50StephenHigh
Tail-anchored Membrane Proteins & Ubiquitin: Strange Bedfellows?
10:15Irmgard Sinning
Mechanisms of Protein Insertion by the SRP and GET Systems
10:40Tslil Ast
Uncovering the Cytosolic Chaperoning and Targeting Factors of an SRP Independent Protein Family
11:00-11:30Coffee break
11:30-13:30Session 2: Folding and Misfolding in the ER
Chair: David Ron
11:30Anne Bertolotti
Surviving Proteasome Inhibition
11:55Maurizio Molinari
ERAD Tuning: Setting The Luminal Concentration Of ERAD Factors By Regulating Their Segregation and Turnover
Tuesday, October 16, 2012 ( Continued)
12:20Ineke Braakman
Protein Folding In The ER
12:45Johannes Buchner
Chaperone-Assisted Quality Control And Secretion Of Antibodies
13:10Karin Romisch
Identification Of New Mutants In The Sec Complex Affecting ERAD
13:30-15:00Lunch
15:00-17:00Poster Session (Posters 1-35)
17:00-19:00 Session 3: Post-translational Modifications
Chair: Maya Schuldiner
17:00Chiara Zurzolo
GPI-Anchored Proteins Sorting To The Apical Surface Of Polarized Epithelial Cells Drives Their Clustered Organization And Their Functional State
17:25Sabine Strahl
Interplay of Protein O-Mannosylation and N-Glycosylation at the Yeast Endoplasmic Reticulum
17:50Gert Bolt
Intracellular Processing and Secretion of Coagulation Factor VII
18:15Lars Ellgaard
Effects Of Manipulating Pathways For Disulfide-Bond Formation In The Mammalian ER
18:40Asvin Lakkaraju
Unconventional Role Of Calnexin In The Control Of Apoptosis
19:00-20:30Dinner
20:30-onwardsPoster Session (Posters 1-35)
Wednesday, October 17, 2012
09:00-11:00 Session 4: ER Stress Responses I
Chair: David Ron
09:00Davis Ng
A Composite Stress Response Buffers Lipid Disequilibrium By Remodeling The Protein Homeostasis Network
09:25Ala Trusina
How Does ER Adapt To Rapidly Fluctuating Stresses: Quantitative Modeling Approach
09:50Federica Brandizzi
Unfolded Protein Response In The Model Species Arabidopsis Thaliana
10:15Eelco Van Anken
Selective Engagement Of ER Stress Sensors By Antibody Subunit
10:40Carmela Sidrauski
Inhibitor Of The PERK Branch Of The Unfolded Protein Response Makes Cells Insensitive To The Effects Of eIF2α Phosphorylation
11:00-11:30Coffee break
11:30-13:00Session 5: ER stress responses II/Contact Sites
Chair: Peter Walter
11:30Kenji Kohno
Ribosomal Stalling Promotes XBP1u mRNA Splicing upon ER Stress
11:55Menachem Rubinstein
C/EBPbeta Attenuates ER Stress-Triggered Cell Death By Inducing Microsomal Glutathione S Transferase 1 (MGST1)
12:10Adabella van der Zand
The ER as a Platform for Peroxisome Biogenesis
12:35Gia Voeltz
Role Of ER Structure And Dynamics At Organelle Contact Sites
13:00-14:00Lunch
13:00Tour to Dali museum (With Packed Lunch)
14:00Tour to vineyard/ Golf activity
Wednesday, October 17, 2012 (Continued)
17:00-19:00Session 6: Trafficking I
Chair: Blanche Schwappach
17:00Randy Schekman
Autophagic Lipidation Of LC3 Organized On An Isolated ERGIC-Enriched Membrane Fraction
17:25Frederick Hughson
Multisubunit Machines In Intracellular Trafficking
17:50Koret Hirschberg
How To Enter ER Exit Sites?
18:15Christoph Kaether
A Microscope-Based High-Throughput Screen Identifies Novel Compounds Interfering With Notch Trafficking/Processing
18:40Colin Adrain
Role of iRhoms in the Early Secretory Pathway
19:00-20:30Dinner
20:30-onwardsPoster Session (Posters 36-70)
Thursday, October 18, 2012
09:00-11:00Session 7: Trafficking II
Chair: Blanche Schwappach
09:00-Paul Lehner
Identifying Novel ERAD Ubiquitin E3 Ligases In The Regulation Of MHC Class I Molecules
09:25Elizabeth Conibear
Regulating The Intracellular Retention Of Chs3 At The ER And Golgi
09:50Liz Miller
Membrane Rigidity, Vesicle Formation And The Protein Quality Control Checkpoint
10:15Chris Hawes
Pull It, Stretch It: In Vivo Manipulation Of Plant ER With Laser Tweezers
10:40Boaz Tirosh
Functional Overlap Between The mTor And The Unfolded Protein Response In Promoting Protein Secretion
11:00-11:30Coffee break
Thursday, October 18, 2012 (Continued)
11:30-13:30Session 8: Ion Homeostasis
Chair: Blanche Schwappach
11:30Karin Schumacher
The V-ATPase - Assembly, Quality Control And ER-Export
11:55Richard Lewis
Mechanisms Of Calcium Trafficking At ER-Plasma Membrane Contact Sites
12:20Ingo Greger
AMPA Receptor Subunit Assembly – Rules And Regulators
12:55Roberto Sitia
Redox Signaling In The Early Secretory Compartment: Generation And Transport Of Hydrogen Peroxide Across Membranes
13:20Christian Appenzeller-Herzog
Endoplasmic Reticulum: Reduced And Oxidized Glutathione Revisited
13:30-15:00Lunch Break
15:00-18:00Poster Session (Posters 36-71)
18:00-19:30Special Session with Antibodypedia
Improving antibody annotation
20:00 - Onwards Banquet
Friday, October 19, 2012
09:00-11:00Session 9: ER in Development and Disease
Chair: David Ron
09:00Hyung Don Ryoo
Regulators Of Mutant Rhodopsin-Associated Toxicity
09:25Lisa Swanton
Torsina And The Molecular Basis Of Torsion Dystonia
09:50Gareth Lavery
Hexose-6-Phoshate Dehydrogenase And The Sarcoplasmic Reticulum
In Skeletal Muscle Homeostasis
10:15Marius Lemberg
Sampling The Membrane: Function Of Intramembrane Proteases In ER Protein Homeostasis
Friday, October 19, 2012(Continued)
10:40Maurizio D’antonio
Modulation Of ER Homeostasis As A Therapeutic Target In CMT Hereditary Neuropathies
11:00-11:30Coffee break
11:30-13:00 Session 10: Lipid Biosynthesis
Chair: Maya Schuldiner
11:30Eva Herker
Diacylglycerol Acyltransferase 1 Acts As A Host Factor For Hepatitis C Virus Replication
11:55Günther Daum
Endoplasmic Reticulum And Lipid Droplets Of The Yeast Interact During Synthesis, Storage And Mobilization Of Non-Polar Lipids
12:20Robert Farese
The ER And Lipid Droplets
12:45Romain Volmer
Endoplasmic Reticulum Lipid Bilayer Acyl Chain Saturation Directly Tunes The Unfolded Protein Response
13:00-13:45Closing Lecture: Howard Riezman
Systematic Lipidomic Analysis of Yeast Mutants Reveals Novel Regulation of Lipid Homeostasis
13:45Lunch and Departure